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Article
The Value of Stroboscopic Examination in the Diagnosis of Hoarseness

Author: Ahmed M. Rasheed
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 1 Pages: 11-14
Publisher: Baghdad University جامعة بغداد

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Abstract

Summary:
Background:
In modem laryngological practice laryngovideostroscopic examination is an important
step for correct diagnosis of vocal cord lesions.
Aims:
To asses the role of laryngovideostroboscopy as a clinical tool in evaluation of hoarse
patients.
Patients and Methods:
Stroboscopic examinations were carried out on 43 patients presented with hoarseness at
the ENT department at Al- Kadhimya Teaching Hospital during the period from “January
2006 to October 2006".
Results:
Stroboscopic examination contributed significant diagnostic information, it changed
the diagnosis made by nonstroboscopic means in 8 cases (19%), this resulted in avoidance
of surgery in 4 cases and 4 cases referred to surgery instead of medical therapy.
Conclusion:
Laryngovideostroboscopy is a useful clinical tool in modem laryngoloical practice so as
to alter the diagnosis and management plan which may result in avoidance of unnecessary
surgical and /or medical-therapies.

Keywords

Larynx --- Stroboscopy.


Article
A REPORT OF A NEW SYNDROME OF LOW LARYNX WITH BAT EARS

Authors: Salam N Asfar --- Husham A Barrak --- Zuhair F Fathalah
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2006 Volume: 12 Issue: 1 Pages: 93
Publisher: Basrah University جامعة البصرة

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Abstract

IntroductionUp to our knowledge, this is the first case of a syndrome of unusually low placed larynx with Bat ears. There are no similar case records in the literature.Congenital laryngeal anomalies are rarely seen in daily practice, these are; laryngomalacia (60%), vocal cord paralysis (20%), subglottic stenosis (15%), and subglottic heamangioma (15%). Other malformations including laryngeal heamangioma, web, cyst and neuromuscular anomalies are very rare1.UAt birth the larynx is located high in the neck between the C1 and C4 vertebrae, allowing concurrent breathing, vocalization and deglutition. By the age of 2 years, the larynx descends inferiorly and bye the age of 6 years it reaches the adult position between C4 and C7 vertebrae. The new position provides greater range of phonation (because of the wider supraglottic pharynx) at the expense of losing this separation of function, ie, deglution and breathing2-4.The auricle developed from a series of six tubercles which form around the margins of the first and second visceral cleft. The laryngeal cartilages developed from the fourth and fifth visceral arches. The trachea is formed by the cranial end of the tracheobronchial tube from the ventral wall of the primitive pharynx during the third week of the fetal life5.Bas J Surg, March, 12, 2006

Keywords

NEW SYNDROME --- LOW LARYNX --- BAT EARS


Article
Validety of total laryngectomy

Author: Dr.Thamir M. Al-rubeai , FICMS (ENT) Dr. Hani M. Bader FICMS , CABMS. (ENT)
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 1 Pages: 145-148
Publisher: Baghdad University جامعة بغداد

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Abstract

BackgroundCarcinoma of the larynx represent 10% of head & neck malignancies. The treatment of advanced carcinoma of larynx may include partial or total laryngectomy, with or without laser , radiotherapy,and or chemotherapy . Carcinoma of the larynx usually affect old age , heavy smoker with possible risk of pulmonary diseases & ischemic heart disease , which add risk to the general anaesthetic complication operative & postoperative - Objectives this study was designed to assess the feasibility of total laryngectomy under local anaesthesia in medically unfit patients for general anaesthesia & to re-establish practice doing total laryngectomy under local anaesthesia in those patients.Methods a prospective study on 12 patients who underwent total laryngectomy under local anaesthesia in the otolaryngology department at Al-Jirahat hospital over a period from September 2007 to the end of July 2010.Results all patients tolerated the surgical procedure under local anaesthesia without disturbing the general condition of the patient, or the technique of surgery , with good postoperative recovery & early mobility of patient .Conclusion total laryngectomy can be done under local anaesthesia in case the patient is medically not fit for general anaesthesia , & in some other selected cases .Key words total laryngectomy, carcinoma , larynx, local anaesthesia


Article
Validety of total laryngectomy Under local anaesthesia

Author: Dr.Thamir M. Al-rubeai , FICMS (ENT) Dr. Hani M. Bader FICMS , CABMS. (ENT) Dr. Samar F. Ali FICMS , CABMS (ENT
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 2 Pages: 147-150
Publisher: Baghdad University جامعة بغداد

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Abstract

BackgroundCarcinoma of the larynx represent 10% of head & neck malignancies. The treatment of advanced carcinoma of larynx may include partial or total laryngectomy, with or without laser , radiotherapy,and or chemotherapy . Carcinoma of the larynx usually affect old age , heavy smoker with possible risk of pulmonary diseases & ischemic heart disease , which add risk to the general anaesthetic complication operative & postoperative - Objectives this study was designed to assess the feasibility of total laryngectomy under local anaesthesia in medically unfit patients for general anaesthesia & to re-establish practice doing total laryngectomy under local anaesthesia in those patients.Methods a prospective study on 12 patients who underwent total laryngectomy under local anaesthesia in the otolaryngology department at Al-Jirahat hospital over a period from September 2007 to the end of July 2010.Results all patients tolerated the surgical procedure under local anaesthesia without disturbing the general condition of the patient, or the technique of surgery , with good postoperative recovery & early mobility of patient .Conclusion total laryngectomy can be done under local anaesthesia in case the patient is medically not fit for general anaesthesia , & in some other selected cases .Key words total laryngectomy, carcinoma , larynx, local anaesthesia .


Article
Anatomical Study of the Larynx In Indigenous Male Turkey (Meleagris gallopava)
دراسة تشريحية للحنجرة في ذكور الديك الرومي المحلي

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Abstract

The study aim to explain the anatomical description of the larynx in the indigenous male turkey (Meleagris gallopava). For making use as a basic information in the study of the respiratory physiology, histopathology, the respiratory diseases diagnosis, and surgery and anesthesia of turkey. Five healthy birds (first year of age and weighing (4715 ± 43.3 gm)) employed in this study. After well bleeding, the larynx detected, and then the shape, position, dimensions of each specimen and its components were recorded. The larynx appeared as a heart-shaped mound in the caudal part of the oropharyngeal cavity. It consisted of a single hyaline cricoid cartilage which consisted of body and left and right wings, double hyaline arytenoid cartilages which consisting of body and rostral and caudal processes, and single hyaline procricoid cartilage which consisted of body dorsally and tail ventrally. Also there were superficial and deep intrinsic and rostral, caudolateral, and caudomedial extrinsic laryngeal skeletal muscles.

الهدف من الدراسة هي لتوضيح الوصف التشريحي للحنجرة في الديك الرومي المربى محليا (Meleagris gallopava ). للاستفادة منها في دراسة فسلجة التنفس وتشخيص الأمراض النسجية للأمراض التنفسية وفي الجراحة والتخدير في الديك الرومي. استخدم في هذه الدراسة خمسة طيور سليمه بعمر سنة واحدة و وزن( 43.3 gm± (4715 بعد النزف الكامل شخصت الحنجرة , ثم سجلت الشكل والمواقع وأبعاد كل عينة ومكوناته. ظهرت الحنجرة على هيئة تل قلبي في الجزء الخلفي للتجويف ألبلعومي الفموي. تتكون من الغضروف الزجاجي الحلقي المفرد الذي يتكون من الجسم والجناحين الأيسر والأيمن والغضروف الزجاجي ألطرجهاري المزدوج الذي يتألف من الجسم والبروزين الأمامي والخلفي والغضروف الزجاجي الدرقي المفرد الذي يتكون من الجسم ظهريا والذنب بطنيا. أيضا توجد العضلات الحنجرية الهيكلية الداخلية السطحية والغائرة والخارجية الأمامية و الخلفية وحشية و الخلفية ألإنسية.


Article
9.EVALUATION OF PHOSPHO-AKT IMMUNOHISTOCHEMICAL EXPRESSION IN PATIENTS WITH LARYNGEAL SQUAMOUS CELL CARCINOMA

Authors: Nisreen S. Wanas نسرين شريف وناس --- , Luma Y. Mehdi --- Liqa K.A. Alzubaidi
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2018 Volume: 16 Issue: 2 Pages: 177-181
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background: Akt, is a serine/threonine protein kinase which act as an important regulator of cell proliferation and survival. The Akt complex is upregulated by phosphorylation producing phospho-Akt, which trigger a continued cell proliferation and survival and inhibit apoptosis, thereby promote cell survival.Objective: To evaluate the immunohistochemical expression of phosphorylated Akt (Phospho-Akt) in laryngeal squamous cell carcinoma (SCC) and to be correlated with different clinicopathological parameters.Methods: Phospho-Akt expression was investigated Immunohistochemically in 49 formalin-fixed paraffin embedded laryngeal SCC tissue sections collected from Teaching laboratories - Baghdad Medical City.Results: Phospho-Akt positive immunostaining appears in 57% of samples. Akt activation present in advanced stages of tumors with p value 0.02.Conclusion: The current findings may provide evidence that aberrant expression of Akt contributes to the pathogenesis (mechanism of disease development) of laryngeal SCC.Keywords: Akt, phospho-Akt, immunohistochemistry, laryngeal SCC, larynxCitation: Wanas NS, Mehdi LY, Alzubaidi LKA. Evaluation of phospho-AKt immunohistochemical expression in patients with laryngeal squamous cell carcinoma. Iraqi JMS. 2018; 16(2): 177-181. doi: 10.22578/IJMS.16.2.9


Article
The role of Laminin111 and Matrix metalloproteinase-2 Immunohistochemistry Expression in Prediction of Laryngeal Squamous Cell Carcinoma Prognosis
دور Laminin111 و Matrix metalloproteinase-2 التعبير المناعي في التنبؤ بتشخيص سرطان الحنجرة الحرشفية

Authors: Aws Rassul Hussain Al-Salih اوس رسول حسين --- Thair Wali Ali ثائر والي علي --- Ali Hassan Ali Murad علي حسن مراد
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2017 Volume: 13 Issue: 23 Pages: 141-149
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Objective: To investigate the role of laminin111 (LAM111) and matrix metalloproteinase-2 (MMP2) as a prognostic predictors in laryngeal squamous cell carcinoma (LSCC). Materials and Methods: The study was carried out on 30 patients with LSCC treated at the ENT Department, Al-Diwaniya Hospital in Al-Qadisiya province- Iraq. The clinical and histological data consisted of sex, age, site, clinical presentation, stage of the tumor, lymph node (LN) metastasis, and immunohistochemical studies (IHC). The IHC study was performed using anti LAM111and anti MMP2 monoclonal antibodies. Results: The majority of patients were above 50 years (73.33%), male affected more than the female with male to female ratio 2.8:1, 50% of tumors were located in glottic region, (86.67%) presented as mass. Most of the tumors were classified as well differentiated LSCC (53.33%), (76.67%) were recorded as negative LN metastasis, and 14 (46.67%) patients were in disease stage II. LAM111showed significant positive correlation with LN metastasis (P=0.027) and tumor stage (P=0.018), while MMP2 revealed significant positive correlation only with LN metastasis (P=0.029). There was a significant positive correlation between LAM111and MMP2 (P=0.014). Conclusion: Both LAM111 and MMP2 are poor prognostic markers for LSCC and predict LN metastasis.

الهدف: التحقيق في دور laminin111 (LAM111) والمصفوفة metalloproteinase-2 (MMP2) بمثابة تنبؤات النذير في سرطان الخلايا الحرشفية الحنجرة (LSCC). المواد والطرق: أجريت هذه الدراسة على 30 مريضاً مصابين بـ LSCC عولجوا في قسم الأنف والأذن والحنجرة ، مستشفى الديوانية في محافظة القادسية - العراق. تتألف البيانات السريرية والنسيجية من الجنس والعمر والموقع ، والعرض السريري ، مرحلة الورم ، ورم العقدة الليمفاوية (LN) ، والدراسات الكيميائية المناعية (IHC). تم إجراء دراسة IHC باستخدام الأجسام المضادة أحادية النسيلة المضادة لـ LAM111 و MMP2. النتائج: كانت غالبية المرضى فوق 50 عامًا (73.33٪) ، وكان الذكور يتأثرون أكثر من الإناث مع نسبة الذكور إلى الإناث 2.8: 1 ، وكانت 50٪ من الأورام موجودة في المنطقة الخلوية ، (86.67٪) تم تقديمها ككتلة. تم تصنيف معظم الأورام كما LSCC متباينة بشكل جيد (53.33 ٪) ، (76.67 ٪) تم تسجيلها كما ورم خبيث سلبي LN ، و 14 (46.67 ٪) من المرضى كانوا في المرحلة الثانية من المرض. أظهر LAM111 علاقة إيجابية كبيرة مع ورم خبيث LN (P = 0.027) ومرحلة الورم (P = 0.018) ، في حين كشف MMP2 عن وجود علاقة إيجابية مهمة فقط مع ورم خبيث LN (P = 0.029). كان هناك ارتباط إيجابي كبير بين LAM111 و MMP2 (P = 0.014). الخلاصة: كلا LAM111 و MMP2 هما علامات نذير ضعيفة لـ LSCC ويتوقعان ورم خبيث LN.


Article
Diode laser microsurgery; a recent treatment for laryngeal cancer: Mosul experience

Author: Daoud S. Allos داود الوس
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 2 Pages: 57-61
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: To evaluate the results of treating laryngeal squamous cell carcinoma using diode laser.
Design: Prospective study.
Setting: Department of ENT-Al Jamhuri Teaching Hospital.
Patients and Methods: Thirty one cases of squamous cell carcinoma of the larynx with age range between 32-66 years. The stage of tumour was Tis: 3, T1: 12, T2:14, & T3:2 cases . Lesions were excised or evaporated using diode laser with safety margin and followed for at least 36 months to evaluate cure rate, recurrences and its relation to site and stage of tumour, need for tracheostomy, complications and quality of voice.
Results: Diode laser was highly effective in treating early laryngeal cancer.Cure rates after 36 month follow up were 100%, 92% & 78% for Tis, T1 & T2 respectively. For more advanced lesions (T3) , the role of laser was limited only for debulking to avoid tracheostomy or biopsy taking in deep seated tumours as alternative to open biopsy. No major intraoperative or postoperative complications happened and no tracheostomy needed. Patients were discharged after twenty four hours. Voice quality was good after surgery in most cases.
Conclusion: Diode laser is safe in treating squamous cell carcinoma of the larynx and highly effective in early stages (Tis, T1, T2) and can avoid tracheostomy or open biopsy in more advanced lesions.

Key words: Diode laser, squamous cell carcinoma of the larynx.


Article
Clinical and pathological staging of primary carcinoma of the larynx
تقييم علامات الاضطرابات المناعية والايضية عند مرضى السكري أيجابي الاجسام المضادة لخلايا الجزر

Author: Musaid H. Hamza Al-badri مساعد لفته حمزه البدري
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2012 Volume: 54 Issue: 1 Pages: 10-14
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Staging of primary carcinoma of the larynx play an important role in surgical management of the disease .This staging depends on the clinical finding and radiological examination , supported by pathological assessment of the excised tumorObjectives: To evaluate the accuracy of clinical and radiological staging Patients’ and methods: Forty-two patients with laryngeal carcinoma were admitted to the ENT Department during the period from June 2009 through October 2010. Each patient was staged by clinical exami¬nation and computed tomography. Evaluation of the results compared to the final diagnosis of staging , based on the pathological staging of specimens of patients who underwent total laryngectomy and the highest T stage was obtained from clinical and CT staging for patients with early laryngeal carcinoma(T1-T2) . Results: The clinical staging of laryngeal carcinoma showed: high accuracy in staging was on glottic tumours (83.3%), especially T1 glottic tumours (100%),(small and superficial lesions), and lower accuracy in staging of supraglottic and transglottic tumors (61.9%) , (55.6% ) respectively.Underestimation of all tumors was 31.4% .The CT staging of laryngeal carcinoma showed: very high accuracy in staging transglottic and supraglottic tumours (100%), (85.7%) respectively in comparison to clinical staging and lower accuracy (75%) in staging glottic tumours.Underestimation of all tumours was 11.5 % of cases (especially small and superficial lesions). Conclusions: High accuracy rate based on clinical examination was found in glottic carcinoma and high accuracy rate based on radiological examination was found in supraglottic carcinoma.Clinical exami¬nation and CT scan are complementary for sraging of carcinoma of larynx .

الخلفية: التصلب اللويحي واحد من الاضطرابات العصبية الواسع الانتشار بشكل متزايد. هناك دراسات للعوامل الوبائية والأسرية وتأثير العوامل الوراثية والبيئية في تحديد قابلية الاصابة بالمرض. هذه التاثيرات تم التحقق منها بدقة في دراستنا. الأهداف: الهدف من هذه الدراسة مقارنة الخصائص الديموغرافية، والاعراض السريرية، ومسار المرض بين الحالات ذات التاريخ الأسري والمتفرقة من المرض. المواد والطرق: هذه المجموعة من المرضى وبأثر رجعي درست في "مركز التصلب" في مدينة الطب في بغداد. تم مسح سجلات المركز في "مستشفى بغداد التعليمي"، وقد تم تحليل البيانات ل 13 مريضا لهم تاريخ أسري إيجابي من المرض. النتائج: فيما يتعلق بالاعراض السريرية لمن لديهم تاريخ عائلي من المرض , فأن أكثر الاعراض شيوعا هي الأعراض الحسية وأعتلال الحبل الشوكي، اما المرضى بدون تاريخ عائلي فان الاعراض الهرمية هي الاكثر شيوعا، لمن لديهم تاريخ عائلي للمرض 11 كان المسار المرضي هو الانتكاسة والتخفيف، و 4 مرضى للتدريجي الثانوي و 2 للتدريجي الأساسي لكن لذوي التاريخ العائلي السلبي 12 مريض كانو من الانتكاسة والتخفيف ، خمسة مرضى للتدريجي الثانوي وكان مريض واحد من النوع التدريجي الأساسي. لا اختلاف كبير في معالم التحقيق، باستثناء العلاقة العكسية بين سن البداية وتأخر وقت التشخيص.الاستنتاج: التاريخ الأسري ليس له تأثير كبير واختلاف من حيث الأنماط الديمغرافية والمسارات السريرية والاعراض الاولية. استثناءا هناك فرق بالنسبة للعلاقة بين سن المرض وقت بداية وتأخير للتشخيص.


Article
Morphological study of the Larynx of the indigenous adult Male Pigeon (Columba domestica)
دراسة شكلية لحنجرة ذكور الحمام البالغة المحلية Columba domestica

Author: H. K. N. AL-Mhanna حازم كريم ناصر المحنة
Journal: Al-Qadisiyah Journal of Veterinary Medicine Sciences مجلة القادسية لعلوم الطب البيطري ISSN: 18185746 23134429 Year: 2013 Volume: 12 Issue: 1 Pages: 52-59
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

Formalistic study elucidate that the larynx in the fourteen healthy indigenous male pigeons (Columba domestica) for benefit in the study of the respiratory physiology, histopathology, and the respiratory diseases analyzes. After bird's preparation, the larynx detected, and then the shape, position and its components studied in details.The larynx emerges in the caudal part of the oropharyngeal cavity as a heart-shaped cartilaginous mass. It composed of a single hyaline cricoid cartilage which consisted of body and left and right wings, double hyaline arytenoid cartilages which consisting of body and rostral and caudal processes, and single hyaline procricoid cartilage which consisted of body dorsally and curved tail caudoventrally. These cartilaginous components surrounded by laryngeal skeletal muscles intrinsic (superficial and deep) and extrinsic (rostral, caudolateral, and caudomedial).

وضحت الدراسات الشكلية للحنجرة لأربعة عشر من ذكور الحمام البالغ المحلي (Columba domestica) للاستفادة منها في دراسة فسلجة التنفس والأمراض النسجية وتحليلات الأمراض التنفسية. بعد تحضير الطيور شخصت الحنجرة ودرس بالتفصيل شكلها وموقعها ومكوناتها.برزت الحنجرة في الجزء الخلفي للتجويف الفموي ألبلعومي على هيئة كتلة غضروفية قلبية الشكل وتتكون من الغضروف الحلقي المفرد الذي يتكون من الجسم والجناحين الأيسر والأيمن والغضروف ألطرجهاري المزدوج الذي يتألف من الجسم والبروزين الأمامي والخلفي والغضروف الدرقي المفرد الذي يتكون من الجسم ظهريا والذنب المقوس خلفيا ظهريا. هذه المكونات الغضروفية للحنجرة محاطة بالعضلات الهيكلية الحنجرية الداخلية (السطحية والغائرة) والخارجية (الأمامية والخلفية الوحشية والخلفية الأنيسة).

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