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Article
Lipid Profile and Menopausal Status

Authors: Ahlam Disher --- Lamia M. Al - Naama --- Fouad Hamad Al - Dahhan
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 8-12
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Dyslipidemia is a major cause of cardiovascular disease, which in turn, is the most common cause of female morbidity and mortality. Postmenopausal women (natural and surgical) are at higher risk of developing cardiovascular disease, especially coronary artery atherosclerosis.
Objective: To observe the relationship between blood lipids: total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C), triglycerides (TGs), and very low density lipoprotein- cholesterol (VLDL-C), LDL-C/ HDL-C ratio (atherogenic index) and menopausal status, and to determine the co-factors that may explain this relationship
Methods: A prospective, cross-sectional study, which includes 279 women, age range from 35-55 years agreed to participate in this study. They were divided into 4 groups according to their menopausal status. These were pre-, peri post- natural and surgical post- menopausal. Data were collected from participants in a pre-coded questionnaire and an overnight fasting blood sample was collected for biochemical analysis.
Results: Postmenopausal women had higher levels of lipids than pre or peri-menopausal. TC concentration and LDL-cholesterol levels were higher in natural and surgical menopause than in pre and pri-menopausal women (p<0.01 and p<0.05 respectively). While LDL/HDL-C ratio (atherogenic index) were higher in the surgical postmenopausal women than in pre-menopausal group (p<0.05). No significant inter-group differences were found in HDL-C. Triglycerides, and VLDL levels were higher in surgical menopause group than in both pre- and peri-menopause groups (p<0.05). No significant differences were demonstrated in pre-, peri-, and natural menopausal women with regard to triglyceride and VLDL levels and LDL/HDL-C ratio.
Conclusion: Dyslipidemia is more frequent among women with natural and surgical menopause groups than in the other groups. This makes those women more susceptible to CVD. Certain co factors appear to have direct associations with lipid levels in each group and those were discussed.
KeyWords: Menapause, Lipid profile

Keywords

menapause --- lipid profile


Article
Effect of amlodipine on serum lipid profilein hypertensive patients

Authors: Rami M. A. Al-Hayali رامي محمد عادل الحيالي --- Ashraf H. Ahmed اشرف هاشم احمد
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2009 Volume: 35 Issue: 1 Pages: 8-12
Publisher: Mosul University جامعة الموصل

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Abstract

ABSTRACT
Objectives: To assess the effect of amlodipine, as monotherapy, in hypertensive patients, on serum lipid profile, as assessed by serum cholesterol, serum triglyceride, high density lipoprotein cholesterol (HDLC), and low density lipoprotein cholesterol (LDLC).
Subjects and methods: Thirty three hypertensive patients were included in the study, 25 of them were males and 8 were females. Serum cholesterol, triglyceride, HDLC and LDLC were measured before and after 2 months of starting treatment with amlodipine.
Results: No significant difference could be found between the pre and post treatment levels of all measured parameters.
Conclusion: Treatment with amlodipine does not produce deleterious effect on lipid profile, so it may be a suitable therapy in a hypertensive patient with underlying hyperlipidaemia.

الخلاصةأهداف البحث: أجريت هذه الدراسة لتقييم تأثير عقار الاملودبين كعلاج أحادي لمرضى ارتفاع ضغط الدم الشرياني على مستوى الكولسترول، الدهون الثلاثية، البروتين الشحمي عالي الكثافة، والبروتين الشحمي منخفض الكثافة. المشاركون وطرق العمل: أجريت الدراسة على 33 مريضا مصابا بارتفاع ضغط الدم الشرياني، 25 مريضا منهم من الذكور و 8 من الإناث. تم قياس مستوى الكولسترول، الدهون الثلاثية، البروتين الشحمي عالي الكثافة، والبروتين الشحمي منخفض الكثافة قبل وبعد شهرين من بدء العلاج بعقار الاملودبين.النتائــــج: أظهرت نتائج الدراسة عدم وجود فرق معنوي في مستوى القيم المقاسة قبل وبعد العلاج.الاستنتاج: العلاج بواسطة عقار الاملودبين لايؤثر على مستوى الدهون في الدم وقد يكون علاجا مناسبا لمرضى ارتفاع ضغط الدم اللذين يعانون من اضطرابات في مستوى الدهون.


Article
Study of Lipid Profile in Patients with Uterine Fibroid

Author: Lilyan W. Sersam
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 2 Pages: 274-279
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Leiomyomas are the most common gynaecological neoplasms. Despite the major public health impact of leiomyomas, little is known about their cause. As fibroids are hormone-dependent tumours and their development can be promoted by estrogens, an inverse association between hypercholesterolemia and fibroids should be observed as well as direct association between high-density lipoprotein cholesterol (HDL-C) levels and the presence of fibroids.OBJECTIVE:To investigate the lipid profile in patients with uterine fibroids and to compare it with the lipid profile of women without fibroids.METHODS:A case-control study was conducted in the Department of Obstetrics and Gynaecology at Al-Yarmouk Teaching Hospital during the period from May 2008 to May 2009. Participants were one-hundred twenty pre-menopausal women aged between 18 and 45 years who were recruited during their visit to the gynaecological outpatient clinic and were not taking hormonal therapy. Cases consisted of 60 women with uterine fibroids, and controls were 60 women visiting the same gynaecological outpatient clinic for routine reasons. Thorough history and examination was done for each participant. Body Mass Index (BMI) was measured in kg/m2. All patients underwent a baseline ultrasound examination and classified into two groups according to the presence or absence of uterine fibroids. All women where scheduled to undergo blood test at the beginning (2nd -5th day) of their next menstrual cycle. Fasting venous blood glucose and lipid profile were determined in blood samples taken for each patient. Atherogenic index was also calculated.RESULTS:Women with uterine fibroids were found to have significantly higher levels of serum HDL-C compared to the controls (P=0.0001). A significantly lower levels of total serum cholesterol, low-density lipoprotein cholesterol (LDL-C) were also found in women with uterine fibroids compared to the controls (P=0.0001). Atherogenic index was significantly lower in fibroid group compared with controls (P=0.0001). There was a significant positive correlation between largest fibroid volume and HDL-C level (P<0.0001).CONCLUSION:Women with uterine fibroid have lower atherogenic index compared to women without uterine fibroid. Larger volume of fibroid is associated with higher level of HDL-C.


Article
The Effect of Obesity on Serum Leptin and Lipid Profile

Author: Kismat Mohammad Turki
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 1 Pages: 27-32
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Obesity has become a leading health concern; this condition is a chronic, complex, multifactorial disease in which a person's weight is ≥ 20% of the ideal weight for a given height.OBJECTIVE:To measure serum leptin level and lipid profiles levels in Iraqi obese individuals comparing the results with matching non obese subjects.METHODS:The study was carried on 30 individuals divided into two groups:1. Obese subjects group (n=20).2. Non-obese subjects group (n=10).For all subjects studied measurements of fasting serum leptin and lipid profile have been done.RESULT:Our study showed that mean serum leptin level was significantly higher in obese than non-obese individuals (P<0.001). In addition serum leptin correlates positively and strongly with body mass index (BMI) ( r=0.765,P<0.01). Serum leptin also correlates positively with both triglyceride (TC)(r =0.394, P<0.05) and low density lipoprotein (LDL) (r=0.366,P<0.05) but correlates negatively with high density lipoprotein (HDL)(r=-0.408,P<0.05).CONCLUSION:circulating leptin levels appear to be one of the best biological markers of obesity and hyperleptinemia is closely associated with several risk factors related to obesity syndrome.

Keywords

obesity --- leptin --- lipid profile.


Article
Effect of Nigella Sativa (Black seed) on the serum lipids of healthy individuals

Authors: Nazar M. Qibi --- Rami M. A. Al-Hayali --- Hazim A. Mohammad
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2006 Volume: 6 Issue: 2 Pages: 10-15
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Black seed (Nigella Sativa) is a common dietary element and has bean traditionally used as a treatment for a variety of health complains over centuries. Dyslipidaemia is an important and common medical problem.Objective: To assess the effect of N. sativa on the serum lipids of normal individuals.Design: Prospective study.Setting: Domain of the College of Medicine and IbnSina Teaching Hospital.Patients and methods: 10 healthy volunteers (8 males and 2 females) received 750 mg of powdered grains of Nigella sativa enclosed in a capsule twice daily for 28 days. Their fasting lipid profile, including triglycerides, total, LDL and HDL cholesterol were measured, before and after treatment.Results: Serum triglycerides, total and LDL cholesterol decreased significantly after treatment with Nigella sativa, P. value <0.0001. While HDL cholesterol increased significantly, P. value <0.0001.Conclusion: N. sativa exerts a favorable effect on lipid profile of healthy individual.


Article
Dill Effected on lipid profile of mice
تأثير الشبنت على مرتسم الدهون في الفئران

Authors: Suhad A. Ahmed --- Abbas A. Mohammed --- Sallal A. Abdullah --- Ali H. Saadoon
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2013 Volume: 31 Issue: 4 Part (B) Scientific Pages: 431-435
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

The present study was carried out to determine the effect of methanol extract of Anethumgraveolens(Dill) on serum lipoproteins in hypercholesterolaemic mice.A total of 24 male mice (average 25gm body weight) were used in this study. Mice were divided into four groups was injected with 100mg/kg ofalloxan to induce hyperglycemic in mice, the first group (1) was used as control (+ve) group (6 mice) which fed on basal diet only and the other three groups fed on basal diet containing 0.5, 1 and 2mg/ml of methanol extract (single daily dose of 1 ml). The experimental feeding period was 21 days.The changes in serum triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-C) and low density lipoprotein-cholesterol (LDL-C) were measured by using enzymatic kits.However, the HDL-Cconcentrate decreased relative to control mice. Treatment of hyperlipidaemic mice with dill extract in concentration 1 and 2mg/ml up to 21 days reversed the serum lipid levels compared to mice which were fed basal diet only.

الدراسة الحالية أجريت لتحديد تأثير المستخلص الميثانولي لنبات الشبنت Anethumgraveolensعلى عملية تمثيل الدهون في مصل الفئران المصابة بـhypercholesterolaemic حيث تم استعمال مجموعة من الفئران (24 فأر ذكر) متوسط وزن الجسم 25 غم. وقد قسمت هذه الفئران إلى أربعة مجاميع حيت تم حقنها بمادة alloxan100ملغم/كغم للحث على زيادة مستوى السكر في الدم. المجموعة الأولى من الفئران تم تغذيتها على الغذاء العادي فقط في حين المجاميع الثلاثة المتبقية تغذت على الغذاء العادي أضافة إلى 0.5 ، 1 و 2 ملغم/مل من المستخلص الميثانولي لنبات الشبت بمعدل جرعة واحدة يوميا وبمقدار 1مل لكل تركيز ولمدة 21 يوميا. تم قياس التغيرات في الدهون الثلاثية في الدم (TG) ، الكولسترول الكلي (TC) ، الكثافة العالية للكوليسترول (HDL-C) والكثافة المنخفضة للكوليسترول (LDL-C). لوحظ انخفاض مستويات HDL-C للفئران المجرعة بالتراكيز 1 و2 ملغم/مل بعد 21 يوما مقارنة مع الفئران غير المجرعة (مجموعة السيطرة).


Article
Relationship between Increased WBC with Increased Lipid Profile in Blood
العلاقة بين ارتفاع نسبة كريات الدم البيضاء بالدم وزيادة الدهون بالدم

Author: Buthaina Ateyah Rashid بثينة عطية راشد
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 5 Issue: 2 Pages: 83-90
Publisher: Diyala University جامعة ديالى

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Abstract

Objective: leucocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials.When increase or decrease in the number of leukocytes in the blood is often an indicator of disease(the normal level of WBC in blood between 4000 to 11000 cell /ml ), , they make up approximately 1% of blood in a healthy adult.[3] An increasing in the number of leukocytes over the upper limits is called leukocytosis, and the decrease below the lower limit is called leukopenia. Method: This research contained study 64 patients (average age between 20 – 35 years ) suffering from increasing WBC " diagnostic by WBC count test "and perform lipid profile test (Triglyceride , cholesterol , LDL , HDL ) for all patients and shows the changes in lipid profileResults: we found relationship between increasing levels of lipid and increasing WBC disease. These result are (45% cholesterol) (58%Triglyceride)(39% LDL)(22% HDL). That is mean, the increasing of lipid profile were stimulation of immune system to increasing the white blood cell. We conclude than an increasing WBC associated with increasing of lipid profile

اشتمل البحث دراسة 64 مريضا تتراوح اعمارهم من 20 - 35 يعانون من زيادة في كريات الدم البيضاء increased WBC مشخصون سابقاً بواسطة فحص حجم كريات الدم المضغوطة ( WBC count) وقد أجرى لهم فحوصات الدهون الكلي lipid profile (Triglyceride , cholesterol , LDL , HDL ) وأظهرت النتائج وجود علاقة بين ارتفاع مستوى تركيز الدهون بالدم وزيادة الـ WBC COUNT على حدٍ سواء , حيث كانت نسبة الزيادة للأشخاص المصابين بالـ increased WBC وارتفاع الدهون كما يلي (45% cholesterol)(58%Triglyceride)(39% LDL)(22% HDL) .


Article
EVALUATION OF LIPID PROFILE IN TYPE 2 IRAQI DIABETIC PATIENTS AND IMPACT OF RELATED VARIABLES
تقييم مـستوى الدهـون لـدى المـرضى العـراقيين المصابين بـداء السكري النـوع الثاني وتأثير بـعض المـتغيرات عـليها

Authors: Huda Abdul Hameed Jassim هدى عبد الحميد جاسم --- Firas Yunis Muhsin د. فراس يونس محسن --- Suad Yunis Ali د. سعاد يونس علي --- Nizar Showky Al-Safar د. نزار شوقي الصفار
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2015 Volume: 28 Issue: 2 Pages: E67-E73
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

Diabetes mellitus had been known to be associated with lipid disorder and cardiovascular complications, the age of the patient; duration of diabetes, body mass index, sex and type of treatment has been variously believed to influence the lipid pattern.The objective is to evaluate the lipid profile and the impact of age, duration of, BMI, sex and type of treatment on lipid profile in type 2 diabetic patients.This study was conducted in the national center for treatment and research of diabetes, 515 type 2 diabetic patients were included in the study, the patients were clinically assessed and brief history taken, and the lipid parameters studied were TC, TG, HDL, LDL.It was observed that the age group, disease duration, sex and type of treatment of subjects did not have significant effect on the values of the respective lipid where as there was significant effect of BMI on TG only and uses of lipid lowering agent on TC and LDL only

كما هو شائع ومعروف ان مرضى السكر تحدث لهم اضطرابات في مستوى الدهون ومضاعفات جهاز الدوران والقلب كما ان عمر المريض ، مدة المرض ، مؤشر كتلة الجسم ، جنس المريض ونوع العلاج الذي يتعاطاه قد تؤثر على مستوى الدهون في الدم.الهدف من الدراسة هو تقييم مستوى الدهون لدى مرضى السكري (النوع الثاني) وتأثير كل من العمر ، مدة المرض ، مؤشر كتلة الجسم ، جنس المريض ، نوع العلاج للمرض على مستوى الدهون في الدم.اجريت الدراسة الحالية في المركز الوطني لعلاج وبحوث السكري/ الجامعة المستنصرية ، وقد اشتملت عينة الدراسة على 515 مصاب بداء السكري النوع الثاني ، وان جميع المرضى المشمولين بالدراسة تم معاينتهم واخذ بعض البيانات منهم ، كما اجريت لهم فحوصات مختبرية شملت مستوى الكولسترول الكلي ، الدهون الثلاثية والدهون عالية الكثافة والدهون الواطئة الكثافة.لوحظ ان العمر ، فترة المرض ، جنس المريض والعلاج الخاص بالسكر للمريض لم تؤثر هذه المتغيرات على كافة انواع الدهون في الدم ، في حين كان مؤشر كتلة الجسم له تأثير واضح وذو دلالة احصائية على مستوى الدهون الثلاثية كما ان استخدام المريض للأدوية والعقاقير الخاصة بخفض الدهون في الدم له تأثير معنوي وذو دلالة احصائية مهمة على نوعين فقط من الدهون وهما الكولسترول الكلي والدهون واطئة الكثافة.

Keywords

Diabetic --- Lipid Profile


Article
21- STUDY THE EFFECT OF CAFFEINE ON BODY WEIGHT GAIN AND LIPID PROFILE IN ADULT MALE RATS TREATED WITH HYDROGEN PEROXIDE.

Author: Faraj H.Joni AL-Bidhani , .Adel M. Hassen Alzobidy .Abdul Razzak N. Khudair
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: 18138497 Year: 2018 Volume: 17 Issue: 1 Pages: 246-256
Publisher: Basrah University جامعة البصرة

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Abstract

The present study was aimed to determine the ameliorative effect of caffeine onBody weight and lipid profile in male rats treated with hydrogen peroxide (H2O2) .Seventy Two adult male rats were used in this study . The study included twoexperiments ,in each experiments 36 males were randomly assigned two six equal groupsof six animals in each group .The animals in both experiments were treated with thesame substances and doses for each group as follows .Group one (control) animals weredrenched normal saline ,Group two animals were treated (5.63 mg/kg. Bw )H2O2 dailyby oral gavage also group three , animals were treated with low dose caffeine (150 mg/kg Bw) daily .Group four , animals were treated with high dose caffeine (250 mg /kgBw) daily . Group five . animals were treated (5.63 mg/kg. Bw )H2O2 dose after 1 hanimals were given low dose of caffeine (150 mg/kg Bw) .Group Six animal weretreated with H2O2 dose(5.63 mg/kg Bw) each rat after one hour was given high dose ofcaffeine (250 mg /Kg Bw) . The first experiments lasted for one month and secondexperiments lasted for two months . At the end of the two experiments, animals of allgroup were sacrificed under chloroform anesthesia .Blood samples were collected from the heart directly by cardiac puncture and the serum was separated to measure the lipidprofile .The result revealed a significant decreased in body weight gain in H2O2in first andsecond experiments compared with control group . While a significant improvementswere recorded in body weight gain in all treated groups compared with H2O2 group butstill significantly lower compared with those of control group. A significant increase inTC ,TG and LDL-c were recorded in H2O2 group in both experiments compared withcontrol group on the other hand no significant difference was recorded in HDL-c levelin H2O2group in first experiments while a significant decreased was recorded in secondexperiments compared with control group . Finally a significant degrees ofimprovement were observed in lipid profile in all treated group compared with H2O2 .


Article
Effects of Ramadan fasting on body weight and metabolic profile
آثار صيام رمضان على وزن الجسم و الشاكلة الاستقلابية

Authors: Namir G. Al-Tawil --- Bashdar M. Hussen --- Saleem S. Qader --- Halgurd F. Ahmed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 3 Pages: 816-821
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Fasting during the Ramadan month is a religious duty and it is obligatory for all healthy adult Muslims. The aim of this study was to investigate the effects of fasting during Ramadan in different times and place on body weight, blood sugar, serum lipids and blood pressure.Methods: Fifty three healthy adult fasting volunteers were included in the study. Peripheral venous blood samples were taken three days before Ramadan, at the end of the first week, and at the end of the fourth week of fasting. The last blood sample was taken one week after the end of Ramadan. Serum total cholesterol, HDL and LDL, triglycerides and glucose were measured. Vital signs and body mass index were taken by one of the researchers.Results: Thirty three (62.3%) volunteers were males, 93.4% were below 40 years of age. Weight changed significantly during Ramadan. Mean systolic blood pressure decreased by 11 mmHg while diastolic blood pressure decreased by 9 mmHg (P <0.001). Fasting blood sugar decreased by 14.96 mg/dl (P <0.001). Plasma lipids; cholesterol decreased by 19.3 mg/dl (P <0.027), LDL by 23 mg/dl (P <0.001), triglyceride by 44 mg/dl (P <0.003) but the HDL increased by 5.4 mg/dl (P <0.002) during Ramadan fasting. Before Ramadan, 19% of participants had abnormal serum cholesterol and 37% had abnormal LDL level, while after Ramadan all had normal lipid levels (P <0.001). The proportion of participants with abnormal HDL decreased from 94% before Ramadan to 50% after Ramadan (P <0.001).Conclusion: Ramadan affects the body physiology and lowers the weight, serum lipids, blood pressure and blood glucose levels.

Keywords

Ramadan --- Fasting --- Lipid profile

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