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Synthesis and antibacterial activity studies of monosubstituted metal cholates against P. aeruginosa and S. aureus isolated from clinical samples

Authors: Suzan S. Hussain --- Saadi M. D. Al-Nuzal --- Saja A. Najim
Journal: Al-Mustansiriyah Journal of Science مجلة علوم المستنصرية ISSN: 1814635X Year: 2019 Volume: 30 Issue: 1 Pages: 58-67
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Clinical specimens from burns, wounds and UTI`s, were collected from four hospitals in Baghdad area, and local isolates of P. aeruginosa and S. aureus were obtained. Five monosubstituted metal cholates were prepared by reacting monoequivalents of sodium cholate with metal salts in two different solvent, viz. 95% ethanol or water. Ten monosubstituted metal cholates were obtained, and characterized by their physical and spectrophotometric properties. It is the first time to report systematic preparation, characterization and study of such monosubstituted metal cholate. The growth curves for P. aeruginosa and S. aureus in the presence of metal cholates, revealed that the time for logarithmic phase were reduced from 25-30 to 5-25 minutes for both bacteria, while the stationary phase from 90-100 to 40-60 minutes. The antibacterial activities of the prepared metal cholates against P. aeruginosa and S. aureus were determined by broth dilution method in the presence of metal cholates. It was found that in the presence of the metal cholates, the MBC values were found to be within the range 8.0×10-5 - 8.35×10-5 M.

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