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Production of antibiotic of Microlides group from a local isolate of the bacterium Streptomyces rimosus
انتاج مضاد حيوي من مجموعة الماكروليدات من عزلة محلية من البكتريا Streptomyces rimosus

Authors: Mohammed B. Ismael --- Safaa I. Al-Obaiede --- Khalid D. Ahmed
Journal: JOURNAL OF EDUCATION AND SCIENCE مجلة التربية والعلم ISSN: 1812125X Year: 2019 Volume: 28 Issue: 3 Pages: 157-167
Publisher: Mosul University جامعة الموصل

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Abstract

Three local isolates of the genus Streptomyces were obtained from ten soil samples collected from different places of Niniva governorate. The isolates showed bioactivity against test Gram positive and negative bacteria and two Genera of fungi. Streptomyces isolates were identified according to microscopic and morphological tests. The Streptomyces isolates were subjected to ultra violet ray for different time periods. The treated isolates showed little increase in inhibition zone and treated period of (5) minutes showed the best inhibition of the test bacteria. The Streptomyces isolates treated with N – methyl – N – nitro – N – nitroso guaniction at the concentration of (50) showed clear increase of antibiotic production. The isolate Streptomyces III showed clear inhibition against Escherichia coli, Pseudomonas aeruginosa and Bacillus subtilis and the diameter inhibition zone was (20,29,20)mm respectively.


Article
The Effects of Some New Macrolides on Psychomotor Performance in Humans.
تأثير بعض أدوية المايكرولايد الحديثة على الأداء الحسي الحركي في الإنسان

Author: Waleed M. S. AL- Mashhadani د. وليد محمود صالح المشهداني
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 2 Pages: 172-177
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Abstract:Objective. The study was designed to show the effects of single oral doses of new macrolides (Clarithromycin, Roxithromycin and Azithromycin) on psychomotor performance by using the computerized Leeds psychomotor Tester...Setting: Department of Pharmacology, College of Medicine, Al-Mustansiriya University, Baghdad- Iraq.Design: double-blind, balanced and controlled study.Main outcome measures: Choice reaction time (CRT), recognition reaction time (RRT) movement reaction time (MRT), and critical flicker fusion Frequency (CFF). These parameters were recorded before treatment and 2 hours interval taking 2 readings post treatmentResults: The results showed that the changes in the CRT,RRT ,MRT and CFF values following the three new macrolides treatments ,not significantly different between the four treated groups , nor across the two hours intervals of the study. Conclusion: Single oral doses of the new macrolides Clarithromycin (500 mg) Roxithromycin (150 mg) and Azithromycin (250 mg)have no impairment effects on the sensorimotor and arousal states in . These findings increase the safely profile of the new macrolides.Key wards: Macrolides, Psychomotor Performance, Clarithromycin, Azithromycin, Roxithromycin

الملخص:في بحث تميز بالتعابرية والتعمية المزدوجة تم دراسة تأثير جرع منفردة فموية لأدوية حديثة من مجموعة المايكرزلايد) كليريثروميسين ,روكسي ثروميسين , و أزي ثروميسين )على الأداء الحسي الحركــي في 32 شخص أصحاء متطوعين وشملت القياسات زمن الاختبار المعقد بجزأيه زمن التميز وزمن الحركة مع قياس التردد الحرج التذبذبي الاندماجي وأعطيت العلاجات عشوائيا حسب تصميم المربعين ألاتينيين 0 تم قياس مؤشرات الأداء الحسـي ـ الحركي قبل العلاج وبعده في الساعة الثانية والساعة الرابع باستخدام جهاز ليدز كومبيوتر لقياس الأداء الحسي الحركي اظهر تحليل النتائج إحصائيا ب ANOVA عدم وجود تغير إحصائي معتد في معدلات زمن الاختبار المعقد وزمني التميز والحركة و كذا في معدل التردد الحرج التذبذبي الاندماجي بعد العلاجات المذكورة مقارنة بالغفل وعلى مدى القراءات جميعا تم الاستنتاج بان الجرع الفموية المنفردة لهذه الأدوية الحديثة ليس لها تأثير مثبط على مؤشرات الأداء الحسي الحركي في الإنسان بعناصرها المختلفة وهذا يزيد من سلامة استعمالها وخاصة أثناء أداء الأعمال التي تتطلب أداء حسيا حركيا كاملا واستجابة صحيحة


Article
Detection of Macrolides Resistance Gene in Proteus mirabilis Strains Isolated from Different Clinical Specimens by Using PCR Based on mef(A) gene

Authors: Oday Mitib Hadi --- Saad Saleem Raheem --- Alaa Hashim Abd-Ali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 225-232
Publisher: Babylon University جامعة بابل

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Abstract

Different species of Proteus mirabilis may vary in type of infections in both the community and hospital environments. Proteus mirabilis can cause a variety illnesses including urinary tract (uncommon in normal hosts), uncomplicated cystitis or pyelonephritis, wound, and blood stream infections (BSI). This study aimed to determine the macrolides resistance gene mef(A) in P. mirabilis strains isolated from different clinical samples by using PCR.This a prospective study involving the analyses of different clinical samples (i. e. sputum, wound swabs, urine and ear swabs) were collected from 86 patients suspected of bacterial infections from Al-Sader Medical City and Al-Zahraa hospital for maternity and children were cultivated to isolate P. mirabilis. Bacterial isolates diagnosed according to Baily and Scott’s Diagnostic Microbiology then further identified by Vitek® 2- system, the sequence of the primer used for detection of mef(A) gene was amplified by using Thermal Cycler. Statistical analysis was performed by using SPSS v.20. Eighty-six patients were randomly recruited; they were (65.12%) males and (34.88%) females. P. mirabilis occupies the lowest percentage 3.5 % among other microorganisms in this study. Other bacterial genera occupied different percentages there were 33.7%, 31.4%, 22.1% and 5.8 % for Pseudomonas aeruginosa, E. coli, Proteus vulgaris and Klebsiella pneumoniae. The antimicrobial activity patterns were detected using Kirby- Bauer method. Augmentin (AUG) occupied the highest value of effectiveness (93%) against the bacterial strains in comparison with other antimicrobial agent while the lowest value was (41.9%) for Ceftazidime (CAZ) (P<000). Only one strain carry the 402 mef(A) gene among the three Proteus mirabilis strains previously reported as macrolides resistant (phenotypically).

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