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Article
Measles in Kirkuk Governorate: Cohort Study

Authors: Sana'a H. Abdul Sahib --- Nazar A Mahmud
Journal: nursing national Iraqi specility المجلة العراقية الوطنية للعلوم التمريضية ISSN: 18122388 Year: 2011 Volume: 24 Issue: 2 Pages: 118-123
Publisher: Baghdad University جامعة بغداد

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Abstract

Objective(s): To describe the demographic attributes, vaccination status of measles patients and the occurrence of the disease according to time and place in Kirkuk governorate during the year 2010. Methodology: The epidemiological study (a descriptive study) on measles cases was carried out in Kirkuk province which is one of the Iraqi governorates from January 20th to July 30th, 2011. Data were collected retrospectively by review of patients' files that were registered at the department of statistic in health directorate of Kirkuk during the year 2010. A purposive "non-probability" sample of (152) confirmed measles cases (clinically and laboratory) that were registered at the department of statistic in health directorate of Kirkuk during the year 2010, were selected for the purpose of the study. These data include demographic data, vaccination status, place and time of reporting the cases by month. The obtained data of the registered cases were entered in to the computer and analyzed through the use of the statistical package social sciences (SPSS 11.5); the data analysis was preformed through descriptive statistical approach, such as (frequency and percentage). Results: The study findings revealed that (49.3%) of measles cases were more than fifteenth years of age, (57.9%) of them were male. Up to half of cases occurred inside Kirkuk city, and according to vaccination status, (47.4%) of measles cases were vaccinated. Recommendations: The study highlighted the necessity of timely measles vaccine campaign, additional dose of vaccine to include also adolescents and adults who may be sensitive to measles, and importance of health education for unimmunized adult person.

الهـدف: تهدف الدراسة الحالية إلى وصف الخواص الديموغرافية، وحالة التطعيم بالنسبة للمرضى المصابين بالحصبة وكذلك وصف حدوث المرض حسب الزمان والمكان في محافظة كركوك خلال سنة 2010. المنهجيّة: دراسة وبائية (وصفية) أجريت على المرضى المصابين بالحصبة للمدّة من العشرين من كانون الثاني لسنة 2011 ولغاية الثلاثين من تموز، 2011. تمّ جمع البيانات عن طريق مراجعة استعادية للحالات المسجلة لمرض الحصبة في قسم الإحصاء بدائرة صحة كركوك خلال سنة 2010. أختيرت عينة غرضية "غير إحتمالية" مكونة من(152) لحالات الحصبة المثبتة )سريرياً ومختبرياً( والمسجلة في قسم الإحصاء بدائرة صحة كركوك خلال سنة 2010. تضمنت هذه البيانات الخواص الديموغرافية، حالة التطعيم، زمان ومكان حدوث الحالات. تمّ تحليل البيانات من خلال تطبيق البرنامج الإحصائي SPSS بأسلوب التحليل الإحصائي الوصفي للبيانات (التكرارات والنسب المؤية).النتائـج: أشارت نتائجَ الدراسة بأنّ (49,3%) من الحالات كانت في عمر أكثر من خمسة عشر سنة و (57,9%) منهم كانت من الذكور، أكثر من نصف الحالات حدثت داخل مدينة كركوك. أمّا بخصوص حالة التطعيم للمصابين، تبين أنّ (47,4%) من المصابن بالحصبة كانوا ملقحين. التوصيات: أوصتْ الدراسةَ بضرورة إجراء حملات التلقيح الإضافية ليشمل أيضاً المراهقين والبالغين الذين قد يكونون من الفئة الحساسة للحصبة، كذلك ضرورة التوعية الصحية للاشخاص الملامسين للمرضى، خصوصاً غير الملقحين منهم أو ليست لديهم إصابة سابقة بالمرض.

Keywords

Measles --- Vaccination


Article
Spectrum of Acute Complications of Measles in Erbil City
طيف مضاعفات الحصبة الحادة في مدينة أربيل

Author: Kawes Omer Hamad
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 1 Pages: 22-27
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Background and Objectives: Measles is an infectious viral disease which is highly communicable and a notifiable disease, it is encountered as a cause of morbidity and mortality. The objective of this study was to find out the most encountered acute complications of measles and relation of these complications to the age of children and vaccination status.Patients and methods: This is a prospective study done in Raparin pediatric teaching hospital, Erbil city, in the period of December 2008 to May 2009. Sixty eight cases of measles admitted with variable complications were studied. History was taken, complete examination and follow up in the hospital for variable complications was done.Results: The mean age was 23.28 ±18.91 months, 42 cases (61.8%) of the admitted children were two years or less. Male children were 35(51.5%) cases and female 33 (48.5%) cases. Most of affected cases were unvaccinated for measles 58 cases (85.3%), history of contact in the family was observed in 33 cases (48.5 %) while10 cases (14.7%) has contact history in the pediatric hospital and 25 cases (36.8%) didn’t show any clear contact history. The most common complications were diarrhea 45 cases (66.2%), pneumonia and vomiting 36 cases (52.9%) for each and febrile convulsions 5 cases (7.4%) and encephalitis 2 cases (2.9%).Conclusions: Children who were infected and developed complications were less than two years of age , most of them were not vaccinated and they were from rural areas.

Keywords

Measles --- Vaccination


Article
A Study of Measles Epidemic in Babylon Teaching Hospital for Pediatrics and Gynecology

Author: Bashar Sahib Khalaf
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 3 Pages: 478 -482
Publisher: Babylon University جامعة بابل

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Abstract

Measles is a viral disease with a distinctive maculopapular rash, and the mortality rate might reach about 25% because of malnutrition and lead to devastating complications. The vaccine and the introduction of oral vitamin A in the management of infected children with severe measles has dramatically changed the epidemiology of measles and the morbidity and mortality is greatly reduced. To study the profile of the measles epidemic in Babylon teaching hospital for Pediatrics and Gynecology. A descriptive observational study was carried out during an outbreak of measles, in 2014, in Babylon City and data was taken from patients᾽ caregivers, admitted to Babylon teaching hospital for Pediatrics and Gynecology. The line lists on measles was investigated include; age, sex, residence, nutritional status, type of feeding, any previous history of vitamin A supplementation, and vaccination status.The mean age of the patients was about two and a half years, most of them were from rural areas. Those whom had taken their vaccination twice, are the least complicated and milder symptoms. Those who received repeated doses of vitamin A had less severe symptoms, fewer complications, and fewer days of hospitalization. The study highlights the urgent need for early recognition and interventions for the emergence of new cases of measles and good vaccination coverage programs especially in the towns.


Article
MEASLES IN IRAQ: IS IT UNDER CONTROL?

Author: MEASLES IN IRAQ: IS IT UNDER CONTROL?
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2006 Volume: 19 Issue: 1 Pages: 71-75
Publisher: Foundation of technical education هيئة التعليم التقني

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Aim of the study:To assess the success of control program of measles infection in Iraq through:1.determining the frequency of measles in Iraq during the year 2001 and the status of vaccination of these patients 2.determining the epidemic picture of the disease in Iraq for the last thirteen yearsPatients and Methods:Data was obtained from the Communicable Disease Control Center (Ministry of Health). The data included number of cases of measles that were reported during the year 2001 from Iraqi provinces, and the number of cases registered during the years from 1989-2001. Data about the status of measles vaccination was obtained from the Immunization Section in the Ministry of Health. Results:There were 491 reported cases of measles in Iraq during 2001. The highest number of cases was in age groups 1-5 years and 6-10 years (33.2% and 27%) respectively, age group 11-15 years had a rate of infection of 19.4%. The rate of vaccination with measles vaccine among patients infected with measles was 53.5%. The coverage rate with the first dose of measles vaccine during the year 2001 in Iraq was 53%, and with the second dose 22%. Three epidemics of measles infection had taken place in Iraq during the period from 1989-2001.Conclusion:Measles infection is still poorly controlled in Iraq with a high number of cases every year as well as epidemics every few years. Poor control may be attributed to poor coverage rate with measles vaccine and insufficient immunity conferred to vaccine by one dose of the vaccine that they receive mostly

هدف الدراسة: تقييم خطة السيطرة على مرض الحصبة في العراق من خلال:1.تحديد عدد الإصابات بمرض الحصبة خلال عام 2001 والموقف التلقيحي للمرضى.2.تحديد الشكل الوبائي للمرض خلال الثلاث عشرة سنة السابقة للدراسة.طريقة البحث: أخذت البيانات من مركز السيطرة على الأمراض الانتقالية في وزارة الصحة. وشملت البيانات معلومات وبائية تخص حالات الحصبة المسجلة في القطر خلال عام 2001 وعدد الحالات المسجلة للسنوات الثلاثة عشر الماضية. أخذت المعلومات التي تخص نسبة التغطية باللقاحات من شعبة التحصين في وزارة الصحة.النتائج: تبين من الدراسة أن هناك 491 إصابة بالحصبة مسجلة لدى مركز السيطرة على الأمراض الإنتقالية لمحافظات القطر خلال عام 2001 ، ولوحظ أن أعلى نسبة إصابات حسب الفئات العمرية كانت في فئة العمرية 1-5 سنوات (33.2%) تليها الفئة 6-10 سنوات (27%) والفئة 11-15 سنة (19.4% ). وبلغت نسبة الملقحين من بين المصابين بالحصبة (53.5%)، والنسبة المئوية للتغطية بلقاح الحصبة خلال عام 2001 كانت (53%) للجرعة الأولى و (22%) للجرعة الثانية . وجدت ثلاثة تفشيات وبائية لمرض الحصبة للأعوام الثلاثة عشر السابقة.الاستنتاج: لاتزال السيطرة على مرض الحصبة ضعيفة في العراق والمرض يتكرر كل سنة بمعدلات عالية مع تفشيات وبائية كل بضعة سنين . العوامل المسببة لضعف السيطرة هي التغطية الضعيفة بلقاح الحصبة وعدم اكتساب الملقحين المستوى الكافي من المناعة بسبب تلقيهم لجرعة واحدة من اللقاح في أغلب الأحيان.

Keywords

Measles --- immunity --- coverage


Article
The Levels Of Some Serum Complement Among Seropositive Individuals After Measles Vaccination

Author: Layla S. Al-Omar
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 1 Pages: 32-35
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Measles remains a major cause of worldwide childhood mortality. The use of current live attenuatedvaccine control the disease, and measles has been targeted by the WHO for global eradicationfollowing the eradication of poliomyelitis.Objective:To determine the C3 and C4 complement response to measles virus in seropositive volunteers aftervaccination with live attenuated measles vaccine.METHODS:Thirty seven measles virus seropositive normal volunteers have been enrolled in this study, they were25 males and 12 females, their age ranged between 15-45 years. 22 of them were vaccinated withmeasles virus vaccine and 15 were injected with diluent supplied with measles virus vaccine(placebo).C3,C4 complement against measles virus were detected in volunteer's sera prior to, 1,2,3 and 4 weeksafter vaccination, using Radial Immunodiffusion Assay method.RESULTS:There was a significant difference in the concentration of serum C3 complement at week 3 ,following receipt of live measles virus vaccine in seropositive individuals, while no marked changewas observed in the concentration of C4.CONCLUSION:Rising C3 level in the sera of seropositive volunteers after measles virus vaccine administration playa role in increasing immune response against measles virus infection


Article
Risk Factors and Common Causes of Death Due to Measles in AL-Kadhimiyia Teaching Hospital.2009

Authors: Lamia Abdul Karim --- Abdul-KaremJasemAlbahadle --- Ali Kadhim Al-Husainawi*
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 1 Pages: 32-39
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Remains a common disease in many parts of the world. According to the World Health Organization (WHO), more than 20 million people worldwide are affected by measles each year. It is the leading cause of vaccine-preventable deaths among young children.OBJECTIVE:To find out the epidemiological criteria of died patients because of measles& the main causes of death.PATIENTS AND METHODS:Prospective study carried out in the pediatric ward of Al-Kadmyia Teaching Hospital between the 1st of January to the 1st of May 2009,the total number of measles cases admitted were 894 , the number of died cases in the same period due to measles were 52 case , the age of the studied sample (1month- 10 years).The data collected through a data sheet asked to the parents of the patient including the age ,sex, body weight, feeding history, history of contact, vaccination history , maternal vaccination status and her educational level.All the patients examined systematically and investigated and followed up till discharged or unfortunately diedRESULTS:The age of the died cases mostly in the 1st2years(27 case), there is male(31) , female(21) died cases.The mortality occur more in under weight cases27 , the died cases were either on mixed feeding 17cases, bottle feeding 10, solid feeding 25 cases.All the died cases had history of contact with measles., there were 49 cases non-vaccinated, the vaccination status of the mothers were 38 mother were not vaccinated. The educational level of the mothers were 29 illitrate,15 primary and 8 secondary school.The most common causes of death :16 encephalitis, 36 pneumonia.CONCLUSION:The death occurs more in infants and toddlers than in other age groups, more in males,underweight, and the non-vaccinated than in the vaccinated patients.Death is more common among children belong to non-vaccinated, illiterate mothers.Pneumonia is the most frequent complication of measles and encephalitis is the most lethal complication.


Article
Epidemiological Study of Measles in Al- Kadhimiyia Teaching Hospital

Authors: Lamia Abdul Karim --- Ali Kadhim Al-Husainawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 2 Pages: 213-222
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT: BACKGROUND: Measles is a highly communicable disease caused by the measles virus. The disease ismarked by prodromal fever, conj unctivitis, coryza, cough, and the pathognomonic koplikspots followed by an erythematous maculopapular rash. Infection confers lifelong immunity. OBJECTIVE:Find out the frequency of measles in the hospital admitted cases in chi l dr en ≤ 12year s accor di ng t o t he vaccination and nutritional status,The causes of non-vaccination andthe vaccine efficiency in preventing measles.The incidence of measles in the exclusively breastfed infants.The presenting signs and symptoms, commonest complications, investigations and theoutcome. PATIENTS AND METHODS:A prospective study was performed from the 1st of January to the 1known as rubeola and is marked by prodromalfever, conjunctivitis, coryza, cough, andpathognomonic Koplik spots, followed by anerythematous maculopapular rash on the 3rd to 7day. Infection confers life-long immunity. st of May in the year 2009, inAl-Kadhimiyia Teaching Hospital.The data was collected through a questionnaire askeddirectly to the parents, and all the patients were systemically examined and followed up clinicallyuntil they discharged home or unfortunately died.The collected data was analyzed and adjustedusing the SPSS version 10 statistical programs.RESULTS:The incidence of measles was (44.29 %).Most of cases were living in crowded houses, allpatients had positive history of contact, mostly during a visit to a medical health facility (49.3%).All age groups were affected by measles, mostly in the 1st (27 %) and the nd (19 %) yearsof life.Higher incidence was reported in males (53.5 %).Most of the cases were nonvaccinated(86.25 %) with non-vaccinated mothers as well (85.25 %). Nineteen percent ofthe cases were malnourished. The incidence was lowest in the exclusively breast fed infants (1.5%).Measles mostly presented with fever for ≥ 3 days (100 %), rash (100 %) and conjunctivitis(98.25 %).The commonest complications were pneumonia (62.75 %), diarrhea (40.25 %).The majority of patients who had developed convulsions had normal CSF analysis results (76.7%). CXR reported pneumonic consolidation in (62.75 %) of the patients. Ninety percent of caseswere discharged home and (10 %) died. CONCLUSION:Measles is higher in the crowded places, in infants and toddlers, in males, in the nonvaccinated,and less in the exclusively breast fed infants. It is more severe in themalnourished patients. Vaccination is the most important preventive measure against measles.Measles mostly present with fever, maculopapular rash, and conjunctivitis, with the mostcommon complications are pneumonia, diarrhea, and encephalitis.The disease usually has no or little effect on the blood counts and CSF analyses, and CXRdocument pneumonic consolidation in the majority of cases.Measles is still a serious disease with high fatality rat

Keywords

measles --- epidemiology --- vaccination.


Article
Seroepidemiological Study of Measles Virus among Young Adults: Response to Revaccination
دراسة مصلية وبائية لفيروس الحصبة بين اليافعين: الاستجابةلإعادة التطعيم

Author: Arwa H. Al –Hamdani اروى هادى الحمداني
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2014 Volume: 11 Issue: 4 Pages: 1493-1502
Publisher: Baghdad University جامعة بغداد

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The 2011 Iraqi Measles Control Campaign had as its aim to improve immunization coverage among young adults' 17-24years and, in the longer term, prevention of measles epidemics. The aim of the study is estimation measles vaccination and revaccination efficacy by evaluate the seroprevalence of antibody and response to reimmunization in young adults. A previously vaccinated 189 young adult medical students were tested for measles specific IgG &IgM pre and post catch-up revaccination by using commercially available ELISA. To assess the seroprevalence of antibody response pre measles reimmunization in previously vaccinated young adults; 45 were found to be seronegative. To differentiate between primary and secondary vaccine failure, anti- measles IgM and IgG titers were assessed again 2-4 weeks after revaccination in 189 seronegative participants [45 seronegative, 144 seropositive individuals: 29 seronegative participants responded to revaccination anamnestically(P < 0.001)and developed immunity; 7 also showed IgM response (probably primary vaccine failure); 144 seropositive participants remained seroprotected without significant increase in antibody titer (P=0.577). Primary vaccine failure was fond to be 3.7%; while secondary vaccine failure was 11.6%.After revaccination, 85.1% were seroprotected. This study demonstrates the waning measles immunity in young adults in Iraqi medical students, which poses the potential risk of transmission of measles. Periodic Serological surveillance and revaccination of susceptible young adults are recommended.

قام الباحث بتقييم معدل الانتشار المصلي لمستضدات الحصبة والاستجابة لإعادة التمنيع (الحملة الوطنية الشاملة لوزارة الصحة في الفترة من 9- 20تشرين الاول 2011) ضد الحصبة لدى 189يافعاً (17-24سنة) سبق تطعيمهم؛ فثبت أن 45 منهم سلبي المصل. وللتفرقة بين فشل اللقاح الأوَّلي والثانوي، تم تقيـيم عيار الغلوبولين المناعي Gوالغلوبولين المناعيM(وذلك باستعمال اختبار قياس الامتصاص المناعي المرتبط بالانظيم )بعد مضي 2-4 أسابيع من إعادة التطعيم لدى كل الافراد، وقد استجاب 29 من سلبيِّي المصل لإعادة التطعيم الإذكاري(0.001 >P)حيث ظهرت لديهم المناعة، بينما أظهر 7اشخاص استجابة للغلوبولين المناعي M (مما يشير غالباً إلى فشل اللقاح الأوَّلي)؛ بينما ظلت الحماية المصلية متوافرة لنحو 144 من المشاركين إيجابيِّي المصل دون زيادة ملموسة في عيار المستضد (0.577=P).وقد كان معدل الإخفاق الأوَّلي3.7%، و11.6%الثانوي;وبعد إعادة التطعيم أصبح85.1 %محميِّـن مصلياً. قد اوضحت الدراسة الحاجة الى المزيد من الحملات الوطنية لإعادة التطعيم من اجل تقليل نسبة الاخفاق وزيادة الحماية المصلية ضد فايروس الحصبة.


Article
Immune-Response of Individuals after Immunization with Rubella Vaccine
تقييم الاستجابة المناعية للأشخاص الملقحين بلقاح الحصبة ألألمانية

Authors: Layla Fouad Ali ليلى فؤاد علي --- Ghanima Sadik M غنيمة صادق محمد
Journal: The Iraqi Journal of Veterinary Medicine المجلة الطبية البيطرية العراقية ISSN: 16095693 Year: 2011 Volume: 35 Issue: 2 Pages: 165-174
Publisher: Baghdad University جامعة بغداد

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Abstract

In this study 72 blood samples were collected from healthy individuals. Thirty blood samples were taken from children with age range (12-18) and twenty blood samples from females with age range (12-15) years old 2-4 after two weeks of vaccination with rubella vaccine. Control group included 12 healthy children and 10 healthy females both did not have rubella vaccine through their life. These samples were tested to evaluate the immune-status of individuals after immunization. In this study specific haemagglutination antibodies and IgM antibodies were measured and total Immunoglobulines (IgM, IgG and IgA) also determined. Lymphocyte transformation and ability of phagocyte cell to phagocytosis were measured. The results showed decrease in total IgG and IgA with an increase in the level IgM in children and females with significant differences (P<0.01), in comparing with control groups. An increase in the percentage of phagocytic activity of phagocyte cells in both groups (children and females) with a significant differences (P<0.05) in comparing with control group. Non significant differences in humeral and cellular immune Response between children and female groups.

شملت الدراسة 72 عينة دم مأخوذة من أشخاص أصحاء ،كان منها ) 30 (عينة دم لأطفال أصحاء ، وقد تراوحت أعمارهم مابين 18-20 شـهر ، )20( عينة دم لإناث تراوحت أعمارهن مابين (12-15) سنة بعد أسبوعين من تلقيحهن بلقاح الحصبة الألمانية حسب الجدول التلقيحي المتبع في القطر أما مجموعة السيطرة فتضمنت (12)عينة دم لأطفال، و10 عينات لإناث بعمر 12-15 سنة لم يتلقوا لقاح الحصبة الألمانية وهذه العينات أجريت لها الاختبارات المناعية لتقييم الاستجابة المناعية الخلطية والخلوية للقاح الحصبة الألمانية. في هذه الدراسة تم قياس أحد معايير الاستجابة المناعية الخلطية ،وذلك بقياس تركيز الأضداد النوعية للحصبة الالمانية ، فضلا عن تقدير التركيز الكلي للكلوبيولينات المناعية صنفM وG وA كما تضمنت الدراسة قياس قابلية الخلايا البلعمية على البلعمة ،وقياس قابلية الخلايا اللمفاوية التي تم تحفيزها بالملزن النباتي (PHA) على التحول والانقسام. أظهرت النتائج إن تركيز أضداد الحصبة الألمانية من نوع IgMارتفع في الأطفال الملقحين مقارنة بمجموعة السيطرة وبفروق معنوية عالية (P<0.001) كذلك كان الحال مع مجموعة الإناث . بينت النتائج إن تركيز الكلوبيولـين المناعيIgG في مصول الأطفال بعد تلقيحهم هو أقل ممـا يقابله في مجموعة السيطرة وبفروق معنوية (P<0.05) والكلوبيولـين المناعي IgA هو أقل ممـا يقابله في مجموعة السيطرة وبفرق معنوية (P<0.05) . أما مجموعة الإناث فلم تكن هناك فروق معنوية في تركيز الاضداد IgG و IgA في مجموعة الإناث الملقحـات عن مجموعة السيطرة (P<0.05). أظهرت نتائج فحص التحول والانقسام اللمفاوي أن هناك انخفاض في نسبة قابلية الخلايا اللمفاوية على التحول والانقسام وبفروق غير معنوية (P<0.05). لقد أظهرت النتائج وجود ارتفاع في النشاط البلعمي للخلايا البلعمية لمجموعة الأطفال والاناث الملقحين عما هو عليه في مجموعة السيطرة وبفروق معنوية (P<0.05).

Keywords

immune --- Rubella vaccine --- measles --- mumps


Article
Sero-Epidemiological Study of Outbreak of Measles among Children in Diyala – 2009

Authors: Ismail I. Latif --- Mehdi SH. Al-Zuheiry --- Nadhim GH. Noaman
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 3 Pages: 236-246
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Measles is a serious infectious disease in children. Despite reaching global measles vaccination coverage of 80% of individuals, measles virus (MV) remains the fifth leading cause of death and the most common cause of vaccine-preventable death in children under 5 years of age. Objectives: to determine the sero-epidemiological characters of the outbreak of measles among children in Diyala province in 2009.Subjects and methods: This study was done during the outbreak of measles in Diyala provinc ( spring and summer of 2009) in Al-Batool hospital of Pediatrics and Gynecology at Baquba city during a 2-month period from 1 April 2009 to 1 June 2009. A sample of 103 child patients presented with clinically suspected measles was studied by thorough history and physical examination with a determination of immunoglobulin M (IgM) antibodies in serum by enzyme- linked immunosorbent assay ( ELISA) testing for measles for each patient. Results: There was 58.3% (66 out of 103) positive blood samples for IgM of measles in children with clinically evident measles. The study showed that there was no significant difference in the distribution of children with measles positive by IgM according to their age and sex, according to residency, according to mothers′ previous vaccination status or previous infection with measles. On the other hand, the study revealed that the distribution of IgM positive measles was significantly more (p<0.05) in children who did not receive previous measles vaccine than those who received vaccination, and in children with low & medium economic status families than those with good status, respectively. Conclusion: It was concluded that the single serum assay of IgM antibodies by ELISA testing has medium sensitivity in the diagnosis of measles in children, there is an increasing susceptibility of infection with measles for infant less than one year of age and for children with poor family economic status.

Keywords

Measles --- IgM --- serology --- Children --- Diyala

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