research centers


Search results: Found 15

Listing 1 - 10 of 15 << page
of 2
>>
Sort by

Article
ANEMIA IN DIABETIC PATIENTS WITHOUT MICROALBUMINURIA; IN RELATION TO TYPE OF DIABETES, GLYCEMIC CONTROL AND hs-C REACTIVE PROTEIN LEVELS

Authors: Adeeb Abbas Al-Shami --- Abbas M. Rahma --- Shatha H. Ali --- Ali Mohammed Ali Hussein
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2010 Volume: 13 Issue: 3 Pages: 110-119
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Recent studies have highlighted on association between anemia and the development andprogression of diabetic nephropathy. There is also an increased cardiovascular risk in patients withdiabetic nephropathy and a clear association between anemia and abnormal cardiac function,although most patients in the previous studies have type 2 diabetes mellitus. The present studyfocused on the possible variations in hematological parameters as well as hs-CRP levels in anemictype 1 and type 2 diabetics without microalbuminuria, in relation to their glycemic indices.The study groups compromised of 50 diabetic patients (25 with type 1 and 25 with type 2) whohad been selected to have haemoglobin levels below the gender specific normal range with negativemicroalbuminurea, in comparism to two control groups of 16 and 18 healthy subjects,respectively,whom are age and sex matching of type 1 and type 2 patients.For this the patientsblood specimens were taken for testing blood levels of haemoglobin, red blood cellscount,reticulocyte count, Hb A1C levels; as well as fasting serum glucose, serum insulin, C-reactiveprotein levels.The results indicated that anemia in both types of diabetes was not related to any of the RBCindices(MCV, MCH, MCHC), results are not shown, but it s related to lowered total number ofRBC as compared to their controls. Meanwhile,their was no evidence of an increased reticulocyte inthe studied groups of either types of diabetes, indicating a defective erythropoiesis rate, although theselected patients were without detectable nephropathy (ve testing for microalbuminuria).Furthermore, the reduction in RBC count was not significantly correlated with glycemic indices(FPG, FPI, HbA1C, QUICKI). However, hs-CRP levels were significantly elevated in diabeticpatients, but CRP levels were significantly correlated with fasting serum insulin in type 2diabetics,but not in type1. Which may indicate a role for inflammation in type 2 diabetes incontribution to insulin resistance that may provide an additional risk factor for cardiovasculardiseases in this type of diabetic whom have anemia as well.

أشارت الدراسات الحديثة على وجود علاقة بين كلمن فقر الدم وظهور وتطور أمراض الكلى لدى المصابينبداء السكري. إضافة إلى زيادة نسبة الخطورة في مرضىالسكري الذين يعانون من اعتلال الكلى نتيجة السكريبسبب وجود علاقة واضحة بين كل من فقر الدم واختلالوظيفة القلب، على الرغم من إن معظم هذه الدراسات تمتعلى النوع الثاني من السكري. ان هذه الدراسة التي تركزعلى احتمالية ظهور اختلافات في بعض مؤشرات الدم وكذلك بمستوى البروتين – سي الفعال في مصل المرضىلكلا النوعين الاول والثاني من السكري من المصابين بفقرالدم بدون اعتلال الكلى (عدم وجود آثار للألبومين فيالادرار).تضمنت الدراسة 50 شخصا من المصابين بالسكري25 منهم من النوع الاول و 25 من النوع الثاني) تم )اختيارهم ليكون مستوى خضاب الدم لديهم اقل من مستواهالطبيعي حسب جنس المريض، من الذين اظهروا نتائجسلبية في فحص وجود آثار للألبومين في الادرار. تماستحصال نماذج الدم بعد الصيام لقياس مستويات كل من خضاب الدم وعدد الكريات الحمر وعدد الخلايا الشبكية فيالدم اضافة الى مستوى الخضاب المرتبط بالسكر وكذلكمستويات كل من السكر والانسولين والبروتين – سي الفعالعالي الحساسية.أظهرت النتائج ان فقر الدم في المجاميع المدروسة لمتبين اي اختلال في معايير الكريات الحمر (معدل حجمالكرية، معدل الخضاب فيها، معدل تركيز الخضاب فيها) –لم تبين النتائج هنا. ولكن كان فقر الدم يعزى بالدرجةالاساس الى انخفاض في تعداد الكريات الحمر لدىالمرضى من كلا النوعين عند المقارنة بالاصحاء.على الغممن عدم وجود اي مؤشر لزيادة مستوى الخلايا الشبكية فيالدم في اي من المجاميع المدروسة من مرضىالسكري.مما قد يؤشر وجود خللا في عملية صنع الخلاياالحمر، على الرغم من اختيار المرضى غير المصابينباعتلال الكلي حسب الفحص السلبي لأثار الالبومين فيالادرار. كما ان تناقص اعداد الكريات الحمر لم يكنمرتبطا احصائيا بأي من المؤشرات علي درجة سكرية الدم(فحص السكر، مستوى الانسولين،مستوى الخضاب المرتبطبالسكر، معدل التحسس للانسولين). في حين كان مستوىسي- بروتين الفعال عالي الحساسية شديد الارتفاع فيالمرضى حين المقارنة بالاصحاء، وكان ايضا مرتبطابمستوى الانسولين في حالة الصيام لدى مرضى النوعالثاني من السكري فقط مشيرا الى احتمالية وجود دورلعملية الالتهاب في مقاومة الانسولين والتي قد تزيدعاملخطورة اومؤشرا اضافيا للاصابة بامراض القلب فيمرضى النوع الثاني من السكري المصابين بفقر الدم


Article
Performance indicators and validity of different analytical methods for measuring urine protein and microalbumin in patients with diabetes mellitus

Authors: Alyaa R. Al-Kateeb علياء الخطيب --- Waad-Allah S. Mula-Abed وعد الله الملا عبد
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2005 Volume: 31 Issue: 2 Pages: 74-82
Publisher: Mosul University جامعة الموصل

Loading...
Loading...
Abstract

Objectives: 1. To derive a reference range for random urine protein:creatinine index (PCI) and albumin: creatinine index (ACI) in apparently healthy subjects, using different analytical methods. 2. To compare and assess the validity of sulphosalicylic acid (SSA) and pyrogallol red (PGR) methods for measuring urine protein as alternatives to immunoturbidimetric (IT) method for measuring urine microalbumin, in Iraqi diabetics with or without microalbuminuria (MA) or/and proteinuria.
Subjects and Methods: Random urine and fasting blood specimens were collected from 400 diabetics (256 females, 144 males) aged 8-87 years, including 48 type 1 and 352 type 2 diabetics. They were attending Al-Waffa Diabetic Clinic in Mosul during 6 months from 1st August 2002 to 31st January 2003. A control group of 145 apparently healthy volunteers (108 females, 37 males) aged 15-72 years were used for comparison. Urine protein was measured using SSA and PGR (for all diabetics and controls) and urine albumin using IT (for 112 diabetics and 75 controls). The statistical methods used included unpaired student Z-test and linear regression analysis. The validity indicators: sensitivity, specificity, negative and positive predictive values and accuracy rate were calculated.
Results: The frequency distribution of PCI and ACI showed log-normal distribution and following log transformation, the reference range for PCI was 20-235 mg/g using SSA and 18-205 mg/g using PGR, and for ACI was 4-55 mg/g using IT. The overall prevalence of proteinuria in the diabetics was 30% using SSA method and 35% using PGR method and MA was 27%. The SSA and PGR methods for measuring proteinuria were compared with IT method for measuring MA. The sensitivity, specificity, positive predictive value, negative predictive value and accuracy rates were 93%, 96%, 90%, 98% and 95.5% respectively for PGR; and 80%, 95.1%, 86%, 93% and 91% respectively for SSA. A highly significant correlation (P < 0.001) was observed between ACI and PCI values (r = 0.85 using PGR, r = 0.88 using SSA) in all control and diabetic subjects. Prediction of ACI from PCI value can be made by multiplying the PCI value by 0.375 using PGR and 0.39 using SSA.
Conclusion: Proteinuria and MA are common among Iraqi diabetics. Simple and cheap methods, particularly the PGR method, have acceptable performance to be routinely implemented in diabetic care. It is recommended to measure random urine PCI in all diabetics during their regular visits to the diabetic clinic.
Keywords: Microalbuminuria, sulphosalicylic acid, pyrogallol red.


Article
Prevalence of Microalbuminuria

Author: Assist. Prof. Safaa Ali Khudhair
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 462-467
Publisher: University of Kufa جامعة الكوفة

Loading...
Loading...
Abstract

AbstractBackground: Diabetic nephropathy accounts for a significant reduction in life expectancy of diabetic patients, approximately 80% of Type 1 diabetic patients and 30% of type 2 diabetic patients with microalbuminuria progress to overt nephropathy after 10–15 years.Objective: To determine the prevalence of micro- and macro-albuminuria in diabetic patients in AL-Najaf city and the predictive value of some risk factors.Method: Urinary albumin-creatinine ratio (ACR) in a spot early morning urine sample was used and the patients were categorized as normo-albuminuric when ACR<30 mg/g, micro-albuminuric when 300>ACR≥30 and macro-albuminuric when ACR≥300 mg/g.Results: Prevalence of albuminuria among Type1 patients was 4(67%) microalbuminuria, 0% macroalbuminuria, i.e. 67% had abnormal urinary albumin-creatinine ratio (ACR). The corresponding prevalence for Type 2 patients was 26(52%) micro-albuminuria, 4(8%) macro-albuminuria and total of 30(60%) for abnormal urinary albumin-creatinine ratio (ACR).Conclusion: The occurrence of microalbuminuria detected in this study was much higher than previously reported in other studies and the duration of diabetes was the strongest predictor.


Article
Evaluation of the effectiveness of candesartan, diltiazem, or their combination on normo-, micro- and macroalbuminuria in type 2 diabetic patients
تقييم فعالية الكانديسارتان، ديلتيازيم، أو كليهما على مستويات الألبومين ذات التركيز القليل، أو التركيز الطبيعي او التركيز العالي في الإدرار في مرضى السكري من النوع الثاني

Loading...
Loading...
Abstract

Background: One third of diabetic patients ultimately develop nephropathy. Microalbuminuria (MIA) is an earliest sign for diabetic nephropathy and its measurement is mandatory for early prevention of end stage renal failure. Drugs which prevent development of MIA may delay deterioration of renal function.Aim: To evaluate effectiveness of candesartan, diltiazem or their combination on MIA in diabetic patients.Methodology: 104 diabetic patients attending outpatient clinic at local Basrah hospitals were recruited for the study, 64 patients had MIA, and 40 patients were normoalbuminuric. Each group was subdivided into three subgroups; each subgroup was treated with either candesartan 8 mg, diltiazem 90 mg, or their combination for six months. Albuminuria, FBS, HbA1c, serum creatinine, serum potassium, total cholesterol and blood pressure were measured after 3 and 6 months. Results: candesartan, diltiazem and the combination significantly reduced MIA at the end of 3 and 6 months treatment in comparison to baseline. Candesartan significantly reduced MIA from 175.8 ± 134 µg/ml at baseline to 76.7 ± 57.4 and 40.1 ± 32.5 after 3 and 6 months respectively. Diltiazem reduced MIA from 122.2 ± 102.8 µg/ml to 67.2 ± 52.6 and 51.0 ± 37.6 at the end of 3 and 6 months respectively. The combination reduced MIA from 174.6 ± 106.4 µg/ml to 93.2 ± 67.2 and 46.1 ± 53.0. In normoalbuminuric patients, the reduction with the three treatment modalities from baseline was small. The three treatments reduced blood pressure without causing hypotension.Conclusions: Candesartan, diltiazem, or the combination reduced albuminuria in diabetic patients with normo-, micro- or macroalbuminuria.

الخلاصة:ثلث مرضى السكري يتعرضون في نهاية المطاف الى اعتلال الكلية. ويعتبر الألبومين ذات التركيز القليل في الإدرار (Microalbuminuria) MIA)) من العلامات المبكرة لأعتلال الكلية السكري و قياسه إلزامي للوقاية المبكرة من الفشل الكلوي وان الأدوية التي تمنع ظهور الألبومين ذات التركيز القليل في الإدرار قد تؤخر تدهور وظيفة الكلى.الهدف: لتقييم فعالية الكانديسارتان، ديلتيازيم، أو كليهما على MIA)) في الأدرار في مرضى السكري.المنهجية: تم تجنيد 104 مريض مصاب بالسكري الذين حضروا العيادة الخارجية في المستشفيات المحلية في مدينة البصرة للدراسة، وكان 64 مريضا لديهم MIA))، و40 مريضا لديهم تركيز معتدل للألبومين في الأدرار. وتم تقسيم كل مجموعة إلى ثلاث مجموعات فرعية؛ وعولجت كل مجموعة فرعية بالأدوية الأتية: 8 ملغم كانديسارتان، 90 ملغم ديلتيازيم، أو الجمع بينهما لمدة ستة أشهر. وتم قياس البول الزلالي، نسبة السكر في الدم، نسبة HbA1c، الكرياتينين، والبوتاسيوم في مصل الدم، و الكوليسترول الكلي وضغط الدم بعد 3 و 6 أشهر من العلاج. النتائج : أدى استعمال الكانديسارتان ، ديلتيازيم والجمع بينهما إلى نقصان كبير يعتد به احصائيا في MIA)) في نهاية 3 و 6 أشهر من العلاج بالمقارنة مع المستويات قبل العلاج. وقد أدى استعمال كانديسارتان الى إنقاص MIA)) من 175.8 ± 134 ميكروغرام / مل قبل العلاج إلى 76.7 ± 57.4 و 40.1 ± 32.5 بعد 3 و 6 أشهر من العلاج على التوالي. وحدث انخفاض في MIA)) باستعمال الديلتيازيم من 122.2 ± 102.8 ميكروغرام/مل إلى 67.2 ± 52.6 و 51.0 ± 37.6 في نهاية 3 و 6 أشهر على التوالي. وأدى استعمال العلاجين معا إلى انخفاض في MIA)) من 174.6 ± 106.4 ميكروغرام / مل إلى 93.2 ± 67.2 و 46.1 ± 53.0. إما في المرضى الذين لديهم التركيز المعتدل للألبومين في الأدرار، فقد كان نقصان MIA)) في المجاميع الثلاثة قليلا. لقد ادى استعمال الأدوية إلى انخفاض في ضغط الدم ولكن لم يصل إلى درجة هبوط الضغط. الاستنتاجات: أدى استعمال كانديسارتان، ديلتيازيم، او الجمع بينهما الى نقصان الألبومين في مرضى السكري والذين لديهم البومين ذات التركيز القليل والطبيعي والمرتفع .


Article
Role of serum IL-18 in type 2 diabetic patients with and without microalbuminuria

Authors: Ali Naser Mohammed Ali AL-Alglani --- AbduladheemYaseen Abbood --- Hazim Abdul Razak Abdul Wahab --- Abbas Mahdi Rahma
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2015 Volume: 14 Issue: 1 Pages: 58-63
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background: Microalbuminuria is a well-known indicator of poor renal outcomes in patients with type 2 diabetes that leads to diabetic nephropathy (DN), but there are many proinflammatary markers that are elevated during injury to the nephrons which lead to chronic kidney disease, one of those is interleukin - 18 (IL-18). Objective: To confirm the role of serum IL-18 as a novel predictor before DN onset. Patients and Methods: The microalbuminuria levels were measured by immunoturbidimetric method, serum IL-18 levels were measured by ELIZA sandwich method, both serum and urine creatinine levels were measured by colorimetric method and hemoglobin A1c (HbA1c) levels were measured by ion exchange - high performance liquid chromatography (HPLC) in 90 individuals, 20 individuals apparently healthy (group I), 40 diabetic patients without microalbuminuria (urinary albumin to creatinine ratio (UACR) ˂ 30 mg/g) (group II) and 30 diabetic with microalbuminuria (UACR 30 -300) (group III).Results: The mean of serum IL-18 in group I, II and III was 189.30 pg/ml ± 3.269 S.E., 220.83 pg/ml ± 0.900 S.E. and 246.67 pg/ml ± 22.341 S.E. respectively. The difference between group I and II, group I and III, and group II and III was significant (P=0.000 for all). The mean of UACR in group I, II and III was 4.25 mg/g ± 2.359 S.E., 4.20 mg/g ± 1.518 S.E. and 34.17 mg/g ± 0.629 S.E. respectively. The difference between group I and II was not significant (P=1. 000) but between group I and III, and group II and III were significant (P=0. 000 for both). The mean of serum creatinine in group I, II and III was 0.885 mg/dl ± 0.0302 S.E., 0.883 mg/dl ± 0.0240 S.E. and 0.933 mg/dl ± 0.0237 S.E. respectively. The difference between group I and II, group I and III, and group II and III was not significant (P=0.998, 0.331 and 0.145 respectively). The mean of hemoglobin A1c (HbA1c) in group I, II and III was 5.9 % ± 0.0211 S.E., 7.7 % ± 0.0445 S.E. and 8.135 % ± 0.0519 S.E. respectively. The difference between group I and II, group I and III, and group II and III was significant (P=0.000 for all). The correlation between urinary albumin to creatinine ratio (UACR) and IL-18 in group III was significant (r=0.983 with P=0.000). The correlation between hemoglobin A1c and IL-18 was significant (r=0.641 with P=0.000) in group II. The correlation between serum creatinine and IL-18 in group III was not significant (r=0.041 with P=0.830). Conclusion: while the increased IL-18 levels were positively correlated with both HbA1c and UACR that leads to the progression of the diabetic nephropathy and it can be one of the cytokines which opens the possibility of its application in clinical treatment in the future.


Article
The Effects of Melatonin On The Oxidative Stress , Protein Glycation , Microalbuminuria and Lipid Profile In Type II Diabetes Mellitus

Loading...
Loading...
Abstract

Previous studies indicated that supplementation with antioxidants has a protective effects against oxidative stress–induced damage in type 2 diabetes. In this study we evaluated the antioxidant effects of melatonin on the oxidative stress parameters and microalbuminuria in type 2 DM patients. 30 patients with type 2 DM were treated with 3mg/day melatonin for 90 days. Erythrocytes and plasma MDA and glutathione, fasting plasma glucose, %HbAIC, microalbuminuria, total plasma protein and lipid profile were measured each 30 days and compared with those obtained from 20 healthy controls.
A decrease in MDA levels associated with the elevation in GSH levels were observed, compared with the pre–treatment levels. Fasting plasma glucose, glycated hemoglobin and microalbuminuria were significantly decreased, associated with an improvement in the total cholesterol, HDL–C and LDL–C levels, with respect to the pretreatment values.In conclusion , treatment of type 2 DM patients with melatonin may have protective effects against the oxidative stress–induced damage during the course of type 2 DM.

لقد أصبحت ظاهرة ازدياد الاجهاد التأكسدي لدى مرضى النوع الثاني من داء السكري أمراً مسلماً به ، ويلعب دوراً مهماً في ظهور مضاعفات المرض . وعليه فقد تم في هذه الدراسة معالجة (30) مريضاً بالنوع الثاني من داء السكري بجرع يومية ( 3 ملغم/ يوم ) من مادة الميلاتونين ولمدة (90) يوماً . وتم قياس المتغيرات التالية :تركيز (MDA) و (GSH) في البلازما وخلايا الدم ومقدار الكلوكوز في بلازما الدم ودرجة كلوزة خضاب الدم (HbIAC) والالبومين الدقيق في البول ، واجمالي بروتينات البلازما وتراكيز صور الشحوم المختلفة في البلازما ، قبل البدء بالعلاج وكل 30 يوماً من العلاج ولمدة 90 يوماً .اتضح من تحليل النتائج بأن استخدام الميلاتونين قد ساهم في تقليل فرط الاجهاد التأكسدي والتقليل من طرح الالبومين في البول وتقليل مقدار الجلوكوز في الدم وكلوزة خضاب الدم ، كما أدى إلى تحسن واضح في مستويات الكولسترول والبروتينات الشحمية عالية وواطئة الكثافة مقارنة بمستوياتها قبل البدء بالعلاج . ومن خلال هذه النتائج يمكن الاستنتاج بان للميلاتونين دوراً فاعلاً في حماية الجسم من الضرر الناتج عن فرط الاجهاد التأكسدي لدى مرضى النوع الثاني من داء السكري .


Article
The Prevalence of Micro albuminuria in Type 2 Diabetes Mellitus Patients

Author: Noor A. Hussein
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 4 Pages: 984-993
Publisher: Babylon University جامعة بابل

Loading...
Loading...
Abstract

This study is performed to assessment of the long term glycaemic hemoglobin (HbA1c) to determine the prevalence of microalbuminuria and to find the risk factors for developing microalbuminuria and consequence nephropathy in patients with type 2 diabetes. The prevalence of microalbuminuria in our study is high (70%) and the risk factors that accompanied microalbuminuria are high blood pressure, elevated fasting blood glucose and poor glycemic hemoglobin.


Article
Relationship between microalbuminuria and glycosylated hemoglobin, and some biomarkers of oxidative stress in type 2 diabetes mellitus

Authors: Hawazin Yousuf Khalaf --- Abdulkareem H. Issa --- Abbas M. Rahmah
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2015 Volume: 28 Issue: 2 Pages: 85-93
Publisher: Al-Mustansyriah University الجامعة المستنصرية

Loading...
Loading...
Abstract

Background: Diabetic nephropathy is a common chronic complication in type 2 diabetes mellitus (T2DM) at the time of diagnosis or later on and to progress with longer duration of the disease. Microalbuminuria (MIC) heralds diabetic nephropathy and precedes proteinuria and is an important risk factor for cardiovascular disease (CVD).Once proteinuria develops after microalbuminuria, progression to end-stage kidney disease occurs rapidly over ~5 years.Objective: To identify the relative importance of glycemic control status and some oxidative stress markers in the discrimination between patients with and without MIC so that the more important ones may be a priority targets in the prevention or treatment of diabetic nephropathy.Subjects and methods: One hundred female T2DM patients and 50 apparently healthy aged-matched women as a control group were enrolled in the study. Diabetic patients comprised two groups; group A: DM patients without MIC; group B: DM with MIC. For each study subject, clinical characteristics were recorded and the following parameters were measured: Urinary Albumin: Creatinine ratio (A:C ratio), and serum levels of fasting glucose , HbA1C, uric acid, thiobarbituric acid-reactive substances (TBARS), and α-tocopherol.Results: Group B patients were found to have a significantly higher mean value of BMI, blood pressure, and longer duration of disease. The mean ratio of HbA1C of group B was significantly higher than in group A (8.7 ± 1.4% vs. 7.1 ± 1%, P < 0.001). On comparison of oxidative stress markers then group B had higher serum TBARS (8±1 vs. 5.9±1 µmol/L, P<0.001), and uric acid (5.8±1vs. 4.9±1.1 mg/dl, P<0.001) than in group A but the two groups showed no significant difference in α-tocopherol. The results revealed that there is a high significant positive correlation between serum TBARS levels and uric acid levels in group B (r = 0.565, p <0.001), while it showed a statistically significant negative correlation between TBARS levels and α-tocopherol levels (r = - 0.837, p<0.001).Receiver operator characteristic (ROC) curve was used to discriminate between group B and A. The area under the curve was highest for serum TBARS (ROC area =0.909) followed by HbA1C (0.814) and their diagnostic accuracy were 85% and 77% respectively.Conclusion: Poor glycemic control and oxidative stress are interrelated states that characterize T2DM patients. Among study analytes, serum levels of TBARS and HbA1c have the highest relative importance in discrimination between patients with and without MIC so that may be, in sequence, a priority targets in the prevention and treatment of diabetic nephropathy.


Article
ASSOCIATION BETWEEN SERUM COPPER, OXIDIZED HDL AND GLYCEMIC CONTROL IN PATIENTS WITH TYPE 2 DIABETES MELLITUS IN RELATION TO MICROALBUMINURIA
الترابط بين النحاس و تأكسد البروتينات الدهنيه عالية الكثافة والسيطرة الأيضيه بالنسبة إلى فرط الزلال الضئيل في الإدرار عند مرضى السكري ( نوع 2)

Loading...
Loading...
Abstract

Background: diabetes mellitus (DM ) is associated with a markedly increased mortality rate from cardiovascular and renal disease, not explainable by traditional risk factors. Although data are not yet conclusive, oxidative stress, dyslipidemia, glycemic control and possibly lipid peroxidation has been increasingly implicated in the pathogenesis of diabetic micro- and macrovascular disease. Little is known, however, about the role of copper in type 2 diabetes.Aim:The present study includes measurement of free radical activity marker (lipid peroxides expressed as malondialdehyde MDA) along with the serum and urine copper, serum lipid profile, glycated haemoglobin (HbA1c) in addition to urinary protein : creatinine ratio in 55 patients with type 2 DM (T2DM) .Results: The patients were divided according to the spot urine albumin excretion (urinary albumin ug / mg creatinine ratio) into two groups:- microalbuminurics & normoalbuminurics.The results were compared with those obtained from 37 age-matched apparently healthy control subjects.There was a significant elevation in serum malondialdehyde MDA , the percentage of oxidized non high-density lipoprotien (ox. non-HDL%) and serum copper with a significant reduction in the percentage of oxidized high-density lipoprotien (ox. HDL%) in the diabetic patients (particulary in the microalbuminurics) as compared with the control subjects. Serum MDA was significantly and positively correlated with serum copper in microalbuminurics and HbA1c% in both diabetic groups.LDL size index was significantly increased in microalbuminuric T2DM patients as compared to the controls and normoalbuminurics indicating smaller LDL size in the diabetics in general and in microalbuminuric in particular. Conclusion: the results of present study suggest an increase in free radical activity , dyslipidaemia and serum copper level favoring atherosclerotic state more in poor glycemic control in type 2 DM particularly in microalbuminurics.The suggested mechanisms underlying these events are discussed.Key words: Copper, lipid peroxides, diabetes mellitus., Microalbuminuria

خلفية الدراسة: يرتبط داء السكري بنسب عاليه من الوفيات بسبب اعتلالات الأوعية الدموية والكلى التي لا تعود للأسباب الأعتياديه المعروفة ، وبالرغم من عدم كفاية الأدلة فان الجهد ألتأكسدي واختلال الدهون ودرجة السيطرة الأيضيه وكذلك زيادة نسبة فوق الأكاسيد لدهون الدم يجعلها من العوامل ألمسببه لأمراض الأوعية الدموية أما علاقة النحاس بكل ذلك فما هو معروف عنه قليل نسبيا.هدف الدراسة: هو قياس دلالات زيادة الجذور الحرة واكاسيد الدهون ممثلة بال- MDAواكاسيد البروتينات الدهنيه وتركيز النحاس ونمط الدهون في الدم وتركيز الهيموغلوبين المتسكر ( HbA1C)ونسبة الزلال في الإدرار عند 55 مريضا بداء السكري ( نوع 2 ) ومقارنتها بمثيلاتها في 37 شخصا طبيعيا ( مجموعة السيطرة ) .ألنتائج: أدت إلى تقسيم مجموعة المرضى إلى نوعين :1- المصابين بفرط الزلال في الأدراربدرجة قليله microalbuminuria 2- المرضى الذين كانت نسب الزلال في الإدرار طبيعيه normoalbuminuria وبالمقارنة مع نتائج مجموعة السيطرة ظهر وجود زيادة ملحوظة عند مرضى السكري في تراكيز أكاسيد الدهون متمثلة بال-MDA وأكاسيد البروتينات الدهنيه عدا العالية الكثافة حيث أظهرت نقصانا مع وجود علاقة طرديه ملحوظة بين تركيز النحاس وال MDA في المجموعة الأولى من المرضى فقط ومع الهيموغلوبين المتسكر HbA1C في كلي المجموعتين.وقد تزامنت هذه التغييرات مع صغر حجم البروتينات الدهنيه الخفيفة LDL عند مرضى السكري بصورة عامه والمجموعة الأولى )المصابين بفرط الزلال في الإدرار) بصورة خاصة.وبينت الدراسة التفسيرات ألمحتمله للظواهر المذكورة.مفتاح الكلمات: النحاس ، أكاسيد الدهون ، داء السكري ، فرط الزلال الضئيل في الإدرار.


Article
Microalbuminuria, Cardiovascular Morbidity, and Mortality in Diabetic and Non–Diabetic Subjects in Kirkuk City

Author: Aseel Sharaf Abdulla
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2010 Volume: 6 Issue: 3 Pages: 113-125
Publisher: Diyala University جامعة ديالى

Loading...
Loading...
Abstract

Ischemic heart disease (IHD) which, leading cause of death in industrialized nations. Traditional risk factors for (IHD) such as hypertension, smoking, diabetes, and hyperlipidemia may not be able to predict cardiovascular events accurately in male and female. Early detection and prevention of (IHD), especially among the elderly, remains a major public health issue. The aim of this study was estimate the frequency of microalbuminuria in patients with and without diabetes mellitus (DM), answering the question: 'How relevant for general practice are epidemiological findings that microalbuminuria is a significant risk indicator for the development of cardiovascular syndromes?' and analyze prospectively whether the urinary albumin to creatinine (A/C) ratio can indepenendently predicts ischemia heart disease (IHD) in a population suffering from diabetes mellitus (DM) in Kirkuk city. The study group conducted on (120) patients with (IHD) and (DM) their age ranging between (20-79) years and (100) aged matched health control subjects .The males consisted (52.27%) of the total patients, while females (47.73%). They characterized by sex, age, body mass index (BMI), blood pressure (Bp), fasting blood glucose (FBG), serum albumin and creatinine.An interaction between microalbuminuria and IHD with DM was observed, and presence of microalbuminuria more than doubled predictive effect of the conventional atherosclerotic risk factor for development of IHD. Urinary albumin/creatinine ratio is recommended for microalbuminuria assessment, because it reflects urinary albumin excretion. Muscular mass could affect albumin/creatinine ratio, because urinary creatinine reflects muscular mass. Prevalence showed significant higher in the normal male than female individuals and this attributed to the difference in the lean muscle mass between the two sex and more fragrantly in (BMI) of (24-26) Kg/m2 in male groups than females. The relationship of obesity on microalbuminuria and (IHD) was statistically significant the (P) values was found to be (<0.05) in the both sexes.The prevalence of the patient groups suffering from previous signs of ( IHD) with type (I) diabetes mellitus in the nonhigh (uACR) groups were (23.3%), high (uACR) without microalbuminuria groups were (30%) and high (uACR) with microalbuminuria groups were (46.7%) while in the groups with patient suffering from previous signs of ( IHD) with type (II) diabetes mellitus were (20%),(32.2%) and (47.7%) respectively. The excess of the patient groups suffering from previous signs of (IHD) with type (II) diabetes mellitus prevalence in the high (uACR) groups reflected the combination of dissimilar data between the subgroups with and without microalbuminuria .In comparison to the nonhigh (uACR), the patient groups suffering from previous signs of (IHD) with type (II) diabetes mellitus prevalence was significantly increased (P<0.05) in the high (uACR) subgroup with microalbuminuria but not in the high (uACR) subgroup without microalbuminuria

Listing 1 - 10 of 15 << page
of 2
>>
Sort by
Narrow your search

Resource type

article (15)


Language

English (12)

Arabic and English (2)


Year
From To Submit

2016 (2)

2015 (2)

2014 (1)

2013 (2)

2012 (1)

More...