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Article
Alteration Of Trophoblastic Tissue Apoptosis And Their Role In Toxoplasmosis Induce Miscarriage
تغييرات موت الخلايا الفسلجي في النسيج المغذي للجنين (التروفوبلاست) ودوره في حث الإجهاض في داء المقوسات الكوندية

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Abstract

ABSTRACT:Toxoplasma gondii ( T. gondii) , a common protozoan parasite. T. gondii infection occurs worldwide and it is one of the most common infections in humans. The infection is mainly acquired by ingestion of undercooked or raw meat containing viable tissue cysts or by ingestion of food and water that is contaminated with oocysts shed by cats . In addition, it has been established that T. gondii can be transmitted from a recently infected mother to her fetus. During pregnancy the primary infection may lead to severe if not fatal complications for the fetus. These direct effects can lead to spontaneous miscarriage, stillbirth or congenital anomalies .apoptosis in villous trophoblast is increased in pregnancy complications such as Toxoplasmosis infection. From our study we found that Toxoplasma gondii downregulated apoptosis when caspase 3 and caspase 9 levels were investigated using immunohistochemistry technique .Aims of Study: So the aims of this search are to investigate the levels of Caspase 3 and Caspase 9 expression within T.gondii infected trophoblastic cells and their association with infection. Method: Fifty patients (aborted women), Their range age between (16 − 46) years, were included in this study. All patients sera were subjected to Enzyme Linked Immunosorbent Assay (ELISA) to detect specific Toxoplasma gondii IgM and IgG . In addition , trophoblastic tissues from the same patients were taken to confirm the infection of the T.gondii and to evaluate the expression of caspase 9 and caspase 3 using immunohistochemstry method.Results : Immunehiostochamical technique is more sensitive than ELISA in diagnosis of T. gondii when 18 patients were positive for Toxoplasmosis by immunohistochemistry While in ELISA only 16 patients were positive for specific anti – Toxoplasma IgM. The levels of Caspase3 and caspase 9 were downregulated in infected group.Conclusion : Caspase 9 expression and Caspase 3 expression are significantly highly decreased in women with spontaneous miscarriage in T.gondii positive group compared to patients control group indicating that Toxoplasma gondii downregulated apoptosis.

خلاصة البحثالمقوسات الكوندية هي طفيليات وحيدة الخلية شائعة . وتحدث الإصابة بها في كل أنحاء العالم . وهي واحدة من اهم الإصابات الشائعة في الإنسان . وتحدث الإصابة بها عادة بهضم اللحم النيئ او المطبوخ بصورة غير كافية والحاوي على كيس النسيج الحي اوبهضم الغذاء او الماء الملوث بالبيوض المطروحة من قبل القطط .بالإضافة الى ذلك داء المقوسات الكوندية ممكن انتقاله من الام المصابة حاليا الى جنينها .خلال الحمل الاصابة ممكن إن تسبب مضاعفات شديدة إن لم تكن مميتة الى الجنين . هذه التأثيرات المباشرة تقود الى الإجهاض التلقائي , ولادة جنين ميت وتشوهات خلقية . موت الخلية الفسلجي في النسيج المغذي للجنين يزيد من مضاعفات الحمل مثل الاصابة بالمقوسات الكوندية .من دراستنا وجدنا انه المقوسات الكوندية تؤدي الى تقليل موت الخلايا الفسلجي عندما تم قياس مستويات انزيم قاطع متسلسلة حامض الاسبارتيك الثالث والتاسع في النسيج المغذي للجنين ( التروفوبلاست ) باستخدام الفحص الكيميائي النسيجي .أهداف البحث :-لملاحظة مستويات تعبير إنزيم قاطع متسلسلة حامض الاسبارتيك الثالث والتاسع ضمن خلايا التروفوبلاست المصابة بالمقوسات الكوندية وعلاقتهم بالإصابة .طرق البحث :- تضمن الدراسة خمسون مريضة ( امرأة مجهضة إجهاض تلقائي ) أعمارهم ما بين 16-46 سنة . أخضعت مصل المريضات الى فحص الاليزا للكشف عن IgMو IgG الخاص بالمقوسات الكوندية بنفس الوقت النسيج المغذي للجنين اخذ من نفس المريضات لتأكيد الإصابة بالمقوسات الكوندية ولقياس تعبير إنزيم قاطع متسلسلة حامض الاسبارتيك الثالث والتاسع باستخدام الفحص الكيميائي النسيجي . النتائج:-الفحص الكيميائي النسيجي أكثر حساسية من الاليزا في فحص المقوسات الكوندية . عندما وجد 18 مريضة موجبة لمستضدات المقوسات الكوندية باستخدام الفحص الكيميائي النسيجي بينما في فحص الاليزا وجد 16 مريضة فقط موجبة للمــضاد المناعي نوع (م (. وان مستويات إنزيم قاطع متسلسلة حامض الاسبارتيك الثالث والتاسع قد قلت في المجموعة المصابة . الاستنتاج :- مستويات تعبير إنزيم قاطع متسلسلة حامض الاسبارتيك الثالث والتاسع هناك فرق معنوي عالي بين المجموعة الموجبة للمقوسات الكوندية مقارنة بمجموعة السيطرة مما يدل على إن المقوسات الكوندية قد قللت الموت الفسلجي للخلايا.


Article
Relationship of Nitric Oxide and Malondialdehyde to Miscarriage
علاقة تركيز اوكسيد النتريك وتركيز المالوندايالدهايد مع الاجهاض

Authors: Asmaa K. Gatea --- Balsam G Hassan --- Ahmed M Issa
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2012 Volume: 9 Issue: 4 Pages: 777-785
Publisher: Babylon University جامعة بابل

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Abstract

AbstractThe present study was conducted to verify the oxidative stress status in miscarriage .To achieve this aim, 70 women with miscarriage (patient group) , and 25 healthy non pregnant (control group) were subjected to the study. The statistical analysis ( student's t-test) showed a significant (p<0.001) increase of nitric oxide (NO) and malondialdehyde (MDA) levels , in women with miscarriage when compared with those of the control group .The linear regression analysis demonstrated a significant positive correlation for both MDA values(r =0.47, p<0.01) and NO values(r =0.45, p<0.01) with gestational ages .The same analysis indicated a significant positive correlation for MDA (r =0.73 , p<0.01) and (r =0.71 , p<0.01) for NO levels with the number of previous miscarriages was observed . The results indicate that oxidative stress may lead to miscarriage.Key words: nitric oxide, malondialdehyde, miscarriage.

الخلاصة تم تصميم الدراسة الحالية للتحقق من تغيرات الإجهاد التأكسدي عند مريضات الاجهاض التلقائي . شملت الدراسة 70 مريضة و 25 امراءة غير حامل سوية بوصفهم مجموعة سيطرة . تم تقدير مستويات اوكسيد النتريك و مالون ثنائي الألديهايد في أمصال المرضى ومجموعة السيطرة . وجد زيادة ملحوظة p<0.001)) في مستوى اوكسيد النتريك و مالون ثنائي الألديهايد لدى مريضات الاجهاض عند مقارنتها مع مثيلاتها في مجموعة السيطرة. اظهرتحليـل الانحدار الخطي ارتبـاطاً معنويا موجباً لكل من مستوى مالون ثنائي الألديهايد ( r=0.47 , p<0.01) ومستوى اوكسي النتريك( r=0.45 , p<0.01) لدى المريضات نسبةً إلى التقدم في مدة الحمل. . كما أظهرت النتائج وجود ارتباط معنوي موجب في مستوى كل من مالون ثنائي الألديهايد ((r=o.73, p<0.0 ومستوى اوكسيد النتريك( r=0.71, p<0.01) مع عدد الاجهاضات السابقة . توضح النتائج ان الاجهاد التاكسدي يؤدي الى الاجهاض.


Article
Thromboprophylaxis in women with unexplained consecutive recurrent ‎miscarriages
موانع تخثر الدم في النساء المصابات بالاجهاض المتكرر غير المفسر

Author: Maysoon Sharief, Teshreen Sabri Ali د.ميسون شريف، د.تشرين صبري
Journal: The Medical Journal of Basrah University المجلة الطبية لجامعة البصرة ISSN: 02530759 Year: 2014 Volume: 32 Issue: 1 Pages: 37-42
Publisher: Basrah University جامعة البصرة

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Objective: To compare the effect of low dose aspirin and enoxaparin on pregnancy in women with recurrent ‎miscarriage.‎Patients& Methods: Randomized controlled trail, conducted in Basrah Maternity and Child Hospital during the period ‎from January 2012 till April 2013. Participants were 221 pregnant women aged 18-41 years with history of at least 2 ‎previous miscarriage without apparent causes. They were divided into 2 groups; the first group included 111 were given ‎enoxaparin and the second group involved 108 which were given aspirin.‎Results: In both groups (75%) of patients had negative serological test for thrombophilia. Enoxaparin group had higher ‎significant incidence of term delivery (86%) with less incidence of preterm delivery (4.5%) and less early pregnancy ‎loss (8%).‎No significant differences in obstetrical complication but higher incidence of abdominal delivery in both groups.‎Higher incidence of postpartum hemorrhage in the enoxaparin group in comparison with aspirin group and no significant ‎systemic adverse effect of enoxaparin were noticed on the first group.‎Conclusion: Since postpartum hemorrhage is treatable, low molecular weight heparin is safe and effective for treating, ‎preventing thrombosis and achieving successful pregnancy.‎

الهدف: دراسة مقارنة بين استعمال الجرع القليلة من دواء الاسبرين ودواء الاينوكسابارين اثناء الحمل للوقاية من الاجهاض المتكرر من الحوامل.‏المرضى وطرق العمل: اجريت دراسة سرية عشوائية في مستشفى الولادة والطفل في البصرة خلال الفترة بين كانون الاول 2012 ونيسان 2013. ‏المشاركون221 امرأة حامل ذوات الاعمار 18-41 سنة ويعانون من اسقاطين سابقة بدون وجود اسباب واضحة. تم تقسيمهم الى مجموعتين؛ ‏تشمل المجموعة الاولى 111 مريضة اعطين دواء الاينوكسابارين بينما اعطيت المجموعة الثانية (108 مريضة) دواء الاسبرين.‏النتائج: لقد تبين ان 75% من النساء الحوامل لديهن نتائج ايجابية لعدم وجود اضطراب في عمل الصفيحات الدموية وقد لوحظ كذلك ان ‏مجموعة الاينوكسابارين هي الاعلى نسبة في الولادة في الشهر التاسع (86%) والأقل نسبة في فقدان الحمل اثناء الاشهر الاولى (8%). لايوجد ‏فرق في مضاعفات الحمل والولادة بين المجموعتين. سجلت اعلى نسبة في الاصابة بنزف مابعد الولادة أي مجموعة الاينوكسابارين اكثر من ‏مجموعة الاسبرين.‏الاستنتاجات: نظراً لامكانية معالجة النزف بعد الولادة ، لذا يعتبر دواء الاينوكسابارين امين في الاستعمال وله تأثير جيد في معالجة ومنع حدوث ‏تخثر الدم وبالتالي المحافظة على الحمل ‏


Article
Glyceryl Trinitrate Versus Misoprostol for Termination of First Trimester Missed Miscarriage

Authors: Ibtissam Y.Al-Saffar --- Eman Marouf
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 3 Pages: 242-248
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:Missed abortion refers to a pregnancy that can manifest as an anembryonic gestation or fetal demise prior to 20 weeks' gestation. Medical management has been used as a treatment options.A common medical regimen used to evacuate the uterus is vaginal misoprostol (Cytotec) in single or multiple doses.OBJECTIVE:To compare the therapeutic efficacy and adverse effects of intravaginal administration of a nitric oxide donor (glyceryl trinitrate) with that of a prostaglandin (misoprostol) to induce cervical changes in women with missed miscarriages to terminate their pregnancies.METHODS:A prospective, randomized comparative trial conducted at Al-Yarmouk Teaching Hospital, Department of Obstetrics & Gynaecology/ Baghdad-Iraq, enrolled Sixty women with first trimester missed miscarriages that requested pregnancy termination. They were randomly selected to receive either two tablets of 500 μg glyceryl trinitrate vaginally (n = 30) or 200 μg misoprostol tablet vaginally (n = 30), every 3 hours to a maximum of four doses or until reaching desirable cervical changes. Baseline vital signs were recorded and repeated with monitoring for adverse side effects every 3 hours until finishing therapy.RESULT:The difference in cervical changes between the two groups was statistically not significant (p > 0.05). The successful outcome taken as cervical dilatation ≥ 10 mm, incomplete, or complete miscarriage was achieved in 30% of women in the glyceryl trinitrate and in 53% of women in the misoprostol group which was statistically not significant ( p>0.05).Systolic & diastolic blood pressure, temperature & heart rate were lower with glyceryl trinitrate than misoprostol, but the differences were not significant (p>0.05).The most frequent side effect associated with glyceryl trinitrate administration was headache, which occurred in 27/30 women, compared with only 5/30 women in misoprostol group; relative risk 5.42 (p <0.05). Women treated with misoprostol reported mainly lower abdominal pain; relative risk 4.2 (p <0.05).CONCLUSION:Although glyceryl trinitrate was less effective than misoprostol when used prior to termination of missed miscarriage, the difference was statistically not significant. Moreover glyceryl trinitrate caused less adverse effects than misoprostol and it could have a role in the management of this obstetrical problem.


Article
Evaluation of Some Spontaneous Abortion-Causative Factors for Women in Baghdad Province A Serological and Histological Study

Authors: Samar A.AL-Gharrawi --- Salim R.AL-Ubaidy --- Bedir M.AL-Azawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2012 Volume: 11 Issue: 3 Pages: 297-302
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:The spontaneous abortion is considered as one of the important clinical problems that may affects pregnant women during the 1st 20-22 weeks of pregnancy causing dangers to the mother and her fetus. The present study was designed to focus on some spontaneous abortion causes and intrauterine fetal death.OBJECTIVE:Study certain risk factors that may play a role in abortion such as serum level of , progesterone hormone , estradiol hormone , interlukine-6 and perform a histological study on placenta to identify any specific histop-METHODS:Seventy (70) Women were selected to represent the samples of spontaneous aborted women. The women were classified into two groups , the first represented aborted women during the first trimester of pregnancy (52) and the second were females in the second trimester of pregnancy (18) , in comparison with result of (20) normally delivered pregnancies. The samples (sera and placenta) were collected during the period from November 2008 to April 2009 in Baghdad.RESULTS:Significant decrease (p<0.01) in the level of progesterone and estradiol hormone was found in all aborted women at different stages of pregnancy compared with control. There was no significant difference (p>0.05) in level of IL-6 between aborted women and control. There was a correlation (positive) between progesterone with IL-6 in first and second trimester (p<0.05, p<0.01), respectively. And progesterone with estradiol (p<0.05) in second trimester. The histological study shows hydropic degeneration fibroids with hyalinization of fibrinosis changes.CONCLUSION:These results suggest an important role of progesterone, estradiol and IL-6 in spontaneous abortion women during first and second trimester. And apparition of the histological changes corresponding to the aborted women.


Article
Determination of Toxoplasmosis Disease Activity by Estimation of IL-6 Cytokine
تحديد نشاط داء المقوسات الكوندية بواسطه تقدير مستوى الانترلوكين 6

Authors: Lina K. Al-Zohairy لينا قاسم الزهيري --- Ban N. AL-Qadhi بان نوري القاضي
Journal: Iraqi Journal of Science المجلة العراقية للعلوم ISSN: 00672904/23121637 Year: 2015 Volume: 56 Issue: 2C Pages: 1600-1611
Publisher: Baghdad University جامعة بغداد

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Toxoplasma gondii (Nicolle and Manceaux ) infects all warm-blooded animals, including humans. Early diagnosis and determining the infective stage are critical for treating immunosuppressed individuals and pregnant women with toxoplasmosis. This parasite modulates pro- and anti-inflammatory responses to regulate parasite multiplication and host survival. The aim of this study was to investigate the probability of using IL-6 as a marker of toxoplasmosis disease activity (acute and chronic) in different groups of women (miscarriage, pregnant and single) and estimate the relationship between infection and gestational age and history of abortion in miscarriage and pregnant women. The most abortion were occurred at the first trimester in chronic infected miscarriage women also, the most abortion were occurred at the first trimester in acute infected pregnant women. The result showed that acute infected miscarriage women with previously abortion scored high significant percentage of infection in comparison to non- abortifacient, chronic infected one and pregnant women. IL-6 was significantly higher in acute infected miscarriage women in comparison to single and pregnant acute one but chronic infected pregnant women characterized by the lowest level of this cytokine in comparison to all studied groups.

طفيلي Toxoplasmaتصيب كل الحيوانات ذوات الدم الحار من ضمنها الانسان. التشخيص المبكر وتحديد الطور المعدي يكون ذو اهميه بالغه في علاج افراد الاشخاص ذوي المناعه المنخفضه والحوامل المصابات بداء المقوسات الكوندية. هذا الطفيلي يتوسط الاستجابه البادئه والمضادة للالتهابات لتنظيم تكاثر الطفيلي وبقاء المضيف. الهدف من هذه الدراسه هو للكشف من امكانيه استخدام انترلوكين 6 كدلاله لنشاط داء المقوسات الكونديه ( الحاد والمزمن ) في مجاميع مختلفه من النساء ( مجهضات ، حوامل وغير متزوجات) وتقدير العلاقة بين الاصابه ومدة الحمل و تاريخ الاجهاض في النساء المجهضات والحوامل. اغلب الاجهاضات حصلت في الاشهر الاولى من الحمل في النساء المجهضات ذوات الاصابه المزمنه ، كذلك اغلب الاجهاضات حصلت في الاشهر الاولى من الحمل في النساء الحوامل ذوات الاصابه الحادة. اظهرت النتائج انه النساء المجهضات ذوات الاصابه الحادة والمجهضة سابقا سجلت اعلى نسبه اصابه للمرض مقارنة بالنساء المجهضات ذوات الاصابه المزمنه غير المجهضات سابقا والنساء الحوامل. وبينت النتائج ان مستوى انترلوكين 6 كان عاليا معنويا في النساء المجهضات ذوات الاصابه الحادة مقارنة مع الغير متزوجات والحوامل ذوات الاصابه الحادة لكن النساء الحوامل ذوات الاصابه المزمنه تميزت بمستوى اقل من هذه ا مقارنة مع كل المجاميع المدروسه.

Keywords

toxoplasmosis --- IL-6 --- miscarriage --- pregnant.


Article
Role of Metformin on Recurrent Miscarriage and Other Pregnancy Complications in Women with Polycystic Ovarian Syndrome

Author: Inaam Faisal Mohammed
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2017 Volume: 7 Issue: 1 Pages: 1-6
Publisher: Al-Nahrain University جامعة النهرين

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Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. Polycystic ovary syndrome signs and symptoms often begin soon after menarche. In some cases, PCOS develops later during the reproductive years, for instance, in response to substantial weight gain. The PCOS produces symptoms in about 5-10% of women of reproductive age(12-45 years) and it is one of the leading causes of female subfertility.Women with PCOS suffer not only from subfertility, but also from a high rate of early pregnancy loss. About 30-50% of clinically confirmed early pregnancy loss are associated with PCOS.In addition to early pregnancy loss, women with PCOS have increased risk of recurrent miscarriage ,which defined as 3 or more consecutive pregnancy loss before 20 week. Metformin hydrochloride, an insulin sensitizing agent, has been shown to have encouraging effects on several aspect of PCOS like insulin sensitivity, plasma glucose concentration & lipid profile.It is found that using Metformin during pregnancy in women with PCOS may reduce the pregnancy loss and also reduce the risk of gestational diabetes,intrauterine growth retardation(IUGR) & preterm labor.


Article
Emotional Response and Beliefs of a Sample of Women Attending Baghdad Teaching Hospital Regarding Miscarriage

Author: Farah A. Abdulrahman*, Ban A. Al Hashimi **, Ahlam A. Tahir***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2018 Volume: 17 Issue: 3 Pages: 232-238
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND: Although the cause of recurrent pregnancy loss is unknown in the majority of cases; advanced maternal age, chromosomal abnormalities, uterine abnormalities and infections could all be potential causes of miscarriage. Miscarriage is a common problem and could affect the women’s psychological wellbeing in the short term and possibly in the long term. OBJECTIVE: To describe the awareness of women age (15-45) years old regarding beliefs and emotional impact of miscarriage.SUBJECTS AND METHOD: A descriptive cross-sectional study was carried out on the total of 393 women with age from 15-45 years old attending gynecology, obstetrics and family planning departments in Baghdad Teaching Hospital in Baghdad/Iraq during the period from 14th of January 2016 to 15th of April 2016.RESULTS: 393 women have been or still pregnant, 171 of those 393 women had a history of miscarriage; giving the prevalence of (43.5%) for women reporting a history of miscarriage. The prevalence of miscarriage in women age 40-45 years old was (38.0%). In this study (63.7%) of women satisfied about the medical care they received after abortion. The beliefs of the respondent about the causes of miscarriage showed that a large number agreed that sexual intercourse during pregnancy (36.4%) and past use of oral contraception (33%) may all be causes for miscarriage, (81%) believed that stressful event was a cause of miscarriage, (58%) knew that pregnancy loss was the result of genetic abnormalities, (46.4%) believed that having had a sexually transmitted disease in the past was the cause of miscarriage, and (68.4%) of women who had experienced a miscarriage reported that they would find a miscarriage to be extremely upsetting, equivalent to the loss of a child.CONCLUSION: There are some misperceptions about the factors associated with miscarriage. Many women had emotional distress after miscarriage which was perceived as a loss of a child.


Article
A comparison between two different doses of sublingual misoprostol in the management of first trimester incomplete miscarriage
مقارنة بين جرعتين مختلفتين من الميزوبروستول تحت اللسان في إدارة الإجهاض الناقص في الأثلوث الأول

Authors: Mina J. Mustafa --- Ishraq M. Shakir
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1260-1266
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Background and objective: Various methods have been described for management of first trimester incomplete miscarriage. The active methods include surgical methods that are highly effective but are associated with anesthetics and surgical risks. Medical methods by Misoprostol had been shown to be effective, acceptable and widely used treatment for incomplete miscarriage. The aim of this study was to compare the efficacy, patients' acceptability and the side effects of sublingual administration of single dose of 400mcg with single dose of 600mcg of misoprostol in the treatment of first trimester incomplete miscarriage. Methods: This study was conducted from April 1st, 2011 to February 1st, 2012 in the Maternity Teaching Hospital in Erbil city, Kurdistan region, Iraq. The study included 120 patients with incomplete miscarriage at a gestational age ≤12 weeks. They randomly received either single dose of 400mcg or 600mcg of misoprostol sublingually. Patients returned for follow-up and re-evaluation of abortion status after 7 days. Patients with a continuous incomplete miscarriage underwent surgical evacuation. Results: The success rate in the first and second group was 90% and 91.7%, respectively, while patients' acceptability in the first and second group was 96.7% and 95%, respectively with no difference between both groups. Gastrointestinal side effects like nausea and diarrhea were more in the second group. Conclusion: Single dose of 400 mcg of sublingual misoprostol is preferred on 600mcg of sublingual misoprostol regarding the development of side effects.


Article
The role of histopathological examination of the products of conception following first-trimester miscarriage in Erbil Maternity Hospital
دور الفحص الهستوباثولوجي لمنتجات الحمل بعد الإجهاض في الأثلوث الأول في مستشفى أربيل للولادة

Author: Payman Anwar Rashid
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 3 Pages: 1938-1942
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Miscarriage represents a common problem that occurs in the first trimester of pregnancy. There is no general agreement on the value of submitting tissues from uterine evacuation in cases of miscarriage for histopathological examination. This study aimed to evaluate the role of histopathological examination in cases of first-trimester miscarriage.Methods: This is a descriptive study was carried out over a period of 14 months, from January 2015 to March 2016, at Erbil Maternity Hospital. A total of 375 biopsies from patients admitted to maternity hospital with the diagnosis of the first trimester miscarriage and cases of spontaneous miscarriage were included in this study. The clinical data including age, parity, gestational age, clinical diagnosis, the method of evacuation, and other relevant information were collected and submitted for histopathological examination.Results: Incomplete miscarriage was the commonest type of miscarriage and constituted 65.3% of the studied group and surgical evacuation was the most common method of termination. The histopathology reports confirmed the pregnancy in all patients and revealed retained product of normal pregnancy in 315 (86.6%) cases, partial mole in 15 (4%) patients, complete hydatidiform mole in one (0.2%) case, decidual reaction in 21 (5.6%) cases and no product of conception in 13 (3.4%) cases.Conclusion: Histopathological examination of the products of conception is an important method in detecting undiagnosed molar pregnancy that needs special follow-up and further management.

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