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The Effect of Some Organic Compounds on Monoamino oxidase Activity

Author: Najlaa Qasim Muftin
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2012 Volume: 15 Issue: 4 Pages: 38-46
Publisher: Al-Nahrain University جامعة النهرين


Imidazole derivatives have occupied a unique place in the field of medicinal chemistry. The incorporation of the imidazole nucleus is an important synthetic strategy in drug discovery. The high therapeutic properties of the imidazole related drugs have encouraged the medicinal chemists to synthesize a large number of novel chemotherapeutic agents. This study was designed to show the effects of new compounds derivatives from 2-Imidazolidine thione on the activity of Monoamino oxidase in sera. All compounds were studied demonstrated inhibitory effects on the enzyme activity and these effects are increased with increasing the concentrations of the compounds. The compound 2-(4,5-dihydro-1H-imidazol-2-ylthio)-N'-(2-hydroxy benzylidene) acetohydrazide has the highest ability to inhibit MAO than the other compounds.Kinatic properties of these inhibitors reveal that compound 4 causes mixed type of inhibtion,componds 1,3 act as non -competitive inhibitor and compound 2 behaves as un- competitive inhibitor.

يوضح هذا البحث تأثير مشتقات جديدة للأيميدأزوليدين ثايون في فعالية انزيم مونوامينو اوكسيديز في مصل الدم. أضهرت جميع المركبات المدروسة تأتير تثبيطي في فعالية الانزيم وان قدرة هذه المركبات على تثبيط الانزيم تزداد طرديا مع زيادة تركيزها. لقد وجد ان المركب2-(4,5-dihydro-1H-imidazol-2-ylthio)-N'-(2-hydroxy benzylidene)acetohydrazide يمتلك أعلى قابلية لتثبيط الانزيم مقارنة ببقية المركبات .كما اظهرت دراسة الخواص الحركية لهذه المثبطات ان المركب (4) يتسبب بتثبيط من النوع المختلط والمركبان 1و3 يسببان تثبيط من النوع اللاتنافسي اما المركب (2) فانه يسبب تثبيط من النوع الغير تنافسي.

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