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Article
The Role of White Blood Cells inAcute Coronary Syndrome

Author: Hilal B. Shawki )
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 4 Pages: 362-368
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:
Inflammation has been shown to play a role in atherosclerosis and acute coronary
syndromes. An elevated total WBC count has been associated with increased cardiovascular
risk, but which leukocyte subtypes carry this risk. is uncertain. This study was designed to
determine the effect of WBC count and other inflammatory markers on severity and
outcome of patients with UA/NSTEMI.
Patients and Methods:
Seventy (70) patients with UA / NSTEMI admitted to CCU at the Iraqi Center for Heart
Diseases were subjected to thorough history and physical examination and WBC indices to
find their relation to clinical severity and outcome for both in-hospital and/month after
discharge. The results were compared with other thirty (30) patients with chronic stable
angina and thirty (30) healthy persons as two control groups.
Fac Med Baghdad
2007; Vol.49, No.4
Received Sept. 2006
Accepted Oct .2007
Results:
High total baseline total WBC was more prevalent in patient with UA/NSTEMI than in
those with stable angina and normal persons (94.1%, 5.9%. and 0%) respectively. High
baseline neutrophil was found only in those with UA./NSTEMI (100%, 0%, and 0%). High
baseline Neutrophil/lymphocyte (N/L ratio) and Positive CRP were more prevalent in
patients with UA/NSTEMI than in other two groups (92.3%. 7.7%. 0%) and (98.5%, 1 .5%.
0%) respectively.
Higher total baseline WBC count was significantly found in more severe Braunwald's
class of those with UA/NSTEMI 6.3%. 31.3%. and 50.5% for patients with class I, II, III
respectively. The same was true for baseline high neutrophil count (6.7%. 33.3% to 60%),
high Baseline N/L ratio (7.7%, 15%. and 21.6%).
Patient in the UA/NSTEMI group with higher baseline WBC count had higher risk for
death as compared to those of low and intermediate WBC count (0.00%. 0.00%. and
100.00%). The same was true for those with higher baseline neutrophil count (0.00%.
1.90%, 20.00%) and those with higher baseline N/L ratio (0.00%. 25.000%. 75.000%)
respectively.
Conclusions:
Total baseline WBC and differential count is simple, cheap and widely available
bedside test that predicted the severity of CAD and one month survival.

Keywords

WBC count --- differential count --- CRP --- UA/NSTEMI


Article
The Relationship between Oxidative Stress and Osteopontin Levelsin Diabetic Patient with Acute Coronary Syndrome

Authors: Bushra Arebie Al-Hussieny --- Tariq Hovthy Al-Khayat --- Monem Makki Al-Shouk
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 956 -968
Publisher: Babylon University جامعة بابل

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Abstract

This study was performed to determine osteopontin levels in sera of diabetic patients having acute coronary syndrome and finding the relationship betweenosteopontin and oxidative stress in the corresponding patients .A case –controlled study for 60Iraqi diabetic patients (33male and 27 female)with acute coronary syndrome (STEMI and NSTEMI) and 20 diabetic patients without myocardial infraction were selectedforthisstudy. Besides,Forty healthy subjects served as control group.The serum levels of Osteopontin (OPN),HbA1c,SOD,CAT and Malondialdehyde (MDA) were determined for the corresponding patients.The result obtained were compared with those 40 subject(20male and 20 female) who are apparently healthy (control group).All the selected patients were non -smokers,non –hypertensive and have no inflammatory disease which may affected the results of the measured parameters. Osteopontin levels were significantly increasedin patientswith DM,STEMI and NSTEMIcompared to the controls. The levels of MDA and HbA1Cin the patients were significantlyhigher compared to the controls whileSOD ,CATwere significantly lower compared to the controls, and a significant positive was found between osteopontin,HbA1C and MDA and negative correlation was found with SOD and CAT levels.The increase Osteopentin levels inrelevance to oxidative stress and HbA1C level may indicate the role of hyperglycemia in the induction of this acute inflammatory marker which can be considered as a prognostic indicator of diabetic complications especially diabetic patients with MI.

Keywords

OPN --- MDA --- DM --- STEMI --- NSTEMI --- SOD --- CAT and HbA1C --- MI.


Article
Correlation of Fetuin A level with ECG types of Acute Myocardial Infarction

Authors: Haydar Hashim Al-Shalah --- Oday Al-Salihi --- Dina Ayed Mohammed
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 4 Pages: 750 -754
Publisher: Babylon University جامعة بابل

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Abstract

Acute myocardial infarction is one of the commonest disease with serious complications and increasing morbidity and mortality. Coronary atherosclerosis plays a crucial role in the underlying pathophysiology. Fetuin-A is a protein which is closely linked with increased risk of cardiovascular disease, and secreted mainly by the liver, produces subclinical inflammation and insulin resistance. This study was aimed to evaluate the association of serum fetuin A level with ECG types of acute myocardial infarction.This is a case–control study included 88 subjects divided into two groups; 44 patients with acute myocardial infarction,36 of them with STEMI and 7 with NSTEMI. The other 44 were apparently healthy individuals taken as a control. Serum fetuin-A levels were measured by using ELISA technique. There was significant differences in serum fetuin-A levels between patients and control, (p value ≤ 0.05).The mean differences between serum fetuin-A levels and both type of AMI (STEMI and NSTEMI),were also significant(p value ≤ 0.05) where higher values observed in STEMI.This study concluded thatfetuin-A level was significantly correlated with type of AMI and higher values of fetuin-A were observed in STEMI .

Keywords

Fetuin-A --- AMI --- ELISA technique --- STEMI --- NSTEMI --- ECG

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