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Article
Demographic features of neuroblastoma in Iraq-Kurdistan Region- Sulaimani

Authors: Basil K. Abdallah --- Nawshirwan Gafoor Rashid --- Shwan Ali Tawfiq
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2018 Volume: 7 Issue: 2 Pages: 62-66
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: Neuroblastoma is the third most common cancer in pediatric age group; it isthe most common malignancy in the 1st year of life. The majority of the patients (50%–65%) haveadvanced disease at diagnosis. Diagnoses, staging investigations, and risk categorization have agreat success in neuroblastoma, trying to classify the patient into risk groups according to the age,stage, and molecular study and this in turn has important value in the treatment strategies. Despiteof this improvement in the early diagnosis and treatment protocol, neuroblastoma stills is one of themalignant diseases that are associated with high morbidity and mortality.OBJECTIVES: The aims of this study were to evaluate the pattern of presentation, studyingthe correlation between age, sex, and site of primary tumor with disease staging in patients withneuroblastoma.PATIENTS AND METHODS: This study was done prospectively over a period of 6 years fromFebruary 2008 to February 2014. Sixty‑two patients with newly diagnosed pediatric neuroblastomaadmitted to Hiwa Hematology/Oncology hospital were included in this study. Age, sex, clinical patterns,staging, and important laboratory findings were assessed. The patients staged according to theInternational Neuroblastoma Staging System. We divided our patients into three groups accordingto the risk categories.RESULTS: Data analyzed using SPSS- 13 and P value obtained by Chi‑square test, a median ageat diagnosis was about 24 months with male predominance. Most common site of the primary tumorwas the abdomen; approximately 69% of our patients with neuroblastoma studied were Stage 4.CONCLUSION: The stage in our study was age dependent, but it was neither depending on the sexnor the site of the primary tumor.


Article
Neuroblastoma: A Clinico-Epidemiological Study in AL-Khadhimyia Teaching Hospital

Author: Sawsan Sati' Abass*, Mais Ryiad**
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2015 Volume: 14 Issue: 4 Pages: 530-536
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Neuroblastoma is the third most common childhood cancer, after leukemia and brain tumors, and is the most common solid extra cranial tumor in children. The term neuroblastoma is commonly used to refer to a spectrum of neuroblastic tumors (including neuroblastomas, ganglioneuroblastomas, and ganglioneuromas) that arise from primitive sympathetic ganglion cells.OBJECTIVE:The aim of this research is to study the epidemiological and clinical feature ofneuroblastoma in a group of Iraqi infants and children who were admitted to the pediatric ward of Al-Khadhimyia Teaching Hospital .PATIENTS AND METHOD:The study was done over a period of three months from 1st of Feb. 2010 to the end of Apr. 2010.In reviewing all files, 18 cases were collected from the Pediatric Hemato-Oncology Consultation Clinic in Al-Khadhimyia Teaching Hospital, they were diagnosed and treated consequently in the pediatric ward / hemato-oncology unit over a period of 9 years (2002-2010). Data regarding age, sex, residence, site of primary disease and clinical presentation were taken from the recording files in the pediatrics Hemato-Oncology Clinic. Methods used to diagnose our patients includes, fine needle aspiration of tumor mass, Bone marrow aspiration & biopsy of different sites. Chemotherapy was the main line of treatment.RESULTS:The total number of studied cases was eighteen cases. The median age was 15 months with male to female ratio of (0.63:1), 9 cases (50%) were below 1 year. Abdominal mass was the commonest site of tumor 12 cases (67%), weight loss was the most common symptom 18 cases (100%) followed by abdominal distention 14 cases(78%), abdominal mass represent the most common sign in 12 cases(67%). Stage IV was noticed in 9 cases (50%), 10 cases (56%) were a high risk group, 7 cases (38.8%) had bone marrow metastases, 6 cases (34%) finished treatment and survive, 4 cases( 22%) relapsed, 2 cases(11%) died.CONCLUSION:The majority of cases were recognized during the first two years of age .Female were involved more than male. The outcome of treated cases was good and accepted. Abdominal mass is the commonest site , weight loss is the commonest symptoms.


Article
PATTERN AND OUTCOME OF NEUROBLASTOMA IN DUHOK CITY, KURDISTAN REGION, IRAQ

Author: KHALID N. ABDURRAHMAN خالد نواف عبدالرحمن
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2011 Volume: 5 Issue: 1 Pages: 50-61
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background and objectives The prognosis of neuroblastoma varies widely depending on the age at diagnosis, extent of the disease and tumor biology. This study was undertaken to evaluate the pattern and the 4-year survival rates of children with neuroblastoma in Duhokcity, Kurdistan region, North of Iraq.Methods A total of 33 children with neuroblastoma who had been diagnosed at Heevi Pediatric Hospital, Duhok city, from January 2000 to January 2007 were evaluated for their age, sex, primary tumor site at diagnosis, histology, staging, treatment and outcome.Results The median age at diagnosis was 23 months (range 3-74 months), 19 patients were males and 14 were females with male-to-female ratio of 1.3:1. Adrenal gland was the commonest site of the primary tumor and abdominal distension was the most frequentpresentation. Favorable histology was seen in 19 (57.5%), and unfavorable histology in 14 (42.5%) patients. Complete surgical resection was performed after diagnosis in 6 patients, incomplete resection/debulking in 18 patients, 5 patients died before surgery, and in infants less than 12 months of age with stage 4S disease (4 patients) only biopsy was taken. Twentythree patients (69.6%) were diagnosed with stage 3 or 4 disease. All patients receivedchemotherapy. The 4-year disease free survival and the overall survival rate were 18.1% and 30.2 %, respectively.Conclusion The 4-year disease free survival and the overall survival rate of neuroblastoma patients in Duhok city were similar to that reported earlier from Baghdad but lower than those reported in other countries. Advanced stage of disease, incomplete tumor excision andincreased age at diagnosis were all associated with poor survival. Exploration of more novel therapeutic approaches is required to improve the outcomes of patients in our region.

خلفية واهداف البحث: ان التكهن بمصير النيوروبلاستوما يعتمد على عمر المريض، ومدى انتشار وبايولوجية الورم.يهدف هذا البحث الى معرفة نمط ومعدل البقاء على قيد الحياة بعد اربع سنوات, للاطفال المصابين بالنيوروبلاستوما في مدينة دهوك / شمال الع ا رق.طرق البحث: تمت د ا رسة 33 طفلا مصابا بالنيوروبلاستوما من الذين شخصوا في مستشفى هيفي التعليمي للاطفال / 2007 من حيث العمر، الجنس، الموضع الاولي للورم، نوع النسيج، مرحلة الورم، - مدينة دهوك للفترة من عام 2000 العلاج والمصير.1. الغدة الكظرية كان : النتائج: معدل عمر المرضى عند التشخيص كان 23 شه ا ر ونسبة الذكور الى الاناث كان 1.3 من اكثر المواضع الاولية للورم وانتفاخ البطن من اكثر علامات المرض. في 57.5 % من المرضى كان نسيج الورم ايجابيا وفي 42,5 % كان النسيج سلبيا. في 6 من المرضى استؤصل الورم كاملا، وفي 18 من المرضى استؤصل ال ورم جزئيا، وتوفي خمس من المرضى قبل اج ا رء العملية الج ا رحية. وفي اربع من المرضى الذين هم دون سنة من العمر تم اخذ خزعة بدون استئصال الورم. معظم المرضى شخصوا في مرحلة متقدمة من المرض، وجميع المرضى عولجوا كيمياويا. معدل البقاء بدون مرض ومعدل البقاء على قيد الحياة كانا 18.1 % و 30.2 % على الترتيب.الاستنتاج: ان معدل البقاء على قيد الحياة لمرضى النيوروبلاستوما في دهوك يشبه الى حد ما معدله في بغداد بينما اقل من الدول الاخرى، وقد ارتبط ذلك بتقدم عمر المريض عند التشخيص ووجود المرض في مرحلة متقدمة، وعدم استئصال الورم بشكل كامل. نحتاج الى طرق حديثة للعلاج من اجل تحسين مصير المرضى


Article
An adult adrenal neuroblastoma presented as a right shoulder pain: A case report
والعصبية الكظرية الكبار كما عرضت ألم الكتف الأيمن: تقرير حالة

Authors: Yasser I. Abbass --- Idreiss J. Khalaf --- Azzawi M. Hadi
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2008 Volume: 2 Issue: 142 Pages: 89-92
Publisher: Tikrit University جامعة تكريت

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Abstract

Neuroblastoma of the adrenal gland is an extremely rare tumor in adulthood although it is one of the most common malignancies in childhood. In this report, a 25-year-old woman who had a left adrenal mass on preoperative imaging. She was operated and the mass was resected in en-block manner along with the left kidney. The histopathological examination of the specimen revealed the diagnosis of neuroblastoma. She had metastasis to the cervical part of the spinal cord operated upon before the time of diagnosis as a suprarenal tumor and received chemotherapy after the operation. Although neuroblastoma of adrenal gland is rare in adulthood, it should be considered in the differential diagnosis for patients with adrenal masses

العصبية من الغدة الكظرية هو ورم نادر جدا في سن البلوغ على الرغم من أنه هو واحد من الأورام الخبيثة الأكثر شيوعا في مرحلة الطفولة. في هذا التقرير، وهي امرأة 25 عاما، الذي كان له كتلة اليسار الكظرية في التصوير قبل الجراحة. اجريت عملية جراحية كانت مقطوعة وكان القداس في EN-كتلة بطريقة جنبا إلى جنب مع الكلية اليسرى. كشف فحص الأنسجة لعينة لتشخيص العصبية. كان لديها ورم خبيث في عنق الرحم جزء من الحبل الشوكي يعمل على قبل وقت التشخيص وجود ورم الكظر، وتلقت العلاج الكيميائي بعد العملية. على الرغم من العصبية من الغدة الكظرية أمر نادر الحدوث في سن البلوغ، ينبغي النظر في ذلك في التشخيص التفريقي للمرضى مع الجماهير الكظرية

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