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Article
Non- Hodgkin's Lymphoma; Epidemiology and Presentation

Authors: Zead Ismael Ibrahim --- Allawi N. Hussein --- AbdulSattar I. AL-Kubaysi --- Tariq A. AL-Shujairi --- et al.
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2013 Volume: 2 Issue: 1 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: The non-Hodgkin lymphomas (NHL) of childhood are a diverse collection of diseasesoriginating in the cells and organs of immune system.Objectives: To determine epidemiology and clinicopathological presentations of children with NHLadmitted to Child's Central Teaching Hospital.Methods: A retrospective study was done from 1st of January 2004 to the 31st of December 2009; thepatients with newly diagnosed NHL, age less than 15 years, who were admitted to thepediatric oncology unit in the Child’s Central Teaching Hospital.Results: The total number of patients was 84; the mean age at diagnosis was 6.3years, with a male tofemale ratio of 2:1. Most of patients were presented in stage III&IV (88%).Most commonpresenting features were abdominal distension or a mass in 51%.Burkitt lymphoma andBurkitt like lymphoma were the most common histological subtype (58.33%).Conclusions: The majority of cases were between 5-9 year age group, and the mean age atpresentation was 6.3 years old, with a male to female ratio of 2:1. The most commonpresenting site was the abdomen. The majority of cases were fallen in advanced stages(III&IV). Histopathologically Burkitt's lymphoma was the commonest subtype.


Article
Immunohistochemical and clinicopathological study of non-Hodgkin's lymphoma in Erbil, Kurdistan
دراسة كيميائية مناعية ونباتية لأورام ليمفوما اللاهودجكين في أربيل، كوردستان

Authors: Maysoon Alhaideri --- Rafal Abdul Razaq Al-rawi --- Tara Sirwan Kamil
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 2 Pages: 756-762
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Non-Hodgkin lymphoma is a cancer of the lymphatic system. Types of non-Hodgkin lymphoma vary significantly in their severity from indolent to very aggressive. The aim of this study was to investigate the incidence, immunohistochemical expression, clinical and histopathological prognostic factors of patients with non-Hodgkin lymphoma.Methods: A total of 59 patients with non-Hodgkin lymphoma cases were reviewed and investigated at Razgary Teaching Hospital in Erbil city during the period from January, 2011 to January, 2013. Data of patients were tabulated and distributed according to their age, sex, site, immunohistochemical expression and WHO classification.Results: Age of non-Hodgkin lymphoma patients ranged from 2 to 88 years with a mean of 45 year. Around 49% of the patients were of age group over 50 years and 54.2% of pa-tients were male. Immunohistochemical investigation indicated that 71.2% of non-Hodgkin lymphomas were of B cell type, the highest percentage (33.3%) of them was of diffuse large cell type. While the T cell type was found in 20.3%, the highest percentage (33.3%) of them was of Anaplastic lymphoma. CD20 and CD3 showed more consistent and strong expression for B and T cells non-Hodgkin lymphoma, respectively. Results showed high BCL2 expression. Nodal non-Hodgkin lymphoma account for 50.8% of the total cases.Conclusion: Most non-Hodgkin lymphomas were of B cell type and highest percentage is of diffuse large cell type. CD20 and CD3 were more reliable as an indicator of B and T cell lineage, respectively. Most non-Hodgkin lymphomas were of intermediate-high grade. Nodal site represent highest rate for primary non-Hodgkin lymphoma.


Article
Prognostic Significance of Immunohistochemical Overexpression of P53 And Bcl-2 Proteins in Patients with Non-Hodgkin’sLymphoma

Authors: Farah Amer Albejow --- Hadeel Abdul-Elah Kerbal --- Najlaa Bader Alawadi --- Ahmed Raji Kharulla
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 721-729
Publisher: Babylon University جامعة بابل

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Abstract

Non-Hodgkin's lymphomas are the hematologic malignancy with the most prevalence worldwide, they are generally classified as B-cell or T-cell lymphoma .Theincidence rate of NHL for the total population is 5.16 % according to Iraqi cancer registry (ICR) in 2010.This study was designed to asses’bcl-2 and p53 overexpression in Iraqi patients with NHL and correlation with different prognostic indices (age, sex, stage, grade, and International prognostic index).Samples included in this study represented as 50 formalin-fixed paraffin embedded lymph node blocks of patients with NHL,during the period from September 2013 till November 2014,and these blocks collected from the histopathology laboratories of Al-Hilla Teaching Hospital as well as many private histopathology laboratories in Hilla city, These blocks stained Immunohistochemically for bcl-2 and p53 protein expression by using L-SAB+ staining methods.Results revealed Significant correlation between bcl-2, p53overexpression and different grades of NHL (p-value < 0.05), while there are no significant relationship between bcl-2, p53 and age, sex, stage, and IPI score (p-value > 0.05).In conclusion there are up regulation of P53 protein associated with down regulation of bcl2 protein in patients with high, intermediate to low grades of NHL while no significant association with IPI score& factors.

Keywords

Non-Hodgkin lymphoma --- P53 --- Bcl-2


Article
Immunophenotypic study of non-Hodgkin lymphomas in adult and elderly patients at National Center of Hematology-Baghdad.

Authors: Abdusalam Hatim Mohammed --- Sajid Saad Mohammed --- Jawad. k. Mashaali
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2014 Volume: 3 Issue: 2 Pages: 127-131
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Non-Hodgkin lymphomas (NHL) are a heterogeneous group of lymphoproliferativemalignancies with different patterns of behavior and responses to treatment. The understanding andhistopathological diagnosis of NHL has improved with the use of advanced technology. Theimmunophenotyping of tumors of hematopoietic origin serves in the first place to distinguish theseneoplasms from others, and to distinguish neoplasms from reactive processes.Objectives: The aim of this study was to determine the percent of each category of NHLPatients and Methods: Sixty eight patients who were diagnosed to have stage 4 non-Hodgkin lymphomaby histopathological examination of bone marrow aspirate and biopsy at National Center ofHematology/Baghdad were subjected to immunohistochemistry examination, two cases diagnosed ashairy cell leukemia by histopathological examination but not by immunohistochemistry as there were noCD markers available at the time of study so they were discarded from this study. Immunohistochemistrywas done either in hospital or in private laboratory for proper subtyping of the disease and yet to receivecorrect therapy and better response.Results: Cases were diagnosed as fallowsB-cell lymphoma constitute 57 cases 86.36%T-cell non-hodgkin lymphoma 6 cases 9.09%Splenic lymphoma 1 case 1.5%Mantle cell lymphoma 2 cases 3.03%Conclusion: Immunohistochemical study is a specific method to aid histopathology in proper diagnosisand subtyping of non-Hodgkin lymphoma


Article
Detection of Epstein - Barr virus Type1 and Type2 in Subtypes of Non- Hodgkin Lymphoma in Kerbela Province by Using Polymerase Chain Reaction
التحري عن فيروس الابسن بار النممط الاول النمط الثاني في الانواع الفرعية للاورام اللمفاوية اللاهودجكن في مدينة كربلاء بواسطة تفاعل الكوثرة .

Authors: Hussein Abd Ali Mohamed Sadeq Al Her --- M ohanad Mohsen Ahmed
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2019 Volume: 17 Issue: 2 Pages: 15-27
Publisher: Kerbala University جامعة كربلاء

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Abstract

Epstein-Barr virus (EBV) is a ubiquitous virus associated with lymphomas. However, in Kerbala as other parts of Iraq, EBV detection is not a part of the workup for lymphoma diagnosis. . Archival formalin-fixed paraffin- embedded blocks from 44 patients with mean age 45.9±22.8 (range from 4 to 86years) diagnosed as Non Hodgkin lymphoma during the period from 2010 to 2018 in Kerbala city included in this study. Histological diagnosis was reviewed. Around 25mg of archival tissue were used to extract DNA. DNA extracts were used Polymerase Chain Reaction (PCR) targeting the EBNA3C region of the viral genome. This PCR system offered detection and typing of the EBV. T-test and chi-square were used to evaluate the association between age with the subtype of Non Hodgkin lymphoma, gender and EBV state. The majority of the Non Hodgkin lymphomas(NHL) belonged diffuse large B cell (DLBC) [n=28, 63.6%], T-cell rich Diffuse large B-cell [n=9, 20.5%], high grade B cell Burkitt- like (BL) [n=3, 6.8%], small Blymphocytic [n=2,4.5%],high grade B cell(CD20-ve,CD30-ve[n=1,2.3%] and peripheral T-cell [n=1,2.3%]. The other subtypes of NHL were not reported in this study. Male and female were equal affected with NHL (22 for each) and the peak age range of NHL over 60 years. EBV was detected in 21(47%) out of all cases. EBV type 1 was more common to EBV2in all subtype of NHL. To our knowledge, this is the first- time such data has been generated in Iraq. In this study present evidence that Non- Hodgkin lymphoma cases in Kerbela are associated with EBV1 and EBV2 types. There is a difference in the distribution of the EBV types according to the subtypes of lymphoma. The aim of this study: to detect types of EBV in the subtype of Non- Hodgkin lymphoma (NHL) among patients from Kerbala province, Iraq

يعتبر فيروس الابسن بار فيروس شائع الانتشار ويكون عادة مرتبط بالأورام اللمفاوية. ومع ذلك ، في كربلاء وفي مدن العراق الاخرى ، لا يعتبر كشف الفايروس جزءًا من عملية تشخيص الإصابة بالورم اللمفاوي. تهدف هذه الدراسة التحري عن مدى انتشار أنماط الفايروس في الانواع الفرعية من الاورام اللمفاوية اللاهودجكين بين المرضى من محافظة كربلاء ، العراق.استخدمت الشرائح النسيجية المثبتة بالفومالين والمغمورة بالشمع لــ 44 مريض بمتوسط العمر 45.9± 22.8 (تتراوح اعمارهم من 4 إلى 86سنة ) المشخصين بورم الغدد اللمفاوية الاهودجكين خلال الفترة من 2010 إلى 2018 في مدينة كربلاء تم دراستها. تم مراجعة التشخيص النسيجي من قبل مختص الانسجة . استخدم حوالي 25 ملغم من المقاطع النسيجية المخزونه لاستخلاص الحمض النووي. تم استخدام مستخلصات الحمض النووي في تفاعلات الكوثرة باستهداف منطقة الجين EBNA3C في الجينوم الفيروسي. استخدم التفاعل لتشخيص الفايروس و تميز انواع فايروس الابسن بار .تم استخدام اختبار تي و مربع كاي لتقييم الارتباط بين العمر بالانواع الفرعية من سرطان الغدد اللمفاوية اللاهودجكين والجنس و مقارنتها مع نتائج تشخيص الفايروس ..اظهرت النتائج ان غالبية الأورام اللمفاوية اللاهودجكين بانها تنتمي إلى النوع الفرعي DLBC حيث كانت 28 (63.6%)حالة ثم النوع الفرعي المختلط صغير وكبير T-cell rich Diffuse large B-cell في 9(20.5%) حالة , و البركت لمفوماBL 3(6.8%) و واحد حالة لكل من HGBC و PTC. و لم تسجل حالات من الأنواع الفرعية الأخرى من الاورام الهوجكن في هذه الدراسة. الذكور , الإناث نفس عدد الاصابات بالاورام اللمفاوية اللاهوجكن (22) . كانت الفئة العمرية اكثر من 60 عاما الاكثر اصابة بالاورام اللمفاوية اللاهوجكن . تم الكشف عن الفايروس في 21 (47%) حالة من جميع الحالات. كان EBV1 أكثر شيوعًا في جميع الانواع الفرعية من النوع. EBV2. على حد علمنا هذه هي المرة الأولى التي يتم فيها تسجيل مثل هذه البيانات في العراق. كانت اهم الاستنتاجات ان كثير من حالات الاصابات بالاورام اللمفاوية اللاهوجكن مرتبطة مع فايرس الابسن بار .هناك اختلاف في توزيع أنواع الفيروس وفقا لأنواع سرطان الغدد اللمفاوية


Article
Determination of Serum Trace Elements and Hematological Parameters in Lymphoma Patients Receiving Chemotherapy

Authors: Zainab Hadi Kamil --- Mufeed Jalil Ewadh --- Abdulsamie Hassan Alta'ee
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2016 Volume: 24 Issue: 9 Pages: 2498-2509
Publisher: Babylon University جامعة بابل

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Abstract

BackgroundTrace elements are essential components of biological structures, some of them play an important role as anticancer and others can be toxic at concentrations beyond those necessary for their biological functions.AimThe objective is to examine changes in serum concentration of trace elements (Cobalt (Co), Germanium (Ge), Molybdenum (Mo), Nickel (Ni) and Vanadium (V)), Mg and hematological changes in Hodgkin and Non-Hodgkin lymphoma patients receiving therapy.Materials and methodsThe study was included 25 patients with Non-Hodgkin lymphoma (NHL) and 25 patients with Hodgkin lymphoma (HL) as compared with 50 healthy subjects. Serum concentration of trace elements are measured by flame atomic absorption spectrophotometer. The total leukocyte count (TLC), hemoglobin concentration (Hb) and packed cell volume or hematocrit (Hct) are determined.Results Statistical analysis of data demonstrated significant decrease (p<0.001) in Mg and Co concentration and (p<0.01) in Ge concentration in patients with lymphomas receiving therapy as compared with healthy adults.V and Ni concentrations are significantly increased (p<0.001) in patients with lymphomas receiving therapy as compared with healthy adults. The study shows significant decrease (p<0.05) in Hb concentration and Hct percentage in patients with lymphomas receiving chemotherapy as compared with healthy subjects. It revealed significant decrease (p<0.005) in female patients with lymphoma who receive chemotherapy. Significant decrease (p<0.001) in TLC in patients with lymphomas receiving therapy as compared with healthy adults are observed. ConclusionLymphoma patients receiving therapy are often low in Mg, Ge and Co levels while Ni and V levels are high in patients with Hodgkin and Non-Hodgkin lymphoma.There is a significant decreased in TLC in patients with Hodgkin and Non-Hodgkin lymphoma whose are receiving chemotherapy..Anemia occurred in patient with lymphomas as a side effect of chemotherapy.

تعتبر العناصر النزرة مركبات أساسية في البناء الحيوي والبعض منها يلعب دوراَ مهماً كمضادات سرطانية والبعض الآخر يمكن ان يكون له تأثير سمي بالرغم من أهميته في الفعاليات الحيوية.الهدف من الدراسة معرفة التغيرات في تراكيز العناصر النزرة (الكوبالت (Co) ، الجرمانيوم (Ge) ، الموليبدينوم (Mo) ، والنيكل (Ni) و الفاناديوم (V) ) والمغنيسيوم (Mg) وكذلك التغيرات الدموية لدى مرضى سرطان الغدد اللمفاوية الهودجكني واللاهودجكني والمتلقين للعلاج الكيمياوي.شملت الدراسة 25 مريضاً بسرطان الغدد اللمفاوية الهودجكني و25 مريضاً بسرطان الغدد اللمفاوية اللاهودجكني مقارنة مع الاصحاء (50 شخصاً). تم قياس تراكيز العناصر النزرة في مصل الدم بجهاز المطياف (flame atomic absorption spectrophotometer) كما تم قياس تركيز الهيموكلوبين (Hb) ونسبة مكداس الدم (Hct) والعدد الكلي لخلايا الدم البيض (TLC).بين التحليل الاحصائي للعينات انخفاضاً معنوياً (p<0.001) في تركيز كل من Mg و Co وانخفاضاً معنوياً (p<0.01) في تركيز Ge لمرضى سرطان الغدد اللمفاوية لكلا النوعين والمتلقين للعلاج الكيمياوي مقارنة مع الاصحاء. كما ارتفع تركيز كل من Ni و V (p<0.001) لدى المرضى في هذه الدراسة.اظهرت الدراسة انخفاضاً معنوياً (p<0.05) في تركيز الهيموكلوبين ونسبة مكداس الدم وانخفاضاً معنوياً (p<0.001) في العد الكلي لخلايا الدم البيض لدى مرضى سرطان الغدد المفاوية والمتلقين للعلاج الكيمياوي مقارنةً مع الاصحاء.الاستنتاج: غالباً ما يكون تركيز كل من العناصر Mg و Ge و Co منخفضاً في مصل دم المرضى المصابين بسرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي بينما يرتفع تركيز كل من Ni و V في مصلهم.حصول انخفاض معنوي في العدد الكلي خلايا الدم البيض لمرضى سرطان الغدد اللمفاوية والمتلقين للعلاج الكيمياوي كما يظهر لديهم فقر دم كعارض جانبي نتيجة للغلاج الكيمياوي.

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