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CAN PERIODONTAL THERAPY REDUCES THE SEVERITY OF ACTIVE RHEUMATOID ARTHRITIS
تاثير علاج امراض اللثة على شدة التهاب المفاصل

Author: HASHIM D. MOUSA هشام موسى
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2016 Volume: 10 Issue: 1 Pages: 40-48
Publisher: University of Dohuk جامعة دهوك

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Abstract

Background: A significant association between periodontitis and Rheumatoid Arthritis (RA)has been reported.Aim: This study was done to determine the effect of periodontal treatment on severity of RA.Patients and Methods: This study was done on 60 patients, age 30-60 years, who wererandomly selected from patients attending Duhok Center for Rheumatic Diseases andMedical Rehabilitation. The patients were classified into two groups: Group 1: patients withdiagnosis of RA and periodontal disease who received Non-Surgical Periodontal Treatment(NSPT) during the study and group 2: patients with diagnosis of RA and periodontal diseasewho were monitored during the study but did not receive periodontal treatment. At the initialvisit, periodontal health status of the patients based on clinical attachment loss and probingpocket depth score, and disease activity score were determined. After six month, theperiodontal status and severity of rheumatoid arthritis were rescored and reassessed for bothgroups following the same procedure.Results: Initially, there were no significant difference in periodontal status and severity ofRA for both groups. After 6 months period, there was significant difference in intra-groupanalysis for both groups regarding periodontal status and severity of RA but there was nosignificant difference in inter-group analysis of periodontal status and disease activity score.Conclusion: There is no significant difference in the improvement of severity of RA andperiodontal disease in patients with RA treated with NSPT, compared to control cases withRA.

الهدف: علاقة معنوǽة بین التهاب اللثة و التهاب المفاصل تم طرحها. الهدف من الدراسة لایجاد مدȐ تاثیر علاج امراض اللثة على التقلیل من شدة التهاب المفاصل.طرȂقة الǺحث: دراسة تتاǼعǽة اجرȄت على ٦٠ مرȄض الذین اعمارهم تتراوح بین ال(٣٠-٦٠ (سنة و الذین اختیروا عشوائǽا من المرضى الذین یراجعون مرȞز الروماتیزم والتهاب المفاصل في دهوك . تم تصنیف المرضى الى مجموعتین المجموعة الاولى: المرضى الذین لدیهم التهاب المفاصل و التهاب اللثة والذین استلمواعلاج امراض اللثة خلال الدراسة. المجموعة الثانǽة: المرضى الذین لدیهم التهاب المفاصل و التهاب اللثة والذین لا ǽستلمون اȑ علاج للثة خلال الدراسة.في البداǽة صحة اللثة و الانسجة الداعمة ǽعتمد على قǽاس جیوب اللثة و قǽاس مدȐ فقدان الانسجة الداعمة و قǽاس شدة المرض Ǽعد ستة اشهر لمعرفة تاثیر علاج اللثة على شدة المرض.النتائج: في البداǽة لم ǽلاحظ اȑ فرق معنوȑ بین اللثة و شدة المرض. Ǽعد ستة اشهر هناك فرق معنوȑ ملحوض داخل المجامǽع للمجموعتبن الاولى والثانǽه ǼالنسǼه لحالة اللثة و شدة التهاب المفاصل.الاستنتاجات: في البداǽة لم ǽلاحظ اȑ فرق معنوȑ بین اللثة و شدة المرض. Ǽعد ستة اشهر هناك فرق معنوȑ ملحوض داخل المجامǽع


Article
Effect of non surgical periodontal treatment on TNF-α levels in serum of patients with chronic periodontitis
تأثير علاج اللثة غير الجراحي على مستويات TNF-α في مصل المرضى الذين يعانون من التهاب اللثة المزمن

Authors: Haween T. Nanakaly --- Sazan Sartip Abdulhameed
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1167-1174
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Chronic periodontitis is a multifactorial inflammatory disease characterized by destruction of tooth supporting tissues. Tumor necrosis factor-α, a key inflammatory cytokine, plays an important role in periodontal destruction. This study aimed to analyze the effect of non-surgical periodontal treatment on tumor necrosis factor-α levels in serum of patient with chronic periodontitis (with and without using chlorhexidine 0.2% mouthwash).Methods: A total of 44 patients with moderate to severe localized chronic periodontitis were divided into: Group I (n=22) without using of chlorhexidine mouthwash and Group II (n=22) with 0.2% chlorhexidine mouthwash. Serum samples collected from each subjectsat baseline and four weeks after scaling and root planning treatment were quantified fortumor necrosis factor-α levels using ELISA technique.Results: The mean concentration of TNF-α were significantly reduced one month after treatment in sera of patients with chronic periodontitis for group I when compared to its mean concentration before treatment (P <0.05), while in group II a highly significant reduction after one month treatment (P <0.001) was observed.Conclusion: The effect of non-surgical periodontal therapy with chlorohexidine mouth wash showed more reduction in the levels of serum tumor necrosis factor-α.

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