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Article
Socio-economic and Medical Predictors for Obesity among Women Aged 50 Years and More: Case-Control Study
المقاييس الاجتماعية الاقتصادية للنساء البدينات اللائي اعمارهن 50 سنة واكثر

Author: Dhafer B. Al-Youzbaki
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2009 Volume: 22 Issue: 2 Pages: 80-87
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Obesity is now reaching epidemic proportions and is increasingly recognized as an important public health problem. Epidemiological studies have consistently shown it to be associated with increased risks of morbidity, disability and mortality. Aim: To examine the impact of different socio-economic and medical characteristics on the development of obesity in women more than 50 years. Study design: Case-control study, where 125 obese women proved by standard anthropometric measures were allocated as cases. Another 125 women proved to be not obese also by standard anthropometric measures were considered as controls. Study period: 1st. February 2007 to 1st. October 2007.Data collection tools: Including, assessment of socio-economic features such as personal characteristics, life events and social context. In addition, previous history of surgical operation, parity, abortion and the presence of one or more of chronic non-communicable diseases were also gained. Social class identification according to occupational social classification then was obtained. Results: Regarding Personal Characteristics; positive family history was found to be significantly associated with the development of obesity (P=0.000), the same thing was applied to sedentary life styles (P=0.000). Furthermore, unhealthy dietary behavior was again significantly associated with the occurrence of obesity (P=0.000). Personality type B, also found to be associated with development of obesity (P=0.000). According to Life Events; only social discontinuities in this work appears to be significantly associated with the development of obesity (P= 0.008). According to Other Variables, the presence of one or more of chronic non-communicable diseases is found to be associated with the occurrence of obesity (P=0.000), and high parity shows significant association in the development of obesity (P=0.004). A significant association between social class III and obesity was also found (P= 0.022), while social class V plays a significant protection against the development of obesity (P= 0.004). Conclusion: Women with positive family history, sedentary life, unhealthy dietary behavior, personality type B, social discontinuities, chronic diseases, high parity and being in social class III, are at risk for development of obesity. Key words: Socio-economic, obese, women.

الخلفية:السمنة الان وصلت الى مرحلة وبائية و بكثير من الاهمية بدأت تصير مشكلة صحية مهمة. الكثير من الدراسات الوبائية كشفت ان السمنة مرتبطة بزيادة خطر الامراضات و العوق و حتى الوفيات.تصميم الدراسة:دراسة العينة و الشاهد.وقت الدراسة:من الاول من شباط 2007 الى الاول من تشرين الثاني 2007.النتائج:تاريخ العائلة الايجابي, الحياة الكسولة, الغذاء غير الصحي, نوع ب من الشخصية, عدم التواصل الاجتماعي, الامراض المزمنة غير الانتقالية, الولادات العلية, و المستوى الاجتماعي الثالث , كلها بدت من هذه الدراسة انها عوامل خطورة لحدوث السمنة عند النساء فوق الخمسين سنة.

Keywords

Socio-economic --- obese --- women.


Article
Could Interleukin (IL)-6 Values be Used in the Identification of Glucose Intolerance in Obese Pediatric Population
هل يمكن استخدام قيم الانترليوكين-6 في تحديد عدم تحمل الكلوكوز عند الأطفال البدناء

Author: Walaa A. Al-Jedda ولاء احمد الجدة
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2012 Volume: 25 Issue: 3 Pages: 232-235
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: Adipose tissue is the source of a wide variety of molecules involved in the regulation of energy output and carbohydrate metabolism. Among these, cytokines, such as tumor necrosis factor (TNF)-α and interleukin (IL)-6, appear to play a role in modulating insulin sensitivity in peripheral tissues and have been associated with the development of insulin resistance in adults. Aim of study: The aim of the study was to ascertain the relationship among the degree of adiposity, circulating fasting insulin levels, with plasma IL-6 in an obese child and adolescent population with or without glucose intolerance.Subjects and Materials: Eighty obese children and adolescents were studied. Plasma interleukin (IL)-6 were measured for those obese with normal oral glucose tolerance Test (OGTT), and obese with glucose intolerance. These patients were compared with eighty healthy children matched for age and sex.Results: Plasma fasting insulin concentration and HOMA (Homeostatic model assessment) were significantly higher in glucose intolerance obese patients [(28.2±14.9µIU/ml),(5.7±4.8)] compared with their results in normotolerance obese patients [(20.9±8.3µIU/ml),(4.5±2.7)] and control subjects[(14.8±6.3µIU/ml),(3.2±1.9)] (p 0.005 ,0.001) respectively, Plasma levels of (IL-6) in glucose intolerance obese patients were significantly higher (2.9±1.3 ng/ml) compared with normotolerance obese patients (2.0±1.1 ng/ml) and control subjects (1.5±0.9 ng/ml)(p 0.005).Interleukin (IL-6) was positively correlated with BMI, (r=0.37; p 0.001), waist and hip circumferences(r=0.35; r=0.33) respectively, (p 0.001), insulin levels (r=0.30; p 0.001), TG and VLDL-C (r=0.27; p 0.001)Conclusion: Plasma IL-6 appears to be involved in glucose metabolism, insulin resistance, and dyslipidemia in obese children and adolescents with glucose intolerance.

الخلاصةالخلفية العلمية: الأنسجة الدهنية هي مصدر لطائفة واسعة من الجزيئات المشتركة في تنظيم إنتاج الطاقة والتمثيل الغذائي للكاربوهيدرات ,من بين هذه الجزيئات الحركيات الخلوية(السايتوكينات) مثل عامل نخر الورم (TNF-) والانترلوكين-6(IL-6) ويبدو انها تلعب دورا في تحوير حساسية الانسولين في الأنسجة المحيطية و كذلك ارتبطت مع تطور مقاومة الانسولين في البالغين الهدف من الدراسة: ان الهدف من الدراسة هو التحقق من العلاقة ما بين درجة السمنة و مستويات الانسولين الصيام الدوار مع نسبة الانترلوكين (IL-6) في بلازما الأطفال البدناء والمراهقين المصابين وغير المصابين بعدم تحمل الكلوكوز.المواد والطرق: تم دراسة 80 من الأطفال و المراهقين البدينين , حيث تم قياس نسبة الانترلوكين-6 (IL-6) في بلازما هؤلاء البدناء ذو التحمل الطبيعي للكلوكوز الفموي والبد ناء المصابين بعدم تحمل الكلوكوز. قورنت هذه النتائج مع نتائج ثمانين من الأطفال الأصحاء من نفس الفئة العمرية والجنس.النتائج : أظهرت النتائج وجود زيادة نوعية في نسبة تركيز الأنسولين و HOMA عند البد ناء المصابين بعدم تحمل الكلوكوز ](28,2± 14,9مايكرو وحدة قياسية/مليلتر) (5,7 ± 4,8 )[ عند مقارنتها عند البد ناء ذو التحمل الطبيعي للكلوكوز الفموي ](20,9 ± 8,3 مايكرو وحدة قياسية/مليلتر) (4,5±2,7) [ والأشخاص الأصحاء ](14,8 ±6,3مايكرووحدة قياسية/مليلتر) (3,2 ± 1,9[(l ] 0,005 p< و0,001 [p< على التوالي. كذلك اظهرت النتائج وجود زيادة نوعية في نسبة الانترلوكين-6 في بلازما البد ناء المصابين بعدم تحمل الكلوكوز](2,9 ±1,3 نانوغرام/مليلتر) [عند مقارنة نسبها في البد ناء ذوي التحمل الطبيعي للكلوكوز الفموي](2,0 ± 1,1 نانوغرام/مليلتر)[ والأشخاص الأصحاء(1,5 ±0,9 نانوغرام/مليلتر), (0,005p<), كذلك أظهرت الدراسة وجود علاقة موجبة بين نسبة الانترلوكين-6 في بلازما المرضى المصابين بعدم تحمل الكلوكوز مع دالة كتلة الجسم (0,37 r= 0,001 P<), محيط الخصر و الورك (0,33و0,35 r=)على التوالي (0,001p<), نسبة الانسولين (0,30 r=)(0,001 p<) والدهون الثلاثية والدهون ذات الكثافة الخفيفة جدا ( 0,27 =r )( 0,001 p<)الخلاصة : يبدو أن مستوى الانترلوكين-6 في بلازما الدم تشارك في استقلاب الكلوكوز,مقاومة الانسولين,واضطراب الدهون لدى الاطفال واليافعين البدناء المصابين بعدم تحمل الكلوكوز.

Keywords

Obese --- interleukin-6.


Article
Epicardial Fat Thickness Obese Patients an Observational Echocardiographic Study

Authors: Faris Abdul Kareem Khazaal --- Ghazi Farhan HajiMD --- Mousa Qasim Hussein --- Yousif Abdul RaheemMD,
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 3 Pages: 416-420
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND:Obesity currently affects nearly one-third of the population in the industrialized world.Traditionally, anthropometric measures such as body mass index (BMI) or waist circumferencehave been used to quantify overall adiposity; however, regional fat depots may be of greaterimportance than overall adiposity. Several studies have highlighted pericardial fat and abdominalvisceral adipose tissue (VAT)as unique, pathogenic fat depot. OBJECTIVE:Recognize the relation of obesity to increase epicardial fat pad thickness in Iraqi patients. METHODS:Epicardial fat thickness was measured in 62 consecutive subjects (28 women 45%, 34 men 55%)mean age of 47.77 years (SD 8.03),using routine transthoracic echocardiogram. Epicardial fat wasidentified as the echo-free space between the outer wall of the myocardium and the visceral layerof the pericardium, and its thickness was measured perpendicularly on the free wall of the rightventricle at end-systole. RESULTS:The results show progressive increase of epicardial fat with increasing BMI which was verysignificant statistically. High mean epicardial fat is significantly associate with increasing waistcircumference. No difference in those below and above 45 years of age in mean epicardial fat andthere is gender difference in epicardial fat, where males had more epicardial fat than females. CONCLUSION:There is increase in the epicardial fat pad thickness in overweight and obese (BMI≥25) patients ifcompared to normal persons epicardial fat increase with increasing waist circumference morelikely in male obese and independent of age


Article
Metabolic Syndrome among overweight and Obese Children Attending Central Pediatric Teaching Hospital in Baghdad

Authors: Deia Kadam Kalaf --- Esraa AbdAl-Hameed AbdAl-Azeez --- Abdul-Kadhim Nassir Dawood
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 2 Pages: 455-462
Publisher: Babylon University جامعة بابل

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Abstract

Metabolic syndrome is one of the serious problems that facing children all over the word, as it can lead to multiple health problems including psychological, cardiovascular, endocrinology and school performance.The aim of this study is to estimate the frequency of Metabolic Syndrome among overweight and obese children, and to detect the relation of age and gender,A cross sectional study conducted on 49 children in Central teaching hospital for children in Baghdad for one year (from 1/1/2013– 1/12/2013). Weight, height, blood pressure, waist circumference were taken. Blood glucose and lipid profile (triglyceride, high density lipoprotein, and cholesterol) were done for all children.Children mean ages were 8.28 ± 2.5 year. Percentage of Metabolic Syndrome among the study group was 28.6%.There was a high significant association of obesity, blood pressure, high density lipoprotein and cholesterol with Metabolic Syndrome (p-value<0.005), and only significant association with hyperglycemia, cholesterol and waist circumference (p-value <0.05), but no association with triglyceride.The difference in distribution of overweight and obese children by risk factors categories was highly significant and there was no significant association between the numbers of risk factors with gender.The prevelance of Metabolic Syndrome was 28.6%. Both age, gender and triglyceride have no significant association. The obesity, hypertension, high density lipoprotein were found to be highly significant association, while hyperglycemia and hypercholesterolemia were just significant association.


Article
Assessment of Adolescents' Self- Esteem in Secondary Schools

Authors: Eqbal Ghanim Ma'ala --- Mohammed Baqer Hassan
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2012 Volume: 2 Issue: 3 Pages: 159-165
Publisher: University of Kufa جامعة الكوفة

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Abstract

Objectives: To assess the secondary schools obese adolescents’ self esteem level. Methodology Adescriptive study is carried out at AL-Najaf AL-Ashraf City, from December 1st, 2011 to April 6th,2012.A multi stage sample of (1350) subjects; it is selected throughout the use of probability sampling.The data are collected through the use of semi-constructed questionnaire, which consist of three parts(1) Economic Sociodemographic data form that consist of 14-items (2) Index of Self Esteem Scale thatconsists of 25-items (3) Anthropometric Measurements which consist of Weight and Height. Reliabilityof the questionnaire is determined through a pilot study and the validity through a panel of (24) experts.Results The finding of the present study indicate that there is highly significant relationship betweenthe obesity and the study participants' gender, their order in the family, mother education level, andfamily socio-economic status. While the obesity and the other variables indicated no significantrelationship. The results also shows highly significant relationship between the obesity and the index ofself esteem. There is a significant relationship between the index of self-esteem domain and the orderof student in family, fathers' education level, and socio-economic status. Other variables indicated nosignificant . Conclusion Present study concluded that the most of the secondary schools obeseadolescents have self-esteem problem, and percentage of obesity (17.3%).Recommendation the studyrecommends that the students would be given an opportunities to participate in social organizations,conferences, and study projects to promote their level of self-esteem constructing and implementingeducational programs for secondary schools teachers about how to decrease obesity among theirstudents. Mass media approach should be employed by the Ministry of education to increase studentsknowledge and awareness of the obesity as a health problem.

أھداف الدراسة لتقییم مستوى تقدیر الذات للمراھقین البدناء في المدارس الثانویة منھجیة البحث دراسة وصفیة أجریت في المدارسالثانویة لمدینة النجف الأشراف للمدة من 1 كانون الأول 2011 إلى 6 نیسان 2012 .اختیرت عینة عشوائیة متعددة المراحل من1350 ) طالب، تم اختیارھا باستخدام عینات احتمالیة. جمعت البیانات باستخدام استبانھ مصممة ومكونة من ثلاثة أجزاء ( 1) نموذج )البیانات الاجتماعیة والاقتصادیة و یحوي 14 فقرة ( 2) مؤشر مقیاس تقدیر الذات الذي یتألف من 25 فقرة ( 3) القیاسات الجسمانیةالذي یشمل الوزن والطول . حددت ثباتیة استمارة الاستبیان من خلال أجراء الدراسة المصغرة وحددت مصداقیتھا من خلال مجموعةمكونة من ( 24 ) خبیرا. النتائج أظھرت نتائج الدراسة أن ھناك علاقة ذات دلالة إحصائیة بین البدانة وبین جنس المشاركین فيالدراسة و تسلسل الطالب في الأسرة، مستوى التعلیمي للام والوضع الاجتماعي والاقتصادي.بینما لا توجد علاقة ذات دلالة إحصائیةبین البدانة وغیرھا من المتغیرات. و أظھرت النتائج أیضا وجود علاقة كبیرة جدا بین البدانة وتراجع مؤشر تقدیر الذات. وھناك علاقةكبیرة بین مؤشر تقدیر الذات وترتیب الطالب في الأسرة، والمستوى التعلیمي للأب ، والوضع الاجتماعي والاقتصادي. في حین كانتعلاقة غیر ھامة مع المتغیرات الأخرى. الاستنتاجات استنتجت الدراسة أن غالبیة المراھقین البدناء في المدارس الثانویة لدیھم مشاكلفي تقدیر الذات، وكانت النسبة المئویة للبدانة (٪ 17.3 ). التوصیات توصي الدراسة إعطاء الفرص للطلاب للمشاركة في المنظماتوالمؤتمرات والفعالیات المدرسیة لتعزیز مستوى احترام الذات وبناء الثقة بالنفس وتنفیذ البرامج التعلیمیة للمدرسین في المدارسالثانویة حول كیفیة خفض البدانة بین طلابھا. وینبغي عمل منھج صحي منظم موجھ لوسائل الإعلام من قبل وزارة التربیة والتعلیملزیادة المعرفة والوعي الصحي لكافة طلاب المدارس حول البدانة ومشاكلھا الصحیة على المراھقین وأثارھا النفسیة على مستوى تقدیرالذات.


Article
Are obese women potential for inflammatory process? A pilot study
هل النساء البدينات تتأثر بالعمليات الالتهابية ؟ دراسة تجريبية

Authors: Sanan Th. Abd-Alwahab سنن ثائر عبد الوهاب --- Amna N. Jassim أمنة نصيف جاسم
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2014 Volume: 11 Issue: 2 عدد خاص بالمؤتمر النسوي الثاني Pages: 848-852
Publisher: Baghdad University جامعة بغداد

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Abstract

This study was designed to look for certain biochemical markers(serum uric acid and serum peroxynitrite) in women presented with obesity and to compare the level of these markers with non-obese women. A total number of 63 women were recruited from outpatients and private clinics to admit in this study. The patients were grouped into non obese women (Group I) and obese women (Group II). The anthropometric and blood pressure were determined and venous blood was obtained from each patient for determination of C-reactive protein, uric acid and peroxynitrite. The results showed that there were no significant differences in age or in concomitant or associated diseases in both groups except rheumatoid arthritis which account 80% of group I and 25% of group II. The body mass index of Group I patients was 25.27±4.19 kg/h2 compared with 40.03±16.64 kg/h2 of Group II (p < 0.001). There were no significant differences in waist to hip ratio between two groups. The means systolic and diastolic blood pressures were higher in Group II compare with Group I. Positive C-reactive protein was observed in 53.3% and 52.1% of patients in Groups I and II respectively. Serum uric acid and peroxynitrite were non-significantly higher in Group II compared with Group I. It was concluded that obesity in women is associated with increased level of metabolic and nitrosative markers as well as alteration in inflammatory marker.

صممت هذه الدراسة للكشف عن العلامات البيوكيميائية في مصل الدم والتي تتضمن حامض اليوريك والبيروكسي نايتريت في النساء البدينات ومقارنة مستوى هذه العلامات مع مستواها في النساء غير البدينات∙ كان العدد الكلي للنساء 63 امرأة أخذت لغرض الدراسة من العيادات الخارجية والعيادات الخاصة وتم تقسيمهن إلى مجموعتين المجموعة الأولى تشمل النساء الغير البدينات والمجموعة الثانية تشمل النساء البدينات أو اللواتي يعانين من السمنة ٬ تم تحديد ضغط الدم واخذ القياسات البشرية التي تشمل (الطول والوزن ومحيط الخصر ومحيط الورك) بعدها تم الحصول على الدم الوريدي من كل مريضة لتحديد البروتين الفعال سي وحامض اليوريك والبيروكسي نايتريت ∙أظهرت النتائج انه لا توجد أي فروق معنوية في العمر أو في الأمراض المصاحبة أو ما يرتبط بها في كلا المجموعتين باستثناء التهاب المفاصل الرثوي والذي يمثل 80% من المجموعة الأولى و25% من المجموعة الثانية وكان مؤشر كتلة الجسم لمرضى المجموعة الأولى (27∙25 ± 19∙4) كغم|م2 مقارنة مع (03∙40±64∙16) كغم|م2 للمجموعة الثانية (001∙0˂ρ) ∙ لم تكن هناك فروق معنوية في نسبة الخصر إلى الورك بين المجموعتين وكان ضغط الدم الانقباضي والانبساطي أعلى في المجموعة الثانية مقارنة مع المجموعة الأولى ٬ وقد لوحظ ايجابية البروتين الفعال سي في 3∙53% و 1∙52% من المرضى في المجموعتين الأولى والثانية على التوالي∙ حامض اليوريك والبيروكسي نايتريت في المصل كان غير معنوي في المجموعة الثانية مقارنة مع المجموعة الأولى.استنتج أن السمنة في النساء مرتبطة مع زيادة مستوى التمثيل الغذائي والعلامات النيتروسيتف فضلا عن التغير في العلامة الالتهابية∙


Article
EFFECTS OF METFORMIN ON HORMONAL PROFILE AND SEMINAL FLUID ANALYSIS IN OBESE INFERTILE MALE

Author: Ahmed R. Abu Raghif احمد رحمه ابو رغيف
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2015 Volume: 13 Issue: 3 Pages: 295-301
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Overweight and obese men have an up to 50% higher rate of sub-fertility when compared with normal weight men. Possible management options include weight reduction by dieting or surgery and medical treatment to correct specific endocrine abnormalities, but as yet none has been proven to be effective.Objective:To verify the impact of decreasing body mass index by giving metformin on hormonal profile and seminal fluid analysis in obese infertile male.Methods:Eighteen obese patients whose body mass index was 30-40 kg/m2 and with mean age of 29 years (range: 22-42 years) with idiopathic asthenozoospermia were enrolled in the study. Standard semen analysis according to WHO and hormones assay which include: follicular stimulating hormone, luteinizing hormone, prolactin, testosterone, and estradiole were performed at baseline and after 12 weeks of therapy. The enrolled patients were asked to take metformin 850 mg twice daily orally for 12 weeks.Results:A significant decrease (p<0.001) in sperm count and sperm activity after 12 weeks of treatment with metformin. While there is no significant differences with respect to other spermiological parameters. A statistically significant decrease in the level of serum prolactin after 12 weeks of treatment with metformin whereas no significant differences with respect to the level of other hormones.Conclusions:Although metformin has the capacity to decrease the level of prolactin, it decreases the number and activity of sperms. Further studies are recommended to investigate whether there is any association between infertility in human males and chronic metformin useKeywords: Metformin, infertility, male, prolactin, overweight, obese.

Keywords

Metformin --- infertility --- male --- prolactin --- overweight --- obese.


Article
Association Ghrelin Level with Insulin Resistance in Type 2 Diabetes Mellitus Obese Patients

Authors: Methak J. H. Al-Jboori --- Ali Hammod Al-Saadi --- Haider Kamel Al-Saadi
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2016 Volume: 13 Issue: 1 Pages: 184 -195
Publisher: Babylon University جامعة بابل

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The aim of this study was to investigate the relationship between serum ghrelin concentration with markers of insulin resistance and obesity in type 2 diabetes, Evaluation of the possible association of the obesity in type 2 diabetes and gene polymorphism. The results show that the Levels of ghrelin (mean ± S.E) ghrelin was significantly lower in obese type 2 diabetes compared to control group (p< 0.0001) and Levels of ghrelin did not differ between the 49men and the 59 women. smoking history was significantly. ghrelin showed significant negative correlation with BMI (r= -0.62), Waist/Hip ratio(r = -0.68), SBP (r= -0.53) and DBP(r= -0.43).A significant negative correlation between Ghrelin level and FBG (r= -0.55), HbA1c (r= -0.60), Insulin (r= -0.44) andinsulin resistance index (HOMAIR HOMA-IR(r= -0.46). There was an inverse correlation between Ghrelin level and cholesterol(r= -0.15), triglycerides(r=-0.38) and VLDL(r= -0.38) respectively, while there is no significant correlation with LDL. As well as there weresignificant positive correlation between Ghrelin level and HDL. A significant negative correlation between Ghrelin level and Syctolic bloodpressure and diastolic blood pressure (r= -0.53 andr=-0.43) was observed in the obese type 2 diabetes groups.


Article
Prevalence and Presenting Features of Polycystic Ovarian Syndrome in Iraqi Obese Females

Authors: Faris Abdul Kareem Khazaal --- Abdul Hadi Liebi --- nsaf Jasim Mahmoud
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: 22180265 Year: 2014 Volume: 4 Issue: 2 Pages: 14-18
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Polycystic ovarian syndrome (PCOS) constitutes the most common endocrinopathyof women of reproductive age. Women with PCOS manifest hyperandrogenemia,hyperinsulinemia, and hypothalamic-pituitary-ovarian axis aberrations.Objective:The objective of the present study was to find the prevalence and the presentingfeatures of PCO patients and associated manifestations in relation to biochemicaland anthropometric parameters in adult obese women attending obesity research andtherapy unit.Methods:Patients diagnosed as PCOS according to Androgen Excess and PCOS Society/2009criteria were grouped into two groups: those with BMI less than 30kg/m2 and thosewith BMI 30kg/m2 and more. Blood was drawn for biochemical and hormonalassay. Information tabulated, means and percentages used, and the results wereanalyzed.Results: The number of adult females 20-40 years of age attending Obesityresearch and therapy unit (ORTU) during February 2013 to February 2014 was 756,(14.3%) of them had PCOS, (65%) were diagnosed during examination. (94.4%) hadmenstrual disturbances, (63.8%) had hirsutism and (91.7%) had PCOS ultrasoundfindings. Mean BMI of the patients with PCOS was 33.62 (SD 4.21). Mean LHexceeded mean FSH in patients with PCOS and it was more evident with increasingBMI where it was doubled in those with BMI more than 30 kg/m2. LH/FSH ratio forBMI above 30 was 2.1, and although testosterone level was elevated showed nostatistical relation to BMI. The fasting glucose level, cholesterol and triglycerideslevels showed the same pattern of elevation that with increasing BMI.Conclusions:The prevalence of PCOS in females (20-40y) attending ORTU was 14%, of them65% were undiagnosed before, 63% had hirsutism, 94% had menstrual disturbancesand 90% had ultrasonic features of polycystic ovary. These findings suggest the needto stress on diagnosing PCOS in adult female during management of obesity.


Article
Assessment of serum interleukin-1receptor antagonist (IL-1RN) levels in overweight-obese women and its relation to the cardiovascular risk using Framingham score
تقييم مستويات مصل مستقبلات الانترلوكين -1 المصل (IL-1RN) في النساء ذوات الوزن الزائد وعلاقتهن بمخاطر القلب والأوعية الدموية باستخدام نقاط فرامنغهام

Author: Zhian M.I. Dezayee
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2017 Volume: 21 Issue: 1 Pages: 1608-1613
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Interleukin 1 receptor antagonist (IL1RN) is an acute-phase protein that blocks the interleukin-1A and 1B receptors and thereby exerting an anti-inflammatory effect. Expression and secretion of IL1R are under the influence of the metabolic derangement. This study aimed to assess the serum levels of IL1RN in obese subjects taking into consideration its relationship to the cardio-metabolic risk factors in asymptomatic obese subjects.Methods: This cross-sectional study was conducted in Martyr LaylaQasm Center for Diabetes Mellitus in Erbil, Iraq. A total number of 170 women were recruited and distributed into three groups according to their body mass index (BMI): Group I (normal; ≤ 24.99 kg/m2); Group II (overweight; 25-29.99 kg/m2) and Group III (obese; ≥30 kg/m2). The measurements of cardio-metabolic risk factors including the anthropometric measurements, blood pressure, lipid profiles and the score of cardiovascular events using Framingham Heart Study scoring were determined. Interleukin 1RN and high sensitive C-reactive protein (hs-CRP) were also determined.Results: Overweight (Group II) and Obese (Group III) women had significant high values of cardio-metabolic risk factors. Group III have significant high values of hs-CRP, and IL IL-1RN levels compared with Group I and II. The serum levels of IL-1RN are increased as the body mass index is increased but is not associated with increased risk of the cardiovascular events or a proportional increased of hs-CRP. A significant correlation between serum IL-1RN levels with cardiovascular risk (%) was observed among subjects of Group II. Conclusion: The study concludes that serum IL-1RN levels are significantly increased withy body mass index in over-weight-obese subjects and its increment is not correlated with low-grade of inflammation assessed by measurement of hs-CRP. The clinical significant of determination of IL-1NR to predict cardiovascular events risk is marginal in overweight subjects.

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