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Article
Effect of Olanzapine and Risperidone on prolactin level in schizophrenic patients
تأثير الاولانزابين و الرزبيريدون على مستويات هرمون البرولاكتين لدى مرضى الفصام

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Abstract

Hyperprolactinemia is a well-established adverse effect associated with the use of typical and atypical antipsychotics. Hyperprolactinemia is associated with both acute and chronic clinical consequences in men and women. Increased prolactin levels received little attention and were rarely monitored. Therefore, the primary objective of this study is to investigate the effects of two atypical antipsychotics (olanzapine and risperidone) on prolactin level in schizophrenic patients. For this purpose, a therapeutic clinical trial was done. We prospectively recruited 28 schizophrenic patients attended to Social and Psychiatric Service Centre in Mosul city. All patients fulfilled the Diagnostic and Statistical Manual of Mental Disorders, 4th edition (DSM-IV) criteria for schizophrenia. They were randomized to receive monotherapy with either olanzapine in a dose 5-20 mg or risperidone in a dose 4-12 mg for 8 weeks (two groups). Also 22 apparently healthy subjects with approximately age and sex matching to the patients groups without previous history of schizophrenia or any other psychiatric disorders were taken as a control group. This study shows that, at baseline, there were no significant differences between the three studied groups in term of prolactin level and, after treatment with these drugs for 8 weeks, both drugs caused a significant increase in the prolactin level compared to baseline levels and that risperidone causes significantly greater increase in the levels of prolactin than olanzapine.

ارتفاع مستوى البرولاكتين في الدم من الاضرار الجانبية المؤكدة التي تصاحب استخدام مضادات الفصام النموذجية واللانموذجية. ارتفاع مستوى البرولاكتين في الدم يصاحبه نتائج سريرية حادة ومزمنة عند الذكور والاناث. الزيادة في مستوى البرولاكتين في الدم يحضى باهتمام قليل ونادرا ما يتم متابعته. لذلك الهدف الرئيسي لهذه الدراسة هو لبحث تاثير اثنان من مضادات الفصام اللانموذجية (الاولانزابين و الرزبيريدون) على مستويات البرولاكتين لدى مرضى الفصام. لهذا الغرض تم استخدام تجربة سريرية علاجية حيث تم تجنيد 28 مريضا مشخصين كمرضى فصام كانو يراجعون مركز الخدمة الاجتماعية والنفسية في مدينة الموصل. كل المرضى كانو مطابقين لمعيار DSM – IVفي تشخيص مرض الفصام. لقد قسم المرضى عشوائيا ليتناولو اما اولانزابين بجرعة تتراوح بين 5-20ملغم او رزبيريدون بجرعة 4-12 ملغم (مجموعتين), كذلك 22 متطوع اصحاء مطابقين للمرضى من ناحية العمرو الجنس لم يعانو من مرض الفصام سابقا او اي مرض نفسي اخر. نتائج هذه الدراسة اظهرت انه قبل اعطاء الادوية لا توجد فروقات معنوية بين المجموعات الثلاث فيما يتعلق بمستويات البرولاكتين, بعد تناول هذه الادوية لمدة 8 اسابيع كلا الدوائين سببا زيادة معنوية في مستويات البرولاكتين في الدم مقارنة بتلك التي تم ملاحظتها قبل اخذ الدواء والرزبيريدون سبب زيادة معنوية اكثر من الاولانزابين.


Article
EFFECTS OF VERAPAMIL AND OLANZAPINE IN TERMINATING PILOCARPINE- INDUCED EPILEPTIC SEIZURES IN MICE.

Authors: Uday A. Hussein عدي عبد الرضا حسين --- Faruk H. Al-Jawad فاروق حسن الجواد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 2 Pages: 180-184
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Epilepsy is one of the oldest known neurological conditions characterized by recurrent seizures.Objective:To explore the possible antiepileptic effect of both Verapamil and Olanzapine in pilocarpine epileptic model in mice.Methods:Fifty healthy male albino mice weighing between 30-35 gm were equally allocated into five groups (10 mice in each group) and were distributed into: normal group (without drug); distilled water group (0.1 ml); diazepam group (1mg/kg); verapamil group (20 mg/kg) and olanzapine group (10 mg/kg). All animals (except normal group) were injected with pilocarpine hydrochloride (350 mg/kg) to induce generalized tonic-clonic seizure 30 minutes after the tested drugs had been administrated. The mean onset of seizure were determined as well as the mean serum concentration of electrolytes, glutathione and malondialdehyde were measured after seizure had been induced.Results:Pilocarpine-induced seizure at approximately 7 minutes after injection. While both verapamil and olanzapine produced highly significant increase in mean onset of seizure 16±1.549 and 13.1±1.566 respectively as compared to D.W. group, also both drugs produced highly significant changes in mean serum concentration of electrolytes, glutathione and malondialdehyde.Conclusion:Verapamil and olanzapine had anticonvulsant activity when used at applied doses in the pilocarpine model of seizures in mice.Key words:Epilepsy, seizure, verapamil and olanzapine.


Article
Retrospective Comparison of Weight Gain between Olanzapine- and Risperidone-Treated Patients
مقارنة بأثر رجعي لزيادة الوزن بين المرضى الذين عولجوا أولانزابين وريسبيريدون

Author: Twana Abdulrahman Rahim
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2010 Volume: 14 Issue: 1 Pages: 35-41
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and Objectives: Weight gain as a side effect of the second generation antipsychotics have been increasingly noted during therapy; however no studies addressed such a valid clinical concern in Iraq till now. The objective of this study was to determine the weight changes among patients treated with either Olanzap-ine or Risperidone.Methods: A retrospective study was performed by reviewing the charts of 80 patients who have been treated with Olanzapine monotherapy (60 patients) or Risperidone monotherapy (20 patients) through the period of April 2008 to April 2009, compar-ing the baseline weight in kilograms with after one month of therapy weight.Results: Among the 60 patients treated with Olanzapine, 42 (70%) gained weight, 70.37% of males and 69.69% of females treated with Olanzapine gained weight. Among the 20 patients treated with Risperidone, 12 (60%) gained weight, 50% of males and 75% of females treated with Risperidone gained weight. Those treated with Olanzapine, gained 3.96 kg after 30 days of treatment, while the amount of gain was 2.25 kg among those treated with Risperidone after the same period. Olanzapine-treated group gained about 6.21% of their baseline weight which was significantly higher than that of Risperidone-treated group who gained about 2.89% of their baseline weight (P value of 0.03). Females gained more amount of weight than males in both group.Conclusions: Both second generation antipsychotics, Olanzapine and Risperidone, are associated with weight gain. However, Olanzapine appears to have a greater potential in inducing weight gain. Both genders affected nearly equally, though females were victims of more amount of weight gain.


Article
Using of Third and Fourth Order Derivative Spectra to Simultaneous Determination of Olanzapine and Ephedrine in Its Pure and Pharmaceutical Formulations
استعمال اطياف المشتقة الثالثة والرابعة في التقدير الآني لعقاري الأولانزابين وهيدروكلوريد الافدرين في بعض اشكالهما النقية والصيدلانية

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Abstract

Two new simultaneous spectrophotometric methods for determination of Olanzapine and Ephedrine depend on third (D3) and fourth (D4) derivative of zero spectrum of two drugs were developed. The peak – to- base line, peak to peak and area under peak were found proportional with concentration of the drugs up to (4-24 µg/ml-1) at known experimental wavelengths. The results showed that the method was precise and accurate through RSD% (0.5026-4.0273),( 0.2399 -6.9888) and R.E% (-2.3889-0.8333) , )-2.9444-0.2273) while the LOD (0.0057- 0.8510 μg.ml-1), ( 0.0953-0.9844 μg.ml-1) and LOQ (0.0173- 2.5788μg.ml-1),( 0.5774-2.9829 μg.ml-1) were found for the two drugs respectively.The methods were applied ide to the determination of Olanzapine and Ephedrine in pharmaceutical preparations successfully.

تم تطوير طريقتين طيفيتين جديدتين لتقدير عقاري الاولانزابين وهيدروكلوريد الافدرين بشكل أنى باستعمال تقنية المشتقة الثالثة (D3) والمشتقة الرابعة (D4) لأطياف هذه المركبات اذ وجد ان هاتين المشتقتين تمكنان من التقدير الاني للعقارين بمدى من التراكيز تتراوح ما بين (4-24 مكغم.مل-1) وتم الاستفادة من ارتفاع القمة-خط القاعدة وقمة الى قمة وكذلك المساحة تحت الحزمة عند اطوال موجية محددة لكل مركب تم تحديدها مسبقا. اظهرت النتائج التي تم الحصول عليها ان الطريقة متوافقة ودقيقة بشكل مقبول، اذ تراوحت R.E% (-2.3889-0.8333)، (-2.9444-0.2273) وRSD%(0.5026-4.0273)، RSD%(0.2399-6.9888) في حين كانت قيمة حد الكشف بين (µg/ml-1 0.0057-5.3804)، (µg/ml-10.0953-0.9844) للعقارين على التوالي، وتم تطبيق الطريقتين على عدد من المستحضرات الصيدلانية التجارية وبصورة ناجحة.


Article
The Spectrophotometric Determination of Olanzapine via Coupling with Diazotized p-Nitroaniline
التقدير الطيفي للاولانزابين باقترانه مع العامل المؤزوت بارا-نيتروانيلين

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Abstract

A new spectrophotometric method has been developed for the assay of olanzapine (OLN.) in pure and dosage forms. The method is based on the diazocoupling of (OLN.) with diazotized p-nitroaniline in alkaline medium to form a stable brown colored water-soluble azo dye with a maximum absorption at 405 nm. The variables that affect the completion of reaction have been carefully optimized. Beer’s law is obeyed over the concentration range of (0.5-45.0 μg.mL-1) with a molar absorptivity of 1.5777×104 L.mol-1.cm-1. The limit of detection was 0.3148 μg.mL-1 and Sandell’s sensitivity value was 0.0198 μg.cm-2. The proposed method has been applied successfully to the determination of olanzapine in tablet pharmaceutical preparations.

تم تطوير طريقة طيفية جديدة لتقدير الاولانزابين بصورته النقية و في المستحضرات الصيدلانية. تعتمد الطريقة على اقتران الدايازو لعقار الاولانزابين مع كاشف البارا-نايتروانلين الدايازوتايزي في وسط قاعدي لتكوين صبغه مستقرة ذات لون بني ذائبه في الماء التي اعطت اعظم امتصاص عند الطول الموجي 405 نانومتر. درست العديد من العوامل التي تؤثر في اكتمال التفاعل بدقة للحصول على الظروف الفضلى للتفاعل. لقد انطبق قانون بير ضمن مدى من التراكيز ما بين (0,5 – 45,0 ) مايكروغرام.مل-1. حيث اعطت امتصاصيه مولارية تقدر 104×1.5777 لتر.مول-1.سم-1. لقد كان حد الكشف مساويا لـ 0.3148 مايكروغرام.مل-1 اما حساسية ساندل فقد كانت تساوي 0.0198 مايكروغرام.سم-2. تم تطبيق الطريقة المقترحة بنجاح في تقدير الاولانزابين في مستحضرات الحبوب الصيدلانية.

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