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Immunohistochemical study of PDGF, IGF of radiated tooth rat embryo

Authors: Rasim Mahdi Salih راسم مهدي صالح --- Athraa Y Al-Hijazi عذراء يحيى الحجازي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 1 Pages: 110-115
Publisher: Baghdad University جامعة بغداد


Background: Exposure to microwaves radiation from microwave oven may be harmful for users especially for the onewho have highest contact with microwave oven. Because the body is electrochemical in nature, any force thatdisrupts or changes human electrochemical events will affect the physiology of the body by destabilization andinterruption of many chemical body substance including growth factors.The insulin-like growth factors (IGFs) are afamily of mitogenic proteins that control growth, differentiation, and the maintenance of differentiated function innumerous tissues. It fulfils an important role in growth and development of teeth, mandible, maxillae, and tongue.Platelet derived growth factors (PDGF) are proteins that regulate cell growth and division. In particular, it plays asignificant role in blood vessel formation (angiogenesis). It seems that IGF and PDGF share in much tissuedevelopmental process. Therefore they included in the present study in correlation to tooth growth & development.This study Illustrates the expression of insulin like growth factor and platelet derived growth factor by dental cells ofrat embryos at periods of gestation 16th,18thday intrauterine life(I.U.L) and one day neonatal life.Materials and Methods: Animal model: Thirty-six female rats were used in this study .Starting from zero days (time ofgestation that recorded) the pregnant rats were divided into three groups. Group A serve as a control, groups Bexposed to microwave oven radiation For (15 /minutes; 5/min /hour for 3 hours continuously) daily and C exposed toEMF radiation for (45 minutes ;15 min /hour for3hours continuously)daily starting from zero day of gestation till the lastday. The embryo of rats at 16thday and 18th day of intrauterine life and one day old rat (new born rat) were studiedimmunohistochemically for localized of platelet derived growth factor (PDGF) and insulin growth factor (IGF) markers.Results:The results showed that experimental group (B) exposed to short duration of radiation (5/ min.) stimulates thedevelopment of tooth germ and faster tooth growing in comparison to control with immunohistochemical resultsshow strong to moderate intense stain for positive expression of growth factors(PDGF,IGF) by dental tissue.For longexposure period of radiation( group C) , it showed retardation in the tooth growth withimmunohistochemical findingsrecord weak to negative intense stain for the expression of growth factors(PDGF,IGF) by dental tissue.Conclusion: Exposure to microwave (oven) radiation during pregnancy may play a role in the expression of IGF andPDGF by cells of tooth germ thatinfluence on cell differentiation and physiological activity of specialized dental cells,depending on exposure time

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