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Article
THE ROLE OF ALLERGIC RHINITIS IN THE AETIOLOGY OF NASAL POLYPS

Authors: Husam Haider --- Hashim AL-Abdul Wahed
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2006 Volume: 12 Issue: 2 Pages: 66-70
Publisher: Basrah University جامعة البصرة

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Abstract

THE ROLE OF ALLERGIC RHINITIS IN THE AETIOLOGY OF NASAL POLYPSHashim AL-Abdul Wahed*, Husam Haider#*CABS, FICMS. ENT Dept., Basrah general hospital, Basrah, Iraq, #FRCS, DLO. ENT Dept. Basrah Medical College, Basrah, IraqAbstractDespite the prevalence and long history since nasal polyps were recognized as a clinical entity, many questions still exist with respect to their aetiology & pathogensis, this study aims to assess the role of allergy in the aetiology of nasal polyps based on their epidemiology in Basrah governorate in Iraq & by utilizing the skin test, from January 2000-december 2000 84 patients with simple nasal polyps 50 males & 34 females with age range between 18-70 years were studied by collecting data regarding the history, physical examination& investigations in a questionnaire form .88 normal subjects were also included as a control group. Both patients & controls were subjected to intradermal skin test using seven common aeroallergens.Out of the 84 patients 58 (69%) had a positive skin test to one or more of the tested allergens, while only 20 (23%) of the control group had a positive test. This difference is statistically significant (p<0.00001), odd ratio=8.0 which means allergic persons were 8 times more prone to have polyps than normal subjects.Allergy appears to play an important role in the aetiology of nasal polyps and the skin test is useful in the assessment of patients with polyps who may therefore benefit from immuno therapy.

Keywords

NASAL --- POLYPS


Article
Proportion of Colorectal Cancer Proved by a Histopathological Study on Patients Who Underwent Colonoscopy

Author: Nadir A. Sanad Al‑Jenabi, Ali Abaid Kadhem, Hamid Fadhel Abbas
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2019 Volume: 16 Issue: 2 Pages: 141-144
Publisher: Babylon University جامعة بابل

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Abstract

Background: Colorectal cancer is the third most common cancer in the world, and the general lifetime risk of development cancer in the UnitedStates is 6%. Many people with colon cancer experience no symptoms in the early stage of the disease. When symptoms appear, they will likelyvary, depending on the cancer size and location in the large intestine. Objective: The objective of this study was to determine the proportion ofcolorectal cancer proved by a histopathological findings on patients who underwent colonoscopy and also to study the association of colorectalcancer with age, gender, and presenting signs. Materials and Methods: This study has been carried out at gastroenterology, and colonoscopyhas been done for 366 patients with signs and symptoms of lower gastrointestinal tract infection. Out of those patients, biopsies have beentaken from 320 patients. Results: Results of distribution of the patients who underwent colonoscopy by presenting signs and symptoms foundthat the majority (80.6%) of the patients presented with bleeding per rectum. The distribution of (320) patients by histopathological findingsfound that only 17.8% of patients had colorectal tumors. Conclusion: Younger age group is more involved in colon cancer and left colon wasthe most common site, and when symptoms occur, the tumor is locally invasive.


Article
Effect Of Nasal Polyps On Spirometric Values Pre And Post Operative Comparison
تقییم تأثیر السلیلات ألجیبیھ الانفیھ على وظائف المجاري التنفسیھ السفلى قبل وبعد الاستئصال الجراحي (دراسھ مقارنة)

Authors: Hameed D.Hussain --- Sajad Y. Alhelo
Journal: kufa Journal for Nursing sciences مجلة الكوفة لعلوم التمريض ISSN: 22234055 Year: 2013 Volume: 3 Issue: 2 Pages: 41-46
Publisher: University of Kufa جامعة الكوفة

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Abstract

Background: Nasal breathing can be crucial to the proper functioning of the lower airway. Nasal obstruction (N.O.)may play an important role in modulating lower airway and lung function.Objective: the study was designed to assess the influence of nasal polyps on spirometeric value and to evaluate theeffect of surgical polypectomy on pulmonary function depend on spirometeric test. Setting: otolaryngology, headand neck surgery center in Al-Sadder teaching hospital in Al Najaf governorate.Patients: Fourty four patients (29men and 15 women) from 20-50 years old were enrolled in this study after taking their consent. All patients hadnasal polyps for many years.Methods: Prospective study of patients who had nasal polyps. All patients underwent spirometeric test preoperatively,only those with abnormal spirometeric value were included in this study. Patients were divided into twogroups according to the presence or absence of chest symptoms as group I and group II respectively. Patients thenwere treated surgically by different surgical methods and followed up for a period of 2-4 months and were assessedfor the improvement of pulmonary function by spirometery.Results: fourty seven patients (39%) of 120 patients with nasal polyps had abnormal spirometery, 3 patients werelost in follow-up. Treatment of both groups improved nasal breathing function in 81% with improvement ofpulmonary function in 11 patients (34.37%) of group I (32 patients) and 6 patients (50%) in group II (12 patients)with overall improvement of spirometery in 44 patients (38.6%).Conclusion: this study presents an evidence for the existence of correlation between nasal polyps and lower airwaydisorders, and shows that effective surgical polypectomy may improve pulmonary function in lower airway diseasepatients with nasal polypsKey words: nasal polyps, spirometry, paranasal sinuses

دراسة مقارنھ للمرضى المصابین بالسلیلات الانفیھ،أجریت في مركز النجف التخصصي في الأنف والأذن والحنجرة في مدینة الصدر الطبیة للفترة. من أیار 2010 ولغایة أیار 2011الھدف لتقییم تأثیر استئصال السلیلات الانفیھ جراحیا على تحسین وظائف الرئھ و ذلك باستخدام جھاز فحص وظائف الرئھ كوسیلة اساسیھ في متابعةنتائج علاج المرضى.50 سنھ.قسم المرضى إلى فئتین اعتمادا على وجود أو عدم وجود - المنھجیة اجریت على 44 مریضا ( 29 ذكرا ، 15 أنثى) تتراوح أعمارھم بین 20أعراضصدریة .النتائج:اظھرت الدراسة دلالھ قویھ على وجود علاقة بین السلیلات الانفیھ و إمراض الجھاز التنفسي وخصوصا الربو القصبي. وأنتجت تحسنا ملحوظا50 %) على التوالي. ، % في وظائف الرئة في الفئتین الأولى والثانیة ( 34التوصیات:نقترح تضمین فئة الاطفال في دراسة لاحقة،ننصح باجراء فحص وظائف الرئة قبل العملیة لكل المرضى المصابین بالسلیلة الانفیة


Article
Bacterial Evaluation and Some Allergic Mediators of Chronic Rhinosinusitis with Nasal Polyps

Author: Oruba Ketoof Al-Bermani
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 4 Pages: 1123 -1128
Publisher: Babylon University جامعة بابل

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Abstract

Chronic rhinosinusitis with nasal polyps (CRSwNPs) is a disorder characterized by persistent eosinophilic Th2 inflammation with sinonasal microbial colonization. It has been postulated that a compromised local mucosal immune response and microbial by-product like super-antigen underlies disease pathogenesisThe affected sinuses fluid swabs and blood samples were collected from 50 a CRSwNP patients to isolate associated bacterial species and to measure serum IL-4 and total IgE and IgG levels. The same sample were collected from health subject as a control study. The sinonasal tract was colonized by S.aureus H.influenzae S.pneumoniae P.aeruginosa Morexella.catarrhalis S.pygenes S.intermedius, where the high prevalence rate was 34% of S.aureus , while the low prevalence rate was 2% of S. intermedius. ELISA revealed an elevation of serum IL-4, and total IgE and IgG levels in the CRSwNP patients compared with the control subject.Bacterial colonization in CRSwNp is implicated with pathgenesis of this disease. The high levels of serum IL-4 and total IgE and IgG which were synthesized locally in the mucosa and diffuse to the blood , serve as an indicator of eosinophilic Th2- inflammation disorder.of CRSwNP


Article
IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTS

Authors: Basim Sh Ahmed --- Mustafa M Ibraheem --- Nawal M Abdullah
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2017 Volume: 23 Issue: 1 Pages: 37-44
Publisher: Basrah University جامعة البصرة

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Abstract

IMMUNOHISTOCHEMICAL EXPRESSION OF STEM CELL MARKERS CD44, CD166 AND ALDH1A1 IN NON-NEOPLASTIC POLYPS OF THE COLON IN SAMPLE OF IRAQI PATIENTSNawal M Abdullah*, Mustafa M Ibraheem@ & Basim Sh Ahmed#*MB,ChB, MSc, Assist. Prof., Department of Anatomy, College of Medicine, University of Basrah. @MB,ChB, MSc, PhD, Assist. Prof., Department of Anatomy, College of Medicine, University of Al-Mustansiryah. #MB,ChB, FICMS, Assist. Prof. Department of Pathology, College of Medicine, University of Al-Mustansiryah, IRAQ.Abstract The aim of this retrospective study on tissue specimens of benign colorectal polyps is to evaluate the significance of IHC markers CD44, CD 166 and ALDH1A1 expression in non-neoplastic (Juvenile and Hamartomatous) polyps and their association with different clinicopathological parameters & to compare their expression in benign polyps with that of normal colonic tissue . Seventy cases enrolled in the study including benign polyps (juvenile & hamartomous polyps) & benign looking colonic tissue obtained from archive of histopathology unit in Gastroenterology and Hepatology hospital in Baghdad Medical City and histopathology unit in Al-Sadder Teaching Hospital in Basrah city for the period Sept. 2015 to Dec. 2016. Four micrometer sections were obtained from formalin fixed paraffin-embedded blocks treated IHC with CD44, CD166 and ALDH1A1 tumor markers. Majority of polyps were juvenile, no difference regarding gender distribution. The common location was rectum/rectosigmoidal region. CD166, CD44 and ALDH1A1 showed high expression regarding age, gender and location in benign tumors when compared with healthy looking tissue. In conclusion, colorectal polyps are critical clinical entity and many of them are a precursors to malignant diseases so colonoscopy is essential screening test, polypectomy and follow up is mandatory for patients with colorectal polyps even if they are benign.


Article
Outcome of Endoscopic Sinus Surgery for Antrochoanal polyps
نتائج جراحة الجيوب الأنفية بالمنظار لالاورام الحميدة غازية منعرية

Author: Nada Khalil Yaseen , Rashid Ali Rashid ندى خليل ياسين ، رشيد علي راشد
Journal: The Medical Journal of Tikrit مجلة تكريت الطبية ISSN: 16831813 Year: 2011 Volume: 2 Issue: 172 Pages: 100-108
Publisher: Tikrit University جامعة تكريت

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Abstract

The antrochoanal polyp (ACP) occurs predominantly in children and young adults. In the treatment, since simple avulsion polypectomy is followed by a high recurrence rate, it is therefore common practice to remove the polyp's antral part as well. Endonasal Endoscopic Sinus Surgery has revolutionized in the treatment of sinonasal diseases as it re-establishes ventilation and mucocilliary clearance by limited resection of the inflammatory pathology or the anatomical defects present. The purpose of this study was to evaluate the outcome of endoscopic treatment of ACPs. Between February 2009-January 2011, we enrolled 21 patients with unilateral ACPs (15 left-sided, 6 right-sided). Factors including age, sex, presenting complaints, associated symptoms, physical findings, surgical procedure, histopathology, follow up and management of recurrence were studied .Completely removing the base of the ACPs was achieved through transnasal endoscopic (TE) or combined endoscopic and transcanine (CET) approach. The CET approach was used in recurrent patient. All patients received CT scan 6 months after surgery to evaluate the outcome of surgery. Most of the ACPs were multitudinous and the distributions of the ACPs’ origin in the maxillary sinus were as follows: posterior wall (90%), lateral wall (56.5%), and inferior wall (44.5). The success rate was 76.2 %in the TE approach and 100% in the CET approach. 5 in the TE approach recurred and all of them had concomitant rhinosinusitis. The three patients were cured in the revision CET operations. No major complications occurred. The present study conclude that endoscopic approach as compared to previous modalities of treatment is an effective and efficient method of treating Antrochoanal Polyps Endoscopic treatment of ACPs in children is safe and effective. Early diagnosis and treatment of ACPs is important because secondary rhinosinusitis can make the disease complicated and the surgeries difficult.

وسليلة غازية منعرية (ACP) ويحدث في الغالب في الأطفال وصغار البالغين. في العلاج، ومنذ ويتبع بسيط استئصال السليلة قلع بنسبة تكرار عالية، وبالتالي فمن الممارسات الشائعة لإزالة جزء من الورم وغاري كذلك. جراحة الجيوب الأنفية بالمنظار داخل الأنف قد أحدثت ثورة في علاج الأمراض sinonasal حيث اعادة انشاء والتهوية، وإزالة mucocilliary بواسطة استئصال محدودة من أمراض التهابات أو عيوب تشريحية الحالي. وكان الغرض من هذه الدراسة لتقييم نتائج العلاج بالمنظار من دالات تلويث قطبية شمالية. بين فبراير 2009 كانون الثاني 2011، التحق نحن 21 مريضا مع دالات تلويث قطبية شمالية من جانب واحد (15 في الجانب الايسر (6)، في الجانب الأيمن). وتمت دراسة العوامل بما في ذلك العمر والجنس وتقديم الشكاوى، والأعراض المصاحبة، والنتائج المادية وإجراء العمليات الجراحية، التشريح، ومتابعة وإدارة تكرار. تماما إزالة قاعدة دالات تلويث قطبية شمالية تم تحقيقه من خلال transnasal بالمنظار (TE) أو الجمع بين التنظير وtranscanine (CET) النهج. وقد استخدم هذا النهج في CET المريض المتكررة. وتلقى جميع المرضى الاشعة المقطعية 6 أشهر بعد خضوعه لجراحة لتقييم نتائج الجراحة. وكان معظم دالات تلويث قطبية شمالية الكثيرة وتوزيع أصل دالات تلويث قطبية شمالية "في الجيب الفكي وكانت على النحو التالي: الجدار الخلفي (90٪)، والجدار الجانبي (56.5٪)، والجدار السفلي (44.5). وكانت نسبة النجاح 76.2٪ في نهج الشركة المصرية للاتصالات، و 100٪ في نهج CET. تكررت 5 في نهج الشركة المصرية للاتصالات وجميع من لهم كان يصاحب ذلك التهاب الأنف و الجيوب. وقد شفي المرضى الثلاثة في عمليات CET مراجعة. وقعت أي تعقيدات كبيرة. هذه الدراسة نستنتج أن نهج بالمنظار بالمقارنة مع الطرائق السابقة من العلاج هو وسيلة فعالة وفعالة لعلاج الاورام الحميدة غازية منعرية علاج بالمنظار من دالات تلويث قطبية شمالية في الأطفال هي آمنة وفعالة. التشخيص المبكر والعلاج من دالات تلويث قطبية شمالية أمر مهم لأن التهاب الأنف و الجيوب الثانوية يمكن أن تجعل من مرض معقد والعمليات الجراحية الصعبة.

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