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Pancytopenia Adult Patients At Baghdad Teaching Hospital

Authors: Khudair Abbas Al-Khalisi --- Azher Sebieh Al-Zubaidy --- Majid Rhaima***
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 4 Pages: 441-448
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:pancytopnia is a triad of findings caused by different diseases affecting bone marrow primarily or secondarily, causing manifestations of anemia, thrombocytopenia, and/ or leucopeniaOBJECTIVE:To identify causes, and presenting symptoms of pancytopnia in patients attending Baghdad teaching hospital.PATIENTS AND METHODS:One hundred and five patients, found on complete blood count having Pancytopenia were included, excluding patients that had been exposed to chemotherapy, and/or radiotherapyRESULTS:Causes in decreasing frequency were acute leukemia (30.47%), aplastic anemia (17.14%), megaloblastic anemia (13.33%), NHL (14.47%), MDS (8.57%), PNH (4.76%), TB, SLE, HD (2.58%) for each, and kalazar, and MM and HCL (1.9%) for each.Manifestations were fatigability (67.6%), bleeding tendency (55.8%), and fever (48%).CONCLUSION:Incidence of Pancytopenia may vary according to geographical, and genetic factors, and depending on parameters, and criteria of inclusion and exclusion. Acute leukemia was found the most common cause, followed by megaloblastic anemia.


Article
Pancytopenia Adult Patients At Baghdad Teaching Hospital

Authors: Khudair Abbas Al-Khalisi --- Azher Sebieh Al-Zubaidy --- Majid Rhaima
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 4 Pages: 441-448
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:pancytopnia is a triad of findings caused by different diseases affecting bone marrow primarily orsecondarily, causing manifestations of anemia, thrombocytopenia, and/ or leucopeniaOBJECTIVE:To identify causes, and presenting symptoms of pancytopnia in patients attending Baghdad teachinghospital.PATIENTS AND METHODS:One hundred and five patients, found on complete blood count having Pancytopenia were included,excluding patients that had been exposed to chemotherapy, and/or radiotherapyRESULTS:Causes in decreasing frequency were acute leukemia (30.47%), aplastic anemia (17.14%),megaloblastic anemia (13.33%), NHL (14.47%), MDS (8.57%), PNH (4.76%), TB, SLE, HD(2.58%) for each, and kalazar, and MM and HCL (1.9%) for each.Manifestations were fatigability (67.6%), bleeding tendency (55.8%), and fever (48%).CONCLUSION:Incidence of Pancytopenia may vary according to geographical, and genetic factors, and dependingon parameters, and criteria of inclusion and exclusion. Acute leukemia was found the most commoncause, followed by megaloblastic anemia.


Article
A Clinical-Hematological Study of Pancytopenia Patients Attending Nanakaly Hospital in Erbil City

Authors: Alan Isaac Isho --- Nawsherwan Sadiq Mohammad
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2016 Volume: 5 Issue: 1 Pages: 129-142
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Pancytopenia is a triad of low hemoglobin, white blood cells and platelets.Although it is a common clinical problem with an extensive differential diagnosis, there is arelatively little discussion of this abnormality in major textbooks of internal medicine andhematology.Objectives: This study aimed to determines the etiology and clinical profile of pancytopenicpatients attending Nanakaly hospital.Materials and Methods: During a period of 6 months, 60 pancytopenic patients attendedNanakaly hospital, their ages ranged between one-81years. A control group of 50 age-matchedapparently healthy person were tested for complete blood picture and reticulocyte count. History,physical examination and hematological parameters at presentation were recorded. Hematologicalprofile included hemoglobin, total and differential leukocyte count, platelet count, reticulocytecount, peripheral blood and marrow smears together with marrow biopsy were assessed.Pancytopenic cancer patients on chemotherapy were excluded. Pancytopenia was defined ashemoglobin less than 10g/dl, WBC less than 4 x109/L and platelet count less than 150 x 109/L.Results: The mean Hb concentration, WBC count and platelet count in studied group weresignificantly lower than in control group. Hematological malignancies were the commonest causeof pancytopenia and accounted for (51.7%), they included: Acute leukemia (35%),myelodysplastic syndrome (11.7%), hairy cell leukemia (3.3%) and myelofibrosis (1.7%). Aplastic and megaloblastic anemia each of them accounted for (16.7%), hypersplenism wasresponsible for (10%). Other less common causes included enteric fever, kalaazar and secondarymetastasis each of them accounted for (1.7%). Pallor was present in every case. Fever was presentin (63.3%) and (25%) had bleeding manifestations at the time of presentation Conclusions: The most common causes of pancytopenia were acute Leukemia, aplastic anemiaand Megaloblastic anaemia, but rare causes like myelofibrosis, enteric fever, kala azar andsecondary metastasis should also be kept in mind.


Article
Clinicohematological profile of patients with peripheral blood cytopenias in clinical practice

Authors: Rajneesh Thakur --- Navjyot Kaur --- Malhotra Arjun --- Sharma Sanjeevan --- et al.
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2019 Volume: 8 Issue: 1 Pages: 1-6
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

BACKGROUND: In clinical practice, the cytopenias may result from relatively benign causes suchas viral infections and Vitamin B12/folic acid deficiency to more sinister causes such as bonemarrow failure. In this study, we looked into the clinicohematological profile and etiological factorsof bicytopenia and pancytopenia.OBJECTIVES: To study the etiology and clinicohematological profile in patients of peripheral bloodcytopenias.MATERIALS AND METHODS: This was a cross‑sectional study conducted at a tertiary care hospitalover a period of 1 year. Cytopenias were defined as pancytopenia when there was simultaneouspresence of hemoglobin <10 g/dL, total leukocyte count <4000/dL, and platelets < 100000/dL or asbicytopenia when two of the three blood cell lines were depressed. All patients who presented withpancytopenia and bicytopenia were included, and their clinicohematological profile was recorded.RESULTS: A total of 204 patients (103 males and 101 females) were diagnosed to have cytopenias.Pancytopenia was observed in 69/204 and bicytopenia was seen in 135/204 cases. The various causesof cytopenias included infections (n = 126 [61.76%]), megaloblastic anemia (MA) (n = 48 [23.52%]),drugs (n = 12 [5.8%]), hypersplenism (n = 8 [3.9%]), bone marrow failure syndromes such as aplasticanemia and myelodysplastic syndrome (n = 7 [3.4%]) and leukemias (n = 3 [1.4%]). We found asignificant association between MA and pancytopenia (odds ratio [OR] = 2.47, P < 0.05) and alsobetween infections and bicytopenia (OR = 5.8, P < 0.05).CONCLUSION: The present study concluded that infections and MA are the most common cause ofbicytopenia and pancytopenia, respectively. The more serious disorders affecting the bone marrowconstitute only <5% of all cases of cytopenias.

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