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Article
Destructive periodontitis, its prevalence among chronic periodontitis patients, with cohort incentive conditions

Author: Abdullatif Al-Juboury, B.D.S., Ph.D. * د. عبد اللطيف الجبوري
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2006 Volume: 3 Issue: 1 Pages: 107-116
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Sixty-six patients have been diagnosed and distinguished as having destructive periodentitis out of one thousand slowly growing chronic periodontitis (S.G.Ch.P.), constituted 6.6%, females was 68.18%, male was 31.81%, a significant difference was found between male and female.Possible activating and inverting factors was studied, restraint stress and depression appear having a significant relationship, nutritional factor as well showed a significant influence on inversion of S.G.Ch.P. into DP.High gingival index, sever bone destruction; deep packet and an eventual tooth mobility with generalized distribution pattern were the characteristic clinical feature of the disease.In conclusion local bacterial and systemic conditions either psychic or somatic may interfere in the activation and inversion of the adult periodentitis into destructive periodontitis under the basis of systemic and psychological factors .


Article
Efficacy of Azithromycin in Comparison with Metronidazole in the Treatment of Chronic Periodontitis

Author: Jawna’a K Mammdoh
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 22 Pages: 323-330
Publisher: Mosul University جامعة الموصل

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Aims: The aim of this study was to evaluate the clinical effects of systemic azithromycin as an adjunct to scaling and root planning (SRP) and compared it with metronidazole in the treatment of chronic per-iodontitis. Materials and Methods: Forty four patients with clinical diagnosis of chronic periodontitis underwent scaling and root planing were divided into three groups. The first group (n = 20) patients received azithromycin 500 mg once daily for 3 days plus SRP. The second group (n= 11) received met-ronidazole 500 mg 3 times daily for 7 days plus SRP. The third control group (n= 13) patient received SRP plus placebo treatment once daily for 3 days. Clinical measurement including gingival index, bleeding on probing and probing pocket depth were performed at the base line visit and 40 days after taking the treatment. Results: The results obtained at 40 days from the base line showed better signifi-cant improvement in all clinical parameters (p≤ 0.05) in the treated groups, except for bleeding on probing in control group were no significant improvement was reported. Azithromycin plus SRP give the greatest improvement in mean gingival index and bleeding on probing (p< 0.05) when compared with the control group but no significant differences were observed between metronidazole treated group and the control group. Conclusions: The adjunctive use of azithromycin with SRP has potential to improve periodontal health over SRP only and could be an interesting alternative to metronidazole from patients with chronic periodontitis


Article
Salivary level of RANKL and OPG in chronic periodontitis

Authors: Batool Hassan Al-Ghurabi بتول حسن الغرابي --- Sara Mohammed Mohssen سارة محمد محسن
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2015 Volume: 27 Issue: 1 Pages: 189-194
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Periodontal diseases are initiated by microbial plaque, which accumulates in the sulcular region andinduces an inflammatory response. The Receptor activator of nuclear factor-kappa B ligand / osteoprotegerin(RANKL/OPG) axis is involved in the regulation of bone metabolism in periodontitis, in which an increase in receptoractivator of nuclear factor-kappa B ligand or a decrease in osteoprotegerin can tip the balance in favor ofosteoclastogenesis and the resorption of alveolar bone that is the hallmark of periodontitis. This study was performedto investigate the role of salivary levels of RANKL and OPG in pathogenesis of chronic periodontitis.Subjects and Methods: Fifty five subjects with chronic periodontitis with ages range from 24-64 years and 25apparently healthy volunteers their ages and sexes were matched with the patients were participated in this study.Periodontal parameters used in this study were plaque index, gingival index, probing pocket depth, clinicalattachment level and bleeding on probing. Saliva samples were collected from all patients and controls. Enzymelinkedimmunosorbent assay was carried out for estimation the salivary level of RANKL and OPG in studied groups.Results: The present data revealed that the median salivary levels of RANKL was elevated in patient as comparedwith control group (P<0.001), whereas the salivary levels of OPG doesn’t show any significant differences betweenthe study groups (p>0.05). In contrast the ratio of RANKL/OPG ratio was significantly higher in patients whencompared with the ratio in control group. Furthermore, negative significant correlation was noticed between RANKLand OPG. Regarding correlation between salivary (RANKL and OPG) and clinical periodontal parameters, RANKLlevels was showed significant positive correlation with each of probing pocket depth and clinical attachment level.Otherwise no association between OPG levels and clinical parameters of periodontitis was found. Moreover; theratio RANKL/OPG was showed significant positive correlation with each of gingival index, probing pocket depth andclinical attachment level.Conclusion: This study demonstrates that salivary levels of RANKL and OPG play a crucial role in pathogenesis ofperiodontitis, and the relative RANKL/ OPG ratio appears to be indicative of disease occurrence

Keywords

chronic periodontitis --- RANKL --- OPG


Article
The Relationship between Periodontal Disease and Predisposing Factors

Authors: Mohemid M. Al- Jebouri. --- Hadeel M. Younis
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2016 Volume: 4 Issue: 1 Pages: 68-80
Publisher: Tikrit University جامعة تكريت

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Abstract

Periodontitis is an inflammatory lesion mediated by host-bacterial interactions which results in a non-resolving inflammation that leads to local connective tissue attachment loss from the tooth surface, loss of alveolar bone and ultimately tooth loss Indeed, periodontal disease is the leading cause of tooth loss in the western world and developing countries. The aims of this study was to estimate the relationships between periodontal disease and predisposing factors. One hundred eighty samples (paper point inserted into periodontal pocket) were examined in the present study . Patients were of both sexes(140 males and 40 females).Their ages ranged from 16-69 years old. Clinical measurements of periodontal parameters used included dental plaque index, gingival index, bleeding on probing, probing pocket depth and clinical attachment loss . The results showed that periodontal disease was the most common in age group 20-29 years old and only a case reported with periodontal disease in 65 years old patients. According to sex distribution of patients, periodontal disease was mostly found in males than females. The periodontitis was more common in non-educated,treated ,smoking patients they living in rural area than educated,non treated ,non-smoking patients . they living in urban area.The most common anaerobic periodontal bacteria isolated from patients were peptostreptococcus prevotii which represented 15(8.3%) isolates, while prevotella intermedia, prevotella melani, prevotella disiens, Bifidobacterium sp., Fusibacterium mortiferum peptostreptococcus tetradius ,and Wolinella sp. represented only 1 (0.5%) of anaerobic isolates .Also another anaerobic subgingival bacteria isolated from inflamed sites in patients were fusibacterium varium, vellionella sp., campylobacter gracilis, capnocytophaga sp., peptostreptococcus magnus, peptostreptococcus micros, peptostreptococcus niger,peptostreptococcus anaerobius, staphylococcus saccharolyticus, streptococcus consellatus, and gemella morbillorum.


Article
Association between periodontitis and acquired coronary heart disease

Author: *Nadia Aftan AL Rawi M.Sc., Ph.D. **Athra M. Al. Waheb M.Sc.
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2016 Volume: 12 Issue: 1 Pages: 10-15
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The association between oral microbial infection and systemic disease is not a new concept. A major confounding issue is that oral infections often are only one of the many important factors that can influence systemic diseases .Objective: This study was conducted to evaluate the periodontal health status of patients with acquired coronary heart disease. Type of the study: Cross-sectional study.Methods: The study group consisted of 200 patients with an age range (35-70) years, having coronary heart disease .This study group were compared to a control group of non-coronary heart disease (200 individuals ) matching with age and gender. The oral parameters were examined including the periodontal conditions, assessment of periodontal loss of attachment as well as the missing teeth according to the World Health Organization criteria (1997)(1) were followed for diagnosis and recording of oral health status.Results: Results of the present study show that the total sample had a highly significantly periodontitis and periodontal loss of attachment with advancing age (P<0.01), while no statistically significant differences were found between males and females with periodontal condition and periodontal loss of attachment among the study group (P>0.05), while there was significant differences among their corresponding controls (P<0.05). High percentage of missing teeth was recorded among the study and control group. Highly statistically significant differences were seen between study and control groups in all the degree of severity related with periodontal conditions (P<0.001).Conclusion: The data showed that 50.5%, 35% of the control group were with periodontal disease and loss of attachment respectively compared with study group 68%, 58.5% . The present study indicate that periodontal disease more common among patients with CHD than among controls matched for age and gender. Thus the possibility that chronic oral infection or similar factor may he positively associated with CHD at least in form patients susceptible to CHD.Although causality cannot be inferred from the present data, the observed association between chronic oral infections and CHD for susceptible patients in the present study can not be excluded.


Article
Antibacterial Effect of Aqueous and Alcoholic Ginger Extracts on Periodontal Pathogen Aggregatibacter Actinomycetem Comitans [An in Vitro Study] (Part 1)

Authors: Sana'a M. Awad سناء عواد --- Maha Abdul-Aziz. Ahmed مها عبد العزيز احمد
Journal: Tikrit Journal for Dental Sciences مجلة تكريت لعلوم طب الاسنان ISSN: 20731213 Year: 2017 Volume: 5 Issue: 2 Pages: 1-10
Publisher: Tikrit University جامعة تكريت

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Abstract

Among natural food sources with antimicrobial activities, gingerrhizome has been used as widely grown food spices and medicinalcrops for centuries. Furthermore, it possess antifungal andantioxidant properties due to the phenols – related constituents(gingerols) that constrain the growth of many Gram positive andGram negative bacteria including some periodontal bacteria. TheActinomycetem comitans is a portion of the normal microbiota innumerous healthy individuals but is also a major etiological agentin some aggressive and chronic types of periodontitis.The present study was conducted to test the effect of aqueous andalcoholic ginger extracts on the growth of Aggregatibacteractinomycetem comitans in comparision to 0.2% chlorohexidinegluconate mouth wash and distilled water in vitro, determinationof ginger extracts minimum inhibitory concentration andminimum bactericidal concentration and detection of activeingredients of ginger extracts by using the high-performance liquidchromatography as well as chemical elements.


Article
EFFECT OF ZINC SUPPLEMENTATION ON PERIODONTAL STATUS
تاثير اعطاء الزنك على حالة اللثة

Authors: DHIA J. AL-TIMIMI ضياء التميمي --- HASHIM D. MOUSA هشام موسى --- SUZAN M. SALIH سوزان سليم
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2014 Volume: 8 Issue: 2 Pages: 30-37
Publisher: University of Dohuk جامعة دهوك

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ABSTRACTBackground and objectives A link between the occurrence of periodontitis and zincdeficiency has been suggested. The aim of this study was to evaluate the effect of zincsupplementation on periodontal status in patients with type 2 diabetes mellitus.Methods Three hundred diabetic patients with chronic periodontitis (age range 45-65 yearsold) were selected. The patients divided into three groups as I :zinc supplement; II: scalingand polishing; III: zinc plus scaling and polishing. At initial visit, the blood samples of allpatients collected and analyzed for serum zinc and glucose. Periodontal status of the patientsbased on clinical attachment loss and probing pocket depth score was determined. Thepatients in group I and group III were assigned to receive 50 mg elemental zinc three times aday for six months period. Periodontal status reassessed after intervention following the sameprocedure.Results At initial, there were no significant differences in any parameter between the threegroups. At the end of the 6 months period, the mean values of clinical attachment loss andprobing pocket depth scores were significantly lower among group III as compared to groupII (P<0.01). The percentage of change in clinical attachment loss and probing pocket depthwere significantly higher in the group III as compared to group II ( p<0.05).Conclusion Zinc supplement for vulnerable population to low zinc status such as type 2diabetes mellitus patients decreases the chance of the occurrence of severe periodontitis.

خلفية واهداف البحث: عامل الريس وفصائل الدم المنتشرة تم د ا رستها بين الشعوب المختلفة ومع ذلك لا توجد معلومات متوفرة للناس الكورد الدين يعيشون في دهوك؛ الع ا رق. ولهذا السبب تمت الد ا رسة لتحديد العلاقة بين حدوث التهاب اللثة ونقصان الزنك. وكان الهدف من البحث لتحديد تاثير اعطاء الزنك على حالة اللثة في المرضى السكري النوع الثاني.٦٥ سنة تم اختيارهم. المرضى تم - طرق البحث: ٣٠٠ مريض سكري مصابين التهاب اللثة المزمن معدل اعمارهم ٤٥ تقسيمهم الى ثلاث مجموعات: المجموعة الاولى تم اعطائهم الزنك والمجموعة الثانية تم لهم تنظيف اللثة والمجموعةاالثالثة تم اعطائهم الزنك مع تنظيف اللثة ومن الزيارة الاولى تم سحب عينات الدم لجميع المرضى ليتم فحص الزنكوالكلكوز في المصل. حالة اللثة للمرضى تم قياسها بمقياس المجموعة الاولى والثانية للمرضى وافقوا لتناول ٥٠ مليغ ا رم زنك ثلاث م ا رت في اليوم لمدة ستة اشهر .حالة اللثة تم قياسها مرة ثانية بعد المقابلة وبنفس الطريقة.النتائج: في البداية لا يوجد فروقات معنوية في اي مقياس بين المجاميع الثلاثة .في نهاية فترة الستة اشهر,معدل قيمفقدان الت ا ربط النسيجي السريري وعمق الجيوب اللثوية كان قليل معنويا في المجموعة الثالثةعندما تم مقارنتها بالجموعة الثانية. النسبة المئوية للتغيير في فقدان الت ا ربط النسيجي السريري وعمق الجيوب اللثوية كان كثير معنويا في المجموعة الثالثة عندما تم مقارنتها بالمجموعة الثانية الاستنتاج: اعطاء الزنك للناس المتطوعين وعندهم نقص بالزنك مثل مرضى السكري النوع الثاني يقلل فرصة حدوث التهاب اللثة الحاد.


Article
P53 IMMUNOHISTOCHEMISTRY IN CHRONIC PERIODONTITIS; RELATION TO SMOKING AND HISTOPATHOLOGIC PARAMETERS
الاظهار الكيميائي النسيجي المناعي ل p53 في التهاب ما حول الاسنان و علاقته بالتدخين و مؤشرات نسيجية مرضية

Authors: AMEERA K. KHALEEL اميره خليل --- CHINAR M. SULAIMAN جنار سليمان
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2014 Volume: 8 Issue: 2 Pages: 57-77
Publisher: University of Dohuk جامعة دهوك

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Abstract

ABSTRACTBackground and objectives Smoking is one of the main and important risk factors that increase risk of oral health problems. There is a dose-response relationship between number of cigarettes smoked and the development of periodontal diseases, in addition, to an elevation of p53 in oral mucosa of smokers. The aim of the study was to examine p53 immune expression in the gingival tissue samples in patients with different severity of chronic periodontitis in relation to different histopathological parameters and smoking status.Methods Gingival tissue biopsies were taken from (30) smokers and (30) nonsmoker subjects with different severity of chronic periodontitis. Staining profiles were classified according to the number of positive cells as well as to the location of the positive cells in the differentepithelial layers of the specimens.Results No significant difference was found between the median p53 labeling indices andany of the smoking status, severity of chronic periodontitis, epithelial thickness and number of blood vessels in the connective tissue. However, a significant association was found between p53 immunostaining and number of inflammatory cells.Conclusions Chronic periodontitis may accelerate smoking effects on p53 gene mutation.

خلفية واهداف البحث: إلتهاب أنسجة ما حول الأسنان هو أصابة سببها مختلف أنواع الأحياء المجهريه والتدخين هو واحد من أهم عوامل الخطورة. الهدف من الد ا رسة هو إيجاد سمك الطبقة الطلائية للثة، عدد الخلايا الإلتهابية والأوعية الدموية فى نماذج نسيج اللثة للمرضى المدخنين وغير المدخنين الذين عندهم إلتهاب أنسجة ما p والتعبي ا رلمناعي للبروتين 53 حول الأسنان المزمن.طرق البحث: ثلاثون شخص مدخن و ثلاثون شخص غير مدخن عندهم مختلف درجات إلتهاب أنسجة ما حول الأسنانالمزمن أختيروا من المركز الصحي فى دهوك فى الفترة من تشرين الاول ٢٠١٠ الى كانون الثانى ٠٢٠١١ نماذج اللثةباستعمال p جمعت ومررت للتصبيغ بمادة هيماتوكسيلين والإيوسين وللتصبيغ الكيميائي النسيجي المناعي لبروتين ٥٣.(Leica NovoLink MT Polymer UK) النتائج: أظهرت النتائج زيادة واضحة فى سمك الطبقة الطلائية الكبير و سمك الطبقة الطلائية فى القاعدة مع زيادة شدة اكثر من p اقل من ٠,٠٥ )، وفرق غير معنوى وجد فى متوسط عدد الخلايا الإلتهابية (قيمة p حالة التدخين (قيمة ٠,٠٥ ) بين غير المدخنين والمعتدلين وكثيرين التدخين، بالاضافة الى ذلك، كثيري التدخين أظهروا أقل عدد من الأوعية اكثر من ٠,٠٥ ) في متوسط p الدموية فى اللثة مقارنة بمعتدلي التدخين. كثيري التدخين أظهروا زيادة غير معنوية (قيمة مع سمك الطبقة p بين المجاميع. علاقات غير معنوية أيضا وجدت بين متوسط معدل مقياس 53 p معدل مقياس 53 .( اكثر من ٠,٠٥ p الطلائية الكبيرو سمك الطبقة الطلائية فى القاعدة وعدد الأوعية الدموية فى النسيج ال ا ربط للثة (قيمة .( اقل من ٠,٠٥ p وعلى العكس علاقة معنوية وجدت مع عدد الخلايا الإلتهابية (قيمة له دور مهم في إلتهاب أنسجه ما حول الاسنان المزمن. p الاستنتاجات: أشارت نتائج الد ا رسة الحالية أن بروتين p53 له دور مهم في إلتهاب أنسجه ما حول الاسنان المزمن.


Article
PREVALENCE OF PERIODONTAL DISEASE AMONG RHEUMATOID ARTHRITIS PATIENTS
مدى انتشار امراض اللثة في المرضى المصابين بالتهاب المفاصل

Authors: MOHAMMED TAHIR RASOOL محمد طاهر رسول --- SUZAN M. SALIH سوزان سليم --- HASHIM D. MOUSA هاشم موسى
Journal: Duhok Medical Journal مجلة دهوك الطبية ISSN: ISSN: 20717334 (online)/ ISSN: 20717326 (Print) Year: 2016 Volume: 10 Issue: 2 Pages: 69-76
Publisher: University of Dohuk جامعة دهوك

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Background: Patients with rheumatoid arthritis (RA) may have higher prevalence ofperiodontitis.Aim: To determine the prevalence of periodontal disease among rheumatoid arthritis patients.Patients and methods: Cross-sectional study was done on 250 patients, who were selected byfrom patients attending Duhok Center for Rheumatic Disease and Medical Rehabilitation.Periodontal health status of the patients based on probing pocket depth score, clinicalattachment loss, and disease activity score was determined. Validated questionnaire was usedto record smoking, body mass index, tooth brushing, duration of rheumatoid arthritis disease.Results: The age range of patients was 35-60 years. All rheumatoid arthritis patients havesome degree of periodontal diseases, 133(53.2%) with mild and 117(46.8%) with moderateperiodontitis.A significant prevalence of periodontal diseases occurred in patients with age group (40-54)years was 144 (57.6%) compared to younger age 46 (18.4%) and older age 60 (24%)respectively, p-value <0.001 The duration of diseases was more significant in intermediate (1year to 3 years) 125 (50%) compared to early (< 12 months) 45 (18%) and longer disease (>3 years) 80 (32%) p-value<0.001.Conclusion: All patients were suffering from some degree of periodontal diseases with nosignificant difference in severity between males and females.

الخلفية والأهداف: احتمالية ان يكون التهاب اللثة اكثر انتشارا في المرضى المصابين بالتهاب المفاصل.تهدف الدراسة الى ايجاد مدى انتشار امراض اللثة في المرضى المصابين بالتهاب المفاصل.طريقة البحث: تمت الدراسة على 250 من المرضى الدين تتراوح اعمارهم بين 30-60 الدين يراجعون مركز التاهيل الصحي لامراض المفاصل. مدى صحة الفم واللثة يعتمد على قياس عمق الجيوب اللثوية و مدى فعالية المرض.النتائج: انتشار امراض اللثة في المرضى المصابين بالتهاب المفاصل كانت 133(53.2%) التهاب لثة خفيف و 117 (46.8%) التهاب لثة متوسط . يوجد اختلاف معنوي في امراض اللثة في المرضى الذين تتراوح اعمارهم بين (40-54) سنة كانت 144 (57.6%) مقارنة بالاقل اعماراً 46 (18.4%) والاكبر أعماراً 60(24%). الاستنتاجات: توصلت الدراسة الى انه لا يوجد اختلاف معنوي في شدة امراض اللثة بين الجنسين ولو ان نسبة الاناث اكثر من نسبة الذ كور.


Article
Bacteriological and immunological study of aggressive periodontitis in Mosul

Authors: Alaa M. Altaei --- Mahmoud Y.M. Taha
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: SpIss Pages: S207-S214
Publisher: Mosul University جامعة الموصل

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Aims of the study: to isolate and identify microorganisms causing aggressive periodontitis, and to estimate the changes in the levels of IL-1, TNF- and CRP in serum as well as to determine peroxidase activity in saliva of patients with aggressive periodontitis. Materials and Methods: This study was carried out on total number of 40 (35 patients with aggressive periodontitis, 18 females and 17 males aged between 16-35 years and 5 control group between 20-30 years old). Samples were taken from the lesion for bacteriological study. Serum and saliva were collected and ELISA test was performed. Results: The bacteriological results showed that A. actinomycetemcomitans was the most prevalent bacteria in aggressive periodontitis, followed by facultative anaerobic. The serological and biochemical studies showed that interleukin-1 was significantly elevated in the study group while tumor necrosis factor was not, whereas peroxidase enzyme activity and C-reactive protein were also highly significant elevated in the study group. Conclusion: Actinobacillus actinomycetemcomitans was the major etiologic bacteria of this disease as well as significantly high levels of, CRP, peroxidase activity and IL-1 could be regarded as strong markers for more precise understanding the immunological aspect of this disease

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