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Article
Plateletpheresis concentrate produced with Fresenius cell separator Iraqi experience

Author: Nidal Karim Al-Rahal
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 1 Pages: 27-32
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Various types of plateletpheresis instruments are available for single donor plateletpheresis. In plateletpheresis blood is withdrawn from the donor in anticoagulant solution and separated into components. Platelets are retained and the remaining components are returned to the individuals.Aims: Evaluation of Fresenius COM.TEC; apheresis machine in regard to processing time, platelet (plt) yield efficiency, white blood cell (WBC) content and safety.Patients and Methods: Twenty two healthy male donors included in single donor plateletpheresis by Fresenius COM.TEC between February 2006 and July 2006 at bone marrow transplantation Center, Medical City Hospital, Baghdad / Iraq.The donor’s age, height, weight, complete blood count, blood group &Rh & vital signs were recorded and they were observed throughout the procedure. Plateletpheresis operational variables and the product variables were assessed.Results: The plateletpheresis product data which includes, donor platelet count with mean 229.424 x10³/cmm (range 185-336 x10³/cmm), product platelet count x10³/cmm mean 1268.5 x10³/cmm (range 604-2525 x10³/cmm), Platelet yield with mean 3.39 x10¹¹/cmm (range 2.51-7.57 x10¹¹/cmm), 90.90%of the product >3x10¹¹plt. No. of yield with WBC <1x106 18 out of 22 donors (81.18%), collection efficiency the mean 48,85% (range 32.18-60.28), the collection efficiency >50% was seen in 13 out of 22 donors (59.09%).Few donors exhibited adverse reactions mainly circumoral paresthesia in two donors (9.09%) mild pain at the phlebotomy site in three donors (13.63%). Only one had dizziness which account for 4.54%.Conclusions: Fresenius COM.TEC; apheresis instrument collected platelets safely, efficiently, with consistent leukoreduction product according to the AABB (American Association of Blood Banks) & with short time.


Article
Evaluation of plateletpheresis procedure in blood component separation unit of Bone Marrow Transplant Center
تقييم اجراء فصل الاقراص الدموية بطريقة أفريسز فى وحدة فصل مكونات الدم فى مركز زرع نخاع العظم

Authors: Waleed Abdelazez د.وليد عبد العزيز عمر --- Omer Amel Amen Ali د.امل امين على
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2007 Volume: 20 Issue: 2 Pages: 360-362
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: Platelet concentrate can be harvested by apheresis using blood cell separator. In this study; plateletpheresis was evaluated , regarding the safety and clinical effect of the procedure , and quality of the product Methods: The study carried out in blood separation unit of Bone Marrow Transplant Center (BMTC) in Children Welfare Teaching Hospital using blood cell separator. The donors selected according to the criteria for whole blood donor selection with limited clinical examination. Hb estimation, WBC counting and platelets counting were carried out on the donors , pre and post donation , and platelets counted in the product. Results: The results reflect the safety of the procedure; there were no significant clinical changes between pre and post donation regarding pulse rate, blood pressure and temperature, beside that there were no significant changes in Hb concentration and WBC count between pre and post donation , while the drop in platelet count of the donors after donation was of no clinical effect. Only 30% of donors show numbness around mouth . Regarding the quality of the product, 20% of platelet units contain more than 3x1011 platelets, while the other units contain less than that slightly. Conclusion: The procedure of platelet pheresis in blood separation unit of BMTC was safe and effective in harvesting platelet from platelet donors in short time.Key Words: Plateletpheresis , platelet concentrate , blood components separation unit

الملخص:أساس البحث: يمكن جمع مركز الاقراص باستخدام جهاز فصل خلايا الدم.فى هذه الدراسة ، تم تقييم اجراء استخراج الاقراص بطريقة افريسز ، اخذين بنظر الاعتبار مأمونية الاجراء والتغيرات السريرية، اضافة الى تقييم جودة المنتوج. الطرائق: اجريت هذه الدراسة فى وحدة فصل مكونات الدم فى مركز زرع نخاع العظم فى مستشفى حماية الاطفال التعليمى , باستخدام جهاز فصل خلايا الدم .كان انتقاء المتبرعين وفقا لضوابط انتقاء متبرعى الدم , مع اجراء فحص سريري محدود . كما اجريت فحوص خضاب الدم وتعداد كريات الدم البيض وتعداد الاقراص الدموية , قبل , وبعد التبرع . كذلك تم اجراء فحص تعداد الاقراص الدموية فى المنتوج .النتائج: النتائج تعكس مأمونية اجرات استخراج الاقراص الدموية ، حيث لم يطرأ تغير ذو أهمية سريرية قبل وبعد التبرع فيما يخص معدل النبض وضغط الدم ودرجة حرارة الجسم . يضاف الى ذلك , لم يطرا تغير ذو اهمية احصائية فى تركيز خضاب الدم وتعداد كريات الدم البيض ، قبل وبعد التبرع . أما بخصوص انخفاض الاقراص بعد التبرع ، فلم يكن له اهمية سريرية.بعض المتبرعين (30%) شعروا ب(تنمّل) حول الفم. بخصوص جودة المنتوج ، فقد كان 20% من الوحدات المنتجة تحتوى على عدد من الاقراص أكثر من 3X10 11، لكل وحدة ، بينما باقى الوحدات تحتوى على أقل من ذلك بقليل .الاستنتاج: اجرات استخلراج الاقراص من الدم بطريقة أفريسز فى مركز زرع نخاع العظم هو اجراء مأمون وفعال فى جمع الاقراص من المتبرعين فى وقت قصير


Article
Plateletpheresis adverse events in relation to donor and plateletpheresis session profile

Authors: Rajni Bassi --- Kusum K. Thakur --- Kanchan Bhardwaj
Journal: Iraq Joural of Hematology المجلة العراقية لامراض الدم ISSN: 20728069/25432702 Year: 2017 Volume: 6 Issue: 2 Pages: 38-42
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

INTRODUCTION: Increasing demand of platelet transfusions for patients has led to a trend in theincreased use of automated blood collections. These share many of the same reactions and injuriesseen with pooled platelets obtained from whole blood donation but also have unique complications.AIMS AND OBJECTIVES: To study the adverse events (AEs) of plateletpheresis procedure andtheir relationship with donor and plateletpheresis procedure session profiles.MATERIALS AND METHODS: This is a retrospective observational study conducted from January2016 to December 2016. A two-hundred and thirteen (213) plateletpheresis procedures wereperformed after taking informed and written consent from the donor. All the donors were male andselected according to the guidelines laid down by Director General of Health Services. The AEs wereclassified into donor related, kit/equipment related and technique related.RESULTS: A total of 13 AEs were noted; of which, 8 (61.53 %) events were associated with donors,3 (23.07 %) were owed to fault in kit/equipment and 2 (15.384 %) were due to technical aberrations.Donor related AEs included vascular injuries [n = 3 (1.40%)], vasovagal reactions [n = 2 (0.938%)]and perioral tingling sensation [n = 3 (1.40%)]. Technique related AEs [n = 2 (0.938%)] and kit/equipment related AEs [n = 3 (1.40%)] were due to faulty technique and defective kits respectively.CONCLUSION: Apheresis donations performed on cell separators are safe. Meticulous donorvigilance, superior technical personnel training and experienced transfusion medicine specialist’ssupervision will make donor’s experience more pleasant.

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