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Article
Prevalence and pattern of endocrinological abnormalities in oligospermic and azoospermic patients.

Author: Ali F. Al Najar علي النجار
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 4 Pages: 402-404
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hormones have very important role in spermatogenesis and production capacity of testis. Disturbances in their vlevels can be very crucial in dysfunction of testis which results in men infertility. This study carried out to evaluate the hormonal disturbances in men infertility and its correlation with semen parameters and types of infertility.Patients and Methods: Blood and semen samples were collected from 91 infertile men and 20 healthy and fertile control who attended Al-Kadymiah hospital and some private clinics in Baghdad from January to December 2009.Semen and serum samples were analysed for semen parameter and FSH, LH, Testosterone and prolactin levels.Results: Fifty one (56%) of infertile men were found with azoospermia, 22(24%) were with mildoligospermia and 18(20%) were with severoligospermia.Semen analysis of infertile men showed very low quality parameters with a non homogenized hormonal results.Elevation of FSH and LH with low level of testosterone were detected in azoospermic and Severoligospermic groups, while elevation of FSH with hyperprolactinaemia were detected in mildoligospermia.Conclusion: FSH and LH elevated levels were found to have a major role in azoospermia and severoligospermia, while prolactine and FSH elevations were correlated with mildoligospermia. Also these hormonal disturbances were found to associate with the quality of the semen where the low semen quality parameters detected in those with FSH, LH elevation and low level of testosterone. We concluded that hormonal disturbances can be considered as a reliable indicator to distinguish between non obstructive (over levels of FSH, LH and decrease level of testosterone) and obstructive (over levels of FSH,prolactin) types of infertility which is very important in therapy.Keywords: FSH, LH, Testosterone, Prolactine, Azoospermia, Oligospermia

Keywords

FSH --- LH --- Testosterone --- Prolactine --- Azoospermia --- Oligospermia


Article
Effect of physical activity on sex hormones in polycystic ovary syndrome Iraqi women

Author: Mothanna A.S. Al-Mahdawi1 , Hussein K. Khadhem2 , Sarah R.H Al- Jebori1
Journal: Iraqi Journal of Biotechnology المجلة العراقية للتقانات الحياتية ISSN: 18154794 Year: 2018 Volume: 17 Issue: 1 Pages: 98-107
Publisher: Baghdad University جامعة بغداد

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Abstract

The study include 50 subject in period (20/12/2016- 28/3/2017) of iraqi women in Diyala governorate (18-25 years), 40 subject with Polycystic ovary syndrome (PCOs) 20 with physical activity who practice sport for 2 hours in day and 20 with no physical activity) and 10 subject control. The study showed no significant difference of the age(˃20, ≤20) and body mass index of PCOs and control, but there were highly significant of sex hormones (LH, Prolactin, Testesteron) in PCOs compared with control, results showed no significant difference in the age, body mass index with physical activity and PCOs, and a highly significant effect of the physical activity on sex hormones (LH, Prolactin, Testestosterone) in the physical activity PCOs women compared with no physical activity PCOs women. This study showed that physical activity improves levels of hormones (LH, Prolactine, and Testosterone) in PCOs Diyala women.


Article
The Effect of Iron Overload on the Function of Some Endocrine Glands in β-Thalassemia Major Patients.
تأثير تراكم الحديد على وظائف بعض الغدد الصم عند مرضى فقر دم البحر الابيض المتوسط نوع بيتا.علاقة خاصة للهبسيدين

Authors: Hussein Kadhem Abdul Hussein Al-Hakeim حسين كاظم الحكيم --- Manal Farhan Mohsen Al-Hakany منال فرحان
Journal: Al-Kufa University Journal for Biology مجلة جامعة الكوفة لعلوم الحياة ISSN: 20738854 23116544 Year: 2013 Volume: 5 Issue: 2 Pages: 104-123
Publisher: University of Kufa جامعة الكوفة

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Abstract

Thalassemia is a term that refers to a group of genetic disorders characterized by a defect in the synthesis of hemoglobin. It is sometimes called Mediterranean anemia. Many biochemical changes in the blood accompany this disease. In this research, some biochemical parameters were measured in thalassemic patients and compared with healthy control group. These parameters include Serum iron, TIBC, were measured Spectrophotometrically. Serum ferritin, Iisulin, GH, Testosterone, T3, T4, TSH, Cortisol, & Prolactine were measured by ELISA technique. The results have revealed a moderate state of iron overload in the thalassemia patients. Furthermore, there is a decrease in the level of serum cortisol, T4, prolactine and pancreatic beta cell function percentage (HOMA%B) in thalassemic while serum TSH level is higher in thalassemic patients in comparing with control group. The changes in the hormone levels in addition to serum insulin, insulin/glucose ratio, and HOMA%B are correlated well with the degree of iron store in the body, concluded mainly from high ferritin level.Insulin resistance parameters showed a significant negative relation with Insulin sensitivity index. There are significant increases in PCV, Hb, T3, and testosterone in male patients in comparing with female thalassemic patients. From the results of the present study, it can be concluded that iron overload state affects some endocrine glands secretions and there is a difference in the effects between male and females in prepubertal thalassemic patients. Therefore, it is important to estimate the endocrine function activity of thalassemia patients and treat the disorders if present as soon as possible.

يطلق مصطلح الثالاسيميا على مجموعة من الاضطرابات الوراثية التي تؤثر في عملية تصنيع الهيموكلوبين ويسمى هذا المرض أحيانا بفقر دم البحر الأبيض المتوسط. يرافق هذا المرض الكثير من التغيرات الكيموحياتية في الدم. درست في هذا البحث تم قياس بعض المتغيرات الكيموحياتية المهمة في المرضى وقورنت نتائجهم بمجموعة السيطرة. شملت القياسات العملية المتغيرات التالية: تركيز الحديد الكلي و TIBC بالطريقة الفوتومترية. كما تم قياس الفرتين والانسولين وهرمون النمو والشحمون الخصوي والثايروكسين ثلاثي الجزيئة والثايروكسين والهرمون المحفز للدرقية و الكورتزول والبرولاكتين بتقنية الاليزا . وأظهرت النتائج حالة متوسطة من حالة تراكم الحديد في الجسم لد ى مرضى الثلاسيميا. وعلاوة على ذلك، هناك انخفاض في مستوى هرمون الكورتيزول , الثايروكسين و البرولاكتين في الدم والنسبة المئوية لوظائف خلايا بيتا في البنكرياس(٪HOMA B) في الثلاسيميا, بينما مستوى مصل الهرمون المحفز للدرقية TSH أعلى لدى المرضى الذين يعانون الثلاسيميا مقارنة مع مجموعة الاصحاء. أظهرت النتائج ارتباط التغيرات في مستويات الهرمونات بالإضافة إلى الأنسولين , ونسبة الانسولين / الجلوكوز و(٪HOMA B) مع درجة تراكم الحديد في الجسم، والذي تم الحصول عليه واستنتاجه من الارتفاع في مستوى الفيريتين. أظهرت عوامل مقاومة الانسولين وجود علاقة سلبية مع مؤشر حساسية الانسولين. وهناك زيادات معنوية في حجم كريات الدم الحمرPCV, خضاب الدم Hb, هرمون الثايروكسين ثلاثي الجزيئة T3 وهرمون الشحمون الخصوي لدى المرضى الذكور مقارنة مع مرضى الثلاسيميا الإناث. ومن نتائج هذه الدراسة، يمكن الاستنتاج بأن حالة تراكم الحديد تؤثر على بعض افرازات الغدد الصماء، وهناك فرق في التأثيرات بين المرضى الذكور والإناث الذين يعانون الثلاسيميا ماقبل البلوغ. ولذلك فمن المهم تقدير فعالية وظائف الغدد الصماء لمرضى الثلاسيميا وعلاج الاضطرابات إذا كانت موجودة في أسرع وقت ممكن.

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