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Article
Evaluation the antioxidant effect of α-L- Fucose injection into rabbit periodontium

Authors: Chenar A. Mohammad --- Khlood A. Al-Safi خلود الصافي --- Bakhtiar M. Ahmed
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: 2 Pages: 119-124
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: α-L-Fucose is a methyl pentose sugar similar to L-galactose except for the loss of alcohol group oncarbon number 6. The objective of this study is to evaluate the biochemical and antioxidant effect of intracrevicularinjection of fucose into rabbits periodontium, throughout measuring the levels of total protein (TP), total fucose (TF),protein bound fucose PBF) , Malondialdehyde (MDA) , and vitamin C in sera of fucose injected rabbit groups.(Materials and Methods: The existing study was carried out on 55 male rabbits and were divided randomly into threegroups ; first group was injected with 50μl of 150mM fucose solution into gingival sulcus ; second group was injectedwith 50 μl of normal saline ; while the third group was not received any injection ( normal group) .Blood sampleswere collected from injected groups at time intervals of 1, 3 ,24 ,72, and 168 hours after injection, for measuring ofserum TP, TF, , PBF , MDA, and vitamin C and compared with normal group.Results: The results showed a significant increase in the mean concentration of TF and PBF reaching its maximumvalue 3hrs after injection, then it decline until reached its normal value 168 hours after injection, whereas serum totalprotein increased significantly only 3 hours after injection. Also serum MDA level did not change after injection, whileserum vitamin C increased immediately after fucose injection, even 72 hours after injection.Conclusion: Intracrevicular injection of α-L- Fucose has an observable effect on TF and PBF this may give anindication about its effect on periodontal tissue and has a role in the body defence against oxidative stress,throughout increasing the production of vitamin C.


Article
The Role of Serum Fucose, Protein Bound Fucose and Other Biomarkers in Patients with Rheumatoid Arthritis

Author: Abbas Toma Joda
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2017 Volume: 16 Issue: 3 Pages: 56-61
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Rheumatoid arthritis (RA) is a chronic, systemic inflammatory disorder that principally attacks synovial joints. Aims: To evaluate the status of serum fucose and protein bound fucose, anti-CCP, TNF-α and RF in serum of RA patients. Subjects and methods: The study has included 30 patients with early RA (with disease duration <1 year) (23 females+ 7 males) with age range (30-61) years and 30 patients with late RA (with disease duration >1 year) diagnosedaccording to the 2010 EULAR criteria (25 females, 5 males) with age range (30-60) and 28 healthy control individuals (22 females,6 males) with age range (30-55), who were age and sex matching with patients. Results: Levels of total serum fucose and protein bound fucose significantly decrease in RA patients than healthy control, while anti-CCP, TNF-α, RF, CRP and ESR significantly increase in RA patients than healthy control. Levels of total serum fucose, protein bound fucose & ACCP were not significant between three stages of activity in late & early RA patients. The level TNF-α & RF were significant only in very active cases in late RA, while not significantly in all cases of early RA. Positive correlation was found between ACCP & ESR in RA patients & early RA patients. Positive correlation found between TSF & PBF, negative correlation found between TNF-α & ESR in late RA patients. Positive correlation found between ACCP & ESR, CRP & ESR in early RA patients. Conclusions: This study illustrate that total serum fucose and protein bound fucose aid to diagnosis RA patient. Also Anti-CCP is a good & specific marker for diagnosis of RA,it is a goodprognostic and as index test of severity.

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