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Article
GROSS ANATOMICAL AND MOROPHMETRICAL STUDIES TO THE SKULL BONES OF THE LOCAL RABBIT (ORYCTOHGUSCUNICULUS ).
دراسة تشريحية عيانية و قياسية لعظام جمجمة الأرنب المحلي

Author: Salih K.M قسمة مظفر صالح
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2013 Volume: 12 Issue: 2 Pages: 267-277
Publisher: Basrah University جامعة البصرة

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Abstract

Ten adult rabbit (5male and 5 female ) were used for gross anatomical and biometrical studies .The main characteristics feature of the local rabbit skulls are : in dorsal surface there are a shallow external sagittle crest , the frontal bone has anterior and posterior supraorbital process , the external acoustic meatus is a short wide bony tube directed caudodorsally , the orbita are large , the external surface of the maxilla is pitted by numerous small opening (fenestrated).A total of 16 linear measurement estimated in the rabbit skulls .There are significant difference between males and females observed in bizygomatic distance , basion-bragma height , maxilla- alveolar length , orbital height and foramen magnum breadth

Keywords

Rabbit --- Skull --- Orbital


Article
ROLE OF AUTO - OMENTAL GRAFT ON THE FRACTURE HEALING AFTER PERIOSTEUM DESTRUCTION, RADIOGRAPHIC STUDY.

Author: M.J. Eesa* H.H-U. Mohammed* H.H.Nahi
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2013 Volume: 12 Issue: 2 Pages: 301-306
Publisher: Basrah University جامعة البصرة

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Abstract

The aim of this study is to evaluate the effect of the auto-omental graft on the fracture healing after destruction of the periosteum around the fracture site in rabbits. Eight mature healthy rabbits of local breed were employed to performed transverse fracture in the mid shift of the femoral bone, under general anesthesia and highly aseptic technique, then destruction of the periosteum was done about 1 cm away from each end of the fragments bone. The immobilization by intramedulary pinning, then the animals were divided into two equal group. The control group was left to follow the healing process, while in the treatment group the auto- omental graft was used to cover the fracture site. This graft was taken from the laparotomy of the left side and weekly radiographic examination performed for 10 weeks. The result is revealed that the omental graft play an important role in promote the fracture healing which was evident during the early new bone formation at the end of the second week compare to the control group which the sign of the callus formation was obvious lately at the end of the third week. The nature of the callus formation of the treatment group was limited to the fracture site and quickly cross the fracture site .While in the control group the new bone formation was heavy unlimited and need 8-9 week to bridge the fracture fragments. The omental graft play role in starting the remodeling phase, by decreasing the amount of the callus formation, with the signs of increase of the callus density, and marked of incorporation of the callus formation with the cortical bone

Keywords

Omentum --- Rabbit --- Periosteum


Article
6-OVERDOSEOF TUSSIRUM INDUCED HISTOPATHOLOGICAL CHANGES OF THE LIVER AND KIDNEY IN MALE DOMASTIC RABBITS

Authors: Zenab M. Abd Al Rahmman --- Yasmeen J. Mohammed --- Abdal J. Rasmy --- Majdy F. Majeed
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2018 Volume: 17 Issue: 1 Pages: 63-73
Publisher: Basrah University جامعة البصرة

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Abstract

In this study, the histopathological changes due to overdose usage of Tussirumdrug(0.75 and 3 ml/Kg)in liver and kidney were assessed in rabbite with lightmicroscopes. Six male rabbites(1 ± 0.5 Kg ) were included and divided into threegroups.Normal saline (3ml/Kg) wasgiven orally as placebo in the control groupI (N= 2).Group II and III(N= 4 for each) was received Tussirum orallyat a single dose of (0.75 and3ml/kg/day) for 30 days respectively. the results were recorded that both doses ofTossirum were induced that blood vessel congestion, aggregation of Kuppfercells,inflamintion infiltrations and Sinusoidal dilatation in the liver parenchyma inaddition to the cytoplasmic vacuolation, degeneration, pyknotic nuclei in the hepatocytesand. On the other hand, renal damage was observed in the kidneys of treated rabbits,necrosis of glomular, degeneration of nucli and degeneration in the lining epithelial cellsof renal, also noted that glomular shrinkage, dilated of reanal tubules and hyperplasia oftubles walls,as well as to necrosis of renal tubules endothelium, closing of renal tubuleslumen, isulation of renal tubules endothelium and density in some nucli chromaticFinally, the investigators concluded that Tossirum toxicity induced hepatocellular andrenal damage

Keywords

Tossirum --- Liver --- Male Rabbit


Article
Histopathological Effects of 5-Fluorouracil on the Liver of Male Rabbits ( with and without Folic Acid administration )

Author: Makarem Hameed Ahmad
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2016 Volume: 16 Issue: 1 Pages: 59-66
Publisher: Mosul University جامعة الموصل

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Abstract

Aims : The objective of this study is to evaluate the effects of 5-fluorouracil (5-FU) on the liver tissue of rabbits, as well as the effect of folic acid on the effectiveness of 5-FU on the rabbit's liver. Materials and Methods: In this study nine adult male rabbits ,aged about 3 months were used and divided into three main groups .Group 1 : served as a control group and received normal saline only.Group 2 : treated by 5fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks. Group 3 : treated by 5-fluorouracil , 10 mg / kg intraperitonealy twice weekly for 8 weeks with 5mg of folic acid orally twice weekly for 8 weeks .The animals were sacrificed and livers were excised and processed for histological study. Results: The liver of the treated group 2 shows disturbance in the architecture of hepatic lobule , swelling and vacuolation of the hepatocytes ,with ballooning degeneration and areas of necrosis. Congestion in the portal blood vessels and congestion in the central vein , together with congestion and dilatation of the sinusoids. Infiltration of mononuclear inflammatory cells in the portal area and around the central vein .While liver sections of group 3 show slight disturbance in hepatic cords architecture , hepatocytes showed no swelling and few vacuolation in their cytoplasm ,mononuclear cells infilitration mainly in the portal area and in lesser degree than that found in group 2 ,necrosis were not present. Conclusion:Toxic effect of 5-FU was observed on the liver tissue of rabbits , and an effective drugs must be applied with anticancer agents to improve liver function .

Keywords

5-fluorouracil --- liver --- rabbit


Article
Pathogenesis of Pasteurella multocida in Rabbits by Intra-nasal and Intra-ocular infection
امراضية جرثومة Pasturella multocida في الارانب بالاصابة في داخل الانف والعين

Author: Al-Najjar S. Sarhad سرهد النجار
Journal: The Iraqi Journal of Veterinary Medicine المجلة الطبية البيطرية العراقية ISSN: 16095693 Year: 2011 Volume: 35 Issue: 1 Pages: 42-53
Publisher: Baghdad University جامعة بغداد

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Abstract

In order to study the pathogenesis of the Pasteurella multocida in its natural rout of infection, this study was done to investigate and compare its pathogenesis after intranasal and intraocular infection.Thirty (30) rabbits were divided into three groups, the 1st group (n=12) infected with 240 CFU of Pasteurella multocida intra-nasal, the 2nd (n=12) infected with 240 CFU of P. multocida intra-ocular (eye drop), and the 3rd group (n=6) served as control negative. The animals were sacrificed if they did not die naturally at 24-48hr, 3, 6, 9, 30 day post-infection (p.i.). The results showed dullness of the animals with nasal and ocular discharge and some animals dead at 48hr and 72 hr p.i. (two animals from the 1st group and four animals from the 2nd group). The gross examination of the dead and sacrificed animals showed hemorrhage in the upper respiratory tract with fibrinous pleuropericaditis and emphysematous lung in the 1st group, while the 2nd group showed eye opacity and in some animal’s eye swelling in addition to the feature noticed in the 1st group. Pasteurella multocida was isolated from the organs of all the infected animals.The histopathological changes in the 1st group were more intense than the 2nd group and concenterated at the upper and lower respiratory tract as acute hemorrhagic treacheatis with fibrinous pneumonia , while the kidney showed hypercellularity of the glomeruli with cellular degeneration of renal tubule and lymphocytic hepatitis, also there is focal gliosis. Conclusion, intranasal infection was the effective route and the main pathological changes observed in the respiratory system characterized by fibrinous pleuropneumonia

اعدت هذه الدراسة لغرض معرفة امراضية جرثومة الباستوريلا مالتوسيدا في الاصابة الطبيعية والمقارنة بين الأصابة التجريبية عن طريق التنفس و عن طريق العين باعتبارها الطرق الطبيعية للاصابة.قسمت ثلاثون (30) ارنبا الى ثلاث مجاميع, المجموعة الاولى (12) ارنبا اصيبت عن طريق التنفس ب (240) CFU من جراثيم الباستوريلا مالتوسيدا, المجموعة الثانية (12) ارنبا اصيبت عن طريق التقطير بالعين ب (240) CFU من جراثيم الباستوريلا مالتوسيدا, والمجموعة الثالثة (6) ارانب عدت كمجموعة سيطرة. أجريت الصفة التشريحية على الحيوانات الهالكة والمقتولة بعد 24, 48ساعة وكذلك3, 6, 9, 30 يوم بعد الاصابة.اوضحت النتائج ظهور الخمول والافرازات الانفية والعينية وموت بعض الحيوانات بعد 48-72 ساعة بعد الاصابة. وبين الفحص العياني للحيوانات الهالكة والمقتولة وجود نزف في المجرى التنفسي العلوي مع التهاب الخلب و التامور الليفيني مع وجود النفاخ في الرئة في حيوانات المجموعة الاولى اما حيوانات المجموعة الثانية عانت من عتامة وتورم العين في بعض الحيوانات أضافتا لما وجد في حيوانات المجموعة الاولى وقد تم عزل جرثومة الباستوريلا مالتوسيدا من كافة الاعضاء الداخلية للحيوانات المصابة.وكانت الافات النسيجية المرضية في حيوانات المجموعة الاولى اكثر شدة من المجموعة الثانية حيث تركزت في المجرى التنفسي العلوي والسفلي والمتمثلة بالتهاب الرغامي النزفي مع التهاب الرئة الليفيني, اما الكلية فاظهرت زريدة خلوية الكبيبة مع تنكس ظهارة النبيبات الكلوية بالاضافة الى التهاب الكبد و الدباق البؤري في متن الدماغ. نستنتج من ذلك بأن الاصابة عن طريق التنفس هي الأكثر تأثيرا وتركزت الغيرات المرضية في الجهاز التنفسي حيث تمثلت بالتهاب الرئة والجنب الليفيني.


Article
Some observations on the spermatogenesis in the testes of rabbit
بعض الملاحظات عن نشأة الخلايا النطفية في خصي الارنب

Author: ِز’زاعسسثهى عامر متعب حسين
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2016 Volume: 15 Issue: 1 Pages: 1-6
Publisher: Basrah University جامعة البصرة

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Abstract

The seminiferous tubules of the testes of rabbits were lined by multilayered germ cells . The first layer was occupied by the spermatogonia , which were differentiated into type A(dusty type) spermatogonia, Intermediate type and type B (crusty type) spermatogonia. Pictures of Preleptotene, Leptotene, Zygotene ,Pachytene, Diplotene and Diakinesis. Primary spermatocytes were found and followed by secondary spermatocytes. Reading the morphological changes, the spermatid proposed 10 stages of cellular association during the cycle of the seminiferous epithelium in rabbit .


Article
Clinical and Anatomical Changes induced by Sciatic Nerve Section of Weaning Age Rabbits
التغيرات السريرية والتشريحية بسبب قطع العصب الوركي في عمر الفطام للارانب

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Abstract

The aim of the study was to explore the clinical and anatomical changes occured after Sciatic nerve section in the weaning age in rabbits. Twenty-five rabbits were used in this study ranging from 1-2.5 months. Divided into five subgroups according to the number of survival days (W7) (W14) (W30) (W60) (W90). Surgery was performed under general anesthesia. The nerve was sectioned using a small surgical scissor. Clinicalay few days later, the sign of right hind paws paralysis was observed clearly. The results revealed of a gap formation between the two nerve stumps [proximal and distal], and the gap increases on the day fourteenth.During the following two weeks, ulcers began to appear in the skin at the dorsal side of the ankle joint, and there was also an enlarged popliteal lymph node. Within 30-60 days another area was invaded by ulcer with or without bone exposure, the anterior part of the posterior side of the hind limb. After 90 days, there was severe ulceration and bone exposure with enlarged lymph nodes and the ulceration extended to the ventral side of the hindlimb. Results showed a gradual worsening of the condition and without improvement in peripheral nerves.

الهدف من هذه الدراسة هو معرفة التغيرات السريرية والتشريحية التي تحدث بعد قطع العصب الوركي في عمر الفطام في الارانب. استعملت 25 أرنبا في هذه الدراسة تتراوح اعمارهم مابين 1-2.5 شهر. تم تقسيمها إلى خمس مجموعات فرعية وفقا لعدد ايام بقائها بعد العملية (W7) (W14) (W30) (W60) (W90) .أجريت العمليات الجراحية تحت تأثير التخدير العام. تم قطع العصب بواسطة مقص جراحي صغير. سريرياً وبعد بضعة أيام، لوحظ بوضوح وجود شلل في الطرف الخلفي الأيمن. وكشفت النتائج عن وجود فجوة بين نهايتي الأعصاب المقطوعة [الدانية والقاصية]،وتزداد الفجوة في اليوم الرابع عشر. وخلال الأسبوعين التاليين بدأ ظهورتقرح في الجلد من الجانب الظهري من مفصل الكاحل، كما لوحظ ان هناك تضخم في العقدة اللمفاوية المأبضية. وخلال فترة 30-60 يوما غُزِيت منطقة أخرى بالقرحة مع أو بدون تعري للعظام، وهي الجزء الأمامي من الجانب الظهري من الطرف الخلفي. وفي يوم 90، كان هناك تقرح شديد وتعري العظام مع تضخم العقد الليمفاوية وأمتد التقرح إلى الجانب البطني للطرف الخلف. دلت النتائج على تردي الحالة بصورة تدريجية وعدم وجود تحسن في الاعصاب الطرفية.


Article
Open Osteotomy of ulna as a ModelFor Fracture Healing Studies in Rabbits

Author: Mahmood A. Aljumaily
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2010 Volume: 52 Issue: 3 Pages: 258-261
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Bone healing of fractures is still an open field for research due to its biological complexity. Adequately adapted experimental model is essential for understanding the factors influencing the biological process of bone healing. Rabbits provide a good animal model for bone healing studies; its bone had Haversian system similar to human.
Material and Methods: Six young locally breaded New Zeeland male rabbits were used in this study, the study conducted in animal house in college of medicine at November and December 2009. Surgical fracture (osteotomy) induced operatively in right ulna under general anesthesia by a hand saw. At the end of fifth weeks, the animals' scarified and the specimens taken for radiological, computerized tomography (CT) scan densimetry and histological examination carried out for bone healing in site of osteotomy
Results: All bone osteotomy united at end of fifth weeks macroscopically and radiologically. There was no significant difference in serum calcium, serum phosphate, and serum alkaline phosphatase preoperatively and at end of fifth weeks. The callus density was measured in site of osteotomy by CT scan densimetry and its mean was 302 ± 142. The histological examination of the bone at site of osteotomy show healing with woven bone predominantly with some lamellar bone and cartilage. Conclusion: The present study demonstrated that the ulnar osteotomy without use of external splintage or internal fixation model is a new, easy to perform and can be used as a model for fractures healing studies.

Keywords

rabbit --- ulna --- osteotomy --- and bone healing.


Article
Reverse effect of laser treatment on hyperthyroidism in female rabbits
التأثير العكسي للعلاج بأشعة الليزر على تضخم الغدة الدرقية في إناث الأرانب

Author: Tahani S. S. AL-Azawi تهاني سلمان العزاوي
Journal: Kufa Journal For Veterinary Medical Sciences مجلة الكوفة للعلوم الطبية البيطرية ISSN: 20779798 Year: 2011 Volume: 2 Issue: 1 Pages: 30-38
Publisher: University of Kufa جامعة الكوفة

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Abstract

Abstract: This experiment was conducted to study the effect of Laser treatment on LH, FSH, Progesterone and Cortisol and the relationship between them and after physiological functions in adult female rabbits serum affected with hyperthyroidism. Eighteen adult female rabbits at eight months and weighing (1.2 - 1.8 Kg) were used in this experiment. At the end of the two weeks of adaptation, the rabbits were divided equally into three groups. The first group was given distilled water and used as a control. The second and third groups were administered orally with L- thyroxine at a dose of 200µg/Kg body weight daily for twenty days. After the induction of hyperthyroidism, the third group was exposed to laser treatment (40J / cm2) at the thyroid gland region for fifteen successive days for ten minutes on each side of the gland. Where as the second ( hyperthyroid ) group was left without laser treatment. Blood samples were collected from ear vein and LH, FSH, Progesterone and cortisol levels in serum were assayed. On the other hand food, water intake, body temperature and weight of all animals were estimated. The result show significant increase in these hormones in the second group with an increase food, water intake and body temperature as compared with control. The relationship between these hormones and thyroid gland was discussed. Laser treatment to the hyperthyroid gland seems to normalize these hormones.

الخلاصة: صمم هذا البحث لدراسة تأثير العلاج بالليزر على الهرمون اللوتيني, هرمون محفز الجريبات, البروجستيرون والكورتيزول والعلاقة بين الهرمونات ووظائف فسلجية اخرى, في الارانب المصابة بتضخم الغدة الدرقية. تم استخدام 18 أرنب بالغ من الاناث بعمر ثمانية اشهر ووزن (1.2- 1.8 كغم). تركت اسبوعين كفترة تاقلم ثم قسمت الى ثلاثة مجاميع متساوية. المجموعة الاولى جرعت بالماء العادي اما المجموعة الثانية والثالثة جرعت بهرمون الدرقين بجرعة 200 مايكروغرام/كغم من وزن الجسم يوميا ولمدة 20 يوماً. بعد ظهور علامات تضخم الغدة تعرضت المجموعة الثالثة لاشعة الليزر بجرعة ( 40جول / سم2 ) على منطقة الغدة الدرقية لمدة خمسة عشر يوماً متتابعة وبواقع 10 دقائق لكل جهة من الغدة بينما تركت المجموعة الثانية بدون علاج بالليزر. تم سحب الدم من الوريد الاذني الحافي واستخدم المصل لقياس هرمونات الكونادوتروبين (الهرمون اللوتيني وهرمون محفز الجريبات) وكذلك هرمون البروجستيرون والكورتيزول. من الناحية الخرى تم حساب كمية العلف والماء المستهلك, درجة حرارة ووزن الجسم للحيوانات. اوضحت النتائج ارتفاع معنوي بمستوى هذه الهرمونات في الحيوانات المصابة بتضخم الغدة الدرقية مع زيادة كمية العلف والماء ودرجة حرارة الجسم ونوقشت العلاقة بين الهرمونات والغدة الدرقية. كما تبين ان العلاج بالليزر أعاد الهرمونات الى مستواها الطبيعي في الحيوانات المصابة بتضخم الغدة الدرقية.


Article
EFFECT OF THE AQUEOUS EXTRACT OF MATRICARIA CHAMOMILLA ON STRESS-ETHANOL INDUCED ACUTE GASTRIC ULCERATION IN RABBITS
تأثير المستخلص المائي لأزهار البابونج على القرحة المعدية المحدثة في الأرانب بواسطة الإجهاد والكحول الاثيلي

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Abstract

ABSTRACTThe anti-ulcer effect of the aqueous extract of Matricaria chamomilla flowers (chamomile extract, CE)had been tested on stress- ethanol induced gastric ulceration in rabbits. The first part of the study was toinduce acute gastric ulceration by stress or stress–ethanol combinations. Stress alone was unable toproduce gastric ulcerations while ulcer was induced in the group of rabbits exposed to stress in thepresence of ethanol (5ml / kg ) with a mean value of ulcer index of 108.3mm ± 29 (n=8). Histopathologicalexamination was done to confirm the effect of stress-ethanol combination on gastric mucosa. The secondpart of the study was performed to investigate the pharmacological effect of various concentrations ofthe aqueous extract of chamomile (1%, 4% and 8%) on gastric ulceration. The extract was given 15minutes before ethanol administration. The results have shown a significant anti ulcer effect ofchamomile extract with mean values of ulcer index of 76. 4mm± 14.2 (P< 0.01); 11mm ± 14.2 (P<0.005)and 53mm±27.9 (P<0.01) for the concentrations 1%, 4% and 8% respectively as compared to the controlvalue of 133.25 mm±46.2 (n=8). It is concluded that the extract of Matricaria chamomilla flowers has antiulcer effect.

تم اختيار التأثير المضاد للقرحة للمستخلص المائي لأزهار نبات البابونج على القرحة المعدية المحدثة في الأرانب بواسطة الإجهاد والكحول الاثيلي المطلق. وكان هدف الجزء الأول من هذه الدراسة هو إحداث القرحة المعدية الحادة بواسطة الإجهاد والكحول معا". وقد أظهرت النتائج إلى إن الإجهاد لوحده غير كاف لإحداث تقرحات وفرط الدم، ولكن هذه التغييرات تحدث في المجموعة المعالجة بالكحول بعد الإجهاد وكان معدل منسب القرحة هو (29+108.3 ملم). وقد اجري الفحص النسيجي الموضعي لتأكد تأثير الكحول والإجهاد على الغشاء المخاطي للمعدة حيث اظهر الفحص وجود تقرحات وموات موضعي واحتقان ووذمة وظهور خلايا التهابية. أما الجزء الثاني من الدراسة فيتضمن دراسة التأثير الدوائي للمستخلص المائي للبابونج وبتراكيز 1% و 4% و 8% على التقرحات المحدثة. وقد تم إعطاء مستخلص البابونج قبل إعطاء الكحول المطلق بــ15 دقيقة. أظهرت النتائج وجود تأثير مضاد للقرحة لمستخلص البابونج بشكل معتد إحصائيا" وكانت قيم المعدلات لمنسب القرحة للتراكيز 1% و 4% هي (76,4 ملم+ 12,2) (P<0.01) و (11ملم+14,2) (P<0.005) و (53 ملم + 27.9) (P<0.01) على التوالي عند المقارنة مع المجموعة الضابطة حيث كان منسب القرحة هو (133,25 ملم + 46,2). وتخلص الدراسة إلى أن المستخلص المائي لأزهار البابونج له تأثير مضاد لقرحة المعدة المحدثة في الأرانب.

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