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Article
Efficacy of topical flax paint for the treatment of recurrent aphthous stomatitis

Authors: Tagreed Altaei تغريد الطائي --- Shaheen A. Ahmed شاهين احمد --- Ahmed A. Haider احمد حيدر
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2011 Volume: 23 Issue: special issue Pages: 100-107
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Recurrent aphthous stomatitis is commonly observed and is mediated by the immune system. Lesionsappear as painful, tiny, discrete vesicles. Flax (Linum usitatissimum) has antiseptic, anti-inflammatory properties. Thepresent study was a randomized, double-blinded, placebo controlled conducted to assess the efficacy of Flax paintin this disease.Methods: Dermal irritation study; was performed by primary irritation to the skin and measured by a patch-testtechnique on the intact skin of the albino rabbit. Clinical study; 64 RAS patients, randomized to receive Flax paint orplacebo topically (three times a day, for five days). The efficacy of the treatment was estimated (healing time, ulcersize reduction, pain score, change in condition), β-2 microglobulin (β-2M), α-1Antitrypsin (α-1AT), CRP & ESR, Safety,tolerance, side effects were assessed.Results: Dermal irritation test in vivo showed no sign of irritation in Flax paint. Clinical study; four days after treatment,95% of Flax group were completely healed from aphthous ulcers, compared with placebo group ( p < 0.0001). Flaxpaint group showed significant pain reduction after the 1st or 2nd dose application compared to baseline andplacebo. Serum β-2M, α-1AT, CRP, & ESR values showed significant reduction in Flax paint treated group comparedto baseline and placebo. No sign of adverse effects or tolerance.Conclusion: This is the first time reporting that Flax paint reduced the time to repair mucosal tissue (ulcer healing), andpain persistence, it has anti-inflammatory, and analgesic effect. There was no evidence of any adverse effects


Article
Aqueous extract of propolis in the treatment of recurrent aphthus stomatitis (Double blind study)

Author: Fa’iz A Al–Sultan
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2003 Volume: 3 Issue: 6 Pages: 96-102
Publisher: Mosul University جامعة الموصل

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Abstract

In this study, aqueous extract of propolis, which is a natural bee product, tested for treatment of recurrent aphthus stomatitis (RAS). A total of 40 patients with RAS divided into 4 groups. Each patient received one of following preprepared mouthwash: Group A received aqueous propolis extract at 1% concentration. Group B received aqueous propolis extract at 0.5% concentration. Group C received dexamethosone at 0.1% concentration. Group D received distilled water. (Control group). The study was double blind and the patient instructed to use the mouthwashes for 5 min 3 times daily. The results of study showed significant difference between groups in pain score assessed at day 2 of study. High percentage of no pain recorded in group A comparing to other groups. However at 5 days of drug therapy no significant difference noticed among the groups regarding pain score. For assessment of healing after 5 days, although no significant difference noticed among the groups, group A reported to show high percentage of complete healing comparing to other groups. Also groups A, B and C showed 50% healing of ulcer comparing to only 20% in patient on group D. In conclusion, aqueous propolis extract at 1% concentration showed good percentage of early reduction of pain score and rapid healing of ulcer with minimal side effect and further studies on other extract and concentration may be recommended.


Article
Role of SalivaryTumor Necrosis Factor-alpha and Immunoglobulin-Ain Recurrent Aphthous Stomatitis

Authors: Mustafa M. Saliah مصطفى محمد صالح --- Batool H Al-Ghurabei بتول الغرابي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2011 Volume: 53 Issue: 2 Pages: 207-210
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:Until today, the etiology of recurrent aphthous stomatitis (RAS) remains unknown, although hints of its etiologic basis lay on genetic susceptibility, infectious agents and alterations in immune mechanics.Objectives:The aim of this study was to investigate the possible alterations in salivarytumor necrosis factor-alpha (TNF-α) and Immunoglobulin-A (IgA) level in patients with RAS and its relation with clinical types of disease.
Subjects and Methods:Salivary TNF-αlevels were investigated in50 RAS patients and 25 healthy controls by enzyme-linked immunosorbent assay (ELISA). Single radial immune diffusion method was used for estimation ofIgAlevel in two studied groups.
Results:Salivary level of TNF-α was significantly higher in RAS patients than in healthy controls (p<0.001), Moreover, the level of TNF-α was significantly increased in minor type of disease than in major and herptiform types (p<0.05).On the other hand, the levelof IgA showed no significant differences between patients and healthy controls and neither among clinical types of disease(p>0.05).
Conclusion: These findings suggestthat saliva provides an ideal medium for the detection of pro-inflammatory markers of the oral cavity, moreover; salivary TNF-α may play an important role in pathogenesis of this disease and it may also have an important role in the search of new treatments for this disease. As well as these results indicated to a possible role of mucosal immune system in pathogenesis of RAS.


Article
Assessment of serum and salivary oxidant and total antioxidant status of patients with recurrent aphthous stomatitis in a sample of Basrah city

Authors: Hussein Sh. Al-Essa حسين العيسى --- Taghreed F. Zaidan تغريد زيدان
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2013 Volume: 25 Issue: special issue 1 Pages: 83-88
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Recurrent Aphthous Stomatitis (RAS) is the most common painful oral mucosal disease, affectingapproximately 20% of the population. RAS presents with a wide spectrum of severity ranging from a minor nuisanceto complete debility. Many of factors thought to have been involved in its etiology; that might have at the same timea direct or indirect impact upon oxidant/antioxidant system and trigger free radicals production. The aim of thisstudy was to determine the possible association of oxidant/total antioxidant status and recurrent aphthous stomatitis(RAS).Subjects, materials and methods: The study consisted of thirty patients with recurrent aphthous stomatitis and thirtyhealthy controls from which saliva and blood samples were collected. Malondialdehyde as an oxidative stressbiomarker and total antioxidant status were measured in serum and saliva.Results: Malondialdehyde in serum and saliva was significantly higher in recurrent aphthous stomatitis patients incomparison to healthy controls (P<0.05). No significant differences were found in total antioxidant status betweenrecurrent aphthous stomatitis patients and control subjects (P>0.05).Conclusions: The changes in the oxidative stress in biological systems can be induced by the consumption ofantioxidants and/or by an overload of oxidant species, so the antioxidant defense system become deficient thatmay be important in the inflammatory reactions observed in recurrent aphthous stomatitis

المقدمة:یعتبر ألتھاب الفم القلاعي المتكررالمتكررة مدیات واسعة من الشدة تتراوح من الانزعاج البسیط الى الوھن الكامل بین المصابین.(Oxidative Stress) ھنالك العدید من العوامل التي یعتقد أنھا من مسببات ألتھاب الفم القلاعي المتكرر والتي یكون لھا في نفس الوقت تأثیر مباشر أو غیر مباشر على الشد التأكسديالضارة للخلایا الحیة. (Free Radicals) وبالتالي أنتاج الجذور الحرة (Antioxidants) و نظام مضادات العوامل المؤكسدة الدفاعیةمن جھة وأصابات ألتھاب الفم القلاعي (Antioxidants) ومضادات الأكسدة (Oxidative Stress) الھدف من الدراسة: الدراسة صممت لتحدید العلاقة الممكنة بین الشد التأكسديالمتكرر من جھة اخرى.الاشخاص والمواد وطریقة العمل: الدراسة شملت ثلاثون مریضا بألتھاب الفم القلاعي المتكرر وثلاثون شخصا طبیعیا للمقارنھ بینھما. وكانت المجموعتان متماثلتین بالجنس والعمر(Malondialdehyde ) MDA -20 ) وبعدھا تم حساب ºC) 55 ) سنة. اخذت العینات من مصل ولعاب المجموعتین وخضعت للطرد المركزي وخزنت عند - الذي یتراوح بین ( 14لكلا المجموعتین. (Total Antioxidant Status) TAS ولا توجد أختلافات ھامة في مؤشر .(P< كمؤشر للشد التأكسدي مقارنة بالأصحاء ( 0.05 (MDA) النتائج:أظھرت النتائج أن في الألتھابات الفمویة القلاعیة المتكررة أرتفاع ملحوظ في.(TAS)أو حمل زائد من العوامل (Antioxidants) في الأنظمة الحیویة ناجم عن أستھلاك مضادات الأكسدة الدفاعیة (Oxidative Stress) الأستنتاجات: أن التغیرات في الشد ألتأكسديالمؤكسدة وبالتالي عدم كفاءة النظام الدفاعي لمضادات العوامل المؤكسدة ومن ھذا نستنتج الدور الفاعل للشد التأكسدي كمسبب لمرض ألتھاب الفم القلاعي المتكرر.كذلك یمكن أستخدام اللعاب كسائل حیوي تشخیصي مؤثر وملائم لقیاس مؤشرات الشد التأكسدي ومضادات الأكسدة للمرضى المصابین بالألتھابات الفمویة القلاعیة المتكررة


Article
The therapeutic effect of viscous solution of curcumine in the treatment of recurrent aphthous stomatitis (RAS)

Author: Maha T Al–Saffar
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2006 Volume: 6 Issue: 11 Pages: 48-52
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: To determine the various therapeutic effect of different concentrations of viscous curcumine solution on the healing of ulcer in patients with recurrent aphthous stomatitis (RAS). Materials and Methods: A total of 83 patients with RAS divided into four groups: Group A: Thirty patients received viscous solution of curcumine 10%; Group B: Thirty three patients received viscous solution ofcurcumine 50%; Group C: Ten patients without treatment (control negative); and Group D: Tenpatients received glycerin treatment (control positive). Results: Females were more affected than maleswith RAS (69.9% female and 30.1% male) and upper and lower labial mucosa were the most commonsite of the lesion. The results also showed significant difference between complete healings in patients using viscous solution of curcumine 50% and 10% respectively, and patients without treatment (control negative), while there was no significant difference between the complete healing in patients use 50% of solution and 10 % of the same solution. Conclusion: Topical application of viscous solution of curcumine at 10% and 50% showed a good percentage of complete healing of ulcer in patients with RAS and further study for its effect on other oral lesion may be recommended.

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