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HISTOPATHOLOGICAL CHANGES OF THE MICE PLACENTA EXPOSED TO LEAD ACETATE

Author: Ibtisam J Sodani ابتسام جاسم سوداني
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2012 Volume: 10 Issue: 4 Pages: 339-347
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background :Lead is one of the most dangerous metals and could be incorporated in various body tissues and thus exposure to it stills a major medical problem in both environmental and occupational setting. Objectives:To detect the deleterious and toxic effects of the lead acetate on the weight and histological features of mice placenta at different dosages.Methods:A prospective study including eighty mature pregnant mice were divided into two groups (experimental and control groups). Forty pregnant mice were divided into two major experimental groups (G1and G2) according to the level of the dose. The other forty animals with same age divided at the same way as in the previous experimental groups considered as control groups (C). Injections of lead acetate 0.1, 0.4 mg/kg body weight /day intraperitoneally (G1, G2 respectively) were started at the first day of gestation and continued for (17 or 20 days). When the female in each experimental and control groups reach day 17 of gestation 10 animals of each group were scarified, whereas the other 10 animals were left to be scarified at 20 day post coitum (dpc). Weight of placentas was recorded, in addition, histological study for these placentas were done.Results:Prenatal lead acetate injection to pregnant mice intraperitoneally for 17 day cause a significant reduction (P<0.05) in placental weight and a highly significant reduction (P<0.01) in placental weight was recorded at 20 dpc experimental groups (G2) but there was no significant decrease in weight of placenta for 17 and 20 dpc in experimental groups (G1) In addition placentas belongs to (G1 and G2) mothers revealed histopathological alterations in the various component of the placenta.Conclusion:Administration of low dose of lead acetate intraperitoneally to pregnant female mice causes significant decrease in weight of their placenta. Lead acetate also causes adverse effects on the histological features of fetal placenta.Key words:Lead, Placenta, Placental transport toxicology, Toxic trace elements, Metallothionein, Reproductive toxicology

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