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In-vitro study the effects of sickle cell disease on phagocytic activity of white blood cells among adult male in Basra city
دراسة مختبريه لمعرفة تأثير فقر الدم المنجلى على فعالية الالتهام الخلوي لكريات الدم البيضاء للذكور البالغين في البصرة

Authors: Nawal K. Ibrahim --- Shaymaa J. Al- Sharrifi --- Nehaya M. Al-Aubody --- Mustafa Abd-Almaged
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2016 Volume: 14 Issue: 2 Pages: 36-41
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background: sickle cell disease (SCD) is an inherited disorder of hemoglobin synthesis that is associated with a significant morbidity and mortality. The patho physiology of the disease involves abnormalities not just in red blood cells but also white blood cells (leukocytes) functions.Objective: this study was tried to identify the effect of sickle cell disease SCD on the phagocytic activity of non- isolated leukocytes from the whole blood, to mirror the in vivo stimulation of leukocytes and the effect of SCD on their phagocytic activity. Materials and methods: this study involved (56) adult male, aged (18-30) years, subdivided into two groups; case group that consist of (26) patient with sickle hemoglobin phenotype (SS) in a steady state at the time of the study and control group that consist of (30) person with normal hemoglobin phenotype (AA). Hemoglobin electrophoresis and leukocytes count were estimated for both groups. The samples of blood were prepared for chemiluminescence (CL) measurements. Luminol was used to increase the amount of measurable light emitted due to liberation of oxygen metabolites during phagocytosis.Results: Show a significant decrease in the phagocytic activity of SCD patients (P ˂ 0.0001) in comparison with normal volunteers

فقر الدم المنجلى هو مرض وراثي ارتكاسى يتولد نتيجة حدوث تغير في بروتين خضاب الدم (الهيموغلوبين) مما يسهم في تزايد ظواهر المرض والوفيات للأشخاص المصابين به. هذه الدراسة شملت (56) شخص من الذكور البالغين, تتراوح أعمارهم بين (18-30) سنه, قسموا إلى مجموعتين إحصائيتين,ألمجموعه الأولى وتتكون من (26) شخص يعاني من فقر الدم المنجلى وهم في حاله مستقره عند بدء الدراسة, إما ألمجموعه الثانية فتتكون من (30) شخص طبيعي الهيموغلوبين فئة (AA) ولقد أجريت التحاليل لمعرفة نوع الهيموغلوبين و عدد الكريات البيضاء لكلا المجموعتين . حاولنا في هذه الدراسة معرفة تأثير فقر الدم المنجلى على فعالية الكريات البيضاء غير المعزولة من عينات الدم بطريقة التألق الكيمياوى, حيث تم استعمال اللومينول لغرض زيادة الضوء المنبعث من تحرر جذور الأوكسجين الحرة الناتجة من عملية الالتهام.وبرهنا على وجود تناسب رقمي هام (P≤ 0.05) في نقص فعالية الالتفاف للكريات البيضاء لمرضى فقر الدم المنجلى مقارنة بالأشخاص الأصحاء. هذا ممكن إن يكون الأساس لتطوير الادويه من اجل منع أو معالجة الالتهابات المرافقة والمتعلقة بفقر الدم المنجلى وذلك لإزاحة العبء عن النظام الصحي العام.

Keywords

SCD --- leukocytes --- phagocytosis


Article
Experience in ICD Implantation and Follow-up in Ibn- Albitar Hospital

Authors: Ali Abdul-Amir M. Al-Musawi --- Kasim Abbas Ismail --- Muthanna Hameed Al-Quraishi --- Amjad Rahman Bairam --- et al.
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 4 Pages: 314-317
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Survivals of sudden cardiac death (SCD) episodes have recurrence rate of 30-50% within two years, with malignant ventricular arrhythmias most often responsible1, 2. The overall survival rate for SCD in USA is 5%. Ninety-five percent of patients suffering their initial event fail to survive to become candidate for secondary prevention1.Because of the wide spread acceptance of implantable cardioverter defibrillator ( ICD ) as a method treating the survivals of SCD, attention has turned to primary prevention 1. Implantable cardioverter-defibrillator (ICD) is highly effective in primary and secondary prevention of SCD due to life threatening ventricular tachycardia (VT).OBJECTIVE:To register and interpret the results of implantation and follow-up of ICD during the period between 2002-2007 in Ibn Al-Bitar hospital.METHODS:Sixty patients with standard indications for ICD; data were pooled from patients history, ECG, Echocardiography, Holter, blood investigation and coronary angiography.75% males and 25% females. After implantation, class III anti-arrhythmic drugs (Amiodarone) were stopped, except for patients with a history of supraventricular tachycardia or recurrent VT.RESULTS:Coronary artery disease (CAD) was the most common presentation of patients for whom implantation was done; coronary artery disease (CAD) 43%, dilated cardiomyopathy (DCM) 26%, and hypertrophic obstructive cardiomyopathy (HOCM) 16%. Sixty-three of them had moderate-severe LV dysfunction (LVEF<40%). Recurrent VT was the most common cause of implantation (76%). Primary prevention was aimed in (60%) of patients and secondary prevention in 40%. Sixty percent of those with ICD implanted due to primary prevention fulfil MADIT II (Multicenter Automatic Defibrillator Implantation Trial II) criteria. The majority of patients had structural heart disease. Most non-sustained VTs reverted to sinus rhythm by antitachycardia pacing (ATP) therapy from ICD (90%).All VF events reverted to sinus rhythm by high energy shock from ICD devices.CONCLUSION:ICD is highly effective in primary and secondary prevention of life threatening VT/VF.

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