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Preparation and evaluation of salbutamol liposomal suspension

Author: Nidhal Khazaal Marie
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2012 Volume: 11 Issue: 2 Pages: 39-44
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Background: Liposomes are new drug delivery systems consist of lipidbilayer membrane that encapsulate water and lipid soluble drugs.Materials and methods: Liposomal suspension was prepared usingchloroform film method. Different amount of cholesterol and lecithin(100, 200, 300, 400 and 600 mg) were used and their effect on particlesize, encapsulation efficiency and drug release was studied. Cholesterolused in different ratios such as (1:1, 1:2 and 2:1) for Cholesterol: Lecithinrespectively to evaluate its effect on particle size, encapsulationefficiency and drug release. The effect of increasing salbutamol HClamount from 10mg to 20mg on encapsulation efficiency was alsostudied.Results: The morphology of the prepared formulae showed uniformunilamellar liposomes enclosing the drug in the internal aqueous phase.The observed results of our work suggest that chloroform film method isa good alternative method for the preparation of liposomes for watersoluble drugs because of its simplicity, low cost, time saving and fewprocessing steps.Conclusions: The work suggests a formula that may improve thepermeability of salbutamol HCl through mucosal membrane.

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