research centers


Search results: Found 4

Listing 1 - 4 of 4
Sort by

Article
Clinical types and possible etiologies of neonatal seizures:A hospital based study

Authors: Meisloon J. Kadum محجوب النداوي --- Numan N.Hameed --- Mahjoob N.AL-Naddawi محجوب النداوي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2011 Volume: 53 Issue: 1 Pages: 1-5
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Seizures in the neonatal period are common. They can present asfocal clonic, focal tonic, myoclonic, generalized tonic and subtle seizures.They can be caused by a variety of conditions, ranging from benign self-limited illnesses to severe life-threatening disorders.Patients and methods: A prospective study included 75 neonates with seizures in the first 28 days of life were admitted to neonatal care unit in Children Welfare Teaching Hospital from January 15th 2009 to August 15th 2009.A Full history was obtained and patients were examined by a specialist in the neonatal care unit and the researcher. Laboratory investigations and neuroimaging studies were done for all patients.Results:Out of 75 neonates,(55%) were males and (45%) were females with a male: female ratio of 1.2:1, (76%) of them was delivered at term. The onset of seizures was reported in the first 72 hours of life in(42.6%) of neonates. The most common type of seizure was tonic type (48%) followed by subtle type (24%), focal clonic 16% and multifocal clonic(12%).Hypoxic ischemic encephalopathy (HIE) was the commonest etiology (25.34%) then sepsis (24%), hypocalcaemia (14.67%), pyogenic meningitis (13.33%), hypoglycemia (9.33%),Kernicetrus(8%), IVH 4%and TORCH (1.33%).The consanguinity was detected in (26.7%) of patients. A response to Phenobarbitone alone was found in (42.1%) and to a combination of bothphenobarbitone and phenytoin in(19.1%).The case fatality was (8%), (50%)of themwere due to IVH.Conclusions: Neonatal seizures occurred mainly in full term neonates with male sex preponderance with the majority reported in their first 72 hours of life and the tonic seizures were the commonest pattern. Hypoxic ischemic encephalopathy is the main etiologic factor of neonatal seizures followed by sepsis. Intraventricular hemorrhage occurs mainly in preterm infants and it was a major cause of death.Keywords: Neonatal seizures, etiology, clinical types.


Article
Risk Factors for Febrile Seizures: A Matched Case Control Study

Author: Essam J AL-Zwaini
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 353-358
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND:A matched case control study was conducted over 6 months period from the 1st of November 1999 to 30th of April 2000 at the maternity and children hospital in Ramadi city with the aim of determining the risk factors that might lead to development of febrile seizures.METHODS:One hundred patients with febrile seizures admitted to the causality department, aged 6-60 months were matched with another one hundred child having fever but without seizure with the same age range, attending the same hospital during the same period.RESULTS:The mean age and standard deviation for cases was 25.8±15.19 months and for control was 29.9 ± 18.5 months .sixty four percent has febrile seizure for the first time and 36 %had recurrent febrile seizures. The mean age and standard deviation for the first FSs was 23.54± 12.8 months and for recurrent FSs was 29.83 ± 12.5 months. This was statistically not significant. The majority of the cases were between 12 -24 months with a peak at the age of 18 -19 months. Respiratory infections were not found to be a risk factor for FSs when compared with control.CONCLUSION:Male sex, degree of temperature on admission, presence of family history or epilepsy, developmental delay, anemia and admission to neonatal care unite were found to a significant risk factor for occurrence of febrile seizures. Patients are susceptible to develop another attack of seizure at a lower temperature after their first attack.

Keywords

Febrile --- Risk factors --- Ramadi --- Seizures


Article
Detection of SCN1A Gene Polymorphisms in Epilepsy Children

Author: Laith Abdul Hassan Mohamed-Jawad1
Journal: Almuthanna Journal of Pure Science (MJPS) مجلة المثنى للعلوم الصرفة ISSN: 22263284 Year: 2017 Volume: 4 Issue: 2
Publisher: Al-Muthanna University جامعة المثنى

Loading...
Loading...
Abstract

Febrile seizure is a common convulsions occur in children from 5 months to 6 years of age whose sufferingfrom high temperature. A total of 50 children with febrile seizures and 50 normal control are included in this study.RFLP used to identify the A/G polymorphisms of the SCN1A gene on chromosome 2q24. Results showed that thegenotype proportions and allele frequencies for SCN1A c.3184 A/G in both groups are not significantly. Proportions ofA homozygote, A/G heterozygote, and G homozygote for SCN1A c.3184 A/G were as follows: in patients with FSs,20%, 50%, and 30%, respectively compared to controls (24%, 62%, and 14%, respectively). The allele A and Gfrequencies for SCN1A c.3184 A/G in patients with FSs was 45% and 55% respectively compared to control group. Thefrequency of AG genotype of SCN1A c.3184 A/G polymorphism was non-significant in FSs compared to control group.There was increased in glucose, phosphorus levels and decrease in sodium, chloride levels. The results do not suggestthat SCN1A p. Thr 1067 Ala or c.3184A/G (rs2298771) are susceptibility factors for febrile seizures and the fever playsan important role in causing disturbances in electrolyte balance.


Article
Clinically diagnosed neonatal seizures in Al- Diwanyah, an epidemiological study
المضبوطات الوليدية المشخصة سريرياً في الديوانية ، دراسة وبائية

Authors: Rahman K. Al-jeboori رحمن كريم الجبوري --- Aqeel K. Abd عقيل عبد --- Thuraya H. Farhan ثريا هادي فرحان --- Hamid S. Dhaher حامد سعد ظاهر
Journal: Al-Qadisiyah Medical Journal مجلة القادسية الطبية ISSN: 18170153 Year: 2019 Volume: 15 Issue: 1 Pages: 131-136
Publisher: Al-Qadisiyah University جامعة القادسية

Loading...
Loading...
Abstract

AbstractINTRODUCTIONNeonatal seizures are the most frequent and distinctive manifestations of neurological disturbances during the neonatal period. This retrospective study aimed to determine the incidence rate, causes and risk factors for neonatal seizures in Al-Diwanyah Province during one calendar year from the 1st of January, 2016 to 31st December, 2016METHODS.Data were extracted from the records at Maternity and children Teaching Hospital in Al-Diwaniyah. All neonates who had developed clinically recognized seizures before 28 days of life were enrolled in the study. These data included gestational age (full or pre-term infant), maternal diseases and drug intake during the last trimester, family history of seizures, number of parities, consanguinity, mode of delivery (normal vaginal delivery or caesarian section) age and gender of neonate, body weight at birth (normal or low body weight), and age at which seizure has developed (early onset or delayed onset). Biochemical tests were blood sugar and serum calcium. RESULTS Out of 3167 recorded birth in the hospital, 113 neonates have developed seizure with overall incidence rate of 3.57%. Four main causes of seizures were recognized which were: asphyxia (34.5%), hypoglycemia (23%), hypocalcemia (14.16%) and intraventricular hemorrhage (7.08%). However, in 21.42% of cases, the cause(s) was/were undiagnosed.DISCUSSION Three risk factors (gender, family history of seizures and number of parities) were found to have no significant association with any of these causes of seizures. The other risk factors associated with these causes in different modes. Each of early onset of seizure, mother’s disease during pregnancy, caesarian section delivery and full term infant were significantly associated with hypoglycemia. Hypocalcemia, on the other hand, was significantly associated with delayed onset of seizures and preterm infants with low body weight, while there was very significant association between asphyxia and normal vaginal delivery. Although less frequent than other causes of seizure, intraventricular hemorrhage was found to be significantly associated with three risk factors (delayed onset of seizures, normal vaginal delivery and preterm infants). Finally, a positive significant association was found between consanguinity and undiagnosed causes of seizuresCONCLUSION. These results pointed out the importance of asphyxia and hypoglycemia as the main causes of neonatal seizures. The most important risk factors associated with these causes are normal vaginal delivery, mother’s disease during pregnancy, and low body weight at birth.

نبذة مختصرةمقدمة المضبوطات الوليدية هي المظاهر الأكثر تميزا ومميزة للاضطرابات العصبية خلال فترة حديثي الولادة. تهدف هذه الدراسة بأثر رجعي إلى تحديد معدل حدوث وأسباب وعوامل الخطر لنوبات حديثي الولادة في محافظة الديوانية خلال سنة تقويمية واحدة من 1 يناير 2016 إلى 31 ديسمبر 2016تم استخراج METHODS.Data من السجلات في مستشفى الأمومة والطفولة التعليمي في الديوانية. تم تسجيل جميع حديثي الولادة الذين وضعوا نوبات معترف بها سريريا قبل 28 يوما من الحياة في الدراسة. شملت هذه البيانات عمر الحمل (الرضيع الكامل أو قبل الأوان) وأمراض الأمهات وتناول المخدرات خلال الأشهر الثلاثة الأخيرة ، والتاريخ العائلي للمضبوطات ، وعدد حالات التكافؤ ، والاقارب ، وطريقة الولادة (الولادة المهبلية الطبيعية أو الولادة القيصرية) وعمرها حديثي الولادة ، وزن الجسم عند الولادة (الوزن الطبيعي أو المنخفض للجسم) ، والعمر الذي نشأت فيه النوبة (بداية مبكرة أو بداية متأخرة). وكانت الاختبارات الكيميائية الحيوية نسبة السكر في الدم والكالسيوم في الدم.النتائج من أصل 3167 حالة ولادة مسجلة في المستشفى ، أصيب 113 حديثي الولادة بالنوبة بمعدل 3.57٪. تم التعرف على أربعة أسباب رئيسية للنوبات وهي: الاختناق (34.5 ٪) ، نقص السكر في الدم (23 ٪) ، نقص كلس الدم (14.16 ٪) والنزف داخل البطيني (7.08 ٪). ومع ذلك ، في 21.42 ٪ من الحالات ، كان السبب / الأسباب لم يتم تشخيصها.نقاش تم العثور على ثلاثة عوامل الخطر (الجنس ، والتاريخ العائلي للمضبوطات وعدد من التكافؤ) ليس لها علاقة كبيرة مع أي من هذه الأسباب من المضبوطات. عوامل الخطر الأخرى المرتبطة بهذه الأسباب في أوضاع مختلفة. وارتبط كل من بداية النوبة المبكرة ، ومرض الأم أثناء الحمل ، والولادة القيصرية والرضع كامل المدة ارتباطًا كبيرًا بنقص السكر في الدم. كان نقص كلس الدم ، من ناحية أخرى ، مرتبطًا بشكل كبير بتأخر ظهور النوبات والخدج ذوي وزن الجسم المنخفض ، في حين كان هناك ارتباط كبير بين الاختناق والولادة المهبلية الطبيعية. على الرغم من أن النزف داخل البطين أقل تواتراً من الأسباب الأخرى للنوبة ، فقد وجد أنه يرتبط بشكل كبير بثلاثة عوامل خطر (تأخر ظهور النوبات ، والولادة المهبلية الطبيعية ، والخدج). وأخيرا ، تم العثور على ارتباط إيجابي كبير بين القرابة والأسباب غير المشخصة للنوباتخاتمة. أشارت هذه النتائج إلى أهمية الاختناق ونقص السكر في الدم كأسباب رئيسية لنوبات حديثي الولادة. أهم عوامل الخطر المرتبطة بهذه الأسباب هي الولادة الطبيعية عن طريق المهبل ، ومرض الأم أثناء الحمل ، وانخفاض وزن الجسم عند الولادة.

Listing 1 - 4 of 4
Sort by
Narrow your search

Resource type

article (4)


Language

English (4)


Year
From To Submit

2019 (1)

2017 (1)

2011 (1)

2006 (1)