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Article
Synthesis & Antimicrobial Evaluation of Open Chain of Organo–Selenium Compounds
تحضير ودراسة الفعالية البايولوجية لمركبات السيلينيوم العضوية مفتوحة السلسلة

Author: Nagham .Mahmood .Aljamali نغم محمود جواد الجمالي
Journal: journal of al-qadisiyah for pure science(quarterly) مجلة القادسية للعلوم الصرفة (فصلية). ISSN: 19972490 Year: 2014 Volume: 19 Issue: 2 Pages: 128-143
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

The organo-selenium compounds are one of important organic compounds in synthesisof different compounds and as anti microbial .The target organo –selenium compounds [3-7]were synthesized from the reaction between diethyl malonate and 4-amino benzoyl chloride toproduce compound [1] ,which is react with sodium hydrogen selenide to give correspondingsodium aroylselenide [2] ,which is react with one of aroyl derivatives as shown in scheme (1)to produce compounds [3-7].All the synthesized compounds have been investigated usingdifferent chemical techniques ,such as ,(C.H.N)-analysis , (H.NMR–spectra ,FT.IR–spectra ) ,melting points and biological study.

تُعد مركبات السلينيوم من أصناف المركبات العضوية المهمة والتي ساهمت كثيرآ في تحضير العديد من المركبات الحلقية غير المتجانسة , أذ تنوعت طرق تحضيرها وظروف تفاعلها حسب نوع المركبات المراد تحضيرها وأهميتها البايولوجية التي أشتهرت بها لما تتمتع به مركبات السلينيوم من صفة مضادة بايولوجيآ للعديد من الفطريات والبكتريا. حيث حُضرت مركبات السلينيوم العضوية )3-7( في هذا البحث من تفاعل مالونات ثنائي الاثيل مع 4-أمينو كلوريد البنزويل ليعطي المركب )1( ,والذي بدوره يتفاعل مع سيلينيد هيدروجين الصوديوم NaHSe ليعطي سيلينيد بنزويل الصوديوم المقابل )2( ,والذي ايضا بدوره يتفاعل مع احد مشتقات البنزويل الموضحة في مخطط التفاعل رقم )1( لينتج المركبات . )7-3(ُشخصت جميع المركبات المحضرة في هذا البحث بتقنيات كيميائية مختلفة منها التحليل الدقيق للعناصر و )طيف الرنين النووي المغناطيسي , ,طيف الاشعة تحت الحمراء( ونقاط الانصهار مع دراسة

Keywords

organo selenium --- sulphur --- selenium


Article
A Spectroscopic Study on the Level Of Serum Selenium in Northern Baghdad Subject

Author: Ahsan.K.Abbas
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 3 Pages: 351-352
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:This work is performed to measure the concentration of serum selenium in northern Baghdad subject. Selenium is one of the trace element that plays an important role in physiological functions of human body.MATERIALS AND METHODS:Selenium levels of blood serum were measured using furnace atomic absorption spectrophotometer.RESULTS :The results obtained in this work showed a decrease in selenium level and the reduction is proportional to the duration of age. This can be explained principally due to the type of diet and malabsorption young subject may differ in certain diet intake.

Keywords

selenium --- spectroscopy.


Article
Evaluation of Patients with Liver InjuriesTreated by Perihepatic Gauze Packing

Author: Laith Naef Hindosh
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 35-44
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The liver is one of the most common organs injured after blunt abdominal trauma. The control of severe hemorrhage remains a problem.
Methods: One-hundred thirty-eight patients diagnosed as liver injury between 09/2003 and 08/2006 had been evaluated prospectively in Al- Kindy Teaching Hospital.
A distinction was made between hemodynamically stable and unstable patients. Different modalities of surgical procedures were done concentrating on perihepatic gauze packing.
Results: (60 out of 138) patients included in the study were clinically evaluated as hemodynamically stable. The average abbreviated injury severity score (ISS) was 25. Twenty patients underwent abdominal surgery. In 12 of them additional liver treatment was performed. The mortality was three, all were non-liver related.
Seventy eight patients were considered to be hemodynamically unstable, and had an average ISS of 38. All of them needed abdominal surgery.
Gauze packing was used as initial therapy for bleeding control from injured liver in 34 patients of both hemodynamically stable and unstable groups with a mortality of 11 patients (32.7%).
Conclusion: perihepatic gauze packing is considered as a life saving and a quick method for controlling ongoing hemorrhage in the treatment of liver injuries before undertaking definitive repair under controlled conditions.
Key words: surgery, liver injury, and gauze packing.


Article
Evaluation of the Potential Role of Serum Seleniumin Diabetic Patients

Authors: * Abdul Kareem Y. J. Al-Sammraie --- Abbas M. R. Al-Mussawi --- Tawfeeq F. R. AL-Auqbi
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2008 Volume: 4 Issue: 2 Pages: 45-49
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The altered status of some essential trace elements observed in diabetes could have deleterious influences on the health of the diabetics.
Objectives: To estimate and study the potential role of serum Selenium in type 1, type 2 diabetics and healthy subjects; and its relation with lipid profile and glycemic index.
Methods: A case control designed study was carried out at the National Diabetes Center (NDC) / Al-Mustansiria University; on a total of 94 participants formed of 32 type 1 diabetics, 32 type 2 diabetics and 30 healthy control participants. Data collected about age, sex and BMI; also, blood samples examined for FPG, HbA1C, serum total cholesterol, HDL cholesterol, non-HDL cholesterol, serum triglyceride and sera were examined for Selenium by using atomic absorption technique.
Results: Type 1 and type 2 diabetic groups show respectively 75% and 65% decrement in S. Selenium, <70 µg/L. The mean of S. Selenium, age, BMI, waist/hip ratio, FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index (total cholesterol/HDL cholesterol) for the type 1 and type 2 diabetics shows statistically significant differences from control group. Type 1 diabetics versus type 2 diabetics shows statistically insignificant differences between mean of the S.Selenium, total cholesterol, HDL cholesterol and atherogenic index (t-test, P > 0.05) while the mean of FPG, HbA1c and triglyceride show highly statistical significant differences (t-test, < 0.001).Simple linear correlation and regression analysis of FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index of the studied groups shows weak to moderate correlation with their serum Selenium levels.
Conclusions: The inverse relationship between Selenium status and glucose tolerance suggest the potential role of Selenium in diabetics. Serum Selenium levels show high statistically significant differences from healthy subjects; while the differences between type1 and type 2 diabetic groups’ shows no statistically significant differences. Inverse correlations and regression were noticed between S.Selenium levels of all studied groups with their FPG, HbA1c, total cholesterol, triglyceride, HDL, Non-HDL and atherogenic index. Low S.Selenium and HDL-cholesterol plus an increase in total cholesterol, non-HDL and atherogenic index enhance risk of cardiovascular diseases progression among the diabetics.
Key Words: Serum Selenium, diabetes mellitus


Article
TOXICOLOGICAL EFFECTS OF SELENIUM ON SOME PHYSIOLOGICAL PARAMETERS IN MALE RATS (RUTTUS RUTTUS)
التأثيرات السمية للسيلينوم في بعض المعايير الفسلجية في ذكور الجرذان

Author: Nabeel Mahdi abed نبيل مهدي عبد
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2014 Volume: 13 Issue: 1 Pages: 303-311
Publisher: Basrah University جامعة البصرة

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Abstract

This study was conducted to detect the effects of Selenium on some physiological and reproductive parameters in rats male, Twenty-four mature male rats were randomly divided into three equal groups; each group consists of eight males. First group was injected intrapretonially with 0.1 ml of normal saline for 30 consecutive days as control group, while second and third groups were intrapritonially injected with 0.1 ml of sodium Selenite at concentration (2,4 mg/kg body Wight ) of selenium for 30 days. The hematological and biochemical parameters including, red blood cells count(R.B.C), white blood cells count(W.B.C), hemoglobin concentration(Hb), package cell volume (P.C.V) , in addition to ALT and AST were performed after animals elimination . The concentration and percentage of normal and abnormal sperms were calculated after epididymis extraction. Statistical analysis reveals that significant differences (p≤0.05) in Red blood cells count, package cell volume, while WBCs count and liver enzymes ALT,AST show increase significant differences (p≤0.05) in comparison with control group . In concern with reproductive parameters, this study indicates there is significant differences in motility and activity of sperms of treated males, in comparison with control group

اجريت هذه الدراسة في كلية الطب البيطري- جامعة البصرة لمعرفة تأثير السيلينيوم على بعض المعاييرالفسلجية و التناسلية لذكور الجرذان المختبرية .استخدم في التجربة (24) ذكرا بالغا , وقسمت عشوائيا الى ثلاثة مجاميع متساوية بواقع 8 لكل مجموعة حقنت المجموعة الاولى ب(0.1 مل )من المحلول الفسيولجي داخل البريتون لمدة 30 يوم واعتبرت كمجوعة سيطرة,حقنت المجموعة الثانية والثالثة ب(2- 4 ملغم/كغم ) على التوالي ب(0.1 مل ) محلول السيلينيوم لمدة 30 يوم داخل البريتون.تم قتل الحيوانات بعد انتهاء فترة التجربة لاجراء الفحوصات الدموية والكيموحيوية والمتمثلة بعدد كريات الدم الحمر والعدد الكلي لخلايا الدم البيض وتركيز الهيموغلوبين وحجم الخلايا المرصوص اضافة الى تركيز انزيمات الكبد (ALT,AST). ثم شرحت الحيوانات وتم عزل(البربخ) وحسب بعدها تركيز ونسبة الحيامن الطبيعية والمشوهة. اظهرت النتائج انخفاضا معنويا(p≤0.05) في عدد كريات الدم الحمر وتركيز خضاب الدم وقيمة الخلايا المرصوص بينما كان هنالك ارتفاعا معنويا(p≤0.05) في العدد الكلي لخلايا الدم البيض وانزيمات الكبد ALT,AST للذكور المعاملة مقارنة بمجموعة السيطرة . كما اظهرت الدراسة انخفاضا معنويا(p≤0.05) في الحركة الفردية والجماعية للنطف وفعالية النطف للذكور المعاملة ,في حين لوحظ زيادة معنوية(p≤0.05) في نسبة النطف الميتة والمشوهه للحيونات المعاملة مقارنة مع مجموعة السيطرة.

Keywords

Selenium --- Rats --- Blood picture .


Article
3-AMELIORATIVE EFFECT OF SELENIUM ON REPRODUCTIVE EFFICIENCY IN ADULT MALE RATS WITH THYROID DISTURBANCE

Authors: Muna H. AL-Saeed --- Ikbal A.H.AL-Rufaei
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2018 Volume: 17 Issue: 1 Pages: 21-37
Publisher: Basrah University جامعة البصرة

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Abstract

This study was designed to evaluate the ameliorative effect of selenium onreproductive efficiency of adult male rats with thyroid disturbance.Hypothyroidism state was induced by administration of antithyroid drug propylthiouracil(PTU) (50mg/kg.B.W.) and hyperthyroid state was induced by administration of LThyroxine(L-T4) (50μg/kg.B.W.). Selenium (Se) treated rat group was given sodiumselenite (10 μg/kg.B.W.).Sixty adult male rats of (180-200 gm) body weight were used in this study and dividedinto six main groups. Control group, PTU treated group, L-T4 treated group, Se treatedgroup, Se+PTU treated group and Se+L-T4 treated group. All these groups weredrenched orally by gavage tube for two months.The obtained results revealed that hypothyroidism is accompanied by significant(P<0.05) decrease in serum T3, T4 concentrations compared with control and anothertreated groups and significant increase (P<0.05) in hyperthyroidism group a comparedwith control. On the other hand, TSH concentration showed a significant (P<0.05)increase in hypothyroidism group and significant decrease (P<0.05) in hyperthyroidismgroup as compared with control and another treated group.A significant decrease in serum concentrations of FSH, LH and testosterone have beenshown in serum of hyper- and hypothyroidism groups.Semen analysis showed a significant decrease (P≤0.05) of epididymal spermconcentration, sperm motility, and viability and a significant increase (P≤0.05) of sperm22abnormalities were recorded in PTU and L-T4 groups compared with control and anothertreated group. While a significant increase (P≤ 0.05) of epididymal sperm concentration,sperm motility and viability and a significant decrease (P≤ 0.05) of sperm abnormalitieswere recorded in Se alone, Se+PTU group and Se+L-T4 group. Also, histologicalexamination on the testis showed that rats treated with Se, Se+PTU and Se+L-T4 hadnormal architecture of seminiferous tubules with different stage of spermatogenesis.Whereas, rats treated with L-T4 alone or with PTU exhibited vacuolation ofspermatogonia and suppression of spermatogenesis.

Keywords

Hypothyroidism --- PTU --- Selenium.


Article
علاقة الفيتامينات المضادة للأكسدة(A,E,C) مع مستوى الأنسولين وعنصر السيلينيوم في مرضى السكرمن النوع 2
Relation of Antioxidant Vitamins (A, E, C) with Insulin Level and Selenium in Diabetic Patients Type 2

Authors: Rana S.Abbood --- Zeina I.Ibraheam --- Khawla A.Kasar
Journal: journal of kerbala university مجلة جامعة كربلاء ISSN: 18130410 Year: 2011 Volume: 9 Issue: 4 Pages: 1-6
Publisher: Kerbala University جامعة كربلاء

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Abstract

Free radicals have important role in the pathogenesis of diabetes mellitus. In diabetes, free radical production is increased whereas capacity of antioxidant system is reduced. In the present study we determined and evaluated changes in levels of selenium and antioxidant vitamins (A, E, C) in serum of patients with Diabetes Mellitus type 2. Total of 200 diabetic patients (110 male, 90 female) with mean age of 47.52±8.46 years were recruited into the study. Control group was composed of 150 healthy volunteers (102 male, 48 female) with mean age of 48.31±11.99 years. In addition to aforementioned parameters, levels of fasting blood glucose, hemoglobin A1c (HbA1C) levels were determined in diabetic patients and controls. There was a significant increase in insulin level, highly significant decrease in antioxidant vitamin level (A, E, C) and highly significant decrease in selenium level. On the other hand negative correlations (p<0.0001) were found between fasting serum insulin level and vitamin A and positive correlation between serum insulin level and vitamins C and E while there is highly positive correlation between serum selenium and vitamin A(p<0.01) and negative correlation between serum selenium level and antioxidant vitamins C and E (p<0.05). In conclusion supplementation of antioxidant vitamins into the daily diets of diabetic patients with type 2 will enhance power of non-enzymatic antioxidant defense systems.

للجذور الحرة دور في الاصابة بمرض السكر , حيث ان انتاج الجذور الحرة يزداد عند مرضى السكر بينما تقل قابلية النظام المضاد للتاكسد . في هذه الدراسة تم حساب التغيرت في مستويات عنصر السيلينيوم والفيتامينات المضادة للتاكسد ( A,B and C) في مصلدم مرضى السكر من النوع 2 . وشملت الدراسة 200 مريضا مصاب بالسكرمن النوع 2 (110 ذكور , 48 اناث) بمعدل عمر8,64±47,52 سنة و 150 خصا كمجموعة سيطرة (102 ذكو و 48 اناث) بمعدل عمر 11,99±48,31 سنة. وبألاضافة للمتغيرا ت السابقة تم قياس مستويات السكرالصائم وهيموكلوبين السكر الصائم في مصل الدم عند المرضى ومجموعة السيطرة . وقد كان هناك ارتفاع ملحوظ في مستوى هرمون الانسولين ,انخاض ملحوظ ي مستوى الفيامينات المضادة للاكسدة (A,E and C)وانخفاض في ملحوظ في مستوى عنصر السيلينيوم عند مرضى السكر . ومن ناحية أخرى وجدت هناك علاق خطية مع ارتباط سالب بين مستوى الانسولين وفيتامين A ,علاقة خطية موجبة بين عنصر السيلينيوم وفيتامين A وعلاقة خطية سالبة بين عنص لسينيوم وفيتامين C,E.وبألنتيجة أضافة الفيتامينات المضادة للاكسدة للغذاء اليومي لمضى السكر من النوع 2 يحسن من قوة الانظمة الدفاعية الضادة للاكسدة غير الانزيمية .


Article
CELLULAR CYTOGENETIC STUDY FOR TREATED ROLE OF SELENIUM AND OLIVE OIL AS AN-ANTIOXIDANTS AGAINST LEAD POISONING IN FEMALES MICE BONE MARROW CELLS
دراسة وراثية خلوية للدور العلاجي للسلينيوم وزيت الزيتون كمضادات للاكسدة ضد التسمم المستحدث بالرصاص في نخاع العظم للفئران المختبرية

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Abstract

The present study was designed to investigate the cellular cytogenetic effect of lead poisoning and the therapeutic role of selenium and olive oil as an antioxidant in mouse bone marrow cells.Twenty one female mice, 12 weeks old, and of 20–25 gram weight were used. The female mice which divided into seven groups each group consist of 3 female mice ,the control group: oral giving by 0.9 % normal saline (N.S) daily for 28 days. The treated groups A,B,C,D,E,F: received orally with 50 mg/kg BW lead acetate, 50 mg/kg of lead acetates + o.5 mg/kg of selenium, 50 mg/kg of lead acetates +0.2 CC of olive oil, 100 mg/kg of lead acetates, 100 mg/kg of lead acetates+ o.5 mg/kg of selenium, 100 mg/kg of lead acetates+0.2 CC of olive oil daily for28 days respectively,The administration of different doses of lead acetate caused a significant increase (P <0.05) in number of chromosomal aberration in mouse bone marrow (ring chromosome, fragment, centric fusions and centromeric attenuation )the high dose caused more increase in number of chromosomal aberration in at 28 days especially ring form.The treatment with antioxidants selenium (0.5mg/kg.B.W) and olive oil (0.2cc) caused decreased chromosomal aberration number.Also, the results showed that lead acetate caused a significant decrease (P <0.05) in the mitotic index parameter whereas the treatment with antioxidant caused an increase number of mitotic index in mouse bone marrow cells during 28 days.


Article
Effects of N-Acetyl Cysteine and/or Selenium on Methionine-Induced Ovary and Uterus Histological Damage and Oxidative Stress in Rats

Authors: Lana S. Al-alim لانا العالم --- Goran Q. Othman --- Yasin K. Amin
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 4 Issue: 1 Pages: 20-32
Publisher: Diyala University جامعة ديالى

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Abstract

Background: Methionine supplementation is considered as one of the main factors inducing hyperhomocysteinemia, which is thought to stimulate inflammation and increase the risk of vascular diseases.Aim of study: The purpose of the present study was to determine the effects of selenium, N-acetyl cystein and their combination on certain biochemical parameters and histological structure of ovary and uterus.Materials and Methods: Four groups (n=6) of female rats were randomly assigned to receive a diet supplement containing (17gm/kg body weight) methionine, while the control group n=6 for each group) were fed standard diet. In group 2, (1gm/kg body weight) N-acetyl cysteine were fed with the methionine diet, while in group 3, (5ppm) selenium was added to the water. The combinations of all treatments (Methionine, N-acetyl cysteine and selenium) were used in group four. After 5 weeks, all rats were dissected for biochemical tests including determination of reduced glutathione (GSH) and thiobarbituric acid reactive substance (TBARS) in sera, also histological evaluation performed in histological paraffin sections of ovary and uterus.Results: The data revealed a significant (P<0.01) elevation of TBARS and significant reduction in GSH in methionine treated rats. The histological sections showed reduced of ovarian follicles associated with infiltration of mononuclear inflammatory cells in myometrium of uterus. Significant restoring of TBARS and reduced GSH levels were produced by all NAC, selenium and combination treatments, except for selenium which failed to decrease TBARS significantly. The developmental stages of ovarian follicles similar to control rats were seen in combination group.Conclusion: This finding explains the oxidative and toxic actions of methionine, and the antioxidant activity of NAC and selenium, also it explains the synergistic therapeutic effects of NAC and selenium combination.


Article
Concentration of Selenium, Copper, and Zinc in Nephrolithiasis Patients

Authors: Mufeed Jalil Ewadh --- Emad Hasan Mahmoud --- Karam Akram Al-akkam
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 209 -215
Publisher: Babylon University جامعة بابل

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Abstract

One of the most popular disease worldwide is nephrolithiasis (kidney stone). Its distributed in many countries specially in the middle east. It may occurred due to changes in electrolytes and minerals. Trace elements are the most important cofactors that contribute in many enzymatic reactions in the body. The most common and important elements are selenium, copper and zinc. The aim of this study is estimate the concentration of the selenium, copper and zinc and compare them between healthy subjects and patients with kidney stones. The flame atomic absorption spectroscopy is the most accurate method to detect the trace elements. The study was conducted on 40 patients and 40 healthy subjects in Hilla city. The results of this study showed that the selenium and zinc levels decreased and copper increased in patients group when compared with the healthy subjects. Selenium and zinc has an inhibitory role to renal stones prevent nucleation of the stones in kidneys.

Keywords

Renal stones --- copper --- zinc --- selenium.

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