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Article
Association of Seminal Plasma Level of NLRP3 Inflammasome Protein with Quality of Seminal Fluid Parameters Among Infertile Men

Authors: Hussain Kh. Kadhem --- Ula A. AL-Kawaz --- Haider F. Ghazi --- Nuha A. Younis
Journal: Iraqi Journal of Embryos and Infertility Researches المجلة العراقية لبحوث الأجنة والعقم ISSN: eISSN: 26166984 / pISSN: 22180265 Year: 2018 Volume: 8 Issue: 2 Pages: 36-42
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:inflammasome protein govern the inflammatory process. The elevationof NLRP3 inflammasome might be related to bad seminal fluid analysisresults.Objectives:This study aimed to evaluate seminal plasma NLRP3 protein and itsrelation with seminal fluid analysis parameters before and after in vitro spermactivation.Patients and Methods: a total of 50 infertile patients were collected form higherinstitute of infertility diagnosis and assisted reproductive technique, there semensamples were processed for seminal fluid analysis before and after in vitrosperm activation. NLRP3 inflammasome protein were measured in seminal plasma.Results:the mean level of NLRP3 protein was 5.12 ng/ml. the higher level ofNLRP3 protein (4.5ng/ml) associated with lower sperm concentration, grade A,B, C and higher level of grade D motility. However, 50% of those patients havean improvement in their seminal fluid analysis after in vitro sperm activation.Conclusion:Elevation of NLRP3 protein in seminal plasma may be associatedwith the increased leukocytospermia, bad sperm quality and unresponsiveness toin vitro sperm activation among infertile male.


Article
The Anthropometric Ratio of Index Finger to Ring Finger (2D:4D) Correlation with Some Seminal Fluid Analysis Parameters.

Authors: Anam Rasheed Al-Salihi --- *,Mohammad Oda Selman --- Hikmat Fakhri Wasif
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2011 Volume: 10 Issue: 2 Pages: 244-248
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT :BACKGROUND:The 2D:4D ratio can be considered as a measure of prenatal androgen exposure, with the lower 2D:4D ratios pointing to higher androgen exposure. Moreover, common molecular signals (HOX genes) control the embryological development of the appendicular skeleton and the gonads.OBJECTIVE:To investigate the correlation between semen quality and an anthropometric measurement of digit ratio. To evaluate the relationship of spermatogenesis and body parts ratio which have a common embryological determinants.METHODS:The study was performed on individuals attending the Institute of Embryo Research and Infertility Treatment /Al-Nahrain University/ Baghdad / Iraq. They were allocated from random pool of individuals required to perform seminal fluid analysis. The total number was (161) males. The index finger to ring finger (2D:4D) ratio was calculated after measuring the fingers with vernier. The ratio was correlated with sperm concentration, percentage of actively motile sperms and the percentage of normal sperms in single ejaculate.RESULTS:sperm concentration was negatively correlated with 2D:4D ratio (P=0.004), while no statistical correlation was found between the digit ratio and percentage of actively motile sperm (P=0.82) and the percentage of normal sperms(P=0.84).CONCLUSION:The ration of (2D:4D) is an indicator of sperm concentration. The lower the ratio (indicating longer ring finger), the higher is the sperm concentration. While no significant statistical correlation was found between the digit ratio and the percentages of actively motile sperms and morphologically normal sperms seminal fluid analysis.


Article
Evaluation of Significance of Prolonged Liquefaction Time of Semen in Hypofertile Men

Author: Siddeek B Mar'ie
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 3 Pages: 328-333
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Until now most of the references adopt a sixty-minute liquefaction time as a guideline for normality in general semen analysis. During the last twenty years of interest in these patients, we found that there is a correlation between primary hypofertility, prolonged liquefaction time and therefore delayed conception worthy for this study. This study represent a clinical biometric case series on (284) patients consulting an outpatient urology clinic with primary hypofertility during the last ten years in Mosul.OBJECTIVE: To signify the impact of prolonged liquefaction time of semen on fertility potential of primary hypofertile men, including its relation with the delay of conception and other semen parameters.PATIENTS AND METHODS: Married males who are sexually healthy supposed to have healthy partners with no pregnancy who were not using any method of contraception. Patients should give their semen for analysis in the laboratory by masturbation. All patients should have at least two separate samples to be analyzed, with not less than 7 days apart. Collected data included age in years and duration of delayed conception in months. Semen parameters collected were: volume in milliliters (ml), liquefaction time in minutes, concentration (density) in millions/milliliters, motility in percentage, and morphology in percentage.RESULTS: The mean age of people in our sample was 29.7 years, mean volume of semen was 2.9 ml, mean liquefaction time was 26 minutes, the mean sperm density was 32.9 millions/ml, while the mean activity percentage was 31.2%, the mean percentage of the normal sperms was 61.9% and the mean duration of delay in conception was 33.7 months. There was a very highly significant correlation of prolonged liquefaction time with impaired motility, and morphology, and a significant correlation with sperm concentration. Also there was a linear positive relationship between prolonged LT in minutes and delayed conception in months, but it was more prominent in those hypofertile men who failed to conceive for ≥ 36 months.CONCLUSION: The prolonged liquefaction time has a possible role as a cause of delay in conception in hypofertile men, and has a significant relationship to defects in other semen parameters.


Article
Possible Role for Cholesterol in Human Seminal Fluid in Relations to Other Semen Parameters & Fertility

Authors: Husain Jassim Eubaid --- Batool Ahmad Al-Haidary --- Loqman Juma Tawfiq
Journal: Journal of University of Babylon مجلة جامعة بابل ISSN: 19920652 23128135 Year: 2015 Volume: 23 Issue: 2 Pages: 654-659
Publisher: Babylon University جامعة بابل

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Abstract

Background: The failure to achieve a clinical pregnancy after 12 months or more of regular unprotected sexual intercourse means a big problem for some married people. The male partner is either the sole or a contributing cause of infertility. Cholesterol is one of the biochemical which may be attributed to sperm function. Aim of study: The purpose of this study was to investigate the correlation between cholesterol levels & seminal fluid parameters.Materials & Methods: One Hundred and twenty seminal fluid samples were collected from subfertile Iraqi patients & evaluated according to the standard seminal fluid analysis (WHO 2010) in relation to cholesterol in the semen plasma samples. The results of these investigations were compared with those for 65 semen samples for apparently healthy individuals as a control group. Results: This study revealed that there was a significant difference between cholesterol concentration and (P < 0.01).Conclusions: In view of the results it could be concluded that there is an association between cholesterol and sperm motility and thereby the fertility of males.

خلفية ألتجربة: يعتبر عدم حدوث ألحمل خلال مدة أثنى عشرة سنة من بداية ألزواج مشكلة حقيقية تواجه ألمتزوجين ألجدد. و قد وجد بان ألزوج هو جزء مهم من هذه ألمشكلة. و يعتبر محتوى ألسائل ألمنوي من ألكولسترول أحد ألأسباب ألمساهمة في خفض قدرة ألحيمن ألبشري لأحداث ألأخصا ب.ألهدف من ألتجربة: ألهدف من اجراء هذه ألتجربة هو معرفة ألعلأقة بين محتوى ألسائل ألمنوي من ألكولسترول و كفاءة و قدرة ألحيمن ألبشري لأحداث ألاخصاب.مواد و طرق ألعمل: تم جمع مئة و عشرون عينة من ألسائل ألمنوي للاشخاص ألغير قادربن على ألانجاب و تم قياس جميع ألتحاليل ألمتعلقة بالسائل ألمني حسب معايير منظمة ألصحة ألعالمية WHO)) لسنة 2010و أجريت مقاربة هذه ألنتائج مع 65 فردا من ألأشخاص ألقادرين على ألأنجاب.ألنتائج: أوضحت ألنتائج بوجود علاقة معنوبة عكسية عالية (P < 0.01) بين تركيز ألكولستيرول و كفاءة ألسائل ألمنوي و ألحيامن لأحداث ألحمل.ألأستنتاجات: من خلال النتائج ألمستقاة من هذه ألتجربة أصبحت واضحا مدى تأثر كفاءة ألسائل ألمنوي لأحداث ألحمل وبما يحتويه من تراكيز ألكولستيرول، و بذلك نوصى بأن تكون معرفة تركيز هذه المادة من ضمن ألتحليل ألروتينتة للمني.


Article
Role of varicocelectomy in improving fertility in infertile male with varicocele
دور استئصال دوالي الخصية في تحسين الخصوبة لدى الذكور المصابين بالعقم مع دوالي الخصية

Author: Hassan Y. Hassan حسن يشار حسن
Journal: JOURNAL OF MADENAT ALELEM COLLEGE مجلة كلية مدينة العلم الجامعة ISSN: 2073,2295 Year: 2019 Volume: 11 Issue: 1 Pages: 19-26
Publisher: City College of Science University كلية مدينة العلم الجامعة

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Abstract

Infertility is considered one of the major health problems. 40%–50% of infertility cases are associated with the male factor. There are several types of male infertility. From all types of male infertility, idiopathic infertility and varicocele are the major types. In general population, varicocele has an incidene of 4.4%-22.6%. The surgical treatment is varicocelectomy which can be performed through subinguinal, transinguinal, or suprainguinal incision. Varicocelectomy can be done either by open, laparoscopic, microscopic, or embolization unilaterally or bilaterally. The aim of the study is to assess effect of varicocelectomy in improving fertility in infertile male with varicocele. Patients and methods: The study was conducted between beginning of March to the end of October 2017. Twenty one (21), infertile male patients with varicocele were collected randomly. The diagnosis of varicocele was done clinically and by doppler ultrasonography. Clinical diagnosis was done by one surgeon and Doppler was conducted by one ultrasonographer. Seminal fluid analysis (SFA) and hormonal assay (Testesterone, FSH, LH and prolactine) were done for patient in initial diagnosis in the same laboratory using mini-vidas automated hormone analyzer. Scrotal subinguinal approach was used for performing varicocelectomy. Postoperatively, SFA was repeated monthly for assessment of patient improvement for 3 months. Results: 21 infertile men with varicocele included in this study and the mean of age of patients were 31.4 ± 9.7 years. Postoperatively, all parameters included in this study improved in a highly significant matter (P <0.001).Conclusion: This study showed that varicocelectomy improves the fertility of infertile males with varicocele.

المقدمه: يعتبر العقم واحدة من القضايا الصحية العامة الرئيسية، ويشارك عامل الذكور في 40٪ -50٪ من حالات العقم. النوع الأكثر شيوعا من العقم عند الذكور هو العقم مجهول السبب، والذي يتميز بوجود واحد أو أكثر من المعلمات السائل المنوي غير طبيعية مع عدم وجود سبب محدد. وهناك سبب شائع آخر لعقم الذكور هو دوالي الخصية. في حين أن دوالي الخصية لديها نسبة 4.4٪ -22.6٪ في عموم السكان، 21٪ -41٪ من الرجال الذين يعانون من العقم الأولي و 75٪ -81٪ من أولئك الذين يعانون من العقم الثانوي لديهم هذه الحالة. العلاج الجراحي هو استئصال الدوالي الذي ينطوي على ربط الأوردة الخصية. ويمكن الحصول على الوصول إلى الأوردة من خلال شق تحت المنطقة الاربية ، او من خلال المنطقة الاربية ، أو من فوقها. ويمكن إجراء هذه العملية عن طريق الفتح،او بالمنظار، او بالميكرسكوب، أو الانصمام من جانب واحد أو الجانبين. والهدف من هذه الدراسة هو تقييم تأثير استئصال دوالي الخصية في تحسين الخصوبة في الذكور العقم مع دوالي الخصية. المرضى وطريقة العمل: أجريت الدراسة بين بداية مارس حتى نهاية أكتوبر 2017. تم جمع 21من المرضى الذكور العقم مع دوالي الخصية عشوائيا. تم تشخيص دوالي الخصية سريريا و دوبلر بالموجات فوق الصوتية. تم إجراء التشخيص السريري من قبل جراح واحد، وأجريت دوبلر من قبل طبيب واحد. تم تحليل السائل المنوي والفحص الهرموني (تستستيرون،و FSH،وLH و برولاكتين) للمريض في التشخيص الأولي في نفس المختبر باستخدام جهاز ميني فيداس (محلل الهرمون الآلي). تم استخدام نهج الصفن تحت المنطقة الاربية لاستئصال دوالي الخصية. بعد العمل الجراحي، تم تكرار سفا شهريا لتقييم تحسين المريض لمدة 3 أشهر. النتائج: متوسط أعمارهم كانت 31.4 + 9.7 سنوات. بعد العمل الجراحي، تحسنت جميع المعلمات المدرجة في هذه الدراسة في مسألة ذات دلالة عالية (P <0.001) .الاستنتاج: أظهرت هذه الدراسة أن فاريكوسلكتومي يحسن خصوبة الذكور العقم مع دوالي الخصية.

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