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Neovascularization in Psoriatic Patients

Authors: Zina Hammad Mohammed --- Yesar Mohammed AL-Shamma --- Hadi Abed Hadi Al-Wakeel
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2015 Volume: 12 Issue: 3 Pages: 638-645
Publisher: Babylon University جامعة بابل

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Abstract

Although angiogenesis may not be the main event in the pathogenesis of psoriasis, identifyingthe pathways leading to angio-proliferation mayaid in discovery of novel antipsoriatic drugs. Vascular endothelial growth factor is a principal regulator of physiological and pathologicalneoangiogenesis.The aim of the study is to assess the serum level of vascular endothelial growth factor in psoriatic patients and its correlation with Psoriasis area and severity index score (PASI score). One hundred consentingpsoriatic patients(males and females)aged 20-60 years who attended different medical centers including Al-Sadr Medical City and department of laser research in AL-Najaf city and Marjan Medical City in AL-Hilla-Iraq.Psoriasis area and severity index assessment was done for each patient. Blood samples were collected for vascular endothelial growth factor measurement.The serum level of vascular endothelial growth factor was significantly increased in all groups of,psoriatic,patients comparedto healthy controls as well as serum vascular endothelial growth factor showed positive correlation with PASI score.

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