research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Serum Tnfα Levels Are Inversely Associated With Insulin Sensitivity in Diabetic Retinopathy Patients

Authors: Shaymaa Zahraw Nada --- Zahraa Saad Hatef --- Hassan Murtadha Alkutubi --- Ali Mansoor Jasim --- et al.
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2017 Volume: 10 Issue: 3 Pages: 3857-3862
Publisher: Kerbala University جامعة كربلاء

Loading...
Loading...
Abstract

background: Diabetic retinopathy is the most important microvascular complication of diabetes mellitus and the inflammation have potent role in the pathogenesis and development of the disease .Tumor necrosis factor alpha is a prominent proinflammatory cytokine that mediated in all inflammatory process so it has unwanted role in diabetic complication, retina inflammation and endothelia disturbance. So the prediction of the TNFα role in the retinopathy will help to find the major treatment approach.Objective: this study conducted to evaluate the effect of TNFα in diabetic retinopathy and to find the association between TNFα and insulin sensitivity.Material & method: this study involved 120 persons were 40 healthy control subjects and 80 diabetic patients which divided into 40 type2 diabetic patients with retinopathy and 40 type2 diabetic patients without retinopathy .The serum level of TNFα ,insulin and lipid profile was measured for all patients and controls and used the SPSS program for the statistic calculation.Results: The serum level of TNFα was significantly higher in diabetic retinopathy patients in comparison to diabetic only patients and control subjects. Also there was negative correlation between TNFα and insulin sensitivity, the lipid profile was significantly higher in diabetic patient compared to control subject and the LDL cholesterol was significantly high in diabetic retinopathy patients in comparison to diabetic only and control subjects.Discussion: The inflammation play prominent role in the development of diabetic complication. TNFα is the most important inflammatory marker that present in the serum of diabetic patients. The TNFα affect mainly on the glucose and lipid metabolism and it worsen the insulin resistance and it correlate inversely with insulin sensitivity and due to this effect it will lead to develop of diabetic complication.Conclusion: The serum TNFα level was elevated in type2 diabetic patients and it may have role in developed the complication of diabetes and it was inversely correlated with insulin sensitivity.


Article
Serum Tumor Necrosis Factor Alpha and High Sensitive C-Reactiveprotein as Biomarkersin Periodontitis in Iraqi Patients with Osteoarthritis

Authors: Enas Nihad Muhammad --- Saif S. Saliem --- Enas Razzoqi Naaom
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2018 Volume: 30 Issue: 3 Pages: 7-12
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

Background: Periodontitis (PD) is well-known chronic disease affecting the periodontal ligament and alveolar bone, Osteoarthritis (OA) is a chronic joint disease with compound reasons characterized by synovial inflammation, subchondral bone remodeling, also the formation of osteophytes, that cause cartilage degradation. Chronic periodontitis and osteoarthritis are considered widely prevalent diseases and related to tissue destruction due to chronic inflammation in general health and oral health. The aim of this study is todetermine the association of chronic periodontitis and osteoarthritits in patients by analysing tumor necrosis factor alpha TNFα and high sensitive c-reactive protein (hsCRP) in the serum.Materials and Method: A total of 80 patients of both sexes aged 35-50 years ,30 patients with osteoarthritis and moderate chronic periodontitis (CP+OA), 30 patients of both sexes aged 35-50 years with moderate chronic periodontitis alone (CP). And control group (C) of 20 healthy patients with healthy periodontium participated in this cross sectional study. we excluded the postmenopausal and pregnant woman from female patient and smoker patient also. All patients are free of medication and have good general health with no history of systemic disease. Participants with OA have documentation or radiographic imaging, consistent with degenerative arthritis in the absence of an inflammatory condition. Venous blood samples were drawn from each subject using pyrogen-free heparinized collection tubes. Tubes were centrifuged according to the manufacturer’s guidelines, then stored at -15°C till analyse. serum TNFα and hs CRP were measured using an enzyme-linked immunosorbent assay (ELISA).Results: A non-significant differences between studied group regarding serum level of hsCRP and TNF-α, as well as, the result revealed that the median of serum levels of hsCRP were little higher in chronic periodontitis with osteoarthritis group than chronic periodontitis group and control groups represent as 0.31, 0.29, and 0.24. Similarly, the medium serum level of TNFα was higher in chronic periodontitis with OAthan in other two groups (10.615, 10.533, and 9.682 respectively). The age and gender showed a non-significant difference between the groupsConclusion: The present study revealed that there’s a strong positive correlation between serum levels of hsCRP and TNFα in patients of all groups but there is no correlation between Osteoarthritis and chronic periodontitis.

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (1)


Year
From To Submit

2018 (1)

2017 (1)