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Article
THE CATHETERIZATION AND ANGIOGRAPHIC VARIATIONS IN IRAQI PATIENTS WITH TETRALOGY OF FALLOT

Author: Sadiq M. Al-Hamash صادق الهماش
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2005 Volume: 47 Issue: 1 Pages: 28-34
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease and the catheterization and angiography still considered (in most centers) as essential preoperative diagnostic step. This retrospective aimed at evaluating the catheterization and angiographic finding in our Iraqi patients with diagnosis of TOFPatients and methods: The catheterization and angiographic study of200 patients with TOF-' referred to Ibn Al-Bitar Cardiac Center had been reviewed.Results: There were 126 males and 74 females and their ages ranged from 11 months to 37 years. The catheterization data showed that 88% of the patients had equal LV and RV pressure. The evaluation of pulmonary artery pressure showed that all patients had normal pressure. The review of angiographic studies revealed that the perimembraneous VSDs were the most common type (91%> of the patients). 13 patients (6.5%) had coronary anomalies, and the patent ductus arteriosus is the most common associated anomalies.Conclusion: The frequency of doubly committed VSD and single coronary artery were higher than other studies and we showed there was no indication to measure the pulmonary artery pressure during catheterization.

Keywords

TOF --- Catheterization --- Angiography.


Article
Electro Cardiographic Features of PtientsWith Tetralogy of Fallot

Authors: Dhia’a Hassan --- Fadhil Al-Rubaiy --- Sadiq M. Al-Hamash
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2007 Volume: 4 Issue: 1 Pages: 19-22
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: For many decades, the ECG was the workhorse of non-invasive cardiac test and today although other techniques provide more details about the structural anomalies in congenital heart diseases, ECG is likely to be part of clinical evaluation of patients with such diseases because it is inexpensive, easy to perform and in certain situations may be both sensitive and specific.
Objective: this study carried out to identify the pattern of ECG study in patients with TOF.
Methods: this is a retrospective study of 200 patients with TOF, referred to Ibn Al-Bitar cardiac center from April 1993 to May 1999. The diagnosis of TOF established by echocrdiographic, catheterization and angiographic study. For each patient, the ECG tracing had been analyzed for rhythm, p-wave, P-R interval, QRS axis, duration and T-wave in V1 and any chamber enlargement.
Results: The ECG analysis revealed that all patients had sinus rhythm, normal P-R interval and normal p-wave duration and amplitude, and normal QRS duration. All studied patients had one criteria of RVH and 95% of them had two or more of such criteria.
Conclusion: we found that in the absence of RVH criteria, the diagnosis of TOF is unlikely and the present of northwest axis should indicate canal type VSD.
Key words: ECG, TOF, congenital heart disease

Keywords

ECG --- TOF --- congenital heart disease


Article
The employment of MALDI-ToF in the chemical analysis of fingermarks.

Authors: Zaid Al-Obaidi --- Simona Francese
Journal: karbala journal of pharmaceutical sciences مجلة كربلاء للعلوم الصيدلانية ISSN: 70272221 Year: 2017 Issue: 13 Pages: 79-105
Publisher: Kerbala University جامعة كربلاء

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Abstract

Background and objectives: Many endogenous and exogenous molecules with different chemical nature including lipids, vitamins, amino acids polymers and other small molecules have been detected by Matrix¬assisted laser desorption/ionization (MALDI). Many studies were done to detect proteins in body fluids; however, few focused on detecting proteins in sweat. Recently peptides and small proteins in finger marks were detected in laboratory experiments including dermcidin and dermcidin-derived peptides. The aim of this study is to confirm the identity of dermcidin and other peptide species that can be found within fingermarks.Methodology: This study was performed with the employment of MALDI following two constitutive enzymatic digestions by trypsin and carboxypeptidase respectively. Bioinformatics tools were employed to identify and verify peptide maps. This work is important to both forensic and biomedical science fields. These sciences are interested in dermcidin and dermcidin-derived peptides. Also this study established the protocols with a high potential for many other detectable peptides.Results: In this work, the detection and identification of dermcidin and dermcidin-derived molecules and possibly dual specificity phosphatase (DUSP27_ HUMAN, formerly known as DUPD1) has been achieved. This has been done by using enzymatic digestions while the expected fragments obtained with MALDI and confirmed by the employment of bioinformatics tools.Discussion and Conclusions: The species of dermcidin and dermcidin tryptic digested peptides have been successfully identified directly in fingermark. Extra efforts are recommended to identify and confirm other peptides detected in fingermarks.


Article
Comparison between the Clinical Assessment, Peripheral Nerve Stimulation (PNS), and Acceleromyography (AMG) to Reverse Neuromuscular Blockade

Authors: Iyad Abbas Salman --- Mortada A. Jubara
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2014 Volume: 13 Issue: 2 Pages: 146-152
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND:Traditionally, most of anesthesiologists in Iraq evaluate the degree of neuromuscular blockade during and after anesthesia using clinical criteria alone, which are inaccurate to assess adequate recovery from neuromuscular block (NMB) which is essential for the patient to have full control of pharyngeal and respiratory muscles. Fade cannot be detected reliably with a peripheral nerve stimulator (PNS) at a TOF ratio > 0.4. The time gap between losses of visual fade by using a PNS until objective TOF ratio has returned to > 0.90 can be considered “the potentially unsafe period of recovery.” OBJECTIVE: To compare between assessment of subjective clinical, subjective TOF by peripheral nerve stimulation (PNS), and objective TOF by acceleromyography (AMG) before reversal of neuromuscular blockadePATIENT AND METHOD: A prospective clinical trial of one hundred females who underwent caesarian section under general anesthesia. Standard anesthesia was conducted for all patients. Giving of neuromuscular reversal was decided by the anesthesia care providers depending on clinical criteria, at that time, TOF measured by 2 ways, 1st: counting the twitches visually (principal of PNS), and 2nd: the device showing the TOF reading objectively (principal of AMG).RESULT: Comparisons between subjective criteria and objective AMG T4T1 ratios revealed no statistical significance (P > 0.05) in all comparisons (except that with the moving limb and lift the head). The association and consistency of subjective criteria and visual PNS was insignificant differences in all comparisons. There was wide discrepancy between objective reading and the visual PNS. CONCLUSION: The moving limbs and sustained lift head 5 seconds clinical criteria were correlated to TOF. Other criteria (protruding tongue, respiratory effort, and swallowing reflex) were not correlated to TOF. Objective AMG more sensitive to detect the fourth twitch than the subjective PNS. KEY WORDS: train of four (TOF), peripheral nerve stimulator (PNS).


Article
EFFECT OF TEMPERATURE AND SODIUM CHLORIDE CONCENTRATION ON GROWTH OF Staphylococcus aureus MUTANTS
تأثير درجة الحرارة وتركيزكلوريد الصوديوم على نمو بكتريا staphylococcus aureus

Author: Hiba Muneer Al-Khafagi
Journal: journal of the college of basic education مجلة كلية التربية الاساسية ISSN: 18157467(print) 27068536(online) Year: 2011 Volume: 17 Issue: 72/ملحق Pages: 117-129
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

The study included the identification of Staphylococcus aureus (wild type and mutant) isolates. All these isolates were identified as coagulase and catalase positive and able to ferment mannitol.Strain number 24 was chosen & undergone mutation with NTG to isolate temperature sensitive osmotically fragile (TOF) mutants. TOF mutants were successfully isolated by exposing the cell suspension to 200 Mg/ml of NTG for 75 minutes. The results of characterization of TOF mutants, showed that these mutants were identical to their mother strain morphologically and biochemically. The result of this mutation is to make the lysozyme able to lyse the cell wall of the TOF mutants in pattern similar to lysostaphin .Antibiotic sensitivity pattern was demonstrated for all the isolates and multiple resistance of some isolates were detected. The obtained results showed that the two mutant isolates were resistant to Methicillin, Benzathin, Penicillin, Cloxacillin Sodium and Lincomycin, wherease these isolates were sensitive to Amoxicillin, Cefotaxine Sodium, Cephalexin Sodium and Tetracyclin but intermediate in resistance to Clindamycin.The effect of different temperature showed that the growth of the mother strain (strain No.24) increased with the increase of temperature.The mutant strains (3M,10M) are not stable in the different temperature and their growth is very low at 40C. The effect of different NaCl concentration showed that the growth of the mother strain (strain No.24) and the 2 mutant strain (3M,10M) would increase with the increase of the NaCl concentration but decrease at NaCl concentration = 1.5 M .

تضمنت هذه الدراسة تشخيص عزلات المكورات العنقودية (النوع العادي والمطفرة). وشخصت كل العزلات على اساس تخميرها لسكر المانيتول و افرازها لكل من coagulase و الكاتلايز.وقد تم اختيار سلاله ( 24 ) للدراسة وعرضت لطفرة بواسطة NTG للعزلات الحساسة للحرارة (TOF). وقد تم عزل الخلايا المطفره TOF بنجاح من خلال تعريض معلق الخلايا إلى 200 ملغ / مل من NTG لمدة 75 دقيقة. نتائج التطفير TOF أظهرت أن هذه الخلايا المطفرة كانت مطابقة لسلالة الأم مظهريا. نتيجة التطفير جعل الليزوزيم قادرة على تحليل جدار الخلية TOF مماثل لـlysostaphin.وقد اظهر نمط الحساسية للمضادات الحيوية لجميع العزلات المقاومة ومتعددة لبعض العزلات تم الكشف عنها. أظهرت النتائج أن عزلتين مطفرة كانت مقاومة للميثيسيلين، بنزاثين, البنسلين, كلوكساسيلين الصوديوم ولينكوميسين وأيضا هذه العزلات كانت حساسة للأموكسيسيلين، Cefotaxine الصوديوم ، الصوديوم وسيفاليكسين وتتيتراسايكلين ومتوسطة في مقاومة كلينداميسين.وأظهرت تأثير درجات الحرارة المختلفة إلى أن نمو السلالة الأم (سلالة رقم 24) تزداد مع زيادة درجة الحرارة والسلالات الطافرة (3M ، 10M) ليست مستقرة في درجات الحرارة المختلفة ونموها منخفضة جدا في 40 م.وأظهرت ان تأثير تراكيز كلوريد الصوديوم المختلفة على النمو من سلالة الأم (سلالة رقم 24) والسلالتين الطافرة (3M ، 10M) تزيد مع زيادة تركيز كلوريد الصوديوم ولكن تنخفض في تركيز كلوريد الصوديوم = 1.5 مولاري.

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