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Article
Biochemical Study of Gonad Hormones in Sera of Iraqi Patients with Thyroid Disorder
دراسة كيمياحياتية لهرمونات المناسل فى امصال المرضى العراقيين بخلل الدرقية

Authors: Mohammed M.AL-Bahadlii محمد مزهر البهادلى --- Fatin F. Al-Kazazz فاتن فاضل القزاز
Journal: Baghdad Science Journal مجلة بغداد للعلوم ISSN: 20788665 24117986 Year: 2013 Volume: 10 Issue: 3عدد خاص بموتمر الكيمياء Pages: 907-914
Publisher: Baghdad University جامعة بغداد

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Abstract

The objective of this study was to evaluate the alteration in levels of gonado trophins hormones i.e.,Leutizing (LH),Follicular(FSH) in sera of patients with thyroid disorders and molecular binding study of (LH ,FSH) with their antibodies The study was conducted at the specialized center for endocrinology and diabetes from January / 2009 to March / 2010.Two hundreds and twenty three Iraqi subjects, 109 patients with thyroid disorders at age range between (40-50) years and 114 healthy individuals as control group were included in this study.The majority of patients were female with hyperthyroidism and (49.54 % ) were at age range between(40 - 50) years. The levels of hormones(LH,FSH.tri iodothyronine(T3).thyroxine(T4), thyroid stimulating hormoneTSH) were measured by using Enzyme Linked Flourscent Assay( ELFA, while residual studies used Immuno Raido Metric Assay(IRMA) method only.It was found that production of TSH was increased with about (15-20) fold in hyperthyroidism over that in control.Sixty percent of patients with hyperthyroidism were underweight BMI≤20.0 (kg/m2) while (44.5%) of patients with hypothyroidism were overweight BMI( 25.0-29.9)kg/m2 . The mean level of LH and FSH had increased significantly (p<0.01) in patients with hyperthyroidism and in females more than in males compared to control group. In contrast , for hypothyroidism the level of LH& FSH were decreased significantly (p<0.01)It can be concluded that patients with hypo and hyper thyroidism would altered their serum LH&FSH levels in female more than in male due to the effects of T3 and T4 on pituitary secretions

تهدف الدراسة الحالية الى تقييم التغيرات فى مستويات هرمونات المناسل المغديةللدرقية( اللوتوزينى وهرمون الجريب)فى امصال المرضى بخلل الدرقية ودراسة الارتباط الجزيئى مابين( ) ومضاداتها . الجزء العملى:اجريت الدراسة فى المركز التخصصى للغددلصم والسكرى بجمع مئتان وثلاثة وعشرين عينة من امصال العراقيين ابتداءا كانون الثانى/2009 الى ادار/2010. شملت العينات 109 لمرضى بخلل الدرقية بمدى العمر ما بين (40-50)سنة و114 لاشخاص اصحاء كمجموعة سيطرة بنفس المدى من العمر . اغلب المرضى كانوا نساءمصابات بارتفاع الدرقية وان (49.54%)منهن كانوا بمدى من العمر مابين (40-50) سنة.تم قياس مستويات هرمونات الثايروكسين ( (T4وثايرونين ثلاثى اليود((T3 والمحفز للدرقية(TSH) و((LH,FSH باستخدام تقنية الفحص التفلورى للانزيم المرتبط(ELFA) واستخدم تتقنبة الفحص الراديوى المناعى المترى لبقية الدراسات((IRMA النتائج: اظهرت نتائج الدراسة ارتفاع انتاج TSHبمقدار20-30 مرة عند المصابين بارتفاع الدرقية اكثر من الاصحاء.ان 60%من المرضى بارتفاع الدرقية لديهم انخفاض فى الوزنBMI≤20.0 (kg/m2) بينما(44.5%) من المرضى بانخفض الدرقية كانواعندهم زيادة فى الوزن BMI( 25.0-29.9)kg/m2 ..كانت معدل مستوى ال LH and FSH ارتفاع ملحوظ p>0.05 عند مرضى ارتفاع الدرقية و للاناث اكثر من الذكورمقارنة بالاصحاء.في حين مرضى انخفاض الدرقية كانت مستويات ال FSH and خفضة بصورة ملحوظة( p<0.01).الاستنتاج:يمكن القول ان مرضى ارتفاع وانخفاض الدرقية سبعانون من تغير فى هرمونات المناسل LH&FSH لاسيما النساء اكثر من الرجال بسبب تاثيرات هرمونات الدرقية T3 و T4 على افرازات الغدة النخامية.

Keywords

Gonadal Hormones --- LH --- FSH --- Thyroid Disorder


Article
Asymptomatic Thyroid Disorders In Type 1 Insulin Dependent Diabetes Mellites of Childhood

Author: Jasim Mohammed Hashim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 3 Pages: 606-612
Publisher: Babylon University جامعة بابل

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Abstract

Objective: The type 1 insulin dependent diabetes mellitus (T1DM) and thyroid dysfunctions are common endocrine disorder and each condition affect the others, The associations between these two conditions are well documented, (T1DM) patients are prone to thyroid disorders for different causes . we aim in this study to evaluate thyroid disorder among children with T1DM . Methods : A hospital based case control study conducted in the clinic of endocrine disorders in Alzahra Teaching Hospital for the period between 1st of May 2012 to 31th of January 2013. Fifty patients with type 1 insulin dependent diabetes mellitus (T1 IDDM) consists of group A. The control group (group B)consist of Fifty healthy children . Serum level of TSH,T3,T4 were measured by using Minividas for both groups . Results: Patients aged 5-11 years, Boys were 27 and girls 23 .The mean age of patients was 7.2±1.53 years. The Mean concentrations of TSH were 4.05 ± 1.98 mlU/L in the patients with type 1 diabetic and this is significantly higher than the control group 2.29±0.87 mlU/L with Statistically significant difference (p <0.008). Whereas mean concentrations of TT3 were 1.82 ± 0.35mlU/L in group A and 2.16±0.43 mlU/L in group B this result is significantly lower than the control group with Statistically significant difference (p <0.01) .while there was no significant difference in TT4 values between the type 1 diabetic patients 103.38±8.4 mlU/L and control group 109.70±6.72 mlU/L with(p=0.15)Conclusion: This study shows Thyroid disorder is common in type 1 diabetic children. Periodic estimation of TSH and a lesser degree TT3 is important for early detection of thyroid disorder in T1DM patients before appearance of any clinical signs of thyroid disease.

خلفية البحث : داء السكري عند الأطفال ( من النوع الأول و المعتمد على الأنسولين ) واضطرابا ت الغدة الدرقية من أمراض الغدد الصماء الشائعة وكلاهما يؤثر على الأخر والعلاقة بينهما موثقة بشكل كبير , مرضى داء السكري معرضون إلى اضطرابات الغدة الدرقية لعدة أسباب .هدف البحث: سيتم في هذا البحث تقييم فحص وظائف الغدة الدرقية لدى مرضى داء السكري( من النوع الأول و المعتمد على الأنسولين ).طرق البحث :تم إجراء دراسة (من نمط الحالات والشواهد) في عيادة أمراض الغدد الصماء في مستشفى الزهراء التعليمي للفترة من الأول من أيار 2012 ولغاية نهاية كانون الثاني 2013 . شملت الدراسة 50 مريض (مصابا بداء السكري من النوع الأول و المعتمد على الأنسولين ) وقد مثلوا المجموعة ( أ ) . ضمت ل المجموعة الضابطة 50 طفلا من الأصحاء مثلوا المجموعة( ب), تم تحديد تراكيز هرمونات الغدة الدرقية((T3,T4 وكذلك هرمون الغدة النخامية المحفز للغدة الدرقية (( TSHفي مصل الدم بواسطة جهاز Minividas لدى كلتا المجموعتينالنتائج : تراوحت أعمار المرضى بين 4 و15 سنة , المعدل العمري للمرضى كان 7.2±1.53 سنة ,منهم (27) ذكرا, (23) أنثى . أظهرت الدراسة ارتفاع متوسط تركيز هرمون TSH في مصل الدم لدى المجموعة (أ ) 4.05 ± 1.98 mlU/L) ) وهو أعلى مقارنة بالمجموعة (ب ) 2.29±0.87 mlU/L)). وكانت النتائج ذات معنوية احصائية هامة بقيمة اقل (p <0.008) بلغ متوسط تركيز هرمون T3 في مصل الدم للمجموعة (أ ) ( 1.82 ± 0.35mlU/L) وهو أقل مقارنة بالمجموعة (ب ) 2.16±0.43 mlU/L)) وكانت النتائج ذات معنوية احصائية هامة بقيمة اقل ((p<0.0. لم تظهر الدراسة وجود علاقة احصائية هامة بين متوسط تركيز هرمون T4 بين المجموعتين (p=0.15). حيث كانت نتائج متوسط تركيز هرمونT4 103.38±8.4 mlU/L)) و109.70±6.72 mlU/L للمجموعتين(أ ) و(ب ) على التوالي.الاستنتاجات : اضطرابات الغدة الدرقية كثيرة الحدوث بين مرضى داء السكري من النوع الأول المعتمد على الأنسولين التوصيات: يجب التركيز على الفحص الدوري لتركيز هرمون TSH وبدرجة اقل تركيز هرمون T3 لدى هؤلاء المرضى لتحديد تلك الاضطرابات قبل ظهور الأعراض السريرية.


Article
Regional Differences of Drinking Water Iodine and Its Association with Thyroid Disorder and Serum Iodine

Author: Jwan Ibrahim Jawzali
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 1 Pages: 198 -208
Publisher: Babylon University جامعة بابل

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Abstract

The study aims to evaluate relationship between drinking water iodine and serum iodine with thyroid disorders in patients with symptomatic thyroid disease in Erbil province, Iraq. Outpatients attending Rizgariy and Hawler teaching hospital, Erbil province, were participated in this cross sectional study and samples of drinking water were collected randomly from different geographical region of Erbil province. Biochemical analyses included; serum thyroid hormones, serum iodine and drinking water iodine. Level of water and serum iodine were deficient 24.1± 6.8 μg/l (SD)μg/l and 24.4 ± 21.4 (SD) μg/l respectively. Highest level of the water iodine was in south west of Erbil city and the lowest one was in the east districts. Water iodine showed significant negative correlation with thyroid stimulating hormone (TSH) in patients with abnormal thyroid function and significant increase risk of hypothyroidism in regions with low water iodine. 20% of patient had hypothyroidism. Serum iodine didn’t correlated with water iodine while there was significant negative correlation of it with TSH hormone. Deficiency of drinking water iodine reflects effect of environmental factors on water quality. It is a potential risk factor for developing thyroid disorder especially hypothyroidism in reproductive age of housewives. Continued monitoring treatment and iodized salt programs could prevent hypo and hyperthyroidism.


Article
Effects of Thyroid Dysfunction in Chronic Kidney Disease Patients

Authors: Maleeha Massud --- Manal Azat Aziz --- Hadeel Munem Jassim
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2017 Volume: 14 Issue: 4 Pages: 663 -669
Publisher: Babylon University جامعة بابل

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Abstract

The interactions between thyroid and kidney functions are well determined thyroid hormones affect renal development and physiology and kidney is required in the regulation of thyroid hormones metabolism.The goal of the current study was to evaluate the prevalence of thyroid dysfunction in patients with chronic kidney diseases (CKD). The study included (50) hemodialysis patients. All subjects were investigated with laboratory tests to estimate thyroid function, including: serum free tri iodothyronine (FT3), free thyroxine ( FT4) and thyroid-stimulating hormone (TSH). Results were compared with the same measurements in (50) control groups. The incidence of CKD detected among those both with subclinical hypothyroidism (40.0%) and overt subclinical hyperthyroidism (34.0%) and low FT3 in H.D patients (5.6976±1.85334) in comparison with control groups. In conclusion. We observed high of thyroid function disorders in CKD patients. Low FT3 syndrome and high subclinical hypothyroidism are the frequently thyroid function disorders in CKD patients.


Article
Chitotriosidase-1 levels in Iraqi Type 2 Diabetic Patients with Thyroid Disorders

Author: Mohammed Alwan Iedan
Journal: Ibn Al-Haitham Journal For Pure And Applied Science مجلة ابن الهيثم للعلوم الصرفة والتطبيقية ISSN: 16094042 Year: 2019 Volume: 32 Issue: 2 Pages: 45-50
Publisher: Baghdad University جامعة بغداد

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Abstract

Study aimed to determination of chitotriosidase-1 levels in Iraqi diabetic and diabetic patients with thyroid disorder. Also, study aimed to found relation correlation for chitotriosidase-1 with FSG, T3, T4 and TSH. Ninety subjects were including in this study, first group consisted of (30) healthy individuals who have no history of any thyroid disorders or diabetes mellitus as control group. Second group (G2) (n=30) patients with diabetic and hyperthyroidism as association disease, and third group (G3) (n=30) include patients with diabetic and hypothyroidism as association disease. Serum used in (FSG, T3, T4, TSH, and Chitotriosidase-1) determination. Results showed a significant elevation in patients’ groups (G2, G3) comparing to control group in FSG. In addition to a significant elevation in G3 compared to G2. Results, also, revealed a significant elevation in T3 and T4 levels in G2 when comparing with G1 and G3. While there is significant decrease in these parameters in G3 compared to G1 and G2. Results revealed a significant decrease in G2 in TSH levels comparing to G1and G3. While there is significant increase in TSH level in G3 compared to G1 and G2. Results revealed a significant increase in Chitotriosidase-1 levels in G2 comparing to G1and G3. Results, also, showed a significant decrease in G3 comparing to G2 and a significant increase was found in G3 comparing to G1. Conclusion could be drowning from this study that chitotriosidase-1 may be helpful in monitoring and early diagnosis of thyroid disorder in these patients.


Article
Influence of Thyroid Stimulating Hormone on Liver Enzymes Levels in Serum of Thyroid Disorder Iraqi Patients

Authors: Marwa Hameed --- Qutaiba Samir
Journal: Al-Nahrain Journal of Science مجلة النهرين للعلوم ISSN: (print)26635453,(online)26635461 Year: 2019 Volume: 22 Issue: 3 Pages: 50-55
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Thyroid hormones are essential element in body growth and influence the formation of many enzymatic proteins. These hormones regulate and have a major role in controlling the metabolism of the entire body. They also play an important role in the normal hepatic function. Thyroid diseases are linked with liver enzymes levels irregularities, cholestatic jaundice resulted from low bilirubin level and bile excretion, hepatic lipid homeostasis, viral hepatitis, an increase in alanine aminotransferase, aspartate transferase and alkaline phosphatase. Thyroid stimulating hormone and serum liver enzymes were analyzed using standard kits. Results showed that hyperthyroidism and hypothyroidism patients had an elevation in the levels of serum alkaline phosphatase, aspartate transferase and alanine aminotransferase when compared to controls. However, the values were higher in hyperthyroidism patients. This work aims to study the effect of thyroid stimulating hormone on the level of liver enzymes in a group of local Iraqi patients with thyroid disorder.

Keywords

TSH --- liver enzyme --- thyroid disorder --- ALP --- AST --- ALT.

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