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Article
EFFECT OF BISPHENOL A ON THYROID, LIVER AND TESTICULAR FUNCTIONS IN ADULT MALE RATS

Author: Jassim. M. A. Alkalby
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 187-206
Publisher: Basrah University جامعة البصرة

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Abstract

This study was carried out in Veterinary Medicine College / University of Basrahto investigate the effect of Bisphenol A on thyroid, liver and testicular functions. Atotal of 24 adult male rats were randomly divided into four equal groups, six animalsin each group. Animal of group (1) served as control and received a daily oraladministration of corn oil throughout the experimental protocol. Animals of group 2,3 and 4 were administered orally 50,100 and 200 mg/kg body weight of BPArespectively dissolved in corn oil, the experiment extended for 30 days. The resultsof the present study showed a significant decrease in serum thyroxin (T4)concentration and a significant increase in serum aspartate aminotransferase ( AST)and alanine aminotransferase ( ALT) concentration in bisphenol A treated groups. Asignificant decrease in serum testosterone and LH concentrations in all BPA-treatedgroups compared with control. On other hand non significant decrease in serumconcentrations of FSH were observed in BPA-treated groups compared with control.A significant decrease in epididymal sperm count and sperms motility in all BPAtreated groups. However no significant differences were noted in sperms viabilitybetween all BPA treatment groups and control. Histopathological changes were foundin thyroid glands of male rats with different doses of BPA, also central vein dilation,enlarged nuclei, vacuolation of hepatocytes were observed in the liver of BPA treatedgroups and different degrees of histological changes include depression ofspermatogenesis, decrease of leydig cells in dose dependent manner were found intesticular tissues of BPA treated groups.

Keywords

Bisphenol A --- thyroxin --- AST


Article
Biophysical effects of continuous X-rayon the level of
التأثيرات الفيزيائية البايلوجية للاشعة السينية المستمرة على مستوى الثايروكسين عند المصابين بفرط افراز هرمون الثايروكسين

Author: Samira Hassan Abdulah سميرة حسن عبدالله
Journal: kirkuk university journal for scientific studies مجلة جامعة كركوك - الدراسات العلمية ISSN: 19920849 / 26166801 Year: 2013 Volume: 8 Issue: 1 Pages: 27-36
Publisher: Kirkuk University جامعة كركوك

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Abstract

The thyroid hormones, thyroxin (T4) and triiodothyronine (T3), are tyrosine-based hormones produced by the thyroid gland primarily responsible for regulation of metabolism. An important component in the synthesis of thyroid hormones is iodine. The major form of thyroid hormone in the blood is thyroxin (T4), which has a longer half-life than T3. The ratio of T4 to T3 released into the blood is roughly (20 to 1). The level of thyroxin is affected by radiation. The aim of the study to determine and to assess the effects of continuous X-rays on thyroxin level in vitro quantitive measures. Thirty patients with hyperthyroidism disease were enrolled in this study. Blood samples were tested and irradiated by x-ray radiation source of total dose rate (0.4).Gry/sec. The level of thyroxin were determine before and after irradiation .The results showed that the level.of.thyroxine.are.significantly.reduced.(P<0.01).after.x-ray.irradiation. It is concluded that x-ray ionizing radiation, reduced thyroxin level by free radical forming and protein damaging.

تفرز الغدة الدرقية هرمون الثايرويد والذي يكون على نوعين ثايروكسين و ثالث يود الثيرونين والمصنع بشكل اساسي من اليود,وهو المسؤول عن تنظيم الايض الغذائي في الجسم .ثايروكسين يمثل معظم هرمون الثايرويد المنفرز في الدم والذي نصفه العمري اطول من ثالث يود الثيرونين حيث تكون نسبة الثايروكسين الى نسبة ثالث يود الثيرونين 20 /1 .يتأثر مستوى هرمون الثايروكسين بالاشعاع ,ان الهدف من هذه الدراسة هو تحديد وتقييم تأثير الاشعة السينية المستمرة على مستوى هرمون الثايروكسين بقياس كمي خارج الجسم. تم إخضاع (30)نموذج من دم للأشخاص المصابين بفرط إفراز هرمون الثايروكسين.حيث تم اختبار نسبة الثايروكسين للنماذج ومن ثم شععت بالاشعة السينية المستمرة بمعدل الجرعة 0,4كري /ثا. تم اختبار النماذج لمعرفة مدى تأثير الثايروكسين بالأشعة السينية المستمرة .أظهرت النتائج بأن مستوى هرمون الثايروكسين تنخفض بشكل واضح (الاحتمالية اقل من 0,01)بعد التشعيع بالأشعة السينية المستمرة عند كل تغيير في زمن التعرض أو الجرعة .نستنتج من هذه الدراسة ان الاشعة.السينية.يقلل.من.مستوى.هرمون.الثايروكسين.بتكوين.جذور.حرة.وتحطيم..البروتين. .

Keywords

Thyroxin --- x-ray --- free radical


Article
Effect of Chronic Exposure of Cadmium Chloride in Drinking Water on Structural and Functional Aspects of Thyroid Gland in Mature Male Rabbits#

Authors: Khtan A. AL-Mzain --- Kalisa K. Khudier --- Samir H. Cheyad
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 1 Pages: 69-73
Publisher: Baghdad University جامعة بغداد

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Abstract

The effect of chronic exposure to two different levels of cadmium chloride (CdCl2) 30 ppb and 40 ppb in drinking water for 12 weeks on thyroid function of mature male rabbits was studied. Eighteen mature male rabbits were randomly divided into three groups (each of six ) , control group (group I ): were offered ordinary tap water , and treated groups (II and III ) were offered tap water containing 30ppb and 40 ppb respectively for 12 weeks .Serum concentration of thyroxin (T4 ) and triiodothyronine (T3) were measured every six weeks ,as an index of thyroid function , further more , section of thyroid gland were prepared for histological studies. The results showed that chronic exposure of male rabbits to two different levels of CdCl2 caused significant decrease (p<0.05) in serum T3 and T4 in both treated groups in compared with control group, in addition, there were histological changes in thyroid gland of treated groups manifested by hyperplasia with presence of large number of varying size of microfollicels and hypertrophic thyrocytes, small colloid with little secretion .

اجريت هذه الدراسة لمعرفة تأثير التعرض المزمن لمستويين مختلفين من كلوريد الكادميوم ( 30 ، 40 جزء بالبليون ) في ماء الشرب ولمدة 12 اسبوع على وظيفة الغدة الدرقية في ذكور الارانب البالغة 0 تم استخدام 18 ارنبا بالغا قسمت عشوائيا الى ثلاث مجاميع متساوية : مجموعة السيطرة (group I ) استلمت ماء عادي طيلة فترة التجربة ومجموعتي المعالجة ( II group ) استلمت ماء الشرب المضاف اليه كلوريد الكادميوم بتركيز (30، جزء بالباليون ) و ( III group ) استلمت ماء الشرب مضافا اليه كلوريد الكادميوم بتركيز 40 جزء بالبليون ولمدة 12 اسبوعا تم قياس هرموني الغدة الدرقية الثايروكسين T4 وتراي ايودو ثايرونين T3 كل ست اسابيع فضلا عن اخذ المقاطع النسيجية للغدة الدرقية. اظهرت النتائج ان تعرض ذكور الارانب المزمن لمستويين مختلفين من كلوريد الكادميوم في ماء الشرب قد سبب انخفاضا معنويا في تركيز هرموني T3 و T4 في مصل الدم في مجاميع المعالجة مقارنة مع مجموعة السيطرة كما اظهرت الفحوصات النسيجية للغدة الدرقية حدوث حالة فرط النسيج ( hyperplasi ) تمثلت بوجود عدد كبير من الخلايا الدرقية وباحجام مختلفة محاطة بطبقة من الخلايا الطلائيــــة ( hypertrophic thyrocyte ) فضلا عن وجود نقص واضح في كمية الغروان ( colloid ) داخل الجريب مع قلة في افرازاته .


Article
Antihyperlipidemic Effect of L-Thyroxine Combined with Carvedilol in Induced Hyperlipidemia in Rabbits

Authors: Muayyad Sraibit Abbod --- Faruk H. Al-Jawad --- Adnan A. Anoze --- Mufeda Ali Jawad
Journal: Medical Journal of Babylon مجلة بابل الطبية ISSN: 1812156X 23126760 Year: 2014 Volume: 11 Issue: 4 Pages: 1047-1059
Publisher: Babylon University جامعة بابل

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Abstract

Background:Hyperlipidemia is defined as an elevation of one or more of the plasma lipids, including cholesterol, cholesterol esters, triglycerides (TG) and phospholipids .An elevation of plasma lipids may be caused by primary or secondary factors.Objective:To evaluate the effect of L-thyroxine - Carvedilol combination on hyperlipidemia induced in rabbits. Material and method:Forty healthy, domestic rabbits of both sexes, weighing (800 – 1100 grams) were used in this study. They were divided into five groups each one contains eight rabbits. The first group (G1) was given a standard diet to be considered as a control group while all other groups fed with high cholesterol diet. The second group (G2) was given high cholesterol diet only, third group (G3) treated with atorvastatin , (G4) treated with L-thyroxine and (G5) received L-thyroxine combined with carvedilol. Then lipid profile, heart rate and body weight were measured for all groups to be compared. Results:Because atorvastatin is a known antihyperlipidemic drug, the results of using combination of L-thyroxin with carvedilol were compared to those produced by atorvastatin alone. The results showed insignificant (p˂0.05) difference in all biochemical parameters, heart rate and body weight of the hyperlipidemic group treated with the combination of L- thyroxin and carvedilol (G5) when compared with those treated with atorvastatin alone (G3). Conclusion:The use of the combination of L-thyroxine and carvedilol has antihyperlipidemic effect similar to that of atorvastatin which is well known antihyperlipidemic drug.


Article
Evaluation of thyroid function at different stages of pregnancy in Iraqi women.

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Abstract

Abstract:The evaluation of thyroid function of either hyperthyroidism or hypothyroidism should beassessed by determination of serum Triiodothyronine (T3),Thyroxin (T4) and Thyroid StimulatingHormone (TSH). Due to specific conditions related to the pregnancy period, there are variousalterations accompanied this stage of life. Some changes required due to physiological demandsof pregnancy. Thyroid function was studied by determination of thyroid hormones using highsensitiveEnzyme Linked Immune sorbent Assay (ELISA) technique in 35 pregnant Iraqi women.The study group comprised 35 full term pregnant women scheduled follows up the alterations ofthyroid hormones, while the control group included 30 healthy women volunteers. Serumconcentrations levels of total T3 (TT3), total T4 (TT4) & (TSH) were estimated using (ELISA)technique. In the study group, blood samples were obtained during various stages of monthlyperiod of pregnancy.Mean age of the study group was (27±5) years, and that of controls were (25±3)years. Infirst trimester: serum TT3 & TT4 levels were significantly higher than that in controls[1.2134±0.0445 vs. 1.0583±0.2439 ng/mL and 8.5266±0.4545 vs 7.0466±1.4460 μ gm/dLrespectively while TSH levels were significantly lower than that of control 2.3866 ±0.3087 vs3.3466±1.3396 μIU/mL; P< 0.05]. In second trimester, there were continuously increase inconcentrations levels of TT3, and TT4 than that in control but TSH significantly was decreased[1.347±0.0191 vs 1.0583±0.2439 ng/ml, 9.5923±0.31005 vs 7.0466±1.4460 μ gm/dL and1.6733±0.1469 vs 3.3466±1.3396 μ IU/mL; P< 0.05]. In third trimester, TT3 showed significantfall [1.2833±0.0447 vs. 1.0583±0.2439 ng/ml and the levels of TT4 significantly increased10.3213±0.0914 vs 7.0466±1.4460 μ gm /dL while TSH significantly decreased1.2685±0.0390 vs3.3466±1.3396 μIU/mL and; P< 0.05]. All alterations, the TT3 in first trimester was risesignificantly, and it was significantly fall in third trimester. TSH was significant fall in thirdtrimester .Conclusion that during pregnancy seemed to be significantly influenced by stresspresent during pregnancy.

الخلاصة:ان تقیم وظیفة الغدة الدرقیة من ناحیة كثرة او قلة افراز ھرمون الثایروكسین یعتمد على قیاس تركیز ال(ثایرونینفي مصل الدم. (TSH) أوالھرمون المحفز للغدة الدرقیة (TT أوالثایروكسین( 4 (TT ثلاثي الیود) ( 3خلال فترة الحمل یوجد الكثیر من التغیرات الوظائفیة حسب متطلبات الحمل، حیث تتأثر وظیفة الغدة الدرقیةاثناءالحمل.في مصل الدم باستعمال جھاز TSH وTT و 3 TT درست وظیفة الغدة الدرفیة اثناء الحمل عن طریق قیاس تركیز ال 4على 35 حامل من النساءالعراقیات. (ELISA) ال


Article
The effect of thyroid hormones on pregnant women who get abortion
تأثير هرمونات الغدة الدرقية على النساء الحوامل اللاتي قد تعرضن لحالات الإجهاض

Author: Inas Sattar Abd ايناس ستار عبد
Journal: journal of al-qadisiyah for pure science(quarterly) مجلة القادسية للعلوم الصرفة (فصلية). ISSN: 19972490 Year: 2015 Volume: 3 Issue: 20 Pages: 1-6
Publisher: Al-Qadisiyah University جامعة القادسية

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Abstract

This study was performed during 2013 in Al-Batool hospital / Baquba, for fifty pregnant women. The ages were between (17-50) years who had been getting abortion as compared with (24) healthy women as control group (same age) . When the activity of thyroid hormones ( Triiodothyronine , Tetraiodothyronine - thyroxine and Thyroid stimulate hormone) were measured for both cases. Results showed that high rates of abortion had been occurred in the first trimester of pregnancy period while the low rates were in the second trimester of pregnancy period. The results also showed no significant relationship with respect to age among women who had undergone abortion, compared with control group. The study also showed that there was significant correlation between high rates Thyroid stimulate hormone with the number of women get abortion.

أجريت هذه الدراسة سنة 2013 في مستشفى البتول في بعقوبة لخمسين امرأة حامل تتراوح أعمارهن ما بين (17-50)سنة قد تعرضن لحالات الإجهاض مقارنة مع (24) امراءة كمجموعة ضابطة )من نفس الفئة العمرية( حيث تم قياس فعالية هرمونات الغدة الدرقية(T3,T4) و(TSH) لكلا الحالتين. أظهرت النتائج بان النسبة العالية من حالات الإجهاض كانت قد حدثت في الثلث الأول من فترة الحمل بينما اقل نسبة كانت في الثلث الثاني من فترة الحمل كما بينت النتائج عدم وجود علاقة معنوية فيما يخص العمر بين النساء اللاتي قد تعرضن لحالات الإجهاض بالمقارنة مع النساء اللاتي استخدمن كمجموعة الضابطة وكذلك أظهرت الدراسة إن هناك علاقة معنوية بين ارتفاع هرمون (TSH) وبين إعداد النساء تعرضن لحالات الإجهاض (p=0.001).


Article
The frequency of autoimmune thyroid disorders in patients with thyroid dysfunction in Erbil city
تواتر اضطرابات الغدة الدرقية الذاتية المناعة في مرضى الغدة الدرقية في مدينة أربيل

Authors: Sanar Ilyas Kamal --- Rawaz Dalzar Tawfeeq --- Zahra Abdulqader Amin
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2018 Volume: 22 Issue: 3 Pages: 372-376
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objective: Thyroid disorders are one of the most frequent pathologies found in the general population, but identifying thyroid disease can be clinically challenging because subclinical thyroid dysfunction and autoimmune thyroiditis are often asymptomatic and usually diagnosed biochemically. This study aimed to distinguish the autoimmune thyroid diseases from other forms of thyroid dysfunctions in patients admitted to PAR hospital in Erbil city.Methods: blood was withdrawn from healthy subjects, and unhealthy patients suffer from thyroid dysfunction, their age and gender were recorded, and their blood serum were subjected to test the thyroid function antibodies including triiodothyronine T3, thyroxin T4, and thyroid stimulating hormone TSH. Also, autoimmune antibodies were tested including anti-thyroglobulin antibody (anti-TGA) and thyroperoxidase antibody (TPO antibodies).Results: no significant differences were shown in T3 levels while contrary highly significant differences were shown in T4, TSH anti-TGA and anti-TPO levels between healthy subjects and unhealthy patients groups. The percentages of autoimmune thyroid diseases were (45.2%) as compared to the other forms of thyroid dysfunctions (54.8%). Most of the patients were females in the age group 30-39 years.Conclusion: In Erbil city population/PAR hospital the prevalence of autoimmune thyroid diseases were more frequent among other thyroid diseases collectively. It is mostly found in females rather than males within the age group 30-39 years.


Article
Evaluation of the new marker interleukin - 33 in Iraqi female patients with hyperthyroidism.
تقدير الدالة الجديدة الانترليوكين -33 في مريضات عراقيات مصابات بفرط نشاط الغدة الدرقية

Author: Bushra H. Ali بشرى حميد علي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2013 Volume: 55 Issue: 2 Pages: 170-174
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Hyperthyroidism refers to overactive of thyroid gland leading to excessive synthesis of thyroid hormones and accelerated metabolism in the peripheral tissue. Objective: The aim of this study is to evaluate a new member of the IL-1 super family of cytokines interleukin-33(IL-33) levels in serum .in order to evaluate its utility as clinical bio marker of autoimmune disease (i.e. hyperthyroidism)Methods: The present study was conducted on 30 patients from the Iraqi female patients with hyperthyroidism attending Baghdad teaching hospital, in addition to 30 healthy controls. All subjects were (35-65) years old. Parameters measured in the sera of patients and healthy groups, were interleukin -33 (IL-33), Thyroxin (T4), Thyroxin (T3) and Thyroid stimulating hormone TSH.Results: A new member of super family cytokines Interleukin -33 was determined in hyperthyroidism, female patients. Higher significant elevation was found when compared with healthy control. Conclusion: From this study a conclusion was drawn, that evaluation of concentration of a new super family cytokines IL-33 could consider as a clinical biomarkers in hyperthyroidism female patients. This finding may indicate that autoimmune disease like hyperthyroidism might influence cytokine like interleukin -33 production in these patients Key word: Hyperthyroidism, Interlukin-33, Thyroxin, Thyroxin, Thyroid stimulating hormone

فرط نشاط الغدة الرقية يشير الى زيادة فعالية الغدة الدرقية بسبب زيادة انتاج هرمونات الثايرويد التي تزيد من العمليات الايضيه للانسجة المحيطة .الهدف : تقدير مستوى العضو الجديد في الانترليوكين -1 من السايتوكينات (انترليوكين -33) في المصل واستخدامه كدالة كيموحيوية سريرية في امراض المناعة الذاتية مثل مرض فرط نشاط الغدة الدرقية . الطريقة : تضمنت الدراسة الحالية 30 مريضة مصابة بفرط نشاط الغدة الدرقية اخذت من مستشفى بغداد التعليمي وبالاضافة الى 30 حالة كمجموعة ضابطة , تراوحت اعمار المجموعتين بين (36-65) سنة وتم قياس الانترليوكين -33, الثايروكسين (T4) ,الثايرونيين (T3)و المحفز لهرمونات الثايرويد(TSH) .النتائج : لوحظ وجود فرق معنوي عالي عند تقدير مستوى العضو الجديد في الانترليوكين -1 من السايتوكينات (انترليوكين -33) عند النساء المصابات بفرط نشاط الغدة الدرقية عند مقارنتهن مع المجموعة الظابطة (مجموعة التحكم سوية)الاستنتاجات :من هذه الدراسة تم تقدير تركيز العضو الجديد في مجموعة الانترليوكين -1 من السايتوكينات واعتباره كموشر كيمو حيوي سريري عند الاناث المصابات بفرط نشاط الغدة الدرقية في العراق وهذا الاستنتاج يعزز ان لاامراض المناعية الذاتية مثل فرط نشاط الغدة الدرقية يزيد من انتاج السايتوكين مثل الانترليوكين -33 عند هولاء المصابات . كما اظهرت نتائج هذه الدراسة وجود علاقة ترابطية سلبية (-) غير معنوية فيما بين IL-33) و T3),و( IL-33 و T4) بينما اظهرت النتائج وجود علاقة ترابطية ايجابية (+) معنوية بين ( IL-33 و TSH ) للمجموعة الظابطة .وكذلك لوحظ وجود علاقة ترابطية ايجابية (+) معنوية بين ( IL-33 و T3) و( IL-33و TSH ) بينما كانت هناك علاقة ترابطية سلبية (-) معنوية بين ( IL-33 و T4)عند الاناث المصابات بفرط نشاط الغدة الدرقية .الكلمات المفتاحية : فرط نشاط الغدة الدرقية , انترليوكين -33, ثايروكسين , ثايرونيين , الهرمون المحفز للغدة الدرقية


Article
EVALUATION OF THYROID FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Author: Arif S. Malik عارف سامي مالك
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 2 Pages: 162-169
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Thyroid function has been extensively evaluated in patients with chronic kidney disease, however the results are variable.Objective:The study was designed to investigate the thyroid dysfunction in uremic patients clinically and biochemically.Methods:The study was conducted in the department of medicine and dialysis unit in AL-Kadhimiya Teaching Hospital in Baghdad. Three groups were taken sixteen patients with end stage renal disease undergoing regular hemodialysis, 22 patients with chronic renal failure treated conservatively and 21 healthy volunteers with no previous history of thyroid disease and their renal function were normal(control group), serum TT3, TT4 and TSH were estimated in all patients and control group by RIA Kits. The results were tabulated and statistically analyzed using Chisequare and t-test.Results:Fifty nine persons included in this study divided into three groups (regular hemodialysis 16, conservative treatment 22 and the control group were 21). Goiter was demonstrated in 12.5% in hemodialysis group, 4.54% of the conservatively treated group. Uremic patients kept on conservative treatment or on regular hemodialysis showed significant reduction of TT3 and TT4 in comparison to the control group, however the level of TSH didn’t show significant alterations, and there were no significant deference in TT3 andTT4 between the patients on conservative management and those maintained on regular hemodialysis.Conclusions:Low TT3 and TT4 are often observed in clinically euthyroid patients with chronic renal failure. These abnormalities do not appear to change significantly after the institution of regular dialysis, on other hand TSH values in clinically euothyroid patients with chronic renal failure were within the normal range, this normal TSH may indicate functional euthyroid status.Key words:Hemodialysis, Chronic renal disease, Triiodothyronin (T3), Thyroxin (T4), Thyroid stimulating hormone (TSH)


Article
Effect of Thyroxinehormone on Blood Parameters of Pregnant and Non-Pregnant Females Mus musculus
تأثیر هرمون الدرقین في المعاییر الدمیة لإ ناث الفئران المختبریة الحوامل وغیر الحوامل خلال مدد متتالیة

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Abstract

The present study was included, treatment of the lab mice with thyroxinhormone after 10-12 weeks of age. Ninety females ,which divided into 2equal groups,45 females of each; for study effect of Thyroxin hormone on blood parameters offemales,(pregnant and non-pregnant). The animals were divided into two groups,control group and the treated group with 0.5mg/kg/day of thyroxine hormone . thenon-pregnant females, treated pregnant ,and non-treated females were Sacrificedduring consecutive days (8,9,10,11,12,13,14 and 15) days post coitus, while the bloodparameters varied during the periods and the groups between decreasing andincreasing during the normal rang ,except in few cases were found significantdecreasing in; white blood cells count, granulocytes, monocytes, lymphocytesgranulocytes %,monocytes% and lymphocytes% during various periods andsignificantly decreased red blood cells values, HGB ,HCT%,MCH ,MCHC ,MCV,RDW ,PLT ,MPV,PDW and PCT% in different periods , and also the results wasexplained significantly increasing in white blood cells, monocytes, lymphocytes,granulocytes, granulocytes %,monocytes% and lymphocytes% during variousperiods and MCHC, HCT%, MCV, RDW, PLT, MPV,PDW and PCT% in differentperiods.

تضمنت الدراسة الحالیة معاملة إناث الفئران المختبریة بهرمون الثایروكسین بعد بلوغها عمر12 ) أسبوعا و تضم 90 إنثى ،و قسمت الإناث على مجموعتین كل مجموعة تضم 45 إنثى لدراسة تأثیر -10)هرمون الثایر و كسین في المعاییر الدمیة لإناث الحوامل وغیر الحو امل ،وقسمت الحیوانات على مجموعتین و هيمجموعة سیطرة ومجموعة المعاملة بهرمون الدرقین بجرعة 0.5 ملغم.كغم- 1.یوم- 1،و قد شرحت الإناثغیر الحوامل و الحوامل المعاملة وغیر المعاملة خلال مدد متتالیة وتشمل بعد8و 9و 10 و 11 و 12 و 13 و 14 و 15 یوما من التزاوج، أما المعاییر الدمیة فقد تباینت خلال المدد والمجموعاتبانخفاضها وارتفاعها ضمن المدى الطبیعي إلا في حالات قلیلة ،إذ وجد هناك انخفاض معنوي في خلایا الدمالبیض والخلایا الحبیبیة والخلایا الوحیدة والخلایا اللمفیة والنسبة المئویة للخلایا الحبیبیة والوحیدة و اللمفیة خلالوالنسبة المئویة لحجم الدم HGB مدد متباینة، وكما تنخفض معنویاً قیم كریات الدم الحمر وكمیة الهیموكلوبینومعدل حجم كریات MCHC ومعدل تركیز الهیموكلوبین MCH ومعدل كمیة الهیموكلوبین %HCT المضغوطو معدل حجم الصفیحات PLT والصفیحات الدمیة RDW وسعة كریات الدم الحمر MCV الدم الحمرفي مدد متباینة،وكما %PCT Procalcitonin و النسبة المئویة ل PDW وسعة الصفیحات الدمیة MPV الدمیةبینت النتائج وجود زیادة معنویة في خلایا الدم البیض والخلایا الحبیبیة والخلایا الوحیدة والخلایا اللمفیة والنسبةوالنسبة المئویة MCHC المئویة للخلایا الحبیبیة والوحیدة و اللمفیة في مدد مختلفة،ومعدل تركیز الهیموكلوبینوسعة كریات الدم الحمر MCV ومعدل حجم كریات الدم الحمر %HCT لحجم الدم المضغوطو النسبة PDW و سعة الصفیحات الدمیة MPV ومعدل حجم الصفیحات الدمیة PLT و الصفیحات الدمیة RDWفي مدد متباینة. %PCT Procalcitonin المئویة

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