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Article
Serum status of selenium and chromium in patients with cardiovascular diseases and controls in Iraq.

Author: Kassim M. Al Doori
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2008 Volume: 50 Issue: 4 Pages: 428-430
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: The importance of essential trace elements plays a major role in medicine mainly cardiovascular diseases.Methods: The study involved 305 patients with either myocardial infarction ( MI ) , angina pectoris ( AP ) or hypertension ( HT ) for evaluation of these trace elements level ( Se & Cr ) as compared with 100 control subjects in Ibin Al Bitar hospital for cardiac surgery between July 2003 and May 2005 by using Atomic Absorption Spectrophotometer ( AAS ) done in the laboratories of ministry of Sciences and Technology in Baghdad.Result: The total numbers of patients enrolled in this study were 305 patients, Ml contributes to 70 patients, 55 male and 25 female with mean age of 60 ± 20 and 58 ± 19 years respectively. Unstable angina contribute to 105 patient in which 70 of them were male with mean age of 63 ± 20 years and 35 female with mean age of 60 ± 19 years and 120 hypertensive patient in which male contribute to 90 with mean age of 64 ± 19 years and the other 30 were female with mean age of 48 ± 13 years, those 305 patients were compared with 100 normotensive control subject in which 65 of them were male with mean age of 56 ± 20 years and the remaining 35 were female with mean age of 46 ± 13 years. The analysis of results show that the level of Se and Cr were significantly lower in both sexes in patient with MI, AP and HT as compared with control, and the concentrations of Se were even much lower in acute MI as compared with AP. Conclusion: The concentrations of trace elements Se and Cr were significantly lower in patients having MI, AP and HT as compared with controlled normotensive persons, besides the concentration of Se was much lower in MI as compared with cases of AP.


Article
Evaluation of serum srace element levels in children with bronchial asthma
تقييم مستويات عنصر مصل الدم لدى الأطفال المصابين بالربو القصبي

Author: Parween Abdulsamad Ismahael
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2011 Volume: 15 Issue: 3 Pages: 50-55
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Abstract

Background and objectives: The metabolism of several trace elements has been reported to alter in bronchial asthma and these elements might have specific roles in the pathogenesis and progress of this disease. The aim of the present study was to investigate serum levels of Zinc, Copper, Calcium, Iron and Magnesium in asthmatic childrenPatients and Methods: The comparative study includes 56 asthmatic patients and 44 healthy non asthmatic control subjects. The trace elements concentrations were measured by means of an atomic absorption spectrophotometer, results were calculated from the calibration curve obtained by statistical analysis of concentration Vs Absorbance data for elements using fitting of straight line by least square.Results: Mean(±SD) zinc level was significantly (p<0.01) decreased in asthmatic children (70.6±8.3 μg /dL) compared with controls non asthmatic children (78.3± 9.2 μg /dL),calcium and iron serum concentrations were significantly(p<0.001) higher in asthmatic patient (10.98±2.53 mg/dL, (113.23 ± 45.47 μg/dl) respectively compared with controls (8.23±3.4mg/dL,83.25±29.43 μg /dL) respectively, on the other hand copper level was significantly (p<0.01) higher in asthmatic children (143±20.8μg/dl) in comparison to the control values (130±22.7 μg/dL). Magnesium concentration was significantly lower in comparison to the control values (p<0.01).Conclusion: The results support that deficiency of Mg, Zn, Cu, Ca and Fe may play a role in the development of asthma.


Article
A Study of Serum Zinc, Iron, Selenium, and Copper levels in patients with bladder cancer
دراسة معدلات كل من الزنك,الحديد,السيلينوم,والنحاس في مصول سرطان المثانة

Authors: Zainab Fadthel Ashoor زينب فاضل عاشور --- Sura Dhafir Dawood سرى ظافر داود
Journal: Iraqi Journal of Cancer and Medical Genetics المجلة العراقية للسرطان والوراثة الطبية ISSN: 20786123 Year: 2010 Volume: 3 Issue: 1 Pages: 40-45
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Back ground: The association of serum trace elements like Zinc, Iron, Selenium, and copper has been found in different types of cancer. Many authors observed direct association between micronutrient deficiency and the cancer mortalities. Many of essential trace element are required for growth “ play an important role in the suitable biochemistry of the body “ and they could also stimulate the growth of tumors.Objectives : Assessment the level of trace element ( Zn, Fe, Se, and Cu ) in serum of patients with bladder cancer.Patients & Methods: Serum samples of (40) male and female patients with bladder cancer and (20) healthy controls were enrolled in this study. Bladder cancer patients were undergo cystoscopy and diagnosed clinically by consultant urologist as newly diagnosed for primary bladder tumor. Tumor characterized by 2 independent pathologists according to the criteria of WHO . Trace element were determined by Automic Absorption Spectrophotometer.Results : Significant increase in serum (Cu) levels and significant decrease in serum (Zn, Fe, and Se) levels in bladder cancer patients when compared with normal group.Conclusion : Low serum ( Zn, Fe, and Se) and high Cu levels in bladder cancer patients when compared with control indicates the role of bladder cancer disorders in trace elements metabolism.

تم إيجاد تصاحب كل من العناصر الضئيلة مثل الزنك, الحديد, السلينيوم, والنحاس في مختلف حالات السرطان. كثير من الباحثين اظهروا تصاحب مباشر بين عوز العناصر الضئيلة ومعدلات الوفاة لمرضى السرطان. كثير من العناصر الضئيلة الأساسية مطلوبة للنمو وتلعب دور مهم في كفاءة الكيمياء الحياتية في الجسم وكذلك ممكن ان تحفز النمو السرطاني.الغاية:تقدير معدلات العناصر الضئيلة (الزنك, الحديد, السيلينيوم, والنحاس) في مصول عدد من مرضى سرطان المثانة .الطريقة: جمعت عينات من مصول مرضى سرطان المثانة وعددها (40) عينة من الرجال والنساء, و(20) عينة تمثل مصل الأصحاء كمجموعة سيطرة ,حيث خضع جميع المرضى للفحص والتشخيص السريري لمرض سرطان المثانة, ودعم هذا التشخيص بالفحص النسيجي . تم قياس العناصر الضئيلة بواسطة الطرق الكيمياوية باستخدام جهاز (Automic Absorption Spectrophotometer), وتحليل النتائج ومقارنتها مع نتائج الدراسات السابقة .النتائج: اظهرت نتائج الفحص وجود ارتفاع في مستوى النحاس, وانخفاض ملحوظ في كل من (الزنك, الحديد, والسيلينيوم) لدى مرضى سرطان المثانة مقارنة مع الاصحاء .الاستنتاج : انخفاض معدلات كل من الزنك, الحديد, والسيلينيوم, وارتفاع معدل النحاس في مرضى سرطان المثانة عند المقارنة مع مجاميع الاصحاء دل على دور اضطرابات سرطان المثانة في العمليات الايضية للعناصر الضئيلة.


Article
Trace Elements in Serum and Seminal Plasma and Their Relationship to Infertility in Iraqi Males

Authors: Basil Y Salah --- Zina A Marrow --- Nahla M Tawfiq
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2007 Volume: 4 Issue: 1 Pages: 11-14
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Environmental chemicals are thought to adversely affect human reproductive function.
Objective : To estimate the concentration of cadmium(Cd) , lead ( Pb ) and Zinc ( Zn ) in serum and seminal plasma among infertile men .
Methods: A sample of 70 infertile men was investigated. The relationship of trace elements concentration in serum and seminal plasma was studied in relation to sperm density, motility and sperm count.
Results: Except for Zinc the concentration of (Pb) and (Cd) were generally higher in serum than in seminal plasma. The mean concentration of (Zn) in seminal plasma was more than 25 times higher than in serum There were no statistical significant differences observed in the serum and seminal plasma levels of trace elements among the normospermic , oligospermic and azoospermic.
Conclusion: It seems that no significant relationship between these trace elements and the clinical classification of the infertile men was noted. Without considering environmental conditions of life and work, way of nutrition smoking and other possible factors, this study does not present great value.
Key words: Trace elements, infertility, seminal plasma


Article
MAGNESIUM, ZINC, AND COPPER IN SERUM, ERYTHROCYTE, URINE AND DIALYZATE FLUIDS OF HAEMODIALYSIS PATIENTS

Author: Sami, N. Najem
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2005 Volume: 14 Issue: 1 Pages: 31-35
Publisher: Baghdad University جامعة بغداد

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Abstract

Copper (Cu) Zinc (Zn) and Magnesium (Mg) in serum, RBC, urine and dialyzate fluids were studied in 39 patients, who have been undergoing chronic haemodialysis treatment. They were divided in to polyuric , oliguric and anuric depending on their urinary output. Elevated serum and RBC Mg was observed before dialysis, while decreased serum and RBC level was noticed except serum Mg of polyuric patients. Before dialysis elevated serum and RBC Zn were observed. While after dialysis these parameters were increased. Normal RBC Cu value before dialysis was observed. While low serum Cu was noticed. After dialysis serum Cu showed raised value, while RBC level decreased in oliguric and increased in polyuric patients. Zn / Cu ratio found to be high in those patients. All these results were discussed in relation to urine content and also to the dialyzate fluid.

قيست تراكيز المغنيسيوم والخارصين والنحاس في مصل وكريات الدم الحمر وإدرار ومحلول الغسيل الناتج لدى تسعةوثلاثين مريضا عولجوا بالإنفاذ الدموي واللذين قسموا حسب كمية الإدرار المطروحة إلى غزيري وقليلي وعديمي الإدرار, ظهرارتفاع في تركيز المغنيسيوم في مصل وكريات الدم الحمر قبل المعالجة في حين انخفض تركيز ه بعده ا, عدا مصل غزيريالإدرار, ارتفع تركيز الزنك في المصل وكريات الدم الحمر قبل وبعد المعالجة, وبقي تركيز النحاس طبيعيا في كريات الدم الحمرقبل المعالجة في حين انخفض تركيز ه في المصل , وارتفع بعد المعالجة بينما انخفض في كريات الدم الحمر في مرضى قليليالإدرار, وارتفع لدى مرضى غزيري الإدرار, وارتفعت نسبة الزنك إلى النحاس في جميع المرضى . نوقشت جميع النتائج علىضوء محتوى الإدرار ومحلول الغسيل من هذه العناصر.


Article
Quantitative analysis of trace elements in saliva of oral cancer patients from Iraq

Authors: Natheer H. Al-Rawi نذير الراوي --- Nazar G. A. Talabani نزار غالب الطلباني
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 2 Pages: 32-35
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Trace elements like iron, zinc, magnesium, cobalt and manganese are some of these elements involved in antioxidant defense mechanism. Many authors observed direct association between trace elements deficiency and the cancer mortality. The study was conducted to measure levels of Zinc (Zn), Copper (Cu), Iron (Fe), Manganese (Mn), Cobalt (Co), Nickel (Ni), Chromium (Cr), Cadmium (Cd), and Magnesium (Mg) in saliva of 50 patients with histologically proved squamous cell carcinoma.Patient and Method: Unstimulated (resting) saliva was collected from oral cancer patients one day before surgical excision of the tumor and one day after surgery using plastic polyethylene tubes. The collected saliva was cold centrifuged at 2500 rpm for 10 minutes at 0-5°C.The centrifuged supernatants were stored frozen at (-20°C) until time of analysis using Atomic Absorption Spectrophotometer.Results: Saliva levels of Zn, Mn, Co and Ni were significantly higher in preoperative saliva of oral cancer patients when compared to the normal control. On the other hand, a highly significant reduction in the levels of Cu, Fe and Mg was observed in preoperative saliva of oral cancer patients. However, no significant changes were seen in saliva trace element levels when preoperative values were compared with postoperative values of same patients.Conclusion: Saliva may be employed alone for trace elements measurements or it can be used supplementary to serum test for confirmation of any finding. However, saliva has the advantage of easy collection without trauma to the patients.

Keywords

Trace elements --- saliva --- oral cancer


Article
Estimation of some trace elements in serum of children with jaundice
تقدير العناصر النادرة فى الاطفال المصابين باليرقان

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Abstract

The objective of this study was to measure the alterations in serum trace elements copper (Cu), chromium (Cr) and zinc (Zn) in children with jaundice and compare them with the results of healthy individuals by using AAS. Significant low serum levels of Zn and high level of serum Cu and chromium were observed in children with jaundice as compared with normal healthy controls.. The study showed that Cu, Zn and Cr concentrations in serum of jaundice were (175.6±47,5 μg /dL ,95±67μg /dL and 7.98±0.54 μg /dL)respectively. In healthy individuals these concentrations were 109.3±13.72 μg /dL,106.55±11.7 μg /dL and3.8 ±0.48 μg /dL) respectively.

موضوع هده الدراسة هو قياس التغيرات فىمستوى العناصر النادرة (الزنك,الكروم والنحاس )فىمصول الاطفال المصابين باليرقان و مقارنتهابالنتا ئج للاطفال الاصحاء باستخدام تقنية الامتصا ص الدرى حيث لوحظ انخفاض ملحوظ فى مستويات الزنك وارتفاع ملحوظ فى مستويات النحاس والكروم فى الاطفال المصابين باليرقان عند مقارنتها بالمصول لطبيعية حيث اوضحت ا الدراسة بان مستويات النحاس ,الزنك والكروم كانت (175.6±75.5 μg/dl) ,( 95± 67 μg/dl),(7.98±0.54 μg/dl) على التوالى فى مصول الاطفال المصابين باليرقان اما فىمصول الاطفال الاصحاءفقد كانت القيم (106.55±11.7μg/dl) (3.8±0.48 μg/dl), (109±13.72 μg/dl) على التوالى.


Article
Trace Elements Levels (Zn, Cr, Mg) in Type 2 Diabetic Patients
مستوى العناصر الكيميائية النادرة )الزنك – الكروم – المغنسيوم( في مرضى السكري النوع الثاني

Author: Sahar Abd Al-Wahab Al-Shaban م . م سحر عبد الوهاب الشعبان
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2011 Volume: 24 Issue: 3 Pages: 222-223
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Introduction: In Diabetes, (both type 1 and type 2) an alteration in the metabolism of the minerals Zinc (Zn); Chromium (Cr) and Magnesium (Mg) have been demonstrated. Little is known about the role of these minerals in type 2 diabetes mellitus.Objective: To examine the hypothesis that there is an alteration in serum level of some trace elements, Zinc (Zn) Chromium (Cr) and Magnesium (Mg) in type 2 D.M.Patients and Method: The study was conducted on 35 type 2 diabetic subjects and 32 age matched control subjects, age range (42-57) years after obtaining their consent for active participation during the entire study period from November 2007 to June 2008, in National Diabetes Center / Al Mustansiriya University. Results: The (Mean±SD) of plasma glucose in patients and controls were (162.16± 25) mg/dl and (78.18±9.5)mg/dl respectively, (p<0.01). The (Mean±SD) of Zn for patients and controls were (125.0±19) µg/dl and (152.5±23.5) µg/dl respectively (p<0.05). For Cr were (0.04±0.03) µ /dl and (0.08±0.03) µg/dl respectively (pالمقدمة: لوحظ في الاونة الاخيرة وجود علاقة مباشرة في مستوى العناصر الكيميائية النادرة (الزنك و الكروم و المغنسيوم( مع مرضى السكري.هدف البحث: تشخيص مستوى الزنك الكروم وكذلك المغنسيوم في مصل الدم للمرضى المصابين بداء السكري من النوع الثاني.طريقة البحث : المرضى واشخاص الاصحاء في الدراسة تم تقسيمهم الى مجموعتين : أ- مجموعة المرضى : اشخاص مصابون بمرضى السكري النوع الثاني = 35)العدد )ب- المجموعة الضابطة : اشخاص غير مصابين بمرضى السكري وهم اصحاء =32)العدد( لكلتا المجموعتين تم قياس مستوى الكلوكوز في البلازما وكذلك قياس تركيز كل من الزنك , Zn الكروم Cr والمغنسيوم Mg في مصل الدم. اختيار (t) استعمل لتقييم الاختلاف في قيمة المتوسط للفحوصات المختارة بين المجاميع, واستعمل عامل الارتباط لفحص الارتباط بين الواسمات الحيوية المختلفة.النتائج: المتوسط ± الانحراف المعياري) لمستوى الكلوكوز في البلازما كان بالنسبة للمرضى والمجموعة الضابطة) ( 25 ± 162.16) ملغم 100/ مل و (9.5 ± 78.18) ملغم / 100 مل على التوالى و ,(0.01 > p ) المتوسط ± الانحراف المعياري لتركيز الزنك Zn و بالنسبة للمرض والمجموعة الضابطة كانت (39.5 ± 138.0) ماكروغرام 100/مل و(32.09 ± 162.5) ماكروغرام / 100مل، على التوالي وقيمة (0.05 > P) ولتركيز الكروم كانت (0.3 ± 0.05) ماكروم غرام / 100مل و (0.03 ± 0.09) ماكروغرام100/مل على التوالي، ولتركيز المغنسيوم Mgللمرضى 1.8±0.31)) ملغم100 / مل و2.4±0.32)) ملغم /100مل على التوالي وقيمة(0.01 > P)..الاستنتاج: هنالك انخفاض في مستوى تراكيز العناصر الكيميائية النادرة (الزنك , Znالكروم ,Cr المغنسيوم (Mg في مرضى السكري النوع الثاني مقارنة بالاصحاء وكذلك وجود علاقة عكسية مابين مستوى الكلوكوز و تراكيز العناصر الكيميائية النادرة في هؤلاء المرضى.


Article
Correlation of Concentrations of Certain Trace Elements in

Author: *Insaf Jasim Mahmoud, **Saad Ali Rashid Al Shammary,*** Hadeel Sameer Abdul Wahab,
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2012 Volume: 8 Issue: 1 Pages: 98-102
Publisher: Baghdad University جامعة بغداد

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Abstract

Background Over the past decade there has been a growing awareness of, and interest in, the trace element concentration differences between normal and diseased tissues. Significant changes in tissue concentrations of Zinc (Zn) and Copper (Cu) have been previously reported in inflammation and cancer of certain human tissues.Aim:(1)To correlate between Zn and Cu concentrations and the histological picture of normal and certain inflamed human tissues, namely the gall bladder (GB) the vermiform appendix (VA), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). (2) to detect whether there is a difference in the above-mentioned parameters between VAT and SAT. (3) to obtain recordings for trace element levels in human tissues.Methods: Diseased GB (10), VA (10), VAT (10) near these organs and SAT (10) were removed by surgery. Tissues from these organs were then processed for histopathology and analyzed for trace elements concentration by Atomic Absorption Flame-Emission Spectrophotometer.Results: Zn concentration was high in VAT (0.410 μg/g ± 0.181), GB (0.478 μg/g ±0.531) and VA (0.419 μg/g ±0.123) when compared to its level in SAT (0.1329 μg/g ± 0.0129) and the difference was significant (<0.007,<0.056 and <0.000 respectively).Cu concentration was high in VAT (0.640 μg/g ± 0.150) and GB (0.919 μg/g ± 0.564) when compared to SAT (0.3893 μg/g ± 0.0130) and the difference was significant (<0.005 and <0.011 respectively). Cu concentration in the VA was low (0.2055 μg/g ±0.0654) and significantly different from all the other tissues (VA vs VAT <0.000, VA vs GB <0.002 and VA vs SAT <0.000).The histology findings were typical of chronic inflammatory reactions in the GB and of acute inflammation in the VA.Conclusions: The increase in tissue concentrations of Zn in VAT, GB & VA is due to inflammation.The high Cu level in chronically inflamed GB and neighboring VAT is due to the increased need for this element during inflammation.Our results, together with findings reported by others, allow us to think of using trace elements, namely Zn and Cu, as tools for diagnosis and treatment in appropriate conditions.Key words: Tissue trace elements – Zinc – Copper


Article
DETERMINATION OF SOME TOXIC TRACE ELEMENTS OF FRESH, FROZEN AND CANNED FISH SPECIES
تقدير بعض العناصر النزرة السامة في عضلاث أنواع من الاسماك الطازجة والمجمدة والمعلبة

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Abstract

In this study, fresh fish (Otolithes ruber, Saurida tumbil, Pseudorhombus malayanus, Acanthopagrus latus, Hypophthalmichthys molitrix and Tenualosa ilisha), imported frozen fish (Megalaspis cordyla, Ctenopharyngodon idella, Labeo rohita and Acanthopagrus latus) and imported canned fish species (sardines, mackerel and tuna) were used to detect and determine some toxic trace elements. All fish samples contained trace elements. The total concentrations mean for Cu, Zn, Pb, Ni, Co, Cd and Mn were between (1.73-11.93), (8.75-25.80), (ND-3.19), (0.11-0.31), (0.10-0.35), (0.23-3.00) and (0.11-1.86) mg/kg dry weight respectively in muscles of fresh fish, and between (13.21-53.74), (6.61-43.93), (0.35-2.10), (0.37-2.30), (0.20-0.54), (1.50-3.53) and (0.13-4.50)mg/kg dry weight respectively in the muscles of frozen fish species, and between(21.75-56.30), (5.21-82.84), (0.25-1.51), (0.33-1.96), (0.20-0.47), (0.51-2.22) and (0.13-0.81) mg/kg dry weight respectively in canned fish . Concentrations average of some trace elements were exceeded the permitted legal limits that set by the Food and Agriculture Organization and the World Health Organization.

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