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The Effect of Tranexamic Acid (Cyclokapron) on Post–Surgical Bleeding Following the Removal of Impacted Lower Wisdom Teeth in Healthy Individuals

Authors: Wael T. Al Wattar --- Wafaa K. Fathi --- Rayan S. Hamid
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2008 Volume: 8 Issue: 2 Pages: 225-230
Publisher: Mosul University جامعة الموصل

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Abstract

Aims: To evaluate the effect of local irrigation with tranexamic acid in minimizing post–operativebleeding following the removal of impacted lower wisdom teeth. Materials and Methods: This clinicaltrial was conducted at the Department of Oral and Maxillofacial Surgery / College of Dentistry / Universityof Mosul. The sample recruited comprised twenty healthy subjects who required surgical removalof clinically as well as radiographically evident impacted lower wisdom teeth. The sample wassubdivided into two groups of ten subjects each. The first group which is the control group included tensubjects where after removal of the tooth, local irrigation of socket was carried out with normal saline.The second group which is the trial group comprised ten subjects also, but in which tranexamic acid(injectable solution) in diluted form was used for local irrigation of socket. Both solutions were of equalamount. Estimation of amount of blood loss immediately following surgery was the criterion for comparisonand was based on weight of gauze used before and after application over extraction socket. Results:The results showed a statistically significant decrease in the amount of blood loss in the trialgroup when compared with the control group. Conclusions: Tranexamic acid as commercially availableor freshly prepared oral rinse may be used as an aid for the reduction or prevention of postoperativebleeding following the removal of third molars in healthy subjects as well as in patients with bleedingproblems.


Article
EFFECTS OF TRANEXAMIC ACID ADDITION ON ELASTICITY AND TENSION OF THE FIBRIN GLUE

Authors: Ibrahem A. Mahmood ابراهيم عبد الله محمود --- Fakhir S. Al-Ani فاخر سلمان شفيق
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2013 Volume: 11 Issue: 4 Pages: 306-310
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Fibrin glue is a natural, biocompatible and biodegradable topical tissue adhesive that initiates and duplicates the final stages of coagulation cascade. To prevent early fibrinolysis, antifibrinolytic agent may be added to the components of the glue. Tranexamic acid is a synthetic antifibrinolytic lysine analogue that competitively inhibits the activation of plasminogen to plasmin, hence, delays the fibrinolysis activation.Objective:To synthesize of the fibrin glue with and without tranexamic acid addition and explore the biomechanical behavior of both formulae with regard to stretching (elasticity) and tension.Methods:Using thrombin and cryoprecipitate (as a source of fibrinogen) for synthesis of the "ordinary fibrin glue". In another preparation; Tranexamic acid was added to both components (thrombin and cryoprecipitate) for synthesis of the "tranexamic acid added fibrin glue". Then, by using displacement and force transducers we measure elasticity and tension of the synthesized fibrin glue (both ordinary and tranexamic acid added fibrin glue) at different durations.Results:Tranexamic acid addition to the fibrin glue causes significantly higher elasticity results at 1 hour, 1 week durations. Significant lower tension results are witnessed at 1 hour duration, while at 1 week duration, comparison of the tension results of both ordinary and tranexamic acid added fibrin glue show no significant difference.Conclusion:Tranexamic acid addition led to change in biological behavior of the glue presents as increase in its elasticity and decreased tension. This change should be taken into consideration when the applicator needs to use this formula in the management of different areas of human body. Keywords:Fibrin glue, tranexamic acid, elasticity, tension.


Article
Systemic effect of tranexamic acid on Prothrombin and clotting times in rabbits after IV injection of heparin (Experimental study)

Author: Raid M Basheer
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2006 Volume: 6 Issue: 2 Pages: 155-160
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: To evaluate the effect of a single dose of tranexamic acid (cyclokapron) in reducing thepostoperative bleeding following minor oral surgery on ten rabbits on anticoagulant therapy (heparin).Materials and Methods: Samples of blood were collected pre and post heparin and tranexamic acidinjection for measuring the Prothrombin and clotting time. Results: There was no significant differencebetween the Prothrombin time and clotting time normal and Prothrombin time and clotting time aftertranexamic acid injection. Conclusion: A single dose of tranexamic acid given postoperatively waseffective in reducing the postoperative bleeding following minor oral surgery in experimental rabbit onheparin anticoagulant therapy without changing the regular heparin regimen doses. The same regimenmay be applied on hospitalized patient on heparin anticoagulant therapy


Article
PROPHYLACTIC TRANEXAMIC ACID VERSUS AUTOLOGOUS BLOOD TRANSFUSION TO REDUCE BLEEDING IN ELECTIVE CORONARY BYPASS GRAFT SURGERY.

Author: Othman Ismat Abdulmajeed*
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2019 Volume: 25 Issue: 1 Pages: 27-31
Publisher: Basrah University جامعة البصرة

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Abstract

Abstract Many blood conservation strategies were developed in the past decades to reduce risk of bleeding and the need for blood products among patients undergoing cardiac surgeries. This study was conducted to define the benefit of reinfusion of preoperative collected autologous blood in reduction of the risk of bleeding and the need for blood and blood products in comparison with tranexamic acid. This single centre single-blinded, randomized study was conducted in Erbil cardiac centre during the period from 1st of November 2018 to 30th of April 2019. A total of 150 patients were divided into three groups with 50 patients for each. The 1st group received nothing, the 2nd group received initially infusion of 200mg/hr of tranexamic acid until reaching 1.5gm/hr, and the 3rd group received one pint of preoperative auto-transfused whole blood. Data on risk of bleeding and the need for blood and blood products were collected using special questionnaire prepared for the reason of this study and were analyzed using appropriate statistical tests. Patients receiving autologous blood showed lower chest tube drainage than the other study groups with a p value of <0.001. Similarly the need for blood and blood products intra or postoperatively was significantly lower among patients receiving autologous blood with p value of <0.001. Therefore, the risk of intra and postoperative bleeding was significantly lower among those receiving autologous blood when compared to other study groups. In conclusion, reinfusion of one pint of preoperative collected autologous blood is higher than tranexamic acid in reducing the risk of postoperative bleeding and the need for blood and blood products among patients undergoing cardiac surgery. Keywords: Autologous, tranexamic acid, bleeding, cardiac surgery, Coronary bypass.

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