research centers


Search results: Found 2

Listing 1 - 2 of 2
Sort by

Article
Effect of Chronic Exposure of Cadmium Chloride in Drinking Water on Structural and Functional Aspects of Thyroid Gland in Mature Male Rabbits#

Authors: Khtan A. AL-Mzain --- Kalisa K. Khudier --- Samir H. Cheyad
Journal: Iraqi Journal of Pharmaceutical Sciences المجلة العراقية للعلوم الصيدلانية ISSN: 16833597 Year: 2010 Volume: 19 Issue: 1 Pages: 69-73
Publisher: Baghdad University جامعة بغداد

Loading...
Loading...
Abstract

The effect of chronic exposure to two different levels of cadmium chloride (CdCl2) 30 ppb and 40 ppb in drinking water for 12 weeks on thyroid function of mature male rabbits was studied. Eighteen mature male rabbits were randomly divided into three groups (each of six ) , control group (group I ): were offered ordinary tap water , and treated groups (II and III ) were offered tap water containing 30ppb and 40 ppb respectively for 12 weeks .Serum concentration of thyroxin (T4 ) and triiodothyronine (T3) were measured every six weeks ,as an index of thyroid function , further more , section of thyroid gland were prepared for histological studies. The results showed that chronic exposure of male rabbits to two different levels of CdCl2 caused significant decrease (p<0.05) in serum T3 and T4 in both treated groups in compared with control group, in addition, there were histological changes in thyroid gland of treated groups manifested by hyperplasia with presence of large number of varying size of microfollicels and hypertrophic thyrocytes, small colloid with little secretion .

اجريت هذه الدراسة لمعرفة تأثير التعرض المزمن لمستويين مختلفين من كلوريد الكادميوم ( 30 ، 40 جزء بالبليون ) في ماء الشرب ولمدة 12 اسبوع على وظيفة الغدة الدرقية في ذكور الارانب البالغة 0 تم استخدام 18 ارنبا بالغا قسمت عشوائيا الى ثلاث مجاميع متساوية : مجموعة السيطرة (group I ) استلمت ماء عادي طيلة فترة التجربة ومجموعتي المعالجة ( II group ) استلمت ماء الشرب المضاف اليه كلوريد الكادميوم بتركيز (30، جزء بالباليون ) و ( III group ) استلمت ماء الشرب مضافا اليه كلوريد الكادميوم بتركيز 40 جزء بالبليون ولمدة 12 اسبوعا تم قياس هرموني الغدة الدرقية الثايروكسين T4 وتراي ايودو ثايرونين T3 كل ست اسابيع فضلا عن اخذ المقاطع النسيجية للغدة الدرقية. اظهرت النتائج ان تعرض ذكور الارانب المزمن لمستويين مختلفين من كلوريد الكادميوم في ماء الشرب قد سبب انخفاضا معنويا في تركيز هرموني T3 و T4 في مصل الدم في مجاميع المعالجة مقارنة مع مجموعة السيطرة كما اظهرت الفحوصات النسيجية للغدة الدرقية حدوث حالة فرط النسيج ( hyperplasi ) تمثلت بوجود عدد كبير من الخلايا الدرقية وباحجام مختلفة محاطة بطبقة من الخلايا الطلائيــــة ( hypertrophic thyrocyte ) فضلا عن وجود نقص واضح في كمية الغروان ( colloid ) داخل الجريب مع قلة في افرازاته .


Article
EVALUATION OF THYROID FUNCTION IN PATIENTS WITH CHRONIC KIDNEY DISEASE

Author: Arif S. Malik عارف سامي مالك
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2011 Volume: 9 Issue: 2 Pages: 162-169
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Background:Thyroid function has been extensively evaluated in patients with chronic kidney disease, however the results are variable.Objective:The study was designed to investigate the thyroid dysfunction in uremic patients clinically and biochemically.Methods:The study was conducted in the department of medicine and dialysis unit in AL-Kadhimiya Teaching Hospital in Baghdad. Three groups were taken sixteen patients with end stage renal disease undergoing regular hemodialysis, 22 patients with chronic renal failure treated conservatively and 21 healthy volunteers with no previous history of thyroid disease and their renal function were normal(control group), serum TT3, TT4 and TSH were estimated in all patients and control group by RIA Kits. The results were tabulated and statistically analyzed using Chisequare and t-test.Results:Fifty nine persons included in this study divided into three groups (regular hemodialysis 16, conservative treatment 22 and the control group were 21). Goiter was demonstrated in 12.5% in hemodialysis group, 4.54% of the conservatively treated group. Uremic patients kept on conservative treatment or on regular hemodialysis showed significant reduction of TT3 and TT4 in comparison to the control group, however the level of TSH didn’t show significant alterations, and there were no significant deference in TT3 andTT4 between the patients on conservative management and those maintained on regular hemodialysis.Conclusions:Low TT3 and TT4 are often observed in clinically euthyroid patients with chronic renal failure. These abnormalities do not appear to change significantly after the institution of regular dialysis, on other hand TSH values in clinically euothyroid patients with chronic renal failure were within the normal range, this normal TSH may indicate functional euthyroid status.Key words:Hemodialysis, Chronic renal disease, Triiodothyronin (T3), Thyroxin (T4), Thyroid stimulating hormone (TSH)

Listing 1 - 2 of 2
Sort by
Narrow your search

Resource type

article (2)


Language

English (2)


Year
From To Submit

2011 (1)

2010 (1)