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Article
Microorganisms Isolated From Foot Ulcers InfectionOf Diabetic Iraqi Patients.

Authors: Saad S. AL-Azawi --- Suhaila M. AL-Salloum --- Ryath shaya AL-Hemedawi
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2006 Volume: 48 Issue: 3 Pages: 297-300
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: - Diabetic foot infections may be classified as superficial or deep. Bacteria are liable to enter any cut or ulcer causing infection. Defect in treatment of infected deep diabetic foot may result in oesteomyelitis, limb loss, and even death.
Methods: - Microorganisms were isolated and identified from both superficial & deep foot ulcers infection of (60) diabetic patients.
Results: - The present results showed that high incidence (30.8%) of Escherichia coli (E-coli) was isolated from dry - superficial foot ulcers followed respectively by Staphylococcus epidermidis (S. epidermidis). 3.1 % and 15.4% of Proteus mirabilis (P. mirabilis), equal Percentages for Klebsiellae Pneumoniae (K. pneumoniae), Klebsiellae ozaenae (K. ozaenae), Citrobacter freundii (C. freundii) and Pseudomonas aeruginosa (Ps. aeruginosa which were 7.7 %. the most common microorganisms isolated from wet - superficial foot ulcers were 14.3% of S. aurous and S. epidermidis, followed by equal by Percentages of E-coli, Enterobacter cloacae (E cloacae) k. pneumoniae, C. freundii; which were 9.5 % also equal Percentages for K. ozaenae, P. mirabilis, Morganella morganii (M. morganii) providencia rettgri (P. rettgri), Enterobacter. aerogenes (E. aerogenes), Acinetobacter baumanii (A. baumanii) & Ps. aeruginosa (4.8%) were isolated The present findings demonstrated that the microorganisms isolated from different depth of deep ulcer were 18.4% of Ps. aeruginosa, followed by equal Percentages (12.2%) of E-coli & P. mirabilis. Then 10.2% of k. Pneumoniae and equal Percentages 8.2% for both S. aureus& S. epidermidis, similar Percentages4.1 for Klebsiellae terrigina (K. terrigina) & providencia stuartii (p. stuartii). the other species from different other genera represent one (2.1 %) isolate only.
Conclusions:- The infected superficial ulcers from diabetic patients demonstrates high incidence of E¬coli followed by S. epidermidis, Proteus and Klebsiella. While the most common microorganisms isolated from wet-superficial foot ulcers were S. aureus, S. epidermidis, E.coli, Enterobacter, Klebsiella, Proteus, Providencia, Morganella, Citrobeacter, Acinetobacter & pseudomonas. The microorganisms isolated from different depth of deep ulcers were pseudomonas, E.coli, Proteus, Klebsiella, S. aureus, S. epidermidis, S.capitis, Streptococcus viridans, Shigella, Serretia, Acinetobacter


Article
The Efficacy of Topically Applied Silymarin in the Treatment of Herpes Labialis Ulcers

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Abstract

Herpes labialis is an infection caused by the herpes simplex virus, characterized by an eruption of small and usually painful blisters on the skin of the lips, mouth, gums, or the skin around the mouth. Although there is no successful treatment available, the local use of compounds with effective anti-inflammatory and cytoprotective effects may be of value in this respect. This project was designed to evaluate clinically the local use of silymarin, a group of flavonoids with powerful antioxidant, anti-inflammatory and cytoprotective activity, in the treatment of herpes simplex ulcer. Fifty three patients with herpes labialis ulcers (HLU) were enrolled in this randomized, single blinded, placebo controlled clinical study, and they were allocated into 4 groups, treated with 1%, 3% and 5% silymarin paste and placebo formula respectively. Patient's responses to treatment were followed by clinical evaluation of healing time, size of the ulcers and pain sensation, in addition to evaluating biochemical and immunological markers of the oxidative stress and inflammatory response. HLU patients showed dose dependent improvement in the healing time, pain score and size of ulcer as a result of treatment with various concentrations (1%, 3% and 5%) of silymarin paste, associated with improvement in the oxidative stress state and immunological parameters. In conclusion, silymarin can be used locally as paste formula for the treatment of HLU, an effect which may be attributed to its antioxidant, anti-inflammatory and cytoprotective properties.

Keywords

Herpes labialis --- ulcers --- silymarin


Article
The Effect of Honey on the Healing of Oral Ulcers(Clinical Study).

Authors: Asmaa S Al-Douri --- Shatha S Mohamed
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2008 Volume: 8 Issue: 2 Pages: 157-160
Publisher: Mosul University جامعة الموصل

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Abstract

Aim: to assess the effect of honey on healing of recurrent aphthous ulcers. Materials and Methods:fifty patients with minor oral ulcers (2–5 mm) were attended to consultant clinic in the College of Dentistry demanding a treatment for their painful ulcers were treated by either kenalog in orabase or theapplication of honey dressing. Results: The ulcerations have almost completely disappeared after 3 days treatment by honey dressing. Conclusions: Honey has an obvious influence on the rate of healingprocess of the oral ulcers.

Keywords

Ulcers --- healing --- honey


Article
HISTOPATHOLOGICAL STUDY OF PLATELETE RICH PLASMA FOR TREATMENT OF INDUCED CUTANEOUS ULCER IN DIABETIC RABBITS INDUCED BY STREPTOZOTOCIN
دراسة نسيجية مرضية للبلازما الغنية بالصفائح الدموية في علاج القرح الجلدية المحدثة في الأرانب المصابة بمرض السكري المستحدث بالستربتوزوتوسين

Author: Mohanned A. Talab., Zainab Waheed مهند عباس, زينب وحيد
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2019 Volume: 18 Issue: 1 Pages: 236-248
Publisher: Basrah University جامعة البصرة

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Abstract

The present study investigates the effect of platelets rich plasma (PRP) on the healing of skin ulcers in rabbits in which diabetes mellitus (DM) was induced using Streptozotocin. The study was applied on 12 adult rabbits of both sexes with a mean weight of 1000-1500 g. They were divided randomly into two equal groups (six rabbits per group). DM was induced in two groups by injected Streptozotosin 65 mg / kg B.W IV. Ulcers were made in 3 cm length and 2 cm width in all rabbits in the gluteal region under the general Anesthesia by mixture of xylazine hydrochloride and ketamine hydrochloride in sterile conditions. The first group was used as control; the second group was treated with platelets rich plasma on the site of ulcers.The first group in the 7 days, showed large ulcers and pus; in the 14 days, were ulcers continued with thickened epidermal. Second group, in the 7days, showed skin ulcers with dermal thickening and a beginning of skin formation. In the 14th days, treated group showed small ulcer remaining with dermal fibrosis.ELISA results have been shown the effect of platelets rich plasma on tumor necrosis factor alpha (TNFα) concentration in blood after 10 daysof skin lesions inducing. The natural concentration of TNFα is 6.4 pg/ml in range (4.2-7.9) pg/ml. The first group had a concentration below 5.3 pg/ml, due to the DM. The second group was highly concentrated in 10.4 pg/ml. The results of the histopathological and ELISA confirmed that there are a marked healing and elevating TNFα concentration in the treated group.

أجريت الدراسة الحالية للتحقق من مدى تاثير البلازما الغنية بالصفائح الدموية على ألتئام القرح الجلدية المحدثة في الأرانب المستحدث فيها داء السكر تجريبيا بأستخدام عقار الستربتوزوتوسین. أجريت الدراسة على 12أرنبابالغةمنكلاالجنسين معدل اوزانها (1000-1500) غم وقد قسمت عشوائيا الى مجموعتينستة أرانبلكل مجموعة تم أستحداث السكري فيها حيث حقنت بعقار الستربتوزوتوسین (65) ملغم/كلغم داخل وريد الأذنلاستحداث السكري وبعدها تم عمل قروح جلدية بطول 3 سموعرض 2 سم جرحفيجميعالأرانبفيالمنطقةالكفليةتحتتأثير خليطزيلازين هيدروكلوريدوهيدروكلوريدالكيتامين في ظروف معقمة. كلا المجموعتين استحدث فيها السكري والقرح الجلديةالمجموعة الاولى تمثل مجموعة السيطرة,المجموعة الثانيةتم علاجها بالبلازما الغنية بالصفائح الدموية على موقع القرح. وأظهرتالدراسة في المجموعة الأولى في اليوم السابع وجود قروح كبيرة متبقية وتكون قيح أما في اليوم الرابع عشر استمرت القروح مع تثخنات في البشرة, المجموعة الثانيةفي اليوم السابع ظهرت القروح الجلدية مع تثخن وبداية تكوين البشرة أما في اليوم الرابع عشر فوجدت بقايا قروح صغيرة مع حدوث تليف في البشرة. نتائج الاليزا اظهرت تاثير البلازما الغنية بالصفائح الدموية على ارتفاع تركيز عامل التنخر الورمي (Tumor Necrosis Factor :TNFα) في الدم في اليوم العاشر من احداث الجروح والقرح الجلدية. TNFα يعتبر من السايتوكينات التي تنتج بواسطة الخلايا البلعمية والوحيدات خلال الألتهاب ويكون مسؤولا عن تحفيز الخلايا المولدة الليفية وافراز عوامل النمو وتنظيم عمل الخلايا البلعمية. التركيز الطبيعي لل TNFα هو6.4 pg/ml معدل pg/ml(4.2-7.9) ففي المجموعة الاولى كان تركيزه أقل من المعدل الطبيعي وهو 5.3 نظرا لأستمرار القروح. المجموعة الثانية كان تركيزه عاليا فيها pg/mL10.4. نتائج الأليزا اكدت بأن هنالك أرتفاع في تركيز TNFα في المجموعة المعالجة بشكل واضح.


Article
A Study of Diabetic Foot Ulcers in Relation to Depth , Location of the Ulcer and Patient's, Age and Sex.

Author: Ryath S.AL-Hemedawi
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2006 Volume: 5 Issue: 4 Pages: 418-421
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Over a nine months period, extending from October, 2002 through July 2003, microorganisms were isolated and identified from foot ulcer infections of diabetic patients. The foot ulcers were clinically identified as superficial (dry, wet) or deep ,the depth of both superficial (wet, dry) and deep foot ulcers in relation to location, patient age and sex were studied from 60 patients of surgical wards.METHODS:The depth of different diabetic foot ulcers were measured by sterile cotton tip applicator inserted from the surface to the deepest point of the ulcer base.RESULTS:It was demonstrated that the superficial ulcers were mostly wet, the site of the ulcers were mainly in the right foot more than in left foot, mostly the toes. The incidence of deep ulcers were mostly in males, while the prevalence of both superficial and deep ulcers increase with advancing age.CONCLUSION:The present study showed a different classification of foot ulcers (superficial &deep) from past literature studies.


Article
Topical Nigella Sativa in the treatment of oro-genital ulceration in Behcet's disease.

Author: Dr. Samara M. Abdali. * د.سمارة عبد علي
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2009 Volume: 6 Issue: 4 Pages: 366-370
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

To assess the effect of Nigella sativa oil as a topical preparation for treatment of oro- genital ulceration of Behcet's disease. This is a double blinded therapeutic trial in which 40 patients with Behcet's disease manifested as recurrent episodes of oral and genital ulceration were enrolled into 2 groups; Nigella sativa oil was applied as 10% in glycerin topically 3 times / daily to the first 20 patients. The other 20 were given glycerin only. Assessment was done 4 days then 8 days after treatment.Results were recorded as they appeared in clinical examination and those records were arranged in tables for both groups concerning oral and genital ulceration cases.Nigella sativa oil is a new topical agent for promotion of healing of oro- genital ulceration of Behcet’s disease which may act through Pits anti-inflammatory effect.


Article
Recurrent aphthous ulcers in relation to some precipitating factors in Baghdad city

Authors: Dr. Ghada Moosa Mustafa, B.D.S, M.Sc* د. غادة موسى مصطفى --- Dr. Ahlam Jaber, B.D.S.** د. احلام جابر
Journal: MUSTANSIRIA DENTAL JOURNAL مجلة المستنصرية لطب الاسنان ISSN: 18138500 Year: 2006 Volume: 3 Issue: 4 Pages: 330-332
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

This study was designed to investigate the recurrence of aphthous ulcers amongthree groups of people in different ages, and to evaluate the most effectiveprecipitating factors in developing recurrent aphthous ulcers RAU.The results of this study showed that the stress, allergy, hormonal disturbances,hematological deficiencies were the most predisposing factors on RAU .About (40-50%) of patients experience recurrences of the ulcers. Data recorded that RAU wasmore common in females than in males and RAU can begin in childhood, but the peakperiod for onset is the second decade of life; frequency and severity diminish withage.


Article
Bacterial infection of Diabetic foot ulcer
الاصابة الجرثومية لقرحة القدم في المرضى المصابين بداء السكري

Authors: . Siham Sh. Al- Salihi سهام شكور عبيد --- Israa A. Mohammed Jumaah اسراء انور محمد جمعة
Journal: Diyala Journal For Pure Science مجلة ديالى للعلوم الصرفة ISSN: 83732222 25189255 Year: 2013 Volume: 9 Issue: 4 Pages: 15-20
Publisher: Diyala University جامعة ديالى

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Abstract

The study included 25 wound samples were collected from type 1 insulin dependent diabetes mellitus (IDDM), and type2 non-insulin dependent diabetes mellitus (NIDDM) foot patients admitted to daquq hospital of both sex and their ages between 41-75 years. The study aimed to screen the aerobic bacterial pathogens present in diabetic pus and to determine their antibiotic susceptibility against common standard antibiotics. Bacteriological diagnosis and antibiotic sensitivity profiles were carried out at two parts: The profile part swab was taken has been cultured in media of blood agar and MacConkey agar depend on biochemical tests and indicators. The results indicate that common pathogen isolates from the diabetic pus included E. coli followed by Proteus mirabilis and Staphylococcus aureus, and the peak proportion of diabetic foot ulcer (DFU) was recorded between 41-75 years in both sexes. The second step were included the performing antibiotic susceptibility according to Kirby-Bauer disc diffusion method on Mueller–Hinton agar using 11 different antibiotics. It was obvious that Nitrofurantoin, Ciprofloxacin and rifampicin is more active against E. coli followed by co-trimoxazole and gentamycin . Ofloxacin is more active against Staphylococcus aureus followed by gentamycin and Amipcillin .Amikacin, Nitrofurantoin and Co-Trimoxazole is active against Proteus mirabilis followed by gentamycin and erythromycin.

شملت الدراسة 25 مريضا بداء السكري من النوع الاول والثاني الوافدين الى مستشفى الداقوق الذين يعانون من تقرحات في القدم ، وكان اعمارهم يتراوح بين 41 – 75 سنة ومن كلا الجنسين. هدفت الدراسة الى عمل مسحة لدراسة البكتريا المرضية الهوائية الموجودة في التقرحات العائدة لمرض السكري ولتحديد استجابتها لبعض المضادات الحيوية. التشخيص لبكتريولوجي والحساسية للمضادات الحيوية تم دراستها في قسمين. القسم الاول المسحة المأخوذة قد تم زراعتها على وسط Blood agar وMacConkey اعتمادا على الفحوصات الكيميائية وبعض المؤشرات كانت النتائج تشير الى ان البكتريا التي تم عزلها كانت Staphylococcus aureus , Proteus mirabilis , E.coli وسجلت اعلى نسبة في الاشخاص تتراوح اعمارهم بين41-75 عاما ومن كلا الجنسين, القسم الثاني هو دراسة حساسية هذه البكتريا المعزولة بطريقة Kirby- Bauer disc diffusion method على وسط مولر هنتون الصلب باستعمال 11مضادا حيويا مختلفة .لوحظ ان المضادات نايتروفيرانيتون ,السبروفلوكساسين, الريفامبسين فعال جدا ضد E. coli ويتبعها ترايمكسسول وجنتامايسين . وكان مضاد اوفلوكساسين فعال جدا ضد Staphylococcus aureusيتبعها جنتامايسين وامبسلين. نايتروفيرانيتون,اميكاسين و ترايمكسسول فعال جدا ضد Proteus mirabilis ويتبعها جنتامايسين وارثرومايسين.


Article
Vanadyl sulfate and Lycopene in prevention of Ethanol induced gastric ulcer
كبريتات الفناديل ولايكوبين لمنع القرحة المحتثة بالكحول

Author: Faruk H Aljawad1, Mohmoud J Jawad2, Osama K. FadhiL3 فاروق حسن ,
Journal: AL-yarmouk Journall مجلة كلية اليرموك الجامعة ISSN: 20752954 Year: 2014 Volume: - Issue: 1 Pages: 1-11
Publisher: College Yarmouk University كلية اليرموك الجامعة

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Abstract

gastric ulcer is a state resulted from imbalance between the erosive action of acid and pepsin & mucosal defense mechanism in the stomach and may be correlated with antioxidant agents.

حدوث القرحة المعدية يعبر عن إختلال الموازنة بين التأثير التأكلي للحامض والببسين والية الدفاع للجدار المخاطي للمعده وما لذلك من علاقة مع البكتريا (H.pylori)استعمل في الدراسة (35) جرذاً أبيضاً وزعوا على خمسة مجموعات أعطيت لكل مجموعة إحدى المواد التالية لانسوبرازول مضاد للقرحة ,كبريتات الفناديل ولايكوبين وهما من مضادات الأكسدة وكذلك الماء المقطر لوحده كسيطرة وكان أستعمالها لمدة خمسة أيام متعاقبة وبعد ساعة من آخر جرعة لها أعطي الكحول المركز 95% حيث تم قتل الحيوانات بعد ساعة واحدة من إعطاء الكحولتم عزل المعدة وإفراغ محتواها وإجراء التثبيت والصبغ لها من أجل حساب عدد التقرحات ومساحتها وحساب معامل الحماية للقرحة بأستعمال المجهر التشريحي وأحتساب الجذور الحرة والكهارل بالمصل أظهرت النتائج أن معامل الحماية من القرحة كان عاليا جدا من قبل لانسوبرازول في حين إنه كان عاليا أيضا لكل من كبريتات الفناديل ولايكوبين مع حدوث تغيرات معنوية معتدة في الجذور الحرة وكذلك مستويات الصوديوم والبوتاسيوم والكالسيوم بالمصل .


Article
Uses of Moist dressing in treatment of Skin Ulcers in Rabbits
استخدام الضمادات الرطبة في علاج القروح الجلدية في الأرانب

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Abstract

The study represent use new kind of dressing which are moist dressing in treatment of skin ulcer, the mechanism of this dressing are keeping the ulcer moist in order to facilitate and enhancing healing process. The study done in the college of veterinary medicine Basrah University in 2013 by making two groups of rabbits each one contain 4 individuals, and inducing different ulcers (in the back, abdomen, around the vagina from out side and on the extremities) by using of caustic material then treated by Comfeel Ulcer and Biatain adhesive with Ag. the result show that using of Comfeel Ulcer dressing in treatment of second degree ulcer had was very good in a period of 4 weeks only, and the Biatain adhesive with Ag treating the deep ulcer (3ed degree ulcer) in 6 weeks. We conclude that the best dressing used in treatment of skin ulcers is the Biatain adhesive with Ag and Comfeel Ulcer with no any complication and without need to antibiotics in case of using Biatain Ag. Although the Comfeel Transparent is the optimum Dressing in treatment of cesarean section induced wound (incision wound).

تتلخص هذه الدراسة باستعمال نوع جديد من الضمادات تعرف بالضادات الرطبة الحديثة قي علاج القروح الجلدية والية عملها هي إبقاء القرحة أو الجرح رطباً لكي تسهل وتسرع عملية الالتئام. أجريت هذه التجربة في البيت الحيواني التابع لكلية الطب البيطري/ جامعة البصرة في 2013 بأخذ مجموعتين من الأرانب كل مجموعة مكونة من 4 أفراد وتم استحداث قرح متنوعة (الظهر، البطن، حول المهبل من الخارج، على الأطراف) باستعمال مواد كاوية ثم علاجها بالضمادات الرطبة الكومفيلComfeel والباياتين اللاصق مع نترات الفضة Biatain Adhesive Ag. بينت النتائج بان استعمال الكومفيل في علاج القرحة من الدرجة الثانية اثبت جودته إذ تم علاج القرحة بفترة 4 أسابيع فقط أما الباياتين فاستخدم لعلاج القرح العميقة في فترة 6 أسابيع تقريبا. نستنتج من هذه الدراسة ان أفضل ضماد لعلاج حالات القرح الجلدية هو الباياتين اللاصق مع الفضة وكومفيل القرح من حيث الفترة الزمنية للعلاج وعدم وجود أي مضاعفات في استخدام الضماد مع عدم الحاجة إلى استعمال مضادات الحياة مع الباياتين كما ان ضماد الكومفيل الشفاف يعتبر الضماد النموذجي في علاج الجروح الناتجة من العمليات القيصرية.

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