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Article
EFFECT OF ACUTE AND CHRONIC LEAD NITRATE EXPOSURE ON SOME PHYSIOLOGICAL PARAMETERS IN EXPERIMENTAL MICE
تأثير التعرض الحاد و المزمن لنترات الرصاص على بعض المعايير الفسلجية في الفئران المختبرية

Author: Shereen Jawad Kadhim Al-Ali *, Asia Fadel Abdula شيرين جواد كاظم العلي* , آسيا فاضل عبد الله**
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2007 Volume: 6 Issue: 2 Pages: 78-88
Publisher: Basrah University جامعة البصرة

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Abstract

The research include the study of the effect of lead in the form of lead nitrate on some hematological parameters (Hb concentration, total WBC count , differential WBC count) and liver enzymes, glutamate-pyruvate transaminase (GPT) or (ALT) and glutamate-oxaloacetate transaminase (GOT) or (AST) levels during the acute and chronic exposure in experimental mice , the research performed by feeding the mice to two different concentration of lead nitrate 50 ppm/kg and 100 ppm/kg for two exposure periods the acute (10days) and chronic (20 days) . the results showed that the lead in 50 ppm/kg con. in chronic period showed much less decrease in hemoglobin concentration, neutrophils percentage ( 6.9 g/100ml , 12.25% respectively) than in the acute period (9 g/100ml , 18.5% respectively) and an increase in total WBCs count, basophils, eosinophils and lymphocytes percentage (5.01×103,2.25% , 4% and 65.25% respectively) much than in the acute period( 3.11×103 , 0.75% , 0.75% , 63.25% respectively) , AST level increase significantly in the acute period of 100 ppm/kg exposure where as ALT level increase significantly in the acute period of 50 ppm/kg exposure , we also found that females were more hematologically affected with lead compared with males while the AST and ALT levels were high in males than females for both periods .

تضمن البحث دراسة تأثير عنصر الرصاص و بشكل نترات الرصاص على بعض المعايير الدموية (تركيز خضاب الدم ، التعداد الكلي لخلايا الدم البيض ، العد التفريقي لخلايا الدم البيض) ومستوى انزيمي الكلوتاميت- بايروفيت ترانسامينيز((ALT و الكلوتاميت – اوكزالواستيت ترانسامينيز (AST ) و التي يحدثها التعرض الحاد و المزمن للعنصر في الفئران المختبرية إذ شمل البحث تعريض الفئران إلى تركيزين من نترات الرصاص هما 50 ppm/kg و 100 ppm/kg و لنوعين من التعرض الحاد (10 أيام) و المزمن (20 يوم) و قد أظهرت النتائج إن الرصاص بتركيز 50 ppm/kg و في التعرض المزمن يؤدي إلى انخفاض أكثر في كل من تركيز الهيموغلوبين و النسبة المئوية للخلايا العدلة يصل إلى ( g/100ml 6.9 ، 12.25% على التوالي) مقارنة مع التعرض الحاد والذي كانت قيمه ( 9 g/100ml ، 18.5% على التوالي ) كما ظهرت زيادة في كل من العدد الكلي لخلايا الدم البيضاء و القعدات و الحمضات و الخلايا اللمفاوية( 5.01×103 ،2.25% ،4% و 65.25% على التوالي ) اكثر في التعرض المزمن مقارنة مع التعرض الحاد و الذي كانت قيمه (3.11×103 ،0.75% ،0.75% و 63.25% على التوالي). و ازدادت مستويات إنزيم AST و بشكل معنوي في التعرض الحاد لـ 100 ppm/kg في حين ارتفعت مستويات إنزيم ALT و بشكل معنوي في التعرض الحاد لـ 50 ppm/kg . كما اوضحت الدراسة ان التغيرات في المعايير الدموية تظهر بشكل اوضح في الاناث منها في الذكور في حين ان مستويات انزيمي AST و ALT ترتفع في الذكور منها في الاناث .

Keywords

Lead nitrate --- WBC --- Hemoglobin.


Article
Relationship between Increased WBC with Increased Lipid Profile in Blood
العلاقة بين ارتفاع نسبة كريات الدم البيضاء بالدم وزيادة الدهون بالدم

Author: Buthaina Ateyah Rashid بثينة عطية راشد
Journal: Diyala Journal of Medicine مجلة ديالى الطبية ISSN: 97642219 Year: 2013 Volume: 5 Issue: 2 Pages: 83-90
Publisher: Diyala University جامعة ديالى

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Abstract

Objective: leucocytes are cells of the immune system involved in defending the body against both infectious disease and foreign materials.When increase or decrease in the number of leukocytes in the blood is often an indicator of disease(the normal level of WBC in blood between 4000 to 11000 cell /ml ), , they make up approximately 1% of blood in a healthy adult.[3] An increasing in the number of leukocytes over the upper limits is called leukocytosis, and the decrease below the lower limit is called leukopenia. Method: This research contained study 64 patients (average age between 20 – 35 years ) suffering from increasing WBC " diagnostic by WBC count test "and perform lipid profile test (Triglyceride , cholesterol , LDL , HDL ) for all patients and shows the changes in lipid profileResults: we found relationship between increasing levels of lipid and increasing WBC disease. These result are (45% cholesterol) (58%Triglyceride)(39% LDL)(22% HDL). That is mean, the increasing of lipid profile were stimulation of immune system to increasing the white blood cell. We conclude than an increasing WBC associated with increasing of lipid profile

اشتمل البحث دراسة 64 مريضا تتراوح اعمارهم من 20 - 35 يعانون من زيادة في كريات الدم البيضاء increased WBC مشخصون سابقاً بواسطة فحص حجم كريات الدم المضغوطة ( WBC count) وقد أجرى لهم فحوصات الدهون الكلي lipid profile (Triglyceride , cholesterol , LDL , HDL ) وأظهرت النتائج وجود علاقة بين ارتفاع مستوى تركيز الدهون بالدم وزيادة الـ WBC COUNT على حدٍ سواء , حيث كانت نسبة الزيادة للأشخاص المصابين بالـ increased WBC وارتفاع الدهون كما يلي (45% cholesterol)(58%Triglyceride)(39% LDL)(22% HDL) .


Article
- EFFECT OF SEASON ON SOME HEMATOLOGICAL, BIOCHEMICAL AND SOME HORMONE OF LOCAL IRAQI BLACK FEMALE GOATS

Author: Abd-Alkareem A. Babe * , Waleed Y. Kasim , Murtada F. AL-Hellou
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2015 Volume: 14 Issue: 1 Pages: 52-61
Publisher: Basrah University جامعة البصرة

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Abstract

This study was conducted at animal farm / Collage of Agriculture, Basrah University, during the period from April to December . A total of 8 blood samples were taken from dry female goats at (2.5-3.5) years old during first day of April , July , October , December months .The aim of this study to evaluate the effect months of year on blood (WBC , RBC, PCV and Hb) and biochemical parameters (Fe , Phosphate, Albumin, Total protein, Cholesterol and Glucose in addition to some hormones like Estrogen and thyroxin. The present study resulted that there were significant (P<0.05) increase in blood red cell count , total white blood cell number , andmonocytes percentage in summer compared with spring and winter . Hemoglobin concentration and PCV percentage were significantly (P<0.05) increased in summer compared with other seasons. Iron concentration was highly significantly (P<0.05) increased in summer and autumn in comparisonwith other seasons. The results also showed that there were significant (P<0.05) increase in Estrogen and decrease in thyroxin hormone concentration in summer compared with other seasons.

Keywords

Goat --- haemoglobin --- WBC.


Article
The Role of White Blood Cells inAcute Coronary Syndrome

Author: Hilal B. Shawki )
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2007 Volume: 49 Issue: 4 Pages: 362-368
Publisher: Baghdad University جامعة بغداد

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Abstract

Background:
Inflammation has been shown to play a role in atherosclerosis and acute coronary
syndromes. An elevated total WBC count has been associated with increased cardiovascular
risk, but which leukocyte subtypes carry this risk. is uncertain. This study was designed to
determine the effect of WBC count and other inflammatory markers on severity and
outcome of patients with UA/NSTEMI.
Patients and Methods:
Seventy (70) patients with UA / NSTEMI admitted to CCU at the Iraqi Center for Heart
Diseases were subjected to thorough history and physical examination and WBC indices to
find their relation to clinical severity and outcome for both in-hospital and/month after
discharge. The results were compared with other thirty (30) patients with chronic stable
angina and thirty (30) healthy persons as two control groups.
Fac Med Baghdad
2007; Vol.49, No.4
Received Sept. 2006
Accepted Oct .2007
Results:
High total baseline total WBC was more prevalent in patient with UA/NSTEMI than in
those with stable angina and normal persons (94.1%, 5.9%. and 0%) respectively. High
baseline neutrophil was found only in those with UA./NSTEMI (100%, 0%, and 0%). High
baseline Neutrophil/lymphocyte (N/L ratio) and Positive CRP were more prevalent in
patients with UA/NSTEMI than in other two groups (92.3%. 7.7%. 0%) and (98.5%, 1 .5%.
0%) respectively.
Higher total baseline WBC count was significantly found in more severe Braunwald's
class of those with UA/NSTEMI 6.3%. 31.3%. and 50.5% for patients with class I, II, III
respectively. The same was true for baseline high neutrophil count (6.7%. 33.3% to 60%),
high Baseline N/L ratio (7.7%, 15%. and 21.6%).
Patient in the UA/NSTEMI group with higher baseline WBC count had higher risk for
death as compared to those of low and intermediate WBC count (0.00%. 0.00%. and
100.00%). The same was true for those with higher baseline neutrophil count (0.00%.
1.90%, 20.00%) and those with higher baseline N/L ratio (0.00%. 25.000%. 75.000%)
respectively.
Conclusions:
Total baseline WBC and differential count is simple, cheap and widely available
bedside test that predicted the severity of CAD and one month survival.

Keywords

WBC count --- differential count --- CRP --- UA/NSTEMI


Article
Intelligent Classifier for WBC Physiology Assignment Based on Active Contour Model

Author: Sammar Jaafar Ismail
Journal: Engineering and Technology Journal مجلة الهندسة والتكنولوجيا ISSN: 16816900 24120758 Year: 2011 Volume: 29 Issue: 10 Pages: 1979-1990
Publisher: University of Technology الجامعة التكنولوجية

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Abstract

White blood cell (WBC) plays an important role insidehuman body, because it is acting as the body defense mechanismagainst infection and cellular injury. Segmentation in biomedicalimaging often the starting point for other process. In this paper anIntelligent classifier has been used to classify the normal andabnormal WBC, this model built using MATLAB 7 package. Theoutput from active contour model (ACM) will be the input to theintelligent classifier . The accuracy of classification is about 90%according to American Heart Association (AHA) to evaluateprocedures for diagnose in biomedical applications. The approachprovide a robust and accurate results.


Article
ASSESSMENT OF COMPLETE BLOOD COUNT IN PATIENTS WITH CORONARY ARTERY DISEASE

Author: Qais A. AL-Oqaily قيس عامر عبد الامير العكيلي
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2014 Volume: 12 Issue: 1 Pages: 82-87
Publisher: Al-Nahrain University جامعة النهرين

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Abstract

Background:Several studies have demonstrated the role of hematological parameters like hemoglobin (Hb), white blood cells (WBC) count and platelet count in the assessment of patients with coronary artery disease; some studies suggest an additional role of platelet indices in the prognosis of patients with coronary artery disease.Objective:To assess complete blood count and platelet indices in patients with coronary artery disease.Methods:Blood sample of 42 newly diagnosed ischemic heart disease patients including 20 patients with myocardial infarction (MI) and 22 patients with unstable angina were studied. The control group included 15 individuals with no history of heart disease and a normal electrocardiogram. Clinical and laboratory information regarding age, sex, packed cell volume, WBC count, platelets count, platelet distribution width and platelet volume were obtained.Results:The frequency of diabetes and smoking was higher in patients with coronary heart disease in comparison to the control group (P < 0.05), while the frequency of hypertension was not significntly different. Significant difference in WBC count and Hb level of patients with coronary heart disease (P < 0.05), while no significant difference in the platelet count, platelet distribution width and mean platelet volume was found. In patients with unstable angina there was a significant difference in the Hb level (P < 0.05) while no significant difference in WBC count, platelet count, platelet distribution width and mean platelet volume was observed. In patients with myocardial infarction, there was a significant difference in the Hb level and the WBC count (P < 0.05), whereas no significant difference in platelet count, platelet distribution width and mean platelet volume was found.Conclusion:Hemoglobin level was significantly lower in patients with coronary artery disease while the mean level of WBC count was significantly higher than that of the control group. There was no significant difference in platelet count and platelet indices between those two groups. In patients with unstable angina the WBC count was not statistically different from that of the control group.Key words:Coronary artery disease, Hb, WBC, PDW, MPV.

Keywords

Coronary artery disease --- Hb --- WBC --- PDW --- MPV.


Article
The efficacy of C-reactive protein, white blood cell count and neutrophil percentage in the diagnosis of acute appendicitis in Kirkuk city

Authors: Hassan Y. Hassan --- Nada Y. Awwad --- Waleed A. Mares
Journal: The Medical Journal of Tikrit University المجلة الطبية لجامعة تكريت ISSN: 18131638 Year: 2019 Volume: 25 Issue: 2 Pages: 40-49
Publisher: Tikrit University جامعة تكريت

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Abstract

ABSTRACTBackground: One of the commonest emergencies in surgical practice (pediatric and generalsurgery) is acute appendicitis which is associated with acute phase reaction. Diagnosis ofacute appendicitis is still a challenging issue for surgeons because lifetime risk of acuteappendicitis is high (in some series reach 8%), rate of negative exploration is also high (insome series reach 35%) and complications of acute appendicitis (mainly perforation ofappendix) are still high, especially in developing countries (in some series reach 62%).Several modalities have been used for diagnosis of acute appendicitis which include scoringsystems (e.g. Alvarado scoring system), imaging techniques (ultrasound and computerizedtomography), and laboratory investigations (white blood cell count, neutrophil percentage,C-reactive protein and some other serological markers) in order to improve diagnosis,reduce negative exploration rate and reduce complications rate. The aim of study is toevaluate efficacy of (CRP, WBC count and neutrophil percentage) in diagnosis of acuteappendicitis. Patients and methods: The study was conducted at the beginning of Januaryto the end of August 2018. Thirty male patients, whose age between 10-40 years andadmitted to emergency department of Kirkuk general hospital and diagnosed clinically asacute appendicitis by same surgeon, were studied. In emergency department, white bloodcell count (WBC) and neutrophil percentage (NP) are estimated by same automated analyzerin same laboratory (as part of complete blood count estimation). C- reactive protein (CRP)was estimated qualitatively by latex agglutination technique in same laboratory.Appendicectomy was done by same surgeon and decision was done regarding whetherappendix was inflamed or not macroscopically (by same surgeon) and microscopically (byhistopathological examination by same histopathologist). Chai-squared test was used tocompare between means of variables. Results: There were significant relations betweenonset of symptoms and results of CRP results, onset of symptoms and end diagnosis, andWBC count and end diagnosis. All other relations were non-significant. Conclusions:Diagnosis of acute appendicitis remains a challenging issue in clinical practice. Frequentclinical examination remains the best method for accurate diagnosis of acute appendicitis.Laboratory investigations can be used as an adjuvant in diagnosis of acute appendicitis..


Article
The impact of industrialization using egg sacks thermally weakened on chicken meat infected experimentally resistant parasite Eimeria tenella
اثر التمنيع بأستخدام اكياس بيض مضعفة حراريا على مقاومة دجاج اللحم المصاب تجريبيا بطفيلي Eimeria tenella

Authors: Sukaina J. سكينة جبار مشتت --- Haitham M. هيثم محمد حمادي --- Hadi R. هادي رسول حسن
Journal: Al-Kufa University Journal for Biology مجلة جامعة الكوفة لعلوم الحياة ISSN: 20738854 23116544 Year: 2016 Volume: 8 Issue: 1 Pages: 340-349
Publisher: University of Kufa جامعة الكوفة

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Abstract

This experiment was designed to see changes to occur on the blood of infected chicks experimental measurements of parasite E. tenella which prevented against infection using bags debilitating parasite eggs Hrraria..astkhaddmt In this experiment, 60 chick cup type KOP is Mjnsh day-old, were randomly divided into three groups in each group of 20 chick, first set a negative control were given ration normal and without the introduction of injury, the second group control is positive given ration normal with the introduction of a pilot injured after the age of 20 days, the third chick was given a normal diet with immunized using 300 eggs bag devitalized thermally oral was the development of the experimental infection where after immunization a week after the age of 20 days, serum samples were collected before and after the injury was conducted physiological tests and biochemical them .ohart results to improve blood measurements in general after the introduction of injury significance level (p <0.5) in the immunized group compared with measurements the positive control group as it recorded a rise in the proportion of RBC, WBC, PCV, H / L., and a highly significant decrease (p <0.5) in the number of bags immunized eggs raised group compared with the control group positive after infection. High moral high (P <0.05) in the level of biochemical blood and the level of total protein, cholesterol level for the group immunized compared with the positive control qualities. High moral decline (P <0.05) in the level of calcium in the positive control group compared with the immunized group.

صممت هذه التجربة لمعرفة التغيرات الي تطرأ على قياسات دم الافراخ المصابة تجريبيا بطفيلي E. tenella والتي منعت ضد الأصابة بأستخدام اكياس بيض الطفيلي المضعفة حراريا..استخدمت في هذه التجربة 60 فرخ نوع كوب KOP غير مجنسة بعمر يوم واحد ،قسمت عشوائيا الى ثلاثة مجاميع في كل مجموعة 20 فرخ ،المجموعة الاولى سيطرة سالبة اعطيت عليقة عادية وبدون استحداث اصابة ،المجموعة الثانية سيطرة موجبة اعطيت عليقة عادية مع استحداث اصابة تجريبية بعد عمر 20 يوم ،المجموعة الثالثة فرخ أعطيت عليقة عادية مع تمنيعها باستخدام 300 كيس بيض مضعف حراريا عن طريق الفم وتم استحداث الاصابة التجريبية فيها بعد التمنيع باسبوع أي بعد عمر 20 يوم ،جمعت عينات المصل قبل وبعد الأصابة وتم اجراء الفحوصات الفسلجية والكيموحياتية عليها .أشارت النتائج الى تحسن قياسات الدم بصورة عامة بعد استحداث الأصابة بمستوى معنوية (p<0.5) في المجموعة الممنعة مقارنة مع قياسات مجموعة السيطرة الموجبة حيث سجل ارتفاع في نسبة RBC,WBC,PCV,H/L.و انخفاض عالي المعنوية (p<0.5) في المجموعة الممنعة بعدد اكياس البيض المطروحة مقارنة مع مجموعة السيطرة الموجبة بعد الأصابة . ارتفاع عالي المعنوي (P<0.05) في مستوى الصفات الكيموحيوية للدم والمتمثلة بمستوى البروتين الكلي ومستوى الكولسترول للمجموعة الممنعة مقارنة مع السيطرة الموجبة . انخفاض عالي المعنوي (P<0.05) في مستوى الكالسيوم في مجموعة السيطرة الموجبة مقارنة مع المجموعة الممنعة .

Keywords

E. tenella KOP RBC --- WBC --- PCV --- H/L --- E. tenella KOP RBC --- WBC --- PCV --- H/L


Article
Effect Of Arginine On The Some Blood And Biochemical Parameters For Local Goat Females.
تأثير الآرجنين في بعض الصفات الدمية والكيماحيوية لإناث الماعز المحلية

Authors: ثائر رشيد محمد --- T.R. Mohammed ثائر رشيد محمد --- A.T. Ahmed* احمد تحسين علي
Journal: Al-Anbar Journal of Veterinary Sciences مجلة الانبار للعلوم البيطرية ISSN: 19996527/27070603 Year: 2019 Volume: 12 Issue: 1 Pages: 24-36
Publisher: University of Fallujah جامعة الفلوجة

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Abstract

This study was conducted in one of the private sector fields in Anbar province - Hit city Albasaer village (70 km west of the Ramadi city,), for the period from 28/6/2018 to 1/9/2018.Twenty one local female goats aged between 2-4 years and weighing between 24.5 to 36.5 kgwere used, Which have previous one birth or more. All female goats were tested usingultrasound to make sure they were not pregnant before the experiment began. Females wererandomly divided into three equal groups (7 goats in each group).Vaginal sponges (60 mgMAP) were injected into the three groups at the same time. The first group T1 was injectedintramuscularly with the amino acid, arginine (US Nevada manufacturing) in the muscles at200μmol.kg Five days before the sponge was pulled out until the 17 day after the sponge waspulled out, While the second group T2 was injected with amino acid (arginine) at 160 μmol.kg.Five days before the sponge was pulled until the 17th day after that. The third group T3 controlgroup was injected with 5 ml Normal Saline intramuscularly of the animal. All animals wereinjected three times daily from the eighth day after the sponge was placed (five days beforeremoving of the sponge) until 17 days after the removing of sponge. Where the total number ofinjection days was 22 days. Blood samples were taken from the jugular vein before injection ofthe arginine on day 7 and day 12 of the sponge placed either after the sponge pulled the bloodsamples were taken on the days 2, 3, 4, 6, 9, 13, 18, respectively of the experiment Aftersponges removing. The objective of the study was to measure changes in the blood,biochemical parameters, during arginine treatment. The results of this study showedasignificant differences. T1 and T2 group were superior compared to control group in bloodproperties which include pcv in periods 2, 5, the number of white blood cells in periods 2, 3, 4,5, 6, 9, MID in periods 3, 9 and Lymphocytes in aperiods 4, 5, 6, 9, While the neutrophil cellsthe period of 3. In terms of biochemical properties, the results showed asignificant differences,between the treatments of T1 and T2 were superior compared to control treatments in the totalprotein concentration in period 6, and the globulin in period 6. We conclude that the use ofdifferent doses of arginine can improve the health status of female goats.

أجريت هذه الدراسة في احد حقول القطاع الخاص في مدينة هيت- قرية بصائر(غرب مدينة هيت) التابعة لمحافظة الأنبار 70 كم غرب مدينة الرمادي, العراق, للفترة من 28/6/2018 ولغاية 1/9/2018. استخدمت 21 أنثى ماعز محلية بعمر تراوح بين 2-4 سنوات وذات وزن يتراوح بين 24,5-36,5 كغم, وذات ولادة واحدة على الأقل فحصت جميع إناث الماعز باستخدام جهاز الموجات فوت الصوتية (السونار) للتأكد من خلوها من الحمل قبل بداية التجربة. قسمت الإناث عشوائيا الى ثلاث مجاميع متساوية (7 معزات في كل مجموعة) تم دفع الاسفنجات المهبلية ( 60 ملغم MAP تصنيع الارجنتين) للمجاميع الثلاثة في نفس الوقت, المجموعة الأولى T1 تم حقن اناث المجموعة بالحامض الاميني الآرجنين (تصنيع شركة Nevada الامريكية) في العضل بمقدار 200 kg/μmol قبل خمسة ايام من سحب الاسفنجات ولغاية يوم 17 من سحب الاسفنجة. اما المجموعة الثانية T2 تم حقن اناث المجموعة بالحامض الأميني الآرجنين في العضل بمقدار 160 kg/μmol. قبل خمسة ايام من سحب الاسفنجات ولغاية يوم 17 من سحب الاسفنجة. اما المجموعة الثالثة T3 معاملة السيطرة تم حقنها بمحلول الملح الفسلجي بمقدار 5 مل (Normal Salin) في عضل الحيوان. تم حقن جميع الحيوانات بواقع ثلاث مرات يوميا من اليوم الثامن بعد دفع الاسفنجة ( قبل خمسة من سحب الاسفنجة) ولغاية يوم 17 بعد سحب الاسفنجة حيث يكون مجموع ايام الحقن الكلي 22 يوم. تم سحب عينات الدم من الوريد الوداجي في اناث التجربة قبل حقن الآرجنين في اليوم 7 واليوم 12 من دفع الاسفنجة اما بعد سحب الاسفنجة سحب الدم في الايام 2, 3, 4, 6, 9, 13, 18 على التوالي من التجربة بعد الازالة. كان الهدف من هذا لقياس التغيرات في الصفات الدمية والكيماحيوية ومجموعة الدهون اثناء المعاملة بالآرجنين. اذ اظهرت نتائج الدراسة وجود فروق معنوية اذ تفوقت T1 و T2 على السيطرة في الصفات الدمية التي شملت كل من حجم الخلايا المرصوصة في الفترات 2, 5, واعداد كريات الدم البيضاء في الفترات 2, 3, 4, 5, 6, 9. و (MID) في الفترات 3, 9. والخلايا اللمفاوية (Lymphocytes) في الفترات 4, 5, 6, 9. اما الخلايا العدلة (Neutrophil) في الفترة 3. وفيما يخص الصفات الكيماحيوية اظهرت النتائج فروق معنوية اذ تفوقت T1 و T2 على السيطرة في تركيز البروتين الكلي في الفترة 6, والكلوبيولين في الفترة 6. نستنتج من الدراسة الحالية ان استعمال جرع مختلفة من الارجنين قد حسنت الحالة الصحية لإناث الماعز.


Article
Effect of High Dose Injection of Methyl Prednisolone Acetate on some Physiological Parameters in Female Rats.
تأثير حقنِ الجرعةِ العاليةِ لميثيلِ Prednisolone ملح حامض الخليك على بَعْض البارامتراتِ الفسلجيةِ في الجرذانِ النسائيةِ.

Author: Jinan Abdul. K Hilal
Journal: Journal of Basrah Researches (Sciences) مجلة ابحاث البصرة ( العلميات) ISSN: 18172695 Year: 2012 Volume: 38 Issue: 3A Pages: 73-77
Publisher: Basrah University جامعة البصرة

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Abstract

This study was conduct on 20 healthy female rats. Ten rats were injected intramuscularly with highly single dose (30mg /kg B.W) of methyl prednisolone acetate (MPA) daily for 60 days. While the other ten injected intramuscularly with normal saline (1ml/kg B.W) and considered as a control. Blood samples were collected from treated and control rats as well. Results revealed that there was significant (p<0.05) decrease in, total serum protein , lymphocytic count ,esinophilic and basophilic counts . There were significant (p< 0.05) increase in estrogen, progesterone, tri-iodthyronine(T3) , thyroxine(T4) hormones , total serum cholesterol , triglyceride ,total WBC count, neutrophilic and monocytiz counts .

هذه الدراسةِ كَانتْ تصرّفاً في 20 جرذِ نسائيِ صحّيِ. عشَر جرذانِ حُقِنتْ intramuscularly بالجرعةِ الوحيدةِ جداً (30 mg / كيلوغرام بي. دبليو) مِنْ ميثيلِ prednisolone ملح حامض الخليك (MPA) صحيفة يومية ل60 يومِ. بينما الآخر العشَر intramuscularly المَحْقُون بالملحِ الطبيعيِ (مليلتر 1 / كيلوغرام B.W) وإعتبرَ كa سيطرة. عينات الدمّ جُمِعتْ مِنْ مُعَالَجةِ جرذانِ سيطرةِ أيضاً. كَشفتْ النَتائِجُ تلك كان هناك هامّةُ (p <0.05) نقصان في، بروتين مصلِ كليِّ، خلايا لمفية تَحْسبُ ,esinophilic وتهم قاعدية. كان هناك هامّ (p <0.05) زيادة في estrogen، بروجسترون، iodthyronine ثلاثي T3) , thyroxine (T4) هورمونات، كولوستيرول مصلِ كليِّ , triglyceride، يُجملُ عد WBC , neutrophilic وتهم عداد monocytiz.

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