research centers


Search results: Found 4

Listing 1 - 4 of 4
Sort by

Article
Study of some Cardiac Biomarkers and Oxidative Stress markers in Patients with Acute coronary syndromes

Authors: Kismat M .Turki --- Ala’a G. Hussein --- Mohammed O. Hamzah
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1102-1108
Publisher: Kerbala University جامعة كربلاء

Loading...
Loading...
Abstract

background: Acute Coronary Syndromes (ACS) represents a pathological, diagnostic, and risk continuum from unstable angina through myocardial infarction (MI) with or without ST-segment elevation. These three conditions share a very similar pathology, although treatment differs. Elevated markers of inflammation, in particular hs-CRP, are associated with an increased risk of future cardiovascular events in healthy subjects, Increased oxidative stress and the generation of the free oxygen radicals can result in modification of LDL to oxidized LDL that could lead to atherosclerotic lesions, Elevated levels of CK-MB have been regarded as biochemical markers of myocyte necrosis.Objective: The aim of this study was to investigate the predictive value of CK-MB and oxidative stress (MDA) in acute coronary syndromes.Patients and Methods: One hundred one (101) cardiac patients were admitted to the coronary care unit, Ibn alnafees Hospital and Al kindy Hospital over the period July 2009 and March 2010 with the clinical diagnosis of acute coronary syndrome their ages range was (24-84) years, the number of male was (65) (64.36%) and female was (37) (36.63%).39 healthy control (age, sex, matched) were enrolled in this study. All cardiac patients have routine ECG, cardiac biomarkers measurements especially(CK-MB), serelogical markers (hs-C-RP),lipid profile test and oxidative stress markers(MDA).10 ml of blood needed for assessment of the above makers.Results: Oxidative Stress and Cardiac Biomarkers in Patients with Acute Coronary Syndromes (ACS) 101 were found significantly high in patients with ACS as compared to healthy subjects but significantly decreased in HDL-cholesterol in ACS patients as compared to healthy controls. ACS is associated with greater than normal lipid peroxidation.Conclusion: Our study shows a significantly increase in lipid peroxidation and cardiac biomarkers in the circulation of patients with ACS. A significant decrease level of HDL-C were observes only in ACS patients. These finding suggest these biomarkers may be useful diagnosis of patients with ACS.


Article
CLINICAL CHARACTERISTICS AND OUTCOMES OF ACUTE CORONARY SYNDROMES IN A GROUP OF IRAQI PATIENTS

Author: Moayed B. Hamid مؤيد بشير حامد
Journal: IRAQI JOURNAL OF MEDICAL SCIENCES المجلة العراقية للعلوم الطبية ISSN: P16816579,E22244719 Year: 2016 Volume: 14 Issue: 4 Pages: 304-311
Publisher: Al-Nahrain University جامعة النهرين

Loading...
Loading...
Abstract

Background:Coronary artery disease (CAD) is one of the most common diseases in the world. Acute coronary syndromes (ACS) represent the acute life-threatening phase of CAD. Epidemiology and management of ACS patients differ a lot between countries and there is a wide gap between guidelines and clinical practice. Objective:To assess contemporary data on clinical characteristics and outcomes of patients with ACS in the Medical City Complex and to evaluate adherence to the guidelines’ recommended treatment.Methods:This is a descriptive study registry, started on January 2014 to June 2014, and involved 348 patients with ACS in the Medical City Complex.Results:The mean age of this study's population was (60.3±11.2 years), ranging between 29 to 90 years old. Most of patients were males (61%). Only 233 (67%) patients have typical angina. Symptom onset-to-admission time was delayed (≥ 12 hours) in 65% of patients. The final diagnosis was: ST elevation myocardial infarction (STEMI) in 126 (36.2%), non ST elevation myocardial infarction (NSTEMI) in 40 (11.4%), and unstable angina (UA) in 182 (52.3%) of patients. Electrocardiography was normal in 29% of patients with UA and 10% of patients with NSTEMI. Anterior territory was the most common location of ischemia (77%). Hypertension (47.9%) was the most significant risk factor followed by diabetes mellitus (41.6%) and smoking (31.8%). Reperfusion therapy for patients with STEMI was applied in 73(57%) patients: 56 (44.4%) by thrombolytic therapy, 24 (19%) by percutaneous coronary intervention (PCI) and 3 (2.3%) by emergency CABG. Overall in-hospital mortality was 7.7% (15%, 7.5% and 2.7% for STEMI, NSTEMI, and UA respectively).Conclusion:There is lack of awareness of ischemic symptoms among our patients. There is high incidence of risk factors that can be modified by primary and secondary measures. There is underutilization of invasive management. We have a high mortality rates in patients with ACS.Keywords:Acute coronary syndromes, registry, in-hospital outcome


Article
Interleukin-8 and Interleukin-10 in Patients with Ischemic Heart Disease

Authors: Muayad Khalid Abdulkareem --- Aida R. Al.derzi --- Basil N. Saeed
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: supplement Pages: 650-658
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

Loading...
Loading...
Abstract

ABSTRACT:BACKGROUND: Ischemic heart disease is the main cause of death throughout the world. Cytokines are key regulatory glycoproteins . They are intimately associated with atherogenesis and modulate plaque morphology and stabilization. OBJECTIVE: To study the role of pro-inflammatory Interleukin-8 , and anti-inflammatory interleukin-10 in patients with Acute coronary syndromes (ACS)(acute myocardial infarction and unstable angina).METHODS: This study included (55) patients with acute coronary syndrome, (30) patients with acute Myocardial infarction ( 24 males and 6 female) and 25 patients with unstable Angina (11 males and 14 females). This project has been carried out on patients at the coronary care unit (CCU) of Baghdad teaching hospital/ Medical City/ Baghdad, during the period from April to June 2010. A twenty five, apparently healthy individuals were taken as a healthy control group. Venous blood sample was taken from each subject. Levels of interleukin-8 and Interleukin-10 were estimated by using enzyme linked immunosorbant assay . {ELISA-kit for detection of IL-8 (BioSource Europe S.A. /catalogue number; KAP1301)} and {ELISA-kit for detection of IL-10 (BioSource Europe S.A./ catalogue number; KAP1321)} RESULTS: Plasma level of pro-inflammatory cytokine (interleukin-8) showed a significant elevation in patients with acute myocardial infarction (Mean ± SD =95.26 pg/ml ± 102.89 ;P value=0.004) and unstable angina (Mean ± SD =146.43 pg/ml ± 154.45 ;P value=0.019) in comparison to control group (Mean ± SD =47.75 pg/ml ± 36.67). Serum level of anti-inflammatory cytokine (interleukin-10) showed a significant decrease in unstable angina patients (Mean ± SD =16.95 pg/ml ± 11.92 ;P value=0.012) in comparison to control group (Mean ± SD =30.29 pg/ml ± 21.17),however, it showed no significant differences among acute myocardial infarction patients (Mean ± SD =27.73 pg/ml ± 23.16 ;P value=0.500) in comparison to control group. The ratio of pro-/anti-inflammatory cytokines (interleukin-8 / interleukin-10) was significantly elevated in acute coronary syndrome; acute myocardial infarction and unstable angina patients (P=0.001, P=0.019, P=0.001 respectively) .CONCLUSION: Interleukin-8 is an important pro-inflammatory cytokine in coronary artery disease which may contribute to the plaque destabilization in acute coronary syndrome especially unstable angina, and low level of anti-inflammatory interleukin-10 which is considers as a risk factor of development of acute events in unstable angina


Article
The association between Oxidized low - density lipoprotein and high sensitivity C reactive protein in acute coronary syndromes patients

Author: Abbas Mosad Ajeed عباس موسى اجياد
Journal: AL-yarmouk Journall مجلة كلية اليرموك الجامعة ISSN: 20752954 Year: 2016 Volume: 8 Issue: 1 Pages: 157-166
Publisher: College Yarmouk University كلية اليرموك الجامعة

Loading...
Loading...
Abstract

Background: Acute Coronary Syndromes (ACS) represents a pathological, diagnostic, and risk continuum from unstable angina through myocardial infarction (MI) with or without ST-segment elevation. These three conditions share a very similar pathology, although treatment differs. Elevated markers of inflammation, in particular CRP, are associated with an increased risk of future cardiovascular events in healthy subjects, Increased oxidative stress and the generation of the free oxygen radicals can result in modification of LDL to oxidized LDL that could lead to atherosclerotic. Increased blood levels of oxidized low density lipoprotein (ox-LDL) could play a role in these circumstances. Objective: The aim of this study was To measure circulating levels of oxidized-low-density lipoproteins (ox-LDL) in patients with AMI (Q-MI &Non-Q-MI), unstable angina and controls, and to investigate their correlation with hs-CRP in acute coronary syndromes. Patients and Methods: Ninty (90) cardiac patients were admitted to the coronary care unit, Ibn alnafees Hospital and Al kindy Hospital over the period July 2013 and March 2014 with the clinical diagnosis of acute coronary syndrome their ages range was (25-84) years, healthy control (age,sex,matched) were enrolled in this study. All cardiac patients have routine ECG,cardiac biomarkers measurements especially Troponine I, (CK-MB),serelogical markers (hs-C-RP) and Ox-LDL.10 ml of blood needed for assessment of the above makers. Results: : Ox-LDL and hs-CRP in Patients with Acute Coronary Syndromes (ACS) 90 were found significantly high in patients with ACS as compared to healthy subjects, and also a significant positive correlation was observed between Ox-LDL & hs-CRP in Q-MI but positive related in UA & Non-Q-MI . Conclusion: OxLDLand hs-CRP levels are higher in ACS patients, and a significant positive correlation was observed between Ox-LDL & hs-CRP in Q-MI,Ox-LDL and hs-CRP might be markers of destabilization of ACS .

الخلفية: المتلازمات التاجية الحادة للقلب (ACS) تمثل سلسلة خطر مرضي تشخيصي متصل من الذبحة الصدرية غير المستقرة من خلال احتشاء عضلة القلب (MI) مع أو بدون ارتفاعT شريحةST-. وتشترك تلك الحالات الثلاثة بنفش الصورة المرضية برغم اختلاف العلاج. المؤشرلت الالتهابية المرتفعة , ولا سيما بروتين سي التفاعلي, ترتبط مع زيادة خطر الحوادث القلبية الوعائية في المستقبل في الاصحاء. زيادة الاكسدة وتوليد الجذور الحرة للأكسجين يمكن أن يؤدي إلى تحول LDL إلى LDL المؤكسد التي يمكن أن تؤدي إلى تصلب الشرايين. زيادة مستويات الدم من البروتين الدهني منخفض الكثافة المؤكسد(oxLDL) يمكن أن تلعب دورا في هذه الظروفالهدف: الهدف من هذه الدراسة قياس مستويات الدم للبروتينات الدهنية المتاكسدة منخفض الكثافة (ox-LDL) في المرضى الذين يعانون من احتشاء القلب (AMI (Q-MI وبدون( Q-MI)، والذبحة الصدرية غير المستقرة والضوابط، والتحقيق في العلاقة مع hs- CRP في متلازمة الشريان التاجي الحادة.المرضى والطرق: احبل تسعون (90) من مرضى القلب إلى وحدة العناية التاجية في ابن النفيس ومستشفى الكندي خلال الفترة من يوليو عام 2013 ومارس 2014 بعد التشخيص السريري لمتلازمة الشريان التاجي الحادة كانت اعمارهم تتراوح بين (25-84) سنة، و ضوابط صحية متطابقين (العمر، الجنس) التحق في هذه الدراسة. جميع مرضى القلب لديهم تخطيط القلب، المؤشرات الحيوية للقياسات القلبية خصوصا Troponine -I ، (CK-MB)، وقياسات مصلية (HS-C-RP و LDL-ox . 10مل من الدم تطلب لتقييم القياسات أعلاه.النتائج: كل من ox-LDL و HS-CRP في المرضى الذين يعانون من متلازمات التاجية الحادة (ACS) تم العثور على 90 ارتفاع كبير في المرضى الذين يعانون من ACS بالمقارنة مع الاشخاص الاصحاء، وكذلك هناك علاقة ايجابية ذات قيمة احصائية لوحظت بين البروتينات الدهنية المتاكسدة منخفض الكثافة (ox-LDL) و البروتين سي التفاعلي عالي الحساسية في مرضى احتشاء القلب (Q- MI)لكن علاقة ايجابية فقط في الذبحة الغير مستقرة و احتشاء القلب بدون Q- Segmentالاستنتاج: مستويات LDL-ox and HS-CRP أعلى في المرضى ACS، ولوحظ وجود علاقة إيجابية ذات دلالة إحصائية بين LDL-ox و HS-CRP في Q-MI، ox-LDL و HS-CRP قد تكون علامات لزعزعة استقرار ACS.

Listing 1 - 4 of 4
Sort by
Narrow your search

Resource type

article (4)


Language

English (3)

Arabic and English (1)


Year
From To Submit

2016 (2)

2013 (1)

2011 (1)