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Assessment of Myeloperoxidase enzyme activity and high sensitivity C-reactive protein as an Inflammatory markers in Ischemic Heart Disease: A prospective & Follow up Study

Authors: Thabit Nouman --- Abd Al-'Hameed Al-Queseer --- Sarah Isam Attallah
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2015 Volume: 28 Issue: 2 Pages: 94-100
Publisher: Al-Mustansyriah University الجامعة المستنصرية


Background: The diagnostic work-up of patients with ischemic heart disease in the cardiac care unit (CCU) is a challenging task. So taken together, high sensitivity C-reactive protein and Myeloperoxidase enzyme activity may be complementary and explore different fields: hs-CRP is a marker of disease activity and vascular inflammation, and is useful for long-term risk stratification while MPO is a marker of plaque instability and neutrophil activation and may be associated with short-term stratification, in particular in patients with troponin negative levels.Objective: To evaluate the activity of myeloperoxidase enzyme and hs-CRP in ischemic heart disease patients in the routine setting of CCU, its value after treatment, and it's interaction with the other inflammatory biomarker hs-CRP.Patients and Methods: Ten patients with angina pectoris and twenty eight patients with acute myocardial infarction recruited from Diayla Teaching Hospital. Demographic data, anthropometric measurement and blood samples were obtained from patients for determination of myeloperoxidase enzyme activity, and high sensitivity C-reactive protein.Results: The results showed that Serum myeloperoxidase enzyme activity on admission was higher than corresponding value after treatment in AMI (62.5±44.6vs 42.0 ±44.5µU/ml).hs-C-reactive protein level is significantly high in all patients, in these with Angina pectoris have significantly higher than corresponding patients with acute myocardial infarction which amounted 19.1±2.5 µU/ml).Conclusion: The activity of myeloperoxidase enzyme is partly enhanced by treatment and there are independent interrelationships between inflammatory biomarkers hs-CRP and MPO.

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