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Article
Bacteriological and immunological study of aggressive periodontitis in Mosul

Authors: Alaa M. Altaei --- Mahmoud Y.M. Taha
Journal: Al-Rafidain Dental Journal مجلة الرافدين لطب الأسنان ISSN: 18121217 Year: 2011 Volume: 11 Issue: 3 Pages: 207-214
Publisher: Mosul University جامعة الموصل

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Abstract

Aims of the study: to isolate and identify microorganisms causing aggressive periodontitis, and to estimate the changes in the levels of IL-1, TNF- and CRP in serum as well as to determine peroxidase activity in saliva of patients with aggressive periodontitis. Materials and Methods: This study was carried out on total number of 40 (35 patients with aggressive periodontitis, 18 females and 17 males aged between 16-35 years and 5 control group between 20-30 years old). Samples were taken from the lesion for bacteriological study. Serum and saliva were collected and ELISA test was performed. Results: The bacteriological results showed that A. actinomycetemcomitans was the most prevalent bacteria in aggressive periodontitis, followed by facultative anaerobic. The serological and biochemical studies showed that interleukin-1 was significantly elevated in the study group while tumor necrosis factor was not, whereas peroxidase enzyme activity and C-reactive protein were also highly significant elevated in the study group. Conclusion: Actinobacillus actinomycetemcomitans was the major etiologic bacteria of this disease as well as significantly high levels of, CRP, peroxidase activity and IL-1 could be regarded as strong markers for more precise understanding the immunological aspect of this disease


Article
PROPOSAL OF INTRAORAL PATTERN OF DISTRIBUTION OF THE GENERALIZED AGGRESSIVE PERIODONTITIS

Author: Abdul Latif Al-Juboury
Journal: AL-TAQANI مجلة التقني ISSN: 1818653X Year: 2006 Volume: 19 Issue: 1 Pages: 33-39
Publisher: Foundation of technical education هيئة التعليم التقني

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Abstract

The generalized aggressive periodontitis is synonymous to the localized form . Each may have unique entity which is often confusable . So the aim of this study is to draw an intraoral pattern of disease distribution depending upon the gingival bleeding index , radiologic bone loss , pocket depth and the clinical tooth mobility . Thirty two GAP patient were examined clinically and radiologically , 19 female constituted 59.375% , their average age was 22.45±0.981 . Male constituted 40.625% (13 patients) , their average age was 25.313±0.89 . A significant difference only in their number was obtained (P<0.05 T and test) .The total present teeth were 891 , teeth involved with 80% and more of bone loss was 523 , constituted 58.698% with significant difference . The mobile teeth were 387 constitute 74.28% with significant difference the GBI score showed two forms , high score (2.089±0.88) and low score (0.89±0.13) with significant difference. The result shows that the clinical parameters are consistent and symmetrical on both arches. The disease could take certain order in its distribution making intra oral pattern realizable .

التهاب اللثة العدواني والعام متشابه مع مثيله المحدود ، كل منهما يحمل مواصفات خاصة له والتي هي غالباً مربكة ومتداخلة ، ولذا كان الهدف من هذه الدراسة وضع صورة من طريقة توزيع التهاب اللثة العدواني العام في داخل الفم اعتماداً على مقياس درجة نزف اللثة وعمق حبوب اللثة وكمية عظم الفك المفقودة جراء الالتهاب وعدد الاسنان المتحركة جراء فقدان العظم الساند . اثنان وثلاثون مريضاً تم تشخيصهم شعاعياً وسريراً كونهم يحملون مرض التهاب اللثة العدواني العام ، 19 أنثى نسبتهم 59.375% ومعدل اعمارهم 22.45±0.981 مع 13 ذكراً نسبتهم 40.625 ومعدل 25.313 ± 0.89 .مجموع عدد الاسنان الموجودة لدى 32 مريضاً كان 981 ، الاسنان المصابة بفقدان بنسبة 20% من العظم الساند او اكثر كان 523 نسبتها 58.698% . عدد الاسنان المتحركة 387 ، نسبتها 74.28% . مقياس نزف اللثة اظهر حالتين ذات النزف العالي وذات النزف المعتدل والفرق بينهما مسند بدلالة علمية وان توزيع الاصابة في الفكين متناسق على كلاهما في آن واحد , وبصورة ثابتة ويبدو ان الاصابة تأخذ شكلاً تسلسلياً ثابتاً . من هذا نستنتج ان المرض يتوزع في الفم بطريقة محددة وبنظام معين .


Article
Detection of Granulocyte Chemotactic Protein 2 in Serum of Periodontitis Patients

Authors: Saja GH. Hussien سجى حسين --- Basima Gh. Ali باسمة غفوري علي
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2016 Volume: 28 Issue: 4 Pages: 122-127
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Chronic periodontitis defined as “an infectious inflammatory disease within supporting tissues of the teeth, progressive attachment loss and bone loss". Aggressive periodontitis is rare which in most cases manifest themselves clinically during youth. It characterized by rapid rate of disease progression .Pro-inflammatory chemokines organized inflammatory responses. Granulocyte chemotactic protein 2 is involved in neutrophil gathering and movement. The purpose of the study is to detect serum of Granulocyte Chemotactic Protein 2 and correlate to periodontal condition in patients with chronic periodontitis, Aggressive periodontitis and Healthy Control subjects and measurement the count of neutrophils for the studied groups.Subjects and methods: Eighty four male and female were enrolled in this study .They were divided into three groups (18) patients with Aggressive periodontitis with age range (20-45) years, (33) chronic periodontitis patients and (33) Healthy control with an age range (30-50). Clinical periodontal parameters were recorded for each group. The concentration of granulocyte chemotactic protein- 2 in serum was quantified by a high-sensitivity enzyme linked immunosorbent assay. Blood neutrophils count were detect for five subjects from each group using light microscopeResult: ANOVA analysis revealed high significant differences in Granulocyte chemotactic protein 2 means between aggressive, chronic and controls. Neutrophils count in aggressive periodontitis is higher than chronic and controls .No significant difference in neutrophils count between aggressive and chronic periodontitis, while significant difference when correlate them with controlsConclusion The concentration of granulocyte chemotactic protein 2 increased with the increase in severity of periodontitis. Higher neutrophils count was found in aggressive periodontitis than chronic and controls. As higher granulocyte chemotactic protein 2 that chemoattract more neutrophils recruitment to the site of inflammation

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