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Article
Treatment of Patchy Alopecia Areata Using Topical 15% Lactic Acid Solution
علاج داء الحاصة البقعية بواسطةعقار محلول حامض اللبنيك 15% الموضعي

Authors: Nabeel O. Kadir نبيل عمر --- Sabeeh A. Al-Mashhadan صبيح عباس --- Makram M. Al-Waiz مكرم مكي
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2006 Volume: 19 Issue: 4 Pages: 361-364
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

AbstractBackground: There are many modalities used in treatment of AA. However, there is no universally accepted therapy. Lactic acid has been tried in diversity of skin diseases such as warts, xerosis, wrinkles, chemical peeling and repigmentation of vitiligo. Objective: The present work has been arranged to evaluate the efficacy and tolerability of topical 15% lactic acid solution in the treatment of patchy alopecia areata.Patients & Methods: A study was designed as a single blind therapeutic trial. Twenty nine patients suffering from 59 patches of alopecia areata were included in the study. Their ages ranged from 1.5-61 years with a mean ±SD of 23.88 ± 14.3 years. Patches were divided into three groups. First group (22 patches) were treated with topical 15% lactic acid solution twice weekly. The second group (17 patches) were treated with topical 15% lactic acid solution thrice weekly. The third group (20 patches) were randomly selected from patients with multiple patches; they were treated with tap water for comparison. Patients with alopecia totalis, alopecia universalis and treated cases were excluded from the study. Patients were regularly evaluated for hair regrowth and side effects every 2 weeks for 3 months. Results: In the first group, the final hair regrowth assessment revealed hair regrowth of 68% of the treated patches .In the second group, 82.4% of the treated patches showed complete hair regrowth. In the control group, the final hair regrowth assessment showed 30% of the patches with hair growth. After four weeks of therapy, erythema with mild scaling was noticed in 90% of treated patches of the first group and in 100% of patches in the second groups. These features disappeared completely at the end of treatment.Conclusion: Topical 15% lactic acid solution is an effective, safe and tolerable method of treating patchy alopecia areata with minimal side effects and cost benefit therapy. Thrice weekly application of topical 15% lactic acid solution achieved better rate of hair regrowth in a shorter period than twice weekly application.

الملخص:المقدمة: هنالك طرق علاجية متعددة لعلاج مرضى الحاصة البقعية. و لكن لا يوجد علاج موحد لهذا المرض. محلول حامض اللابنيك استخدم في امراض جلدية متعددة مثل الثئاليل, جفاف الجلد, التجاعيد الجلدية, القشط الكيميائي و البهق.الغرض من الدراسة: لقياس فاعلية و تقبل محلول حامض اللبنيك 15% الموضعي لعلاج المرضى المصابين بداء الحاصة البقعية.المرضى و طرق العمل: هذه الدراسة تمثل دراسة علاجية مفردة. تسعة و عشرون مريضاَ مصاباَ بداء الحاصة البقعية (داء الثعلب) تم ادخالهم في هذه الدراسة، 22 ذكرا و 7 اناث, تراوحت أعمارهم بين1.5-61 سنة و بمعدل 23.88 سنة ±14.28 سنة. كانوا من المرضى المصابين بالمرض لفترة لا تتجاوز الثلاثة اشهر ممن لم يسبق لهم العلاج. طريقة العلاج: تضمنت وضع محلول حامض اللابنيك 15% الموضعي على المناطق المصابة بداء الحاصة البقعية مرتين اسبوعيا للمجموعة الاولى و ثلاث مرات للمجموعة الثانية. المرضى المصابين باكثر من بقعة مرضية اخذت واحدة كمجموعة ثالثة وضعت الماء المجرد كمجموعة مقارنة. بلغ عدد البقع الداخلة في البحث تسعة و خمسين بقعة مصابة بداء الثعلب.النتائج: أظهرت ان (82%) من البقع التي عولجت بحامض اللابنيك ثلاث مرات اسبوعيا و (68%) من البقع التي عولجت بحامض اللابنيك مرتين اسبوعيا تحسناَ واضحاَ في مرضهم بينما (30%) فقط من البقع في المجموعة المقارنة اظهرت نموا للشعر. الاعراض الجانبية التي لوحظت اثناء فترة الدراسة كانت قليلة وبسيطة مثل الحكة و الاحمرارالجلدي لكن هذه الاعراض اختفت بصورة تلقائية بدون الحاجة الى ايقاف العلاج.الاستنتاج: أمكن لنا أن نستنتج من هذه الدراسة ان استخدام محلول حامض اللابنيك 15% الموضعي هوعلاج فعال لمعالجة داء الحاصة البقعية ويمكن استخدامه كبديل للعلاجات الاخرى المستخدمة في علاج هذا المرض وهي طريقة سهلة، بسيطة، وذات تكلفة منخفضة ويمكن للمريض استخدامها في البيت دون الحاجة للقدوم الى المستشفى لمرات عديدة .


Article
16- EVALUATION OF USING TISSUE EXPANDER FOR RECONSTRUCTION OF POST BURN ALOPECIA OF SCALP

Authors: Suzan Fadil Jabber --- Ari Raheem Qader
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2011 Volume: 17 Issue: 1 Pages: 117
Publisher: Basrah University جامعة البصرة

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Abstract

Ari Raheem Qader*& Suzan Fadil Jabber@*Assistant Professor, Department of Surgery, College of Medicine, University of Sulaimania.@Diploma in plastic surgery, Department of Surgery, Sulaimania Plastic and Burn surgery Hospital.*Email:drzangana@yahoo.com, Mobile no.-009647701526316AbstractTissue expansion represents one of the major advances in surgery and is particularlyapplicable to burn reconstruction. The technique provides tissue of similar texture and color tothe defect to be covered and has the added advantage of minimal donor site morbidity.This study aimed to assess the results & complications in the correction of post burn scalpalopecia using a tissue expansion, prevention of implant extrusion, lower the infection rate intissue expansion and expander selection.Forty patients with scalp burn alopecia treated with tissue expansion of the scalp, wereincluded in this prospective study in Sulaimania hospital of burn and reconstructive surgery fromFebruary 2002 to September 2009 with age groups ranging from (4-30) years with an averageof 15.5 years. Twenty three patients were females.The time period between burn injury and reconstruction ranged between (4-25) years, theirscalp defects ranging between (5x10cm -13x25cm). We were able to completely reconstruct77.5% of the total patients with single or multiple sessions of expansions. The remaining 22.5%patients have benefited from reduction in the percentage of alopecia and recreation of anteriorhair line to camouflage their defects. Major complications occurred in 6 cases(15%), in whichthe expansion process interrupted with removal of the expander.In conclusion, It is not always possible to measure the absolute efficacy of a surgical techniqueor determine a general guideline its indication of the tissue expansion procedure althoughafflicted with a broad range of possible complications, the tissue expansion procedure remains avaluable and reliable technique for the reconstruction of post burn alopecia of the scalp.


Article
The Role of Oxidative Stress in Vitiligo and Alopecia Areata
دور الاجهاد المؤكسد في داء البهاق وداء التعلب

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AbstractBackground:The pathogenetic mechanism in vitiligo and alopecia has not been completely clarified. One of the major hypotheses in the pathogenesis of these diseases is oxidative stress hypothesis. Oxidative stress may be induced by increasing the generation of reactive oxygen species (ROS) and other free radicals. Objectives: The objective of the present study is to evaluate the role of oxidative stress in pathogenesis of vitiligo, and Alopecia areata. Materials & Methods: Twenty patients with generalized and localized vitiligo, 20 patients with alopecia areata, and 25 controls were included in this study. We examined serum levels of malondialdehyde (MDA), super oxide dismutase (SOD) and vitamins E and A in patients with vitiligo and alopecia areata and control subjects.Result: The level of MDA in serum with patients with vitiligo and alopecia (2.07±0.43, 1.73±0.31, respectively) were significantly higher than those of control (0.85±0.12; p<0.0001). The SOD activity (8.94±0.38, and 8.809±0.44, correspondingly) in serum of patients with vitiligo and AA were significantly lower than that of controls (10.142±2.61). The level of vitamin A in serum of patients with vitiligo and AA (53.47±2.27, 52.85±2.34, respectively) were significantly lower than control (59.48±0.92, p<0.0001), while vitamin E levels in serum did not differ statistically. Conclusion: increased lipid peroxidation may relate to decrease in SOD activity and vitamin A levels. These results demonstrate the presence of an imbalance in the oxidant-antioxidant system and provide further support for a free radical-mediated damage as an initial pathogenic event vitiligo and AA.Key Words: Oxidative Stress, Vitiligo, Alopecia Areata

الملخصالخلفية:ميكانيكية نشؤ المرض في داء البهاق وداء الثعلب لم تتضح بصورة كاملة, احدى اهم الفرضيات في نشؤ هذه الامراض هي فرضية الاجهاد المؤكسد.الاجهاد المؤكسد ممكن ان يتكون بواسطة ازدياد توليد عوامل الاوكسجين الفعالة والجذور الحرة الاخرى.الهدف من البحث:الهدف من الدراسة الحالية هو لتقييم دور الاجهاد المؤكسد في النشؤ المرضي لمرضى داء الثعلب وداء البهاق.الطرائق:اجريت الفحوصات على نماذج دم 20مريضا مصابا بداء البهاق المحدد الانتشار والعام الانتشار, 20 مريضا من المصابين بداء الثعلب و25 اشخاص اصحاء غير مصابين بالامراض (مجموعة السيطرة).تم قياس مستويات مالونديهايد(MDA), سوبر اوكسيد ديسميوتيز(SOD) وفيتامينات (أ) و (ي ) في دم مرضى البهاق وداء الثعلب ومجموعة السيطرة.النتائج:اظهرت النتائج ان مستويات MDA في دم المرضى المصابين بداء البهاق وداء الثعلب (2.07±0.43 , 1.73±0.31 على التوالي) ذا قيمة احصائية اعلى من تلك الماخوذة في مجموعة السيطرة, وكذلك اظهرت النتائج ان فعالية انزيم SOD (,8.94±0.38 8.809±0.44,بالتتابع) و مستوى فيتامين أ (53.47±2.27 , 52.85±2.34على التوالي) في دم المرضى المصابين بداء البهاق وداء الثعلب ذا قيمة احصائية اقل من تلك الماخوذة في مجموعة السيطرة. اما بالنسبة لفيتامين( ي) لم تظهر الدراسة فروق معنوية.الاستنتاجات:ان زيادة اكسدة الدهون في دم المصابين بداء البهاق والثعلب قد يكون بسبب وجود انخفاض في مستوى فعالية انزيم SOD ومستوى فيتامين( أ) وهذه النتيجة تشير الى عدم وجود توازن في نظام المؤكسدات-مضادات المؤكسدات وتعطينا دلائل اضافية بان اضرار الجذور الحرة هو الحدث المرضي الاولي المسبب في داء البهاق وداء الثعلب.


Article
Postburn head and neck reconstruction using tissue expanders
إعادة بناء الرأس والرقبة بعد الحرق باستخدام موسعات الأنسجة

Author: Jalal Hamasalih Fattah
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2014 Volume: 18 Issue: 3 Pages: 786-792
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Background and objective: Tissue expanders are useful adjuvant in reconstruction after burn. The technique provides tissue of similar texture and color to the defect to be covered and has the added advantage of minimal donor site morbidity. The study aimed to assess the outcome and complications of using tissue expansion for head and neck postburn reconstruction. Methods: Thirty patients with head and neck burn scar, treated with thirty eight tissue expanders, were included in this prospective study at the Plastic Surgery Department in Rizgari Teaching Hospital in Erbil from April 2009 to November 2012, with the mean age of 14 years. Statistical package for social sciences (SPSS version 18) was used for data entry and analysis.Results: The commonest use of tissue expander was for treating postburn scar alopecia (18 patients, 60%), followed by postburn cheek scar (six patients 20%). The scar size ranged from 4x10cm to 16x24cm. Complete burn scar excision was possible in 80% of cases with single or multiple sessions of expansion. Early exposure of the expander followed by infection occurred in three cases (10%), which led to interruption of the expansion and expander removal. Satisfactory results were achieved after reconstruction in 90% of cases.Conclusion: Tissue expansion, if carefully planned and conducted, is one of the treatments of choice for post-burn reconstruction of the head and neck, allowing an expanded flap suitable for versatile coverage.


Article
Female Pattern Alopecia and Lipoproteins

Authors: Khalifa E. Sharquie --- Adil A. Noaimi --- Husam Ali Salman --- Nibras A. Hindy
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2009 Volume: 8 Issue: 2 Pages: 120-122
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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ABSTRACT:BACKGROUND:The meaningful association of androgenetic alopecia and coronary heart disease had been well documented, but few studies had been focused on the importance of lipid parameters in patients with androgenetic alopecia.OBJECTIVE:To investigate the lipid profile and its relation to female pattern alopecia.PATIENTS & METHODS:This is a case controlled study conducted at the Department of Dermatology & Venereology- Baghdad Teaching Hospital, between January 2001 and April 2002. Sixty female patients with androgenetic alopecia were enrolled in this work. From each patient a detailed history and full clinical examination were performed regarding all demographic points relative to the disease, grading of alopecia and measurement of serum lipoproteins was done. Female pattern alopecia was classified according to Sharquei’s classificationSixty age and weight matched females with normal hair status were considered as a control group. Measurement of serum lipoproteins also performed for them.RESULT:Sixty patients, their ages ranged between 20-60 years with mean + SD of 30.3 + 9.4 years. Twenty (33.3%) patients were having grade I, 20 (33.3%) patients grade II and another 20 (33.3%) patients grade III.. The mean levels of total serum cholesterol, triglycerides, low density lipoprotein and very low density lipoprotein in all patients and those with grade II and III separately were significantly higher when compared to the control group. On the other hand, the mean levels of high density lipoprotein in all patients and those with grade I and III separately were lower in comparison to the control.CONCLUSION:The atherogenic index or risk ratio was found to be significantly high in patients with female patteren alopecia and this goes parallel with the severity of baldness.


Article
•Trace elements levels in serum and hair of patients with vitiligo and alopecia areata

Author: Wasan Taha S. Al-Rubayee
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2011 Volume: 4 no 2 Issue: 10 Pages: 1117-1121
Publisher: Kerbala University جامعة كربلاء

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background: Vitiligo is the most prevalent pigmentary disorder which occurs worldwide. The etiopathogensis of vitiligo is complex, and includes genetic factors, autoimmune process, and infectious factors. Alopecia areata is a recurrent, nonscarring type of hair loss considered to be an autoimmune process. Though its etiopathology is not fully understood, there are claims that imbalance of trace elements may trigger the onset of alopecia areata.Objectives: The objective of this study was to evaluate the levels of zinc, copper and magnesium in serum and hair of vitiligo and alopecia areata patients hopefully to gain a better understanding of the role of these trace elements in both diseases.Methods: Twenty alopecia areata patients, twenty vitiligo patients, and twenty age and sex matched controls were studied. Samples were analyzed using atomic absorption spectrophotometric methods.Results: Serum and hair zinc levels were significantly decreased in alopecia areata patients and also in vitiligo patients compared with controls. Serum and hair levels of copper and magnesium showed insignificant rise in both diseases when compared with controls.Conclusions: Copper and magnesium levels are not altered in alopecia areata or vitiligo, but decreased zinc levels may play an important role in the etiopathogensis of both diseases.

Keywords

Trace elements --- serum --- hair --- alopecia areata --- vitiligo


Article
Reconstruction of post-burn scalp alopecia using tissue expansion in Erbil
إعادة بناء ثعلبة فروة الرأس بعد الاحتراق باستخدام تمدد الأنسجة في أربيل

Author: Sabir Osman Mustafa
Journal: Zanco Journal of Medical Sciences مجلة زانكو للعلوم الطبية ISSN: 19955588/19955596 Year: 2016 Volume: 20 Issue: 1 Pages: 1254-1259
Publisher: Hawler Medical Univeristy جامعة هولير الطبية

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Background and objective: Reconstruction of post burn scalp alopecia using tissue expansion represents, nowadays, the standard method of treatment for this pathology. Tissue expansion is a straightforward technique, providing large skin flaps whose color and texture matches the area to be reconstructed, achieving optimal final aesthetic result. The aim of this study was to evaluate the results and complications of using tissue expansion for post burn scalp alopecia reconstruction. Methods: Thirty four patients having post burn scalp alopecia were treated with scalp tissue expansion, using forty tissue expanders at Rizgary Teaching Hospital in Erbil from February 2009 to December 2014. The age group ranged from 7-35 years and the mean age of the patients was 16 years. Statistical package for the social sciences (version 18) was used for data entry and analysis. Results: Complete reconstruction of post burn alopecia was achieved in 82.35% of the total patients with either a single or multiple sessions of expansions. The remaining 17.65% were benefited from reduction in the percentage of scar and recreation of anterior hair line. The size of scalp alopecia ranged between 4x7cm-11x20cm. Major complications occurred in 3 cases (8.8%), in which the expansion process was interrupted with removal of expander, while minor complications happened in 4 cases (11.76%), which did not interrupt the expansion. Conclusion: The use of tissue expansion for reconstruction of post burn alopecia is a useful and safe technique, since it is the only procedure that allows the development of normal hair bearing tissue to cover the areas of alopecia


Article
Progeria

Author: Abdul-Karem Jasem albahadle
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 2 Pages: 221-224
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

BACKGROUND:Hutchinson-Gilford Progeria Syndrome (HGPS) is a very rare genetic disorder with a frequency of 1 in 8 million live births. It is characterized by premature aging phenotype. The median age at death is 13.4 years


Article
Effect of topical minoxidil solution in promoting hair growth in male mice

Author: Najah R. Hadi, Muhsin A. AL-Dhalimi, keisar j. Fadheel. University of Kufa, College of Medicine,
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2011 Volume: 14 Issue: 1 Pages: 245-252
Publisher: University of Kufa جامعة الكوفة

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The present study was designed to asses the efficacy of topical minoxidil solution in promoting hair growth in mouse model . This study aimed at finding the more efficacious drug for the treatment of androgenetic alopecia since the available regimens have many limitations. Alopecia or Hair loss is the absence or thinness of the hair . Androgenetic alopecia is commonly referred as male pattern hair loss or female pattern hair loss in genetically susceptible men and women . 45 albino-Webster male mice were included in this study , they were divided randomly into two groups, each one included 15 mice . One day before starting the experiment the dorsal skin of each mouse was shaved by an electric shaver , then stained by using commercial dye and then the animals were photographed . group No. 1 was considered as control group . It included mice which did not get any treatment . Group No. 2 received topical minoxidil solution 5% . At the end of treatment ( 21 day), the animals were photographed to asses the degree of hair growth , it was carried out by means of special computer program called Photoshop-visual basic-8 program , this program found the ratio of area showing hair regrowth to the ratio of area denuded of hair . Histological sections were obtained from each mouse to asses the effect of drugs on the number and diameter of hair follicles. The results of this study showed that significant hair growth ( P-Value <0.05) occurred with topical minoxidil solution as compared to the control group , insignificant increase in the number of hair follicles as compared to the control group, significant increase in diameter of hair follicles as compared to the control group . From the results of this study , we concluded that topical minoxidil solution can promote hair growth efficiently and can increase the diameter of hair follicles . Also in the present study the concentration of the following hormones were measured after 21 day treatment with topical cyproterone acetate . These hormones are ( 17β-Estradiol , Free Testosterone and Progesterone ). The results showed that there was no significant difference in concentration of these hormones among control and treatment groups after 21 day treatment, they are all within the normal range

أجريت هده الدراسة لمعرفة مدى تأثير المينوكسديل على نمو الشعر لدى الفئران استعمل في الدراسة 30 من ذكور الفئران بيض اللون قسمت عشوائيا إلى مجموعتين كل مجموعة تضم 15 فأر في اليوم الذي سبق القيام بالتجربة تمت حلاقة منطقة الظهر لكل فأر بواسطة آلة حلاقة كهربائية ومن ثم صبغ المنطقة المحلوقة بصبغة تجارية وبعدها تم تصوير الحيوانات. المجموعة الأولى اعتبرت مجموعة السيطرة لم يتم إعطائها أي علاج المجموعة الثانية تم علاجها بالمينوكسديل بنسبة 5% موضعيا على منطقة الظهر.حيث كانت مدة علاج المجموعتين ثلاثة أسابيع. بعد نهاية مدة العلاج تم تصوير الحيوانات لقياس درجة نمو الشعر ومن ثم أخذت مقاطع نسيجية من كل فار لغرض دراسة تأثير الأدوية على عدد وحجم بصيلات الشعر. وقد بينت الدراسة النتائج التالية:1- نمو الشعر: حيث كان نمو الشعر معنويا (P< 0.05) في المجموعة التي تم علاجها بالمينوكسديل مقارنة بمجموعة السيطرة.2- عدد بصيلات الشعر: حدثت زيادة غير معنوية في عدد بصيلات الشعر في المجموعة التي تم علاجها بالدواء سابق الذكر.3- قطر بصيلات الشعر: حدثت زيادة معنوية في قطر بصيلات الشعر في المجموعة التي تم علاجها بالدواء المذكور سابقا.نستنتج من هده الدراسة بان المينوكسديل يمتلك كفاءة جيدة في المساعدة على نمو الشعر وسبّب زيادة في عدد وحجم بصيلات الشعر.كذلك في الدراسة الحالية تم قياس تركيز الهورمونات التالية بعد نهاية فترة العلاج المحددة والبالغة 21 يوما , هذه الهورمونات هي: (17β-Estradiol, Free Testosterone, and Progesterone)وقد تبين من حلال النتائج أنه لايوجد اختلاف جذري في تركيز الهورمونات بين مجموعة السيطرة والمجموعة المعالجة, جميعها تقع ضمن المدى الطبيعي .


Article
TREATMENT OF ALOPECIA AREATA WITH TOPICAL GARLIC EXTRACT

Author: Dr. Azar H. Maluki, DDV, FICMS, CABDV.*
Journal: KUFA MEDICAL JOURNAL مجلة الكوفة الطبية ISSN: 1993517X Year: 2009 Volume: 12 Issue: 1 Pages: 312-318
Publisher: University of Kufa جامعة الكوفة

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Abstract

SUMMARY:BACKGROUND: Alopecia areata is a non scarring localized hair fall, probably of autoimmune ateology, that responds to treatment with many topically applied irritant substances. Garlic had been known for a long time by its unique chemical composition that has many pharmacological implications.AIM of STUDY: To determine the efficacy of topical garlic extract in the treatment of alopecia areata.PATIENTS & METHODS: Ten patients complaining of single or multiple patches of alopecia areata on the scalp region (total of 18 patches) were enrolled in this study from July 2006 to July 2007, in the out patient clinic in Najaf city. All patches were treated by topical garlic extract twice daily, for two months. Re-growth of terminal coarse hairs was evaluated every two weeks.RESULTS: Four females and six males were studied, their ages ranged from 10 – 45 years (mean 27 yrs.). Total of 18 patches of alopecia areata were treated. All patients (100%) responded to this treatment. Hair growth started by the end of second week in eight patches (44.4%), within four weeks in seven patches (38.9%), and within six weeks in three patches (16.7%). Erythema was observed in all patients, in addition to itching in 8 patches (44.4%) and burning sensation in 5 patches (27.7%).CONCLUSIONS: Garlic is an efficient and rapid topical treatment for alopecia areata. It is cheep, available and with negligible side effects.

مقدمة الدراسة: يعتبر داء الثعلب من الامراض المناعية التي تسبب تساقط شعر موضعي وهو قابل للعلاج بالمستحضرات الطبية المخدشة للجلد ومن ضمنها مادة الثوم المعروف باحتوائه على العديد من المواد الكيميائية ذات المفعول العلاجي.هدف الدراسة:تقييم كفاءة مستخلص مادة الثوم في علاج داء الثعلب موضعيا" .المرضى وطريقة الدراسة: تم دراسة عشرة حالات ممن يعانون من داء الثعلب الموضعي المنفرد او المتعدد في منطقة الراس في مدينة النجف للفترة من تموز 2006 الى تموز 2007 . بلغ مجموع البقع هو 18 بقعة. كان العلاج بطريقة الدلك المباشر لمستخلص حبة الثوم في منطقة التساقط ويكرر المسح مرتان يوميا . استمرت فترة العلاج مدة شهرين وكان فحص نمو الشعر يتم كل اسبوعين .نتائج الدراسة: اشتملت الحالات على اربع اناث وست ذكور تراوحت اعمارهم بين 10 الى 45 سنة (متوسط العمر 27 سنة). مجموع البقع المعالجة كان 18 بقعة. كانت الاستجابة جيدة في جميع الحالات حيث بدأ نمو الشعر في الاسبوع الثاني في ثمانية بقع (44.4% ) وفي الاسبوع الرابع في سبعة بقع (38.9%) وفي الاسبوع السادس في ثلاثة بقع (16.7%). اقتصرت الاعراض الجانبية على احمرار الجلد في كافة البقع اضافة الى حكة جلدية في ثمانية بقع (44.4%) وحرقة في الجلد في خمسة بقع (27.7%).الاستنتاج: يعتبر استخدام الثوم موضعيا من الطرق العلاجية الناجحة والسريعة في علاج حالات داء الثعلب الموضعي مع ظهور ادنى حد ممكن من الاعراض الجانبية.علاج داء الثعلب بمستخلص مادة الثوم موضعيا

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