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Comparative study of the renoprotective effects of captopril and aminophylline against cainst cisplatin – induced nephrotoxicty in rats

Author: Adel .H .Sheeh عادل شيح
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 28-32
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Cisplatin is one of the most commonly used anti-cancer drugs , but its clinical use was limited by its nephrotoxicity .Methods: In this study we try to investigate the renoprotective effect of captopril and aminophylline against cisplatin induced nephrotoxicity .For this purpose a 36 Sprague Dawley rats was divided randomly to 6 groups , each group consist of 6 rats. The first group given normal saline and act as control group, while the other 5 groups given cisplatin ( 7.5 mg/kg ) , captopril ( 60 mg/kg ) , aminophylline ( 24 mg/kg ) , captopril with cisplatin and aminophylline with cisplatin respectively. All drugs are given as single dose through intraperitonial route. After 6 days blood urea and serum creatinine, malondialdehyde and glutathione are measured and compared with control group.Results: The data show that both captopril and aminophylline posses renoprotective effect against cisplatin – induced nephrotoxicity, also the data show that captopril renoprotective effect is more than that produced by aminophylline.Conclusions: This data can help in increase the dose of cisplatin in clinical uses together with use of renoprotective agent , specially if the patient already need such renoprotective drugs for treatment of disease a way from cisplatin as hypertension .Also more clinical studies required for more assessment of the clinical pattern of this renoprotective effect


Article
The Influences of Aminophylline and Indomethacin in Glycerol-Induced Acute Renal Failure in Rats

Author: Estabraq M.Mahdi استبرق مهدي
Journal: Al-Kindy College Medical Journal مجلة كلية الطب الكندي ISSN: 18109543 Year: 2010 Volume: 6 Issue: 1 Pages: 62-70
Publisher: Baghdad University جامعة بغداد

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Abstract

¬ Background: Adenosine mediates homodynamic changes and resulted in the production of acute renal failure (ARF) in female Albino-Wister rats, therefore, adenosine level increases highly in ARF. Objective: This experiment was designed to investigate the effect of the adenosine antagonist aminophylline and the adenosine agonist indom-ethacin on glycerol-induced ARF.Method: Glycerol induced ARF was produced by a single dose (10ml/kg, 50%v/v with distilled water i.m) in rats, which were restricted to drinking water. Aminophylline was used in our study in a dose of 25mg/kg, i.p) while the dose of indomethacin was 10mg/kg, i.p), assessment of renal function was done by measuring blood urea nitrogen (BUN), serum creatinine (Scr), and creatinine clearance (Ccr)Results: Aminophylline exert its protective effect against glycerol induced-ARF by lowering the elevation in concentrations of BUN, Scr, and mortality rate with a markedly attenuation of the sever impairment Ccr. On the other hand, indomethacin potentiates glycerol induced-ARF by significantly increase the elevation in concentrations of BUN, Scr and mortality rate with severely suppressed the decrement in Ccr.Conclusion: Aminophylline has ameliorating effect on glycerol induced ARF while the prostaglandin inhibitor indomethacin has reversed effect.

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