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Observations on the ultrastructure of a rat mammary gland treated with harmal and borage

Authors: Salim R. Hamoudi ** --- Shatha M. Al-Faisaly*** --- Wasan Al- Saidi * --- Malak A. Al- Yawer **Ph.D
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: 00419419 Year: 2007 Volume: 49 Issue: 1 Pages: 151-156
Publisher: Baghdad University جامعة بغداد


Background : It had been indentified by histological, histochemical and morphometrical studies that peganum harmala is a mammogenic herb and borage officinalis is a lactogenic one . To complete our investigation about these two herbs , we performed electron microscopical study . Materials and methods : Rats were grouped according to their physiological status into three groups . Each group was subdivided in to three subgroups : one control and two experimental . The two experimental group were treated daily; the 1st one with an aqueous extract of peganum harmala seeds and the 2nd with an aqueous extract of borage officinalis flowers . After two weeks of treatment , mammary glands were employed for electron microscopical study . Results : In virgin rats , the epithelial and myoepithelial cells were partially differentiated when harmal was given and completely differentiated when borage was given . In pregnant rats , harmal and borage optimize mammary parenchymal growth and induce lactation when these herbs were given. In lactating rats ,these herbs exhibited a picture similar to control lactating group but the budding of lipid droplets and the swelling of secretary vesicles were markedly increased . Conclusion: Both harmal and borage stimulate the release of prolactin and induce galactogenesis during pregnancy and promote it during lactation . Key Words : Mammary gland , Electron microscope , Harmal , Borage

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