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The Risk Factors of Inhibitor Development and Hepatitis C Virus among Hemophilic Patients in Children Welfare Teaching hospital

Author: Dhia H. Al-Beldawi ضياء البلداوي
Journal: Journal of the Faculty of Medicine مجلة كلية الطب ISSN: PISSN: 00419419 / EISSN: 24108057 Year: 2010 Volume: 52 Issue: 1 Pages: 4-8
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: Inhibitor development and HCV are considered the most serious complications of hemophilia treatment. Many factors may increase the risk of complications which include: type of hemophilia, age of the patient, age of onset, duration of the disease, & number of replacement per month.Patients and methods: A descriptive study included 200 patients less than 20 years of age admitted to the Hemophilia Center in Children Welfare Teaching Hospital , medical city in Baghdad , their data ( ag , sex , disease onset and duration , severity of hemophilia ) were collected over 8 months period from 1st January to 31st August 2006. Mixing tests and serology tests for HCV and HBV were performed for all patients.Results: The study showed that 156 (78%) patients had hemophilia A, 44(22%) patients had hemophilia B, and 122 (61%) patients were older than 10 years, in 166 (83%) patients the disease was diagnosed before 2 years of age. Twenty (12.8 %) patients with hemophilia A and 4(9%) patients with hemophilia B developed inhibitors (+ve mixing test). Age more than 10 years, disease onset before 2 years and severe hemophilia were the most common associated findings in patients with inhibitors in 19(79%) , 22(91%), 15(62.5%) patients respectively. Eighty (40%) patients had HCV and 6(3%) patients had HBV, patients older than 10 years , disease duration more than 5 years and severe hemophilia were the most common associated findings with HCV in 68(57.6%), 64 (56%), and 44(45%) patients respectively.Conclusions: The risk of inhibitor development was associated more with Hemophilia A, age more than 10 years, early onset and severe disease but the association was statistically insignificant. The rate of HCV infection was high, that needs special attention and effective screening program. Keywords: Hemophilia, Inhibitors, and Hepatitis.


Article
PREVALENCE OF HEPATITIS B AND HEPATITIS C AMONG PREOPERATIVE SURGICAL PATIENTS AT BASRAH GENERAL HOSPITAL

Authors: Mazin H AL-Hawaz --- Mohammed H AL-Hijaj --- Shatha A AL-Mansori
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2014 Volume: 20 Issue: 1 Pages: 62-65
Publisher: Basrah University جامعة البصرة

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Abstract

Viral hepatitis is a worldwide health problem which requires a thorough knowledge and orientation. Clinical awareness of medical and paramedical staff regarding hepatitis portfolios so important to avoid serious short and long term sequel of hepatitis distribution to other individuals therefore a fundamental strategy has been planned and made in our local surgical field to highlight that issue in different types of surgery. Patients and methods: Retrospective descriptive study was carried out at Basrah General Hospital; Department of Surgery between Sept 2012 and Sept 2013 for patients underwent elective surgery in surgical department. Data was collected on the patients’ clinical history and laboratory findings of hepatitis screen for preoperative patients. The findings were recorded in a structured compilation. Results: A total of one thousand and seven hundred and thirty patients entered the study and those were analyzed in terms of general patient data in respect to age and sex as well as analysis of hepatitis screening findings. There were 1034 (59.7 %) males and 696 (40.3 %) females, with ages ranging from 8 months -70 year. The highest prevalence of Hepatitis B and C occurred in the same age group of 40 to 49 years. The sex related distribution of Hepatitis in general patients revealed more female patients than male ones (45/43).This figure is similar among patients in Hepatitis C (22/19) and both Hepatitis B and C (2/1). Hepatitis B showed a reverse pattern of being male predominance with a male to female distribution (23/21). In conclusion: Clinical awareness is the master of prevention of Hepatitis spread as proper knowledge about transmission and precautions could be of value in reducing disease transmission.

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