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Antiemetic activity of ginger in childrenreceiving cancer chemotherapy

Author: Mazin M. Fawzi مازن محمود فوزي
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2009 Volume: 35 Issue: 2 Pages: 104-110
Publisher: Mosul University جامعة الموصل


Objective: To evaluate the antiemetic effect of ginger versus metoclopramide in children receiving cancer chemotherapy.
Methods: A sample of 50 patients aged 6 – 14 years attending the Haematooncology unit in Ibn Al – Atheer Children's Teaching Hospital in Mosul city and receiving chemotherapy for their malignancies were included. They were randomly subdivided into 2 groups and received different types of treatment including ginger and metoclopramide.
Results: The study showed that cancer was more common in female than in male with male to female ratio 0.85/1. Acute lymphoblastic leukemia was the most common type of cancer and constituted 60% of the cases and it revealed that response rate was higher in those treated by ginger compared to metoclopramide (72% and 32% respectively); response was found to be higher in males than in females (86.6% and 50% respectively).
Conclusions: Nausea and vomiting are common problems in children receiving chemotherapy. Ginger (Zingiber officinale) appears to be promising in controlling these problems.

الهدف: تهدف الدراسة إلى البحث في التأثير المضاد للغثيان والقئ لمادة الزنجبيل مقارنة بعقار الميتوكلوبرامايد عند الأطفال الذين يخضعون للعلاج الكيمياوي.المشاركون في الدراسة: شملت الدراسة 50 طفل بعمر 6-14 سنة.مكان الدراسة: وحدة أمراض الدم والسرطان في مستشفى ابن الأثير التعليمي في مدينة الموصل.قياس المحصلة النهائية: تم تحليل النتائج باستخدام مربع كاي ونسبة الخطورة باستخدام الحاسبة الالكترونية.النتائج: أظهرت الدراسة أن نسبة الاستجابة للعلاج بمادة الزنجبيل هي أعلى مقارنة بعقار الميتوكلوبرامايد (72% و 32%) بالتعاقب، وان هذه الاستجابة كانت أعلى عند الذكور مقارنة بالإناث (86,6% و 50%) بالتعاقب، وكانت حالات السرطان أعلى نسبة لدى الإناث مقارنة بالذكور، وشكل سرطان الدم اللمفاوي الحاد أعلى نسبة بين حالات السرطان الاخرى (60%). الاستنتاج: في ضوء النتائج المستخلصة من الدراسة يمكن الاستنتاج بأن الغثيان والقئ يشكلان مشكلة لدى الأطفال الخاضعين للعلاج الكيمياوي، ومادة الزنجبيل تبدو مشجعة في السيطرة على هذه المشاكل.


ginger --- antiemetic --- vomiting

Comparison of the Effect of Dexamethasone and Metoclopramide in Prevention of Post-Operative Nausea and Vomiting in Laparoscopic Cholecystectomy

Authors: Iyad Abbas Salman --- Redha Mohamed Abdul Hussien Alkabee
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 3 Pages: 443-448
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية


ACKGROUND: Postoperative Nausea and vomiting is Common complication depending on the type of surgery, technique and duration of anesthesia.OBJECTIVE: To evaluate the effect of Dexamethasone as antiemetic in comparison with Metoclopramide.METHODS: Is aprospective study carried on (100) patients undergone elective cholecystectomy in a periodfrom Jan. 2009 to April. 2010 in Baghdad Teaching Hospital / Medical city/Baghdad/Iraq. The patients were allocated into two groups of 50 patients each. Group A received 8mgDexamethasone, group B received 10mg metoclopramide intravenously, both groups monitoredpostoperatively for nausea and vomitting for 24 hours every 4 hours.RESULT:Regarding Nausea, for 24 hrs the results were not significant except at 24th hr., in which nauseamore significant in metoclopramide group.Regarding Vomiting, there was no significant from postoperative period to 12hr, while from 16 24 hr. there were significant fewer incidences in dexamethasone group.CONCLUSION: A single dose of Dexamethasone is effective same as Metoclopramide in prevention of PONV ,and it is better in late prevention postoperativel

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