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Evaluation of Serum Electrolytes and Uric Acid in Iraqi Epileptic Patients

Author: Hind Hani Abdul Wahid
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2010 Volume: 9 Issue: 1 Pages: 84-87
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND:Epileptic patients exhibited variably altered status of electrolytes, and antioxidant.OBJECTIVE:The aim of this study is to investigate the effect of epilepsy and long-term antiepileptic drug therapy on the level of serum electrolytes (calcium, sodium, and potassium) and antioxidant ( uric acid) .PATIENTS AND METHODS:Thirty epileptic patients and twenty normal healthy individuals as a control were recruited in this study. The mean± SD of age of treated and untreated patients was (24.0±10.0) and (31.0±11.0) respectively.Spectrophotometric technique was used to determine all the parameters in this study.Data were expressed as mean ± SD. Statistical comparison among different groups was performed by using ANOVA tests. Statistical significance was defined. as P<0.05.RESULTS:The treated group (particularly with valproate), show increases in the levels of calcium, sodium, with no difference in potassium. however among untreated epileptics, uric acid level was increased.CONCLUSION:The above parameters differs in epileptics comparable to controls and hence their correlation to seizures pathophysiology and their degree of control or resistance to antiepileptic drug therapy


Article
Synthesis and spectrometric study of some nucleophilic reactions of the antiepileptic molecule; 5,5-diphenyl imidazolidine-2,4-dione.
تحضير ودراسة طيفية لبعض التفاعلات النيوكليوفيلية من جزيء مضاد للصرع 5,5-ثنائي فينل إيميدازوليدين-2،4-داي اون

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Abstract

New reaction routs were performed for the compound 5,5-diphenyl 2,4-imidazolidinedione (I) to give derivatives (II – VII). These reactions include acylation, halogenation, reduction, and nucleophilic substitutions. Most of the derivatives showed variable chemical reactivities and thermal stability, and the N1 and N3 disubstituted analogue were found much less stable, and hydrolyzes easily in the reaction medium. According to 1H and 13C NMR measurement's, 1,3-Dichloro-5,5-diphenyl imidazolidine-2,4-dione (V) was found to chlorinate the methyl group of the solvent DMSO-d6. Sodium hydroxide consumption analysis was established to reveal the molecularity against NaOH, by following acid-base volumetric method.

تم إجراء تفاعلات جديدة للمركب 5،5-ثنائي الفينل إميدازوليدين-2،4- ديون (I) لإعطاء المشتقات (II - VII). وتشمل هذه التفاعلات أستلة، هلجنة، اختزال، و الاستبدال نيوكليوفيلي. وأظهرت معظم المشتقات استقرارا كيميائيا متغيرا وثباتا، وتم العثور على التناظرية N1 و N3 غير المستقرة أقل استقرارا بكثير، ويتحلل بسهولة في وسط التفاعل. وفقا 1H و 13C NMR القياس، وعند اجراء دراسه على المركب 1،3-داي كلورو-5،5-ثنائي الفينيل إيميدازوليدين-2،4-داي اون (V) وجد انه يُكلور مجموعة الميثيل في المذيب DMSO-d6. تم إنشاء تحليل استهلاك هيدروكسيد الصوديوم للكشف عن الجزيئية ضد هيدروكسيد الصوديوم، باتباع طريقة الحجمية حامض – قاعدة.

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