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Article
A comparative study between the effects of two different antihypertensive drugs on the salivary flow rate and salivary compositions

Author: RafiL H. Rasheed رافل رشيد
Journal: Journal of baghdad college of dentistry مجلة كلية طب الاسنان بغداد ISSN: 16800087 Year: 2005 Volume: 17 Issue: 1 Pages: 43-46
Publisher: Baghdad University جامعة بغداد

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Abstract

Background: This study investigated the possible abnormalities and variations in salivary flow rate and compositions in two groups of patients under the effects of two different types of antihypertensive drugs (Atenolol and Captopril) one on hand compared with third group of normotensives (As control) on the other hand.Results: It was obvious that there is marked reduction in the salivary flow rate in those taken the antihypertensive drugs in comparison with control group of normotensives. Significantly elevated levels of potassium, phosphorus, and proteins had been realized as first result of this study which might be explained due to the continuous adrenergic over stimulation of salivary gland in hypertensives under taking Atenolol, magnesium in saliva appear reduced in treated hypertensives with Captopril than with Atenolol. Whereas there is dropping in the level of sodium in the two groups than in the control.


Article
Noncompliance With Antihypertensive Drugs Among Patients with Essential Hypertension in Sulaimani City

Authors: Omed H.K Hawrami --- Manar Hisham Abdulla
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2016 Volume: 15 Issue: 2 Pages: 140-147
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT:BACKGROUND: Hypertension is a common chronic disease in Iraq, noncompliance with medications is one of the most important reasons for uncontrolled hypertension.OBJECTIVE: This study was designed to detect the percentage and the causes of noncompliance with antihypertensive drugs among the study sample.PATIENTS AND METHODS: A cross-sectional study was conducted during the period from August 1st 2012 to February 28th 2013, at four primary health care centers in Sulaimani city, 309 patients were included in the study. Non compliance was tested by using self reported Morisky- Green adherence scale.RESULTS: 54.7% of the patients were non compliant with the antihypertensive drugs, ( 55%males and 45% females), Statistically significant factors were: young age( 62.5%), female gender (63.3%), low educational level (80.5%), being unemployed (71.7%), duration of hypertension > 10 years( 65.2%), and when the source of medication was from health care centers (75.6%).CONCLUSION: A significant percentage of the patients were non compliant with their anti-hypertensive drugs, the main causes of non compliance were patient, physician, and drugs related, respectively.


Article
The Effect of Hypertension and Beta-Blocker Antihypertensive Drug on Bone Mineral Density Value At the Mandibular Cortex in Mental and Gonial Regions in Hounsfield Unite Using Computed Tomographic Study
تأثير ارتفاع ضغط الدم نوع حاصرات (ب) على قيمة كثافة العظم في لحاء الحافة السفلى للفك الأسفل في منطقتي الثقب الذقني وزاوية الفك الأسفل بوحدة الهاونسفيلد باستخدام جهاز المفراس الحلزوني

Author: Marwa K. Hussein أحلام أحمد فتاح
Journal: Al-Rafidain University College For Sciences مجلة كلية الرافدين الجامعة للعلوم ISSN: 16816870 Year: 2016 Issue: 38 Pages: 33-47
Publisher: Rafidain University College كلية الرافدين الجامعة

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Abstract

Computed tomography is a medical technique that measures bone mineral density. Both hypertension and Beta-Blocker antihypertensive drug are associated with abnormality in calcium metabolism .The aim of this study was to study the effect of hypertension and Beta Blocker antihypertensive drug on bone mineral density in Hounsfield unite using computed tomography. Material and Method: This prospective study was conducted on computed tomographic image of 150 men aged between (35- 85) years. Data were grouped into three categories according to their blood pressure: normotensive group (n=50), Hypertensive treated for > 8 months group (n=50) and Untreated hypertensive/recently diagnosed group (n=50).. Bone mineral densities were measured in each sample in both mental and gonial areas in Hounsfield unite.Results: There were a statically significant difference in bone mineral density in both mental and gonial area among the three study groups. Bone mineral density was highest in group 2 and lowest in group 3. P value was < 0.001 among the three study groups. There was a positive linear correlation between bone mineral density and the duration of antihypertensive drug used and there was a negative linear correlation between bone mineral density and duration of hypertension diseaseConclusion: Computed tomography is a good diagnostic method to measure the value of bone mineral density in hypertensive patients. Bone mineral density is highly affected by increasing blood pressure and by antihypertensive treatment and affected by duration of the disease and the treatment.

المفراس الحلزوني هو التقنيه الطبيه التي تقيس كثافة العظم بمقياس ثابت ويحول وحدة القياس في صورة المفراس الهاونسفيلد الى قيم كثافة العظم. إرتفاع ضغط الدم مرتبط بعدم انتظام الايض الخلوي للكالسيوم. استمرار فقدان الكالسيوم قد يؤدي الى زيادة نقصان معادن العظم عند الاشخاص ذوي ضغط الدم العالي.من جهة اخرى مضادات المستقبلات غير الانتقائيه (ب) كضري المنشأ لديها تأثير على الايض الخلوي للعظم.العديد من الدراسات اقترحت انه حاصرات (ب) تحفز تكوين العظم وتثبط امتزاز العظم.هدف الدراسة: هو اكتشاف تأثير ارتفاع ضغط الدم والادويه المضادة لارتفاع ضغط الدم نوع حاصرات (ب) على قيمة كثافة العظم في لحاء الحافة السفلى للفك الاسفل في منطقتي الثقب الذقني وزاوية الفك الاسفل في وحدة قياس كثافة العظم الهاونسفيلد باستخدام جهاز المفراس. هذه الدراسة الاستعادية موصولة بصور مقطعيه بالمفراس الحلزوني لـ 150 رجل تتراوح اعمارهم بين 35 الى 85 سنة. البيانات صنفت الى ثلاث مجاميع حسب ضغط الدم: طبيعي ضغط الدم (50عينة) وذوي ضغط دم مرتفع يتناولون العلاج لأكثر من 8 أشهر (50عينة) والمجموعه الثالثة ذوي ضغط دم عالي بدون علاج أو المشخصين حديثا (50عينة). مؤشر كتلة الجسم كان في معدلاتها الطبيعية لجميع العينات المأخوذه في الدراسة.كثافة العظم تفحص لكل عينة في منطقتي الثقب الذقني وزاوية الفك الاسفل لوحدة هاونسفيلد لقياس كثافة العظم. النشاطات الفيزيائيه وثقت عن طريق ورقة استطلاع. وجد احصائيا ان هناك فرق ملحوظ في كثافة العظم في منطقتي الثقب الذقني وزاوية الفك الاسفل بين المجاميع الدراسية الثلاثة. حيث ان كثافة العظم هي الاعلى في المجموعه الثانية والاقل في المجموعه الثالثة. حيث ان القيمة المعنويه بين المجاميع الثلاثه عالية وكان هناك علاقة موجبه بين كثافة العظم ومدة استخدام الدواء المضاد لارتفاع ضغط الدم وهناك علاقة سالبة بين كثافة العظم ومدة الاصابة بمرض ارتفاع ضغط الدم.بعد تثبيت العمر ومدة المرض ومدة استخدام العلاج والوظائف الفيزيائيه فالقيمة المعنويه كانت عالية بين المجاميع الثانية والثالثة ووجد ان علاج ضغط الدم ومدته هما المؤشران القويان في كثافة العظم يليهما العمر ونوع العمل بمقياس الوظائف الفيزيائيه.الاستنتاج: كثافة العظم تتأثر جدا بإرتفاع ضغط الدم وبالادوية المضادة لارتفاع ضغط الدم وتتأثر بمدة المرض والعلاج.


Article
Antihypertensive Drugs patterns in Diabetes Mellitus and Their Impact on Glycemic Control

Author: Amir Omran
Journal: Karbala Journal of Medicine مجلة كربلاء الطبية ISSN: 19905483 Year: 2016 Volume: 9 Issue: 2 Pages: 2534-2542
Publisher: Kerbala University جامعة كربلاء

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Abstract

background: Hypertension management is paramount important in diabetic patients for cardiovascular events reduction. The utilization patterns of antihypertensive agents in diabetic patients must be consistent with recommended guidelines practice to produce a positive metabolic effect on glycemic control with proper control blood pressure and good compliance.Objectives: The study aims to evaluate utilization prescribing pattern of five groups of antihypertensive agents among Type2 diabetic hypertensive patients and to explore the adherence to prescribing existing guidelines and their impacts on glycemic control.Design: retrospective descriptive ,cross sectional studyPatients and Methods: A total of 230 Hypertensive Type2 diabetes patients on diet , Metformin and sulphonylureas drugs were enrolled in the study in diabetic clinic at Imam Al-Hussien medical city . The study was done between Jan 2009 And Jan 2014. The attendants' patients used five groups of the Anti-Hypertensive agents in single or in combinations patterns Angiotensin Converting enzymes inhibitor(ACEI), Angiotensin Receptor Blocker(ARB), Calcium Channels Antagonist(CCA), Beta Blocker(BB), Diuretics(Thiazide)). The study followed five groups of antihypertensive drugs for three months to evaluate prescribing patterns accordance to the evidence base guidelines and compare their impact on glycemic control. The study include gender, Age, age distribution, Glycemic control. The study excluded endocrine, liver, and renal diseases, and patients using steroids.Results: The majority of the patients on Antihypertensive drugs 191 patients (83%) were receiving monotherapy including ACEI 77 ( 33.5%) patient, ARB 46( 20%)patient, BB 60(26.1%) patint, CCB 6 patients (2.6%),Thiazide 2 (0.9%) patients, while two or three drugs combined patterns formed 39 ( 16.95%) patient.The proper and adequate glycemic control of both genders are 25.2% . The proper glycemic control of males 40.9% and in females16,7%( P˂0.05) , There were no significant differences of the impact on glycemic control compared between five groups, ACE or ARB compared with single BB (Atenolol, Metaprolol) or CCB, Diuretics, as monotherapy or polytherapy combination patterns. Conclusion; The utilization patterns of Antihypertensive agents (ACEI,ARBS,BBS) were more commonly prescribed followed by CCB, Thiazide Diuretics ,irrespective of mono or polytherapy. The majority of the patients were on monotherapy pattern.There was no significant difference among the five groups of Antihypertensive drugs regarding the impact on glycemic control.

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