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Article
7- DIAGNOSTIC VALUE OF ANTIBODIES TO CITRULLINE CONTAINING PEPTIDES IN PATIENTS WITH RHEUMATOID ARTHRITIS IN SOUTHERN IRAQ43

Authors: & THURAYA J MEZAL --- ADNAN T AL-KHAFAJI --- HASSAN J HASONY --- ALI M BARAKAT
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2009 Volume: 15 Issue: 1 Pages: 43-50
Publisher: Basrah University جامعة البصرة

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Abstract

A serological study has been done in Al-Nassiriyha, southern Iraq, from December 2006 toAugust 2007 designed to determine the frequency of anti-cyclic citrullinated peptide antibody(anti-CCP) in a group of patients with rheumatoid arthritis for specific period of time comparedwith other rheumatic diseases and healthy controls. Also to show the diagnostic value ofanti-CCP antibody in relation to other markers [rheumatoid factor (RF), antinuclear factor (ANF),C-reactive protein (CRP) and cytokines such as interleukin–6 (IL-6), tumor necrosis factor–α(TNF-α)] to discriminate between those patients with and without RA.Blood samples were taken from 121 patients with rheumatoid arthritis, 88 patients of otherrheumatic diseases from AL-Hussein Teaching Hospital in AL-Nassiriyah and 120 healthycontrols from medical personnel and school students who were healthy. All the information wastaken from the patients and controls.An Enzyme-linked immunosorbent assay was used for estimation of anti-CCP, IL-6, TNF-α andslide agglutination test for the estimation of RF, CRP and ANF. The seropositivity to anti-CCP inRA patients group was 61.2% among them 23% with low levels of anti-CCP, 25% withmoderate levels and 51.3% with high levels (> 60 units /ml.).The high levels of anti-CCP persistfor long durations up to 10 years (54.7%). However, anti-CCP was rarely detected among non-RA rheumatic diseases and healthy controls (2.3% and 2.5% respectively). Anti-CCP showedthe greater specificity (97.6%) and sensitivity (61.2%) compared to the other marker used in thisstudy. The overall agreement between the tested parameters in their ability to detect RA patientwas higher for anti-CCP combined to IL-6 (91.7%) in comparison to the effect of other markerscombination. Although anti-CCP was more common in RA patient with 2-10 years duration ofillness, anti-CCP, IL-6 and TNF-α positivity as estimated by ELISA were persistently with hightiters regardless the duration of illness. The majority of RA patients with high anti-CCP levelswere among stage three of clinical RA. Smoking has a positive relation to the increased levelsof all tested parameters compared to the non-smokers.

Keywords

RHEUMATOID --- ARTHRITIS


Article
Incdence of Rheumatoid Arthritis [2001 to 2011]

Author: Ali Mohammed Hussein Alkazzaz
Journal: Iraqi Academic Scientific Journal المجلة العراقية للاختصاصات الطبية ISSN: 16088360 Year: 2013 Volume: 12 Issue: 4 Pages: 568-572
Publisher: The Iraqi Borad for Medical Specialization المجلس العراقي للاختصاصات الطبية

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Abstract

ABSTRACT: BACKGROUND :The incidence of rheumatoid arthritis[RA] varies from country to another which not depend on genetic bases alone but can explained by environmental exposure and genetic and environmental interaction, area of military conflict ,there was stress induced pathway that elevates the risk for rheumatoid arthritis, in Iraq rheumatoid was 1% of population in 1975.OBJECTIVE:To evaluate incidence of RA in Babylon –Iraq from 2001-2011PATIENTS AND METHODS:This study was done to examine the incidence of RA in Babylon between 2001-2011 by Retrospective cohort study in Merjan Teaching Hospital ,Rheumatology unit .Data included sex .birth year ,residency and latex test , from 2001 to 2011.All patients were diagnosed as Rheumatoid Arthritis according to American College of Rheumatology ACR 1987revised criteria of RA .the numbers of patients of RA who were received DMRADs included methotrxate therapy were recorded each year and incidence of each year was found then the cumulative incidence was calculated.RESULTS: There were1039 patients with rheumatoid arthritis from 53786 patients in rheumatology unit. 50.1% living in urban area while 49.9% in rural area. The incidence in 2001 was 1.60 while in 2011 was 3.02 for the same population and the cumulative incidence in 2011 was22.74. Latex test was 52% in2001 while in2011 was 58% in rheumatoid patients in the same year. The P value for age mean difference between female and male was [0.009].CONCLUSION:The incidence of RA was increasing from 1.60% in 2001 to 3.02% in 2011 and the cumulative risk wasb22.74% in Babylon –Iraq.KEY WARDS: rheumatoid arthritis.


Article
TUBERCULOUS ARTHRITIS IN MISSAN GOVERNORATE

Authors: Zamil Shiaa Al-A reeby --- Yaseen Obaid Yaseen
Journal: Misan Journal of Acodemic Studies مجلة ميسان للدراسات الاكاديمية ISSN: 1994697X Year: 2016 Volume: 15 Issue: 30 Pages: 1-11
Publisher: Misan University جامعة ميسان

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Abstract

SummaryIn this study ,records of 696 patients with different types of tuberculosiswere reviewed. Tuberculous arthritis was recognized in 5.3% of all cases withtuberculosis, a finding that seems to be comparable to or a bit higher than insome other countries. Men were been more affected by tuberculous arthritis thanwomen. Spines were found to be at the top of list of affected joints (43.3%),while , sternoclavicular, wrist, and distal interphalyngeal were found to be theleast affected joints (2.7% for each). Pulmonary tuberculosis was found to be themost common associating disease or risk factors for TB of the joint .Aim of the studyTo shed light on the problem and extent of joint involvement in patients withtuberculosis in Missan governorate, so that to consider preventive andtherapeutic measures to decrease the impact of this disease on public health


Article
Dyslipidemia and biological agents among a sample of patients attending Baghdad Teaching Hospital

Authors: Atta AH Mousa --- Ali Hussein --- Nazar Abdull Latif
Journal: IRAQI JOURNALOF COMMUNITY MEDICINE المجلة العراقية لطب المجتمع ISSN: 16845382 Year: 2016 Volume: 29 Issue: 3 Pages: 129-132
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Background: Tumor necrosis factor-alpha (TNF-α) is a multifunctional pro-inflammatory cytokine that had a major role in the etio-pathogenesis of psoriasis and psoriatic arthritis, rheumatoid arthritis, inflammatory bowel disease (IBD), and other dermatologic and rheumatologic conditions. A new era in the treatment of rheumatic diseases began with the development of TNF-α-inhibitorsObjectives: To evaluate lipid profile changes after anti-TNF therapy in patients with psoriatic, rheumatoid arthritis and ankylosing spondylitis Patients & Methods: A prospective study included 90 patients presenting with ((30) Psoriatic arthritis, (30) ankylosing spondylitis (30) rheumatoid arthritis (who were treated with anti-TNF therapy (infliximab, rituxmab etanercept) and assessed during follow-up period after 6month of therapy.Results: Regarding (TC,TG, HDL and LDL) Significance differences(p<0.000) were seen after biological therapy with infliximab infusion in patients with psoriatic arthritis , The current study had Significance differences regarding TG and HDL after 6 month of treatment of rheumatoid arthritis patients with rituximab., Significance differences were seen regarding TG and LDL in ankylosing spodylitis patients treated with etanerceptConclusion: Significance differences were seen regarding lipid profile and antitumor necrosis factor alpha therapy regarding psoriatic ,Rheumatoid arthritis and ankylosing spondylitis


Article
Rheumatoid Arthritis of the Temporomandibular Joint, A Clinical and Radiographical Study

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Abstract

To determine the extent of temporomandibular joint (TMJ) involvement in patients with rheumatoid arthritis compared with a matched control group. And to evaluate the correlation between clinical findings and radiographical findings.The studied sample comprised 50 patients with rheumatoid arthritis, age ranged from 18 to 72 years with the mean age of 40.98 (± 13.67.The control group consisted of 63 subjects age–matched non rheumatic patients: Each patient was informed about the purpose of the investigation and that it would include questionnaire, clinical and radiographical examinations. The radiographic examination was done by using double TMJ lateral panoramic technique.It was found that 64% of RA patients complained of two or more clinical signs and symptoms compared with 44% of the control group ,the difference was statistically significant (P< 0.05), the most important clinical findings were pain on palpation and on opening and closing, crepitation, limitation of jaw opening and morning stiffness, difference were statistically significant (P< 0.05). Among the clinically involved subjects in study RA group 28 subjects (56%) had bilateral involvement, 3 subjects (6%) had right side involved and 1 subject (2%) had only left side involvement. The radiographic involvement of TMJ was found in 16 subjects (32.0 %) of the study group compared with 1subject (1.6 %) of the control group. There is a highly statistically significant difference between the study group and the control group (P< 0.05); the most common radiographical finding was erosion. Complete condylar destruction was found in 1 patient which resulted in anterior open bite. Among involved cases 11 subjects (22%) had bilateral involvement, 5 subjects (10%) had unilateral involvement (3subjects (6%) had left side involved and, 2 (4 %) subjects had only right side involved. There was no correlation between clinical and radiographic find ings. There was correlation between the extent of radiographical findings and duration of Rheumatoid Arthritis p value (P< 0.05).The clinical and radiographic findings were more common in RA group than in control individual. The clinical and radiographic findings are not always bilateral in TMJs of patients withrheumatoid arthritis.


Article
Arthroscopy in the treatment of knee septic arthritis

Authors: Ahmad I. Al- Jibbory احمد الجبوري --- Mahmood A. Aljumaily محمود عبد الجميلي
Journal: Annals of the College of Medicine Mosul مجلة طب الموصل ISSN: 00271446 23096217 Year: 2007 Volume: 33 Issue: 1&2 Pages: 20-25
Publisher: Mosul University جامعة الموصل

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Abstract

Objective: to evaluate the use of arthroscopic irrigation in the treatment of septic arthritis of the knee joint.Methods: This case series study. Was conducted in Al-Jamhori Teaching Hospital in Mosul, from August 2003 to December 2005, on twenty patients with septic arthritis of knee joint who presented with pain, fever, swelling and limitation of movements of their affected knee joint. The mean age of the patients was 31.5 years, and the female to male ratio was 1:1.5. Arthroscopic irrigation was arranged within 24 hours of admission, suction drain used, with the use of intravenous antibiotic for 7 days then change to oral antibiotic for 5-6 weeks. laboratory investigation and X-ray were done, aspiration of synovial fluid was send for analysis, direct gram stain, culture and sensitivity.Results: Synovial biopsy confirmed the diagnosis and showed typical changes of septic arthritis. We achieved 60% excellent, 30% good and 10% acceptable results of the knee joint depending on clinical evaluation and laboratory investigation. Most of patients were delayed in presentation. Staphylococcus aureus was the commonest causative organism. Conclusion: Arthroscopic irrigation of knee joint has encouraging results in the treatment of septic knee with low incidence of complications.

الهدف: تقييم الرحض المنظاري في معالجة التهاب مفصل الركبة الخمجي.التصميم: دراسة حالات متتابعة.المكان: أجريت الدراسة في المستشفى الجمهوري التعليمي في الموصل للفترة من آب 2003 إلى كانون الأول 2005م . المشاركون : عشرون مريضاً يشكون من التهاب مفصل الركبة الخمجي , يعانون من الآلام , ارتفاع في درجة الحرارة , تورم وتحدد في حركات مفصل الركبة المصابة.الطرق : أجريت الاستقصاءات المختبرية والرقائق الشعاعية وسفط سوائل الركبة وإرسالها إلى التحليل والزرع والحساسية. الرحض ألمنظاري رتب خلال 24 ساعة من دخول المريض مع اخذ خزع من بطانة المفصل. استخدم مصرف ارتشافي مع استخدام مصدات حيوية .النتائج: وجدنا ارتفاع في معدل تثقل كريات الدم الحمر وبروتين سي المستحث. وارتفاع عدد كريات الدم البيض في السائل المفصلي متجاوزة حد الحساب وكانت المكورات العنقودية البرتقالية هي المسبب الشائع. حققنا نتائج 60% ممتاز و 30% جيد و10% مقبول وظيفيا معتمدين على التقييم ألسريري والاستقصاءات المختبرية. كان اغلب المرضى متأخرين في التشخيص و المعالجة.الاستنتاج: الترحيض ألمنظاري لمفصل الركبة هو بديل جيد للتداخل الجراحي مع نسبة اقل من المضاعفات.

Keywords

Arthroscopy --- arthritis --- septic


Article
Hand Deformities in Patients with Rheumatoid Arthritis

Author: R. R. Merza
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2009 Volume: 8 Issue: 1 Pages: 27-32
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective To estimate the types of hand deformities in patients with rheumatoid arthritis (RA). Methods: A group of 100 patients who had been admitted to the department of rheumatology and rehabilitation center in Sulaimany general hospital and those who had been attended to the rheumatology and rehabilitation center between June 2006 and January 2007 were included in this study.86% were females and 14% were males . Patients who had undergone articular surgery and patients below 16 years had been excluded. Results Hand deformities recorded in 47% of cases. The frequency of deformities was as follow; swan neck deformity (48.90%), boutonniere deformity (43.04%), Z deformity(59.5%), ulnar deviation of the metacarpophalangeal joints (MCPJ) (78.7%), radial deviation of the wrist (91.48%), subluxation of the wrist (27.6%), and subluxation of the MCPJ(36.17%).There was a significant correlation between disease duration and development of deformities,other factors that had been studied but had no effect on the development of deformities were rheumatoid factor positivity ;occupation of the patients ;effect of weather;and geographical distribution of the patients. Conclusion Rheumatoid arthritis is an important disease that affects the hands and cause deformities. Understanding these deformities is necessary for the proper management of these patients. This study is representative for RA related hand deformities and factors that contribute to their development.


Article
Hand Deformities in Patients with Rheumatoid Arthritis

Author: R.R.Merza
Journal: Mustansiriya Medical Journal مجلة المستنصرية الطبية ISSN: 20701128 22274081 Year: 2008 Volume: 7 Issue: 2 Pages: 27-32
Publisher: Al-Mustansyriah University الجامعة المستنصرية

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Abstract

Objective: To estimate the types of hand deformities in patients with rheumatoid arthritis (RA).Methods: A group of 100 patients who had been admitted to the department of rheumatology and rehabilitation center in Sulaimany general hospital and those who had been attended to the rheumatology and rehabilitation center between June 2006 and January 2007 were included in this study.86% were females and 14% were males . Patients who had undergone articular surgery and patients below 16 years had been excluded.Results: Hand deformities recorded in 47% of cases. The frequency of deformities was as follow; swan neck deformity (48.90%), boutonniere deformity (43.04%), Z deformity(59.5%), ulnar deviation of the metacarpophalangeal joints (MCPJ) (78.7%), radial deviation of the wrist (91.48%), subluxation of the wrist (27.6%), and subluxation of the MCPJ(36.17%).There was a significant correlation between disease duration and development of deformities,other factors that had been studied but had no effect on the development of deformities were rheumatoid factor positivity ;occupation of the patients ;effect of weather;and geographical distribution of the patients.Conclusion: Rheumatoid arthritis is an important disease that affects the hands and cause deformities. Understanding these deformities is necessary for the proper management of these patients. This study is representative for RA related hand deformities and factors that contribute to their development.


Article
RADIOLOGICAL STUDY USING STATIC MAGNETIC FIELD AND CONVENTIONAL TREATMENT TO TREAT ARTHRITIS IN RABBIT: COMPARATIVE STUDY.
دراسة إشعاعية لاستخذام مجال مغناطيسي مستقر و العلاج التقليدي لعلاج التهاب المفصل في الارانب ,دراسة مقارنة

Author: Rafid Majeed Naeem Hussein رافد مجيد نعيم
Journal: Basrah Journal of Veterinary Research. مجلة البصرة للابحاث البيطرية ISSN: Print:18138497 E; 24108456 Year: 2012 Volume: 11 Issue: 1 Pages: 334-341
Publisher: Basrah University جامعة البصرة

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Abstract

Fifteen rabbits were used in present study, all rabbits were infected with septic arthritis experimentally by injection Staphylococcus aurous (108 diluted) in knee joint. Animals were divided into three groups, 1st group which was treated with static magnatic field 350 gaus/daily; 2nd group was treated with penicillin- streptomycin (antibiotics) and dexamethazone (anti inflammatory drug) daily and 3rd group was control group which leaved without treatment. After seven days, 1st and 2nd groups were not different in radiographic image and there were no degenerative change in the articular surface of the joints, but in control group we found degenerative change in the aticular surface. In total white blood cell count of the synovial fluid, there were no significant change in 1st and 2nd group because of normal synovial fluid were founded in 1st and 2nd groups but in control the synovial fluid is turbid and containing high number of white blood cells. In conclusion both treatments (the magnetic field therapy and antibiotics and anti inflammatory treatment) were efficient and statically significant, so we can use the magnetic therapy as replacement to treat septic arthritis


Article
10-THE MEANING OF DACTYLITIS IN PATIENTS WITH ITH PSORIATIC ARTHRITIS

Authors: ABDALLRAHMAN ALRASHIDI --- FAISAL ALSAQABI
Journal: Basrah Journal of Surgery مجلة البصرة الجراحية ISSN: 16833589 / ONLINE 2409501X Year: 2009 Volume: 15 Issue: 1 Pages: 61-66
Publisher: Basrah University جامعة البصرة

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Abstract

This study aimed to describe dactylitis in a cohort of patients resident in Kuwait with psoriaticarthritis followed prospectively in our Rheumatology clinic and identify whether dactylitis isassociated with a worse outcome in patients with psoriatic arthritis.Between 2005 and 2008, (53) patients with psoriatic arthritis in Kuwait were followedprospectively every two months intervals and all patients files information were searched forpatients with dactylitis. Descriptive statistics were used to describe the population and x2 tests torelate dactylitis to radiographic changes.Dactylitis was documented in 32 patients (59%); 70% most of the cases were recorded atpresentation to the clinic. Dactylitis affected feet only in 63% of cases, hands only in 12%, andboth hands and feet in 5%. Recurrent dactylitis occurred in 36% of the patients. Increasedradiological progression was noted in digits showing dactylitis compared with those withoutdactylitis (54% v 31%, respectively; p<0.0001).It is concluded that dactylitis is common among patients with psoriatic arthritis resident inKuwait. It most often affects the feet, in an asymmetrical distribution. It is associated with agreater degree of radiological damage than occurs in digits not affected by dactylitis.

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